Sedimentasi Dan Dampaknya Pada Dps Citarum Hulu

Pemanfaatan air dan lahan dan pengembangan suatu daerah aliran sungai selalu menyebabkan berbagai masalah teknis dan lingkungan. Begitu pula dengan lebih mendalami masalah proses erosi dan sedimentasi yang terjadi, merupakan hal yang sangat penting dalam memecahkan masalah dasar yang berkaitan dengan tingginya tingkat erosi dan sedimentasi dalam suatu daerah aliran sungai. Proses sedimentasi yang komplek agar dapat dipecahkan, untuk itu sungai harus dipandang dari berbagai unit kelompok yang terintegrasi dalam suatu ekosistem. Dengan pendekatan pengukuran dan monitoring, serta penggabungan dengan pendekatan sistem model spasial dapat dipecahkan masalah yang timbul di per sungaian dan waduk, ehingga antisipasi terhadap berkurangnya umur waduk dapat diatasi. Dengan prediksi erosi dan sedimentasi secara spasial dapat diperoleh gambaran yang lebih jelas daerah-daerah mana saja yang terkena tingkat erosi-sedimentasi yang tinggi, sehingga daerah mana saja dalam DAS yang perlu konservasi dan prioritas penanggulangannya. Dan konservasi yang tepat pada DAS Citarum hulu dapat menurunkan laju sedimentasi, sehingga diharapkan umur waduk Saguling akan lebih panjang

Pengaruh Penerapan System Manajemen Mutu Iso 9001-2000 terhadap Mutu Pelayanan Instalasi Rawat Darurat

Penelitian ini didasarkan pada tuntutan pelanggan terhadap mutu produk pelayanan dan peningkatan perbaikan pelayanan yang berkesinambungan dalam rangka menghadapi globalisasi dan untuk memenangkan persaingan. Mutu pelayanan di rumah sakit merupakan salah satu tolok ukur untuk keunggulan daya saing guna memuaskan pelanggan. Salah satu metode yang digunakan adalah sistem manajemen mutu berstandar Internasional ISO 9001:2000 Guna mengetahui seberapa besar pengaruh ISO terhadap mutu pelayanan, maka dilakukan penelitian pengukuran sesudah kejadian (ex post facto design). dengan variabel yang akan diteliti adalah mutu pelayanan. Penelitian ini melibatkan Pasien yang dirawat Unit Gawat Darurat yang telah menerapkan ISO 9001:2000, sebanyak 61 orang. Berdasarkan hasil analisis diperoleh hasil bahwa ada hubungan anata manajemen mutu ISO 9001:2000 terhadap mutu pelayanan di IRD RSD Kabupaten Jombang

Excitation of surface plasmons in thin noble metallic film of copper, silver and gold paper

The formation of surface plasmons in a different type of noble metallic film was successfully simulated using MATLAB program software. The thicknesses of copper, silver and gold metal films were varied between 20 nm to 80 nm. The narrowness and depth of surface plasmon resonance (SPR) curves were observed to determine the excitation of surface plasmons. The simulation results indicate that the maximum excitation of surface plasmons can be achieved by using silver thin film with thicknesses of 50 nm at the minimum reflectivity of 0.0038 a.u and full width at half maximum value of 0.2592°. The silver film that produces a deeper and sharper SPR curve has potential in the development of a low cost and high sensitivity of SPR sensing device

Association of Physical Activity with Co-morbid Conditions in Geriatric Population

To find out association of physical activity with co-morbid conditions in geriatric population, a cross-sectional study was conducted in different cties of Pakistan in 2015. A total of 114 participants were inducted by non-probability convenience sampling technique. Data was collected after informed verbal consent by a validated questionnaire that is Rapid Assessment of Physical Activity (RAPA). Participants were categorized into two groups i.e. physically active and physically inactive. Data was entered and analyzed in SPSS version 20. There were 66 (57.9%) males and 48 (42.1%) females with mean age of 57.04±7.348 years. Among hypertensive individuals (n=43, 37.7%) there were 39 (90.7%) physically inactive, among individuals having angina (n=17, 14.9%) there were 15 (88.2%) physically inactive. Out of 37 (32.5%) diabetics, 35 (94.6%) were physically inactive. Among individuals suffering from arthritis (n=40, 35.1%), there were 38 (95%) physically inactive. A significant association was found between physical activity and diabetes and arthritis with p-value of 0.048 and 0.029 respectively. Physical activity is significantly associated with diabetes and arthritis in geriatric population. Adequate physical activity should be performed to reduce the risk of co-morbid conditions and improve the quality of life in geriatric population

Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels

Endothelial lipase (LIPG) and zinc finger protein 202 (ZNF202) are two pivotal genes in high density lipoprotein (HDL metabolism). We sought to determine their genetic contribution to variation in HDL-cholesterol levels by comprehensive resequencing of both genes in 235 individuals with high or low HDL-C levels. The selected subjects were 141 Whites (High HDL Group: n = 68, x¯=76.90mg/dl; Low HDL Group: n = 73, x¯=32.55mg/dl) and 94 Hispanics (High HDL Group: n = 46, x¯=74.85mg/dl; Low HDL Group: n = 48, x¯=29.95mg/dl). We identified a total of 185 and 122 sequence variants in LIPG and ZNF202, respectively. We found only two missense variants in LIPG (T111I and N396S) and two in ZNF202 (A154V and K259E). In both genes, there were several variants unique to either the low or high HDL group. For LIPG, the proportion of unique variants differed between the high and low HDL groups in both Whites (p = 0.022) and Hispanics (p = 0.017), but for ZNF202 this difference was observed only in Hispanics (p = 0.021). We also identified a common haplotype in ZNF202 among Whites that was significantly associated with the high HDL group (p = 0.013). These findings provide insights into the genetics of LIPG and ZNF202, and suggest that sequence variants occurring with high frequency in non-exonic regions may play a prominent role in modulating HDL-C levels in the general population

Biohydrolysis of Saccharum spontaneum for cellulase production by Aspergillus terreus

Saccharum spontaneum, a wasteland weed, is utilized for cellulase production by Aspergillus terreus in solid state fermentation. S. spontaneum served as good carbon source and solid support. Various process parameters including optimal nitrogen source, initial moisture level, incubation time, initial pH, incubation temperature and inoculum size were evaluated. The maximum cellulase production was attained at 70% of initial moisture with incubation of 96 h at 30±2°C, and pH 4.5. Ammonium sulphate in concentration of 0.2% (w/w) was the most preferable nitrogen source among all tested nitrogen sources. The results indicate that S. spontaneum could be utilized as a substrate in solid state fermentation (SSF) for economic production of cellulase.Key words: Cellulase, solid state fermentation, Saccharum spontaneum, Aspergillus terreus

The genetics of intellectual disability: advancing technology and gene editing [version 1; peer review: 2 approved]

Intellectual disability (ID) is a neurodevelopmental condition affecting 1–3% of the world’s population. Genetic factors play a key role causing the congenital limitations in intellectual functioning and adaptive behavior. The heterogeneity of ID makes it more challenging for genetic and clinical diagnosis, but the advent of large-scale genome sequencing projects in a trio approach has proven very effective. However, many variants are still difficult to interpret. A combined approach of next-generation sequencing and functional, electrophysiological, and bioinformatics analysis has identified new ways to understand the causes of ID and help to interpret novel ID-causing genes. This approach offers new targets for ID therapy and increases the efficiency of ID diagnosis. The most recent functional advancements and new gene editing techniques involving the use of CRISPR–Cas9 allow for targeted editing of DNA in in vitro and more effective mammalian and human tissue-derived disease models. The expansion of genomic analysis of ID patients in diverse and ancient populations can reveal rare novel disease-causing genes