Setting Expectations: An Onsite Orientation for Intern Abroad Programs in London

International internships have been continuously rising in popularity over the past decade, with participation in work, internships, and volunteering abroad (WIVA) more than tripling over a ten year span from 1999/2000 to 2010/2011(Farrugia, 2013). One of the most important elements of an intern abroad program is to set expectations so that students can have a successful program, both personally and professionally. The onsite orientation is therefore a vital piece of an effective intern abroad program. Setting Expectations: An Onsite Orientation for Intern Abroad Programs in London is a four-day orientation program in London, England developed for participants in the Intern in London program administered by London Study Abroad Experience (SAE). This orientation has been redesigned to fit the specific needs of the students in order to equip them with the tools necessary for a positive internship experience, and prepare them for future endeavors. With a strong focus on experiential learning, the orientation engages participants during every aspect of the program. Participants will gain knowledge about the city, its history and culture, health and safety information, and business etiquette specific to their internship program. This program design is grounded in the theoretical underpinnings of experiential learning, diverse learning styles, and student development; and emphasizes the importance of onsite orientations. Key stakeholders were surveyed and interviewed in order to develop a well-rounded and successful orientation. Staff and participants evaluate its effectiveness in order to continuously improve the onsite programming

cpc-3, the Neurospora crassa Homologue of Yeast GCN2, Encodes a Polypeptide with Juxtaposed eIF2α Kinase and Histidyl-tRNA Synthetase-related Domains Required for General Amino Acid Control

Based on characteristic amino acid sequences of kinases that phosphorylate the α subunit of eukaryotic translation initiation factor 2 (eIF2α kinases), degenerate oligonucleotide primers were constructed and used to polymerase chain reaction-amplify from genomic DNA of Neurospora crassa a sequence encoding part of a putative protein kinase. With this sequence an open reading frame was identified encoding a predicted polypeptide with juxtaposed eIF2α kinase and histidyl-tRNA synthetase- related domains. The 1646 amino acid sequence of this gene, called cpc-3, showed 35% positional identity over almost the entire sequence with GCN2 of yeast, which stimulates translation of the transcriptional activator of amino acid biosynthetic genes encoded by GCN4. Strains disrupted for cpc-3 were unable to induce increased transcription and derepression of amino acid biosynthetic enzymes in amino acid-deprived cells. The cpc-3 mutation did not affect the ability to up-regulate mRNA levels of cpc-1, encoding the GCN4 homologue and transcriptional activator of amino acid biosynthetic genes in N. crassa, but the mutation abolished the dramatic increase of CPC1 protein level in response to amino acid deprivation. These findings suggest that cpc- 3 is the functional homologue of GCN2, being required for increased translation of cpc-1 mRNA in amino acid-starved cells

Características acústicas de las vocales del español de Chile producidas por sujetos residentes en la ciudad de Santiago

The aim of this study was, firstly, to describe the acoustic characteristics of isolated vowels produced by Chilean young people from Santiago, Chile, secondly, to compare the results obtained between men and women and, finally, to compare the data with information collected from Argentinian speakers (Rio de la Plata) and Chilean speakers (Concepción). 117 university students were selected for this study. Neither vocal nor auditory pathologies were found in the participants. Vowels produced by the participants were registered in isolation and they were analyzed using the software PRAAT. In general, the comparison shows that women from Santiago produce higher frequency than men in the analyzed formants (F0, F2, F3 y F4), except in F1. It was also observed that women and men from Santiago show a higher F0 formant than speakers from Rio de la Plata. Finally, no differences were found between speakers from Santiago and speakers from Concepción. In each comparison, a detailed description of the vowel formants is also presented.El presente estudio tuvo por objetivos describir las características acústicas de las vocales aisladas en jóvenes chilenos residentes en Santiago, comparar en ellos los resultados obtenidos para hombres y mujeres y también realizar una comparación con datos de hablantes en Río de la Plata (Argentina) y de Concepción (Chile). Se seleccionó una muestra de 117 estudiantes universitarios en quienes se descartó patología vocal y auditiva. Se registraron las voces de los sujetos produciendo las vocales aisladas y, posteriormente, se analizaron sus registros vocales con el software PRAAT. En general, en las comparaciones se advierte que en los sujetos de Santiago las mujeres presentan mayor frecuencia que los hombres en los formantes analizados (F0, F2, F3 y F4) excepto en F1. A su vez, las mujeres y hombres de Santiago evidencian una F0 mayor que sus pares rioplatenses. Por último, no se advierten diferencias importantes en la comparación con hablantes de Concepción. En cada comparación, se comentan también en forma detallada los formantes de cada una de las vocales

A systematic review of factors influencing spatiotemporal variability in urban water and energy consumption

Understanding which factors influence urban metabolism is a prerequisite for designing policies and plans that effectuate sustainable resource management. A growing number of publications is concerned with these factors. Yet, this emerging field of research lacks a common framework that supports researchers in interpreting their findings, such as generalizability to other cities, and making informed decisions on their research design. Aiming to contribute to building such a framework, we systematically reviewed urban metabolism literature. This review paper presents an overview of factors influencing urban water and energy consumption and their effect on consumption, and it describes the interconnectedness of these factors for six different types of relationships. Results disclose fourteen drivers, changes in societal context that shape consumption patterns, and twenty-one facilitators/constraints. The latter type of factors include consumer, resource and urban landscape characteristics that affect resource consumption by facilitating or constraining specific activities. Findings indicate commonalities between primary studies in terms of prevalent observed effect direction for a given factor. However, the interconnections between different factors can influence the direction and magnitude of effects and thereby result in case-specific variability in consumption patterns. Future research should enhance the understanding of these interconnections, strengthen the evidence for the factors presented here and provide insight in additional factors of influence. It is essential to align these studies in terms of a common terminology, transparent quality assessment and a unified approach to measuring and expressing factors of influence. Connecting with related disciplines working on a common systems approach is key to realize the full potential of urban metabolism research to advance our understanding of cities.</p

Perceptions of recent medical graduates and their workplace supervisors towards a medical school clinical audit program

Objectives: This study explores how medical graduates and their workplace supervisors perceive the value of a structured clinical audit program (CAP) undertaken during medical school. Methods: Medical students at the University of Notre Dame Fremantle complete a structured clinical audit program in their final year of medical school. Semi-structured inter-views were conducted with 12 Notre Dame graduates (who had all completed the CAP), and seven workplace supervisors (quality and safety staff and clinical supervisors). Purposeful sampling was used to recruit participants and data were analysed using thematic analysis. Results: Both graduates and workplace supervisors perceived the CAP to be valuable. A major theme was that the CAP made a contribution to individual graduate’s medical practice, including improved knowledge in some areas of patient care as well as awareness of healthcare systems issues and preparedness to undertake scientifically rigorous quality improvement activities. Graduates perceived that as a result of the CAP, they were confident in undertaking a clinical audit after graduation. Workplace supervisors perceived the value of the CAP beyond an educational experience and felt that the audits undertaken by students improved quality and safety of patient care. Conclusions: It is vital that health professionals, including medical graduates, be able to carry out quality and safety activities in the workplace. This study provides evidence that completing a structured clinical audit during medical school prepares graduates to undertake quality and safety activities upon workplace entry. Other health professional faculties may be interested in incorporating a similar program in their curricula

Inequality in cataract blindness and services: moving beyond unidimensional analyses of social position.

OBJECTIVE: Inequalities in cataract blindness are well known, but data are rarely disaggregated to explore the combined effects of a range of axes describing social disadvantage. We examined inequalities in cataract blindness and services at the intersection of three social axes. METHODS: Three dichotomous social variables (sex (male/female); place of residence (urban/rural); literacy (literate/illiterate)) from cross-sectional national blindness surveys in Pakistan (2001-2004; n=16 507) and Nigeria (2005-2007; n=13 591) were used to construct eight subgroups, with disadvantaged subgroups selected a priori (ie, women, rural dwellers, illiterate). In each data set, the social distribution of cataract blindness, cataract surgical coverage (CSC) and effective cataract surgical coverage (eCSC) were examined. Inequalities were assessed comparing the best-off and worst-off subgroups using rate differences and rate ratios (RRs). Logistic regression was used to assess cumulative effects of multiple disadvantage. RESULTS: Disadvantaged subgroups experienced higher prevalence of cataract blindness, lower CSC and lower eCSC in both countries. A social gradient was present for CSC and eCSC, with coverage increasing as social position improved. Relative inequality in eCSC was approximately twice as high as CSC (Pakistan: eCSC RR 2.7 vs CSC RR 1.3; Nigeria: eCSC RR 8.7 vs CSC RR 4.1). Cumulative disadvantage was observed for all outcomes, deteriorating further with each additional axis along which disadvantage was experienced. CONCLUSIONS: Each outcome tended to be worse with the addition of each layer of social disadvantage. Illiterate, rural women fared worst in both settings. Moving beyond unidimensional analyses of social position identified subgroups in most need; this permits a more nuanced response to addressing the inequitable distribution of cataract blindness

Community perceptions of mental health needs: a qualitative study in the Solomon Islands

<p>Abstract</p> <p>Background</p> <p>Psychosocial and mental health needs in the aftermath of conflict and disaster have attracted substantial attention. In the Solomon Islands, the conceptualisation of mental health, for several decades regarded by policy makers as primarily a health issue, has broadened and been incorporated into the national development and social policy agendas, reflecting recognition of the impact of conflict and rapid social change on the psychosocial wellbeing of the community as a whole. We sought to understand how mental health and psychosocial wellbeing were seen at the community level, the extent to which these issues were identified as being associated with periods of 'tension', violence and instability, and the availability of traditional approaches and Ministry of Health services to address these problems.</p> <p>Methods</p> <p>This article reports the findings of qualitative research conducted in a rural district on the island of Guadalcanal in the Solomon Islands. Key informant interviews were conducted with community leaders, and focus groups were held with women, men and young people. Wellbeing was defined broadly.</p> <p>Results</p> <p>Problems of common concern included excessive alcohol and marijuana use, interpersonal violence and abuse, teenage pregnancy, and lack of respect and cooperation. Troubled individuals and their families sought help for mental problems from various sources including chiefs, church leaders and traditional healers and, less often, trauma support workers, health clinic staff and police. Substance-related problems presented special challenges, as there were no traditional solutions at the individual or community level. Severe mental illness was also a challenge, with few aware that a community mental health service existed. Contrary to our expectations, conflict-related trauma was not identified as a major problem by the community who were more concerned about the economic and social sequelae of the conflict.</p> <p>Conclusion</p> <p>Communities identify and are responding to a wide range of mental health challenges; the health system generally can do more to learn about how this is being done, and build more comprehensive services and policy on this foundation. The findings underscore the need to promote awareness of those services which are available, to extend mental health care beyond urban centres to rural villages where the majority of the population live, and to promote community input to policy so as to ensure that it 'fits' the context.</p

Impairment of chondrocyte biosynthetic activity by exposure to 3-tesla high-field magnetic resonance imaging is temporary

The influence of magnetic resonance imaging (MRI) devices at high field strengths on living tissues is unknown. We investigated the effects of a 3-tesla electromagnetic field (EMF) on the biosynthetic activity of bovine articular cartilage. Bovine articular cartilage was obtained from juvenile and adult animals. Whole joints or cartilage explants were subjected to a pulsed 3-tesla EMF; controls were left unexposed. Synthesis of sulfated glycosaminoglycans (sGAGs) was measured by using [(35)S]sulfate incorporation; mRNA encoding the cartilage markers aggrecan and type II collagen, as well as IL-1β, were analyzed by RT–PCR. Furthermore, effects of the 3-tesla EMF were determined over the course of time directly after exposure (day 0) and at days 3 and 6. In addition, the influence of a 1.5-tesla EMF on cartilage sGAG synthesis was evaluated. Chondrocyte cell death was assessed by staining with Annexin V and TdT-mediated dUTP nick end labelling (TUNEL). Exposure to the EMF resulted in a significant decrease in cartilage macromolecule synthesis. Gene expression of both aggrecan and IL-1β, but not of collagen type II, was reduced in comparison with controls. Staining with Annexin V and TUNEL revealed no evidence of cell death. Interestingly, chondrocytes regained their biosynthetic activity within 3 days after exposure, as shown by proteoglycan synthesis rate and mRNA expression levels. Cartilage samples exposed to a 1.5-tesla EMF remained unaffected. Although MRI devices with a field strength of more than 1.5 T provide a better signal-to-noise ratio and thereby higher spatial resolution, their high field strength impairs the biosynthetic activity of articular chondrocytes in vitro. Although this decrease in biosynthetic activity seems to be transient, articular cartilage exposed to high-energy EMF may become vulnerable to damage