Ductal-cutaneous fistula secondary to recurrent Bartholin’s cysts: a case report

Background: Disorders of the Bartholin’s duct and gland, including cyst and abscess formation, account for 2% of gynecologic visits annually. An uncommon complication of a Bartholin’s duct or gland abscess is fistula formation. Literature has described cases of recto-Bartholin’s and recto-vaginal fistulas. Case: We present a case of fistula development between the perineum and the Bartholin’s duct and gland. The patient was successfully managed with fistulectomy and Bartholin’s gland excision. Conclusion: Though fistula formation is a rare complication of Bartholin’s duct and gland pathology, investigation is warranted. A ductal-cutaneous fistula is possible in the setting of recurrent cysts located beyond the vaginal introitus. The best method of prevention is appropriate execution of a marsupialization. Complete removal of the fistulous tract and Bartholin’s duct and/or gland can result in resolution of symptoms

A Flavin-Binding Cryptochrome Photoreceptor Responds to Both Blue and Red Light in Chlamydomonas reinhardtii

Beel B, Prager K, Spexard M, et al. A Flavin-Binding Cryptochrome Photoreceptor Responds to Both Blue and Red Light in Chlamydomonas reinhardtii. THE PLANT CELL. 2012;24(7):2992-3008.Cryptochromes are flavoproteins that act as sensory blue light receptors in insects, plants, fungi, and bacteria. We have investigated a cryptochrome from the green alga Chlamydomonas reinhardtii with sequence homology to animal cryptochromes and (6-4) photolyases. In response to blue- and red light exposure, this animal-like cryptochrome (aCRY) alters the light-dependent expression of various genes encoding proteins involved in chlorophyll and carotenoid biosynthesis, light-harvesting complexes, nitrogen metabolism, cell cycle control, and the circadian clock. Additionally, exposure to yellow but not far-red light leads to comparable increases in the expression of specific genes; this expression is significantly reduced in an acry insertional mutant. These in vivo effects are congruent with in vitro data showing that blue, yellow, and red light, but not far-red light, are absorbed by the neutral radical state of flavin in aCRY. The aCRY neutral radical is formed following blue light absorption of the oxidized flavin. Red illumination leads to conversion to the fully reduced state. Our data suggest that aCRY is a functionally important blue and red light-activated flavoprotein. The broad spectral response implies that the neutral radical state functions as a dark form in aCRY and expands the paradigm of flavoproteins and cryptochromes as blue light sensors to include other light qualities

Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

ABSTRACT Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile

Chronic lymphocytic leukemia in Brazil: A retrospective analysis of 1903 cases

Univ Fed São Paulo, UNIFESP, EPM, São Paulo, BrazilHosp Sirio Libanes, São Paulo, BrazilUniv Estadual Campinas, Campinas, BrazilHemope, Hemoctr Pernambuco, Recife, PE, BrazilSanta Casa de Misericordia São Paulo, São Paulo, BrazilHosp Samaritano, São Paulo, BrazilHosp Brigadeiro, Hosp Transplantes Euryclides de Jesus Zerbini, São Paulo, BrazilHosp Amaral Carvalho, Jau, BrazilUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilHosp Israelita Albert Einstein, São Paulo, BrazilHosp Servidor Publ Estadual, São Paulo, BrazilCasa Saude Santa Marcelina, São Paulo, BrazilUniv Fed Goias, Goiania, Go, BrazilUniv Fed Ceara, Fortaleza, Ceara, BrazilInst Canc São Paulo, São Paulo, BrazilUniv Fed Parana, Curitiba, Parana, BrazilHosp Sao Vicente de Paulo, Passo Fundo, BrazilUniv Fed São Paulo, UNIFESP, EPM, São Paulo, BrazilWeb of Scienc

Chronic lymphocytic leukemia in Brazil: A retrospective analysis of 1903 cases

Univ Fed São Paulo, UNIFESP, EPM, São Paulo, BrazilHosp Sirio Libanes, São Paulo, BrazilUniv Estadual Campinas, Campinas, BrazilHemope, Hemoctr Pernambuco, Recife, PE, BrazilSanta Casa de Misericordia São Paulo, São Paulo, BrazilHosp Samaritano, São Paulo, BrazilHosp Brigadeiro, Hosp Transplantes Euryclides de Jesus Zerbini, São Paulo, BrazilHosp Amaral Carvalho, Jau, BrazilUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilHosp Israelita Albert Einstein, São Paulo, BrazilHosp Servidor Publ Estadual, São Paulo, BrazilCasa Saude Santa Marcelina, São Paulo, BrazilUniv Fed Goias, Goiania, Go, BrazilUniv Fed Ceara, Fortaleza, Ceara, BrazilInst Canc São Paulo, São Paulo, BrazilUniv Fed Parana, Curitiba, Parana, BrazilHosp Sao Vicente de Paulo, Passo Fundo, BrazilUniv Fed São Paulo, UNIFESP, EPM, São Paulo, BrazilWeb of Scienc

The First Habitable-zone Earth-sized Planet from TESS. I. Validation of the TOI-700 System

We present the discovery and validation of a three-planet system orbiting the nearby (31.1 pc) M2 dwarf star TOI-700 (TIC 150428135). TOI-700 lies in the TESS continuous viewing zone in the Southern Ecliptic Hemisphere; observations spanning 11 sectors reveal three planets with radii ranging from 1 R⊕ to 2.6 R⊕ and orbital periods ranging from 9.98 to 37.43 days. Ground-based follow-up combined with diagnostic vetting and validation tests enables us to rule out common astrophysical false-positive scenarios and validate the system of planets. The outermost planet, TOI-700 d, has a radius of 1.19 ± 0.11 R⊕ and resides within a conservative estimate of the host star's habitable zone, where it receives a flux from its star that is approximately 86% of Earth's insolation. In contrast to some other low-mass stars that host Earth-sized planets in their habitable zones, TOI-700 exhibits low levels of stellar activity, presenting a valuable opportunity to study potentially rocky planets over a wide range of conditions affecting atmospheric escape. While atmospheric characterization of TOI-700 d with the James Webb Space Telescope (JWST) will be challenging, the larger sub-Neptune, TOI-700 c (R = 2.63 R⊕), will be an excellent target for JWST and future space-based observatories. TESS is scheduled to once again observe the Southern Hemisphere, and it will monitor TOI-700 for an additional 11 sectors in its extended mission. These observations should allow further constraints on the known planet parameters and searches for additional planets and transit timing variations in the system