System of antioxidant protection of young cattle under cadmium load

It is known that free radical oxidation of lipids is an essential stage in the influence of heavy metals on the animal body. That is why the work aimed to investigate the indicators of the antioxidant system in young cattle under conditions of cadmium loading. For research, 15 clinically healthy six-month-old bulls of the black and spotted breed were selected, from which 3 groups of five animals were formed. The animals in the control group were on a regular diet. The animals of the experimental groups with compound feed were fed cadmium chloride in doses of 0.03 and 0.05 mg/kg of body weight. Feeding young cattle with cadmium chloride feed caused a decrease in the activity of the enzyme system of antioxidant protection of their body. These changes are confirmed by a decrease in their blood activity of superoxide dismutase by 31 %, catalase by 13.4 %, glutathione peroxidase by 23.2 %, glutathione reductase by 22.2 %, and glucose-6-phosphate dehydrogenase by 32.4 %, respectively. A decrease in the level of indicators of the non-enzymatic link of the system of antioxidant protection of the body of young cattle under cadmium load was also established, where, accordingly, a decrease in the content of reduced glutathione was established – by 10.4 %, selenium – by 14.8 %, vitamin A – by 31.3%, of vitamin E – by 30.8% in their blood compared to the control. It is worth noting that on the sixteenth and twenty-fourth days of the experiment, the lowest value of the enzymatic and non-enzymatic links of the antioxidant protection systems of young cattle under conditions of cadmium loading was observed. In the future, a practical scheme for preventing cadmium toxicosis in young cattle by studying indicators of the antioxidant system is planned

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial

Background: Bullous pemphigoid (BP) is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline conveys acceptable short-term blister control whilst conferring long-term safety advantages over starting treatment with oral corticosteroids. Methods: Pragmatic multi-centre parallel-group randomised controlled trial of adults with BP (≥3 blisters ≥2 sites and linear basement membrane IgG/C3) plus economic evaluation. Participants were randomised to doxycycline (200 mg/day) or prednisolone (0·5 mg/kg/day). Localised adjuvant potent topical corticosteroids (<30 g/week) was permitted weeks 1-3. The non-inferiority primary effectiveness outcome was the proportion of participants with ≤3 blisters at 6 weeks. We assumed that doxycycline would be 25% less effective than corticosteroids with a 37% acceptable margin of noninferiority. The primary safety outcome was the proportion with severe, life-threatening or fatal treatment-related adverse events by 52 weeks. Analysis used a regression model adjusting for baseline disease severity, age and Karnofsky score, with missing data imputed. Results: 132 patients were randomised to doxycycline and 121 to prednisolone from 54 UK and 7 German dermatology centres. Mean age was 77·7 years and 68.4% had moderate to severe baseline disease. For those starting doxycycline, 83/112 (74·1%) had ≤3 blisters at 6 weeks compared with 92/101 (91·1%) for prednisolone, a difference of 18·6% favouring prednisolone (upper limit of 90% CI, 26·1%, within the predefined 37% margin). Related severe, life-threatening and fatal events at 52 weeks were 18·5% for those starting doxycycline and 36·6% for prednisolone (mITT analysis), an adjusted difference of 19·0% (95% CI, 7·9%, 30·1%, p=0·001). Conclusions: A strategy of starting BP patients on doxycycline is non-inferior to standard treatment with oral prednisolone for short-term blister control and significantly safer long-term

Child Internalizing Problems in Ukraine: The Role of Prosocial and Antisocial Friends and Generalized Self-Efficacy

Child internalizing problems in Ukraine: the role of prosocial and antisocial friends and generalized self-efficacy / Viktor Burlaka, Oleksii Serdiuk, Valerii Sokurenko and etc. // Societies. – 2022. – Vol. 12, Issue 5. – Art. 144. – DOI: https://doi.org/10.3390/soc12050144.Burlaka, V.; Serdiuk, O.; Sung Hong, J.; O’Donnell, L.A.; Maksymenko, S.; Panok, V.; Danylenko, H.; Linskiy, I.; Sokurenko, V.; Churakova, I.; Ilchyshyn, N. Child Internalizing Problems in Ukraine: The Role of Prosocial and Antisocial Friends and Generalized Self-Efficacy. Societies 2022, 12, 144. https://doi.org/10.3390/soc12050144.Burlaka V, Serdiuk O, Sung Hong J, O’Donnell LA, Maksymenko S, Panok V, Danylenko H, Linskiy I, Sokurenko V, Churakova I, Ilchyshyn N. Child Internalizing Problems in Ukraine: The Role of Prosocial and Antisocial Friends and Generalized Self-Efficacy. Societies. 2022; 12(5):144. https://doi.org/10.3390/soc12050144Burlaka, Viktor, Oleksii Serdiuk, Jun Sung Hong, Lisa A. O’Donnell, Serhii Maksymenko, Vitalii Panok, Heorhii Danylenko, Igor Linskiy, Valerii Sokurenko, Iuliia Churakova, and Nadiya Ilchyshyn. 2022. "Child Internalizing Problems in Ukraine: The Role of Prosocial and Antisocial Friends and Generalized Self-Efficacy" Societies 12, no. 5: 144. https://doi.org/10.3390/soc12050144.У дослідженні обговорюються культурні та гендерні аспекти соціалізації дитини в контексті асоціальних і просоціальних друзів, а також розвиток проблем інтерналізованої поведінки.The current study examines the association between peer behaviors, self-efficacy, and internalizing symptoms in a sample of 1545 children aged 11 to 13 years old who attended middle schools in eastern Ukraine. We used structural equation modeling (SEM) to examine the role of self-efficacy in the relationship between child internalizing behaviors (anxiety, depression, and somatic complaints) and exposure to prosocial and antisocial friends among girls and boys. Higher self-efficacy was linked with fewer internalizing symptoms for girls and boys. For both boys and girls, exposure to prosocial friends was not statistically associated with changes in internalizing behaviors. However, girls and boys who reported having more antisocial friends had significantly more internalizing symptoms. For girls, association with a greater number of prosocial friends and fewer antisocial friends has been linked with higher self-efficacy and fewer internalizing symptoms. For boys, having more prosocial friends was also linked with higher self-efficacy and fewer internalizing symptoms; however, there was no statistically significant association between having more antisocial friends and self-efficacy. The study discusses the cultural and gender aspects of child socialization in the context of antisocial and prosocial friends, and the development of internalizing behavior problems.В исследовании обсуждаются культурные и гендерные аспекты социализации ребенка в контексте асоциальных и просоциальных друзей, а также развитие проблем интернализирующего поведения

Sulfamethoxypyridazine-responsive pemphigoid nodularis: a report of two cases.

Pemphigoid nodularis is a chronic and uncommon variant of bullous pemphigoid. The condition is characterized by the presence of prurigo nodularis-like lesions, possible history of blistering, and immunohistochemical findings of bullous pemphigoid. These patients are often unresponsive to conventional therapy with potent topical and systemic steroids and different immunosuppressive agents used alone or in combination. We describe two cases of pemphigoid nodularis treated successfully with sulfamethoxypyridazine without any adverse effects