定時手術患者における術前・術中のフローボリューム・カーブを用いた換気力学的特性の検討

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 中島 淳, 東京大学准教授 池田 均, 東京大学講師 二藤 隆春, 東京大学講師 田中 剛, 東京大学講師 坊垣 昌彦University of Tokyo(東京大学

Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers

Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region. Brain-derived neurotrophic factor (BDNF), a neurotrophin family protein that activates Trk neurotrophin receptors, is highly expressed in the stratum lucidum in an activity-dependent manner. The addition of a Trk neurotrophin receptor inhibitor, K252a, to cultured hippocampal slices induced aberrant extension of mossy fibers into ectopic regions. BDNF overexpression in granule cells ameliorated the mossy fiber pathway abnormalities caused by a submaximal dose of K252a. A similar rescue was observed when BDNF was expressed in CA3 pyramidal cells, most notably in mossy fibers distal to the expression site. These findings are the first to clarify the role of BDNF in mossy fiber pathfinding, not as an attractant cue but as a regulator, possibly acting in a paracrine manner. This effect of BDNF may be as a signal for new fibers to fasciculate and extend further to form synapses with neurons that are far from active BDNF-expressing synapses. This mechanism would ensure the emergence of new independent dentate gyrus-CA3 circuits by the axons of new-born granule cells

Infrared luminosity functions based on 18 mid-infrared bands: revealing cosmic star formation history with AKARI and Hyper Suprime-Cam*

Much of star formation is obscured by dust. For a complete understanding of the cosmic star formation history (CSFH), infrared (IR) census is indispensable. AKARI carried out deep mid-infrared observations using its continuous nine-band filters in the North Ecliptic Pole (NEP) field (5.4 deg2). This took a significant amount of the satellite’s lifetime, ∼10% of the entire pointed observations. By combining archival Spitzer (five bands) and WISE (four bands) mid-IR photometry, we have, in total, 18-band mid-IR photometry, which is the most comprehensive photometric coverage in the mid-IR for thousands of galaxies. However, we only had shallow optical imaging (∼25.9 AB magnitude) in a small area, 1.0 deg2. As a result, thousands of AKARI’s infrared sources remained undetected in the optical. Using the new Hyper Suprime-Cam on the Subaru telescope, we obtained deep enough optical images of the entire AKARI NEP field in five broad bands (g ∼ 27.5 mag). These provided photometric redshift, and thereby IR luminosity, for the previously undetected faint AKARI IR sources. Combined with the accurate mid-IR luminosity measurement, we constructed mid-IR luminosity functions (LFs), and thereby performed a census of dust-obscured CSFH in the entire AKARI NEP field. We have measured restframe 8 μm and 12 μm LFs, and estimated total infrared LFs at 0.35 z z ∼ 2

Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner

Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females

Extinction-free Census of AGNs in the AKARI/IRC North Ecliptic Pole Field from 23-band Infrared Photometry from Space Telescopes

In order to understand the interaction between the central black hole and the whole galaxy or their co-evolution history along with cosmic time, a complete census of active galactic nuclei (AGN) is crucial. However, AGNs are often missed in optical, UV and soft X-ray observations since they could be obscured by gas and dust. A mid-infrared (mid-IR) survey supported by multiwavelength data is one of the best ways to find obscured AGN activities because it suffers less from extinction. Previous large IR photometric surveys, e.g., WISE and Spitzer, have gaps between the mid-IR filters. Therefore, star forming galaxy (SFG)-AGN diagnostics in the mid-IR were limited. The AKARI satellite has a unique continuous 9-band filter coverage in the near to mid-IR wavelengths. In this work, we take advantage of the state-of-the-art spectral energy distribution (SED) modelling software, CIGALE, to find AGNs in mid-IR. We found 126 AGNs in the NEP-Wide field with this method. We also investigate the energy released from the AGN as a fraction of the total IR luminosity of a galaxy. We found that the AGN contribution is larger at higher redshifts for a given IR luminosity. With the upcoming deep IR surveys, e.g., JWST, we expect to find more AGNs with our method

Search for Optically Dark Infrared Galaxies without Counterparts of Subaru Hyper Suprime-Cam in the AKARI North Ecliptic Pole Wide Survey Field

We present the physical properties of AKARI sources without optical counterparts in optical images from the Hyper Suprime-Cam (HSC) on the Subaru telescope. Using the AKARI infrared (IR) source catalog and HSC optical catalog, we select 583 objects that do not have HSC counterparts in the AKARI North Ecliptic Pole wide survey field (~5 deg2). Because the HSC limiting magnitude is deep (gAB ~ 28.6), these are good candidates for extremely red star-forming galaxies (SFGs) and/or active galactic nuclei (AGNs), possibly at high redshifts. We compile multiwavelength data out to 500 μm and use them for fitting the spectral energy distribution with CIGALE to investigate the physical properties of AKARI galaxies without optical counterparts. We also compare their physical quantities with AKARI mid-IR selected galaxies with HSC counterparts. The estimated redshifts of AKARI objects without HSC counterparts range up to z ~ 4, significantly higher than for AKARI objects with HSC counterparts. We find that (i) 3.6 – 4.5 μm color, (ii) AGN luminosity, (iii) stellar mass, (iv) star formation rate, and (v) V-band dust attenuation in the interstellar medium of AKARI objects without HSC counterparts are systematically larger than those of AKARI objects with counterparts. These results suggest that our sample includes luminous, heavily dust-obscured SFGs/AGNs at z ~ 1–4 that are missed by previous optical surveys, providing very interesting targets for the coming era of the James Webb Space Telescope

The evolution of merger fraction of galaxies at z < 0.6 depending on the star formation mode in the <i>AKARI</i> NEP-Wide Field

We study the galaxy merger fraction and its dependence on star formation mode in the 5.4 deg2 of the North Ecliptic Pole-Wide Field. We select 6352 galaxies with AKARI 9 µm detections, and identify mergers among them using the Gini coefficient and M20 derived from the Subaru/Hyper Suprime-Cam (HSC) optical images. We obtain the total infrared luminosity and star formation rate of galaxies using the spectral energy distribution templates based on one band, AKARI 9 µm. We classify galaxies into three different star formation modes (i.e. starbursts, main-sequence, and quiescent galaxies) and calculate the merger fractions for each. We find that the merger fractions of galaxies increase with redshift at z Herschel/Spectral and Photometric Imaging Receiver (SPIRE). We find that Herschel-detected galaxies have higher merger fraction compared to non-Herschel-detected galaxies, and both Herschel-detected and non-Herschel-detected galaxies show clearly different merger fractions depending on the star formation modes

Identification of <i>AKARI</i> infrared sources by the Deep HSC Optical Survey: construction of a new band-merged catalogue in the North Ecliptic Pole Wide field

The North Ecliptic Pole field is a natural deep-field location for many satellite observations. It has been targeted many times since it was surveyed by the AKARI space telescope with its unique wavelength coverage from the near- to mid-infrared (mid-IR). Many follow-up observations have been carried out, making this field one of the most frequently observed areas with a variety of facilities, accumulating abundant panchromatic data from the X-ray to the radio wavelength range. Recently, a deep optical survey with the Hyper Suprime-Cam (HSC) at the Subaru telescope covered the NEP-Wide (NEPW) field, which enabled us to identify faint sources in the near- and mid-IR bands, and to improve the photometric redshift (photo-z) estimation. In this work, we present newly identified AKARI sources by the HSC survey, along with multiband photometry for 91 861 AKARI sources observed over the NEPW field. We release a new band-merged catalogue combining various photometric data from the GALEX UV to submillimetre (sub-mm) bands (e.g. Herschel/SPIRE, JCMT/SCUBA-2). About ∼20 000 AKARI sources are newly matched to the HSC data, most of which seem to be faint galaxies in the near- to mid-infrared AKARI bands. This catalogue is motivating a variety of current research, and will be increasingly useful as recently launched (eROSITA/ART-XC) and future space missions (such as JWST, Euclid, and SPHEREx) plan to take deep observations in the NEP field