Integrated On-Silicon and On-glass Antennas for Mm-Wave Applications

The paper presents several integrated high frequency antenna prototypes based on Si/CMOS and on-glass technologies for millimeter-wave (mm-wave) applications. On-chip loop antenna and dipole radiator are presented. In addition, a wide-band dipole-patch antenna design for the range of 74 – 104 GHz is integrated into a CMOS chip with an on-chip pulse generator. In addition, an implementation of a fully on-Silicon antenna array integrated with a timed-array transmitter. To control the beam-forming of this array, a digital-based time adjustment circuit is integrated together with the antenna array. Simulated and measured data including return loss, and radiation patterns are presented. This paper also introduces an on-glass antenna prototypes fabricated on quartz substrate. The on-glass antenna is to demonstrate for handset or automobile’s windshield/windows applications where radio waves could be transmitted and received from various directions. The results show several compact antenna candidates integrated by both Silicon and quartz substrates towards mm-Wave/sub-mm-Wave sensing and communication applications

キムラ ブザン コレクション ニオケル キッタン キンコウヒン キムラ ブザン ト チュウゴク ビジュツ コレクション

学習院大学東洋文化研究所一般研究プロジェクト「木村武山と中国美術コレクション」（研究代表者 鶴間和幸（文学部教授）、2017 ～ 2018年度）の研究成

Metallurgical Re-investigation of Ancient Chinese Coins in the Collection of Tokyo Institute for the Oriental Culture, now in University of Tokyo

Metallurgical re-investigation of ancient Chinese coins in the collection of Tokyo Institute for Oriental Culture, now in Institute of Advanced Studies on Asia, University of Tokyo has been carried out by scanning electron microscopy and semi-quantitative X-ray analyses. Cross-sections of 132 objects, mostly from the Warring States Period, were studied and were classifies as metallic copper (Cu) and bronze (Cu-Sn) objects. Based on chemical compositions, Cu-objects were divided into 3 groups, such as almost Cu-metal, Cu with Pb + Arsenic (As), and Cu with Pb + As + antinomy (Sb). Likewise, bronze objects were divided into 4 groups, such as bronze with Pb, bronze with Pb + As, bronze with Pb + Sb, and bronze with Pb + As + Sb. Leaded bronze are separated in low (<3 wt.％) and high-Pb (up to 45 wt.％) groups. Sn ratio (Sn/[Cu+Sn]) in bronzes range from low (2％) to high (20％) Sn. Most of objects contain a few amounts of miner elements, such as iron (Fe), silver (Ag), cobalt (Co) and some Cu and/or Fe sulfides. There elements might be originated from metallic ores and low qualities of parent metals. Since As and Sb are characteristic elements in metallic objects of “the eastern Eurasian steppe”, it might be suggested such origin. Pb is a fusion agent to lowering of melting temperature of molten Cu and bronze. In comparison to the Pb contents in Anyang (Yinxu) Bronzes in the Academia Sinica collection (many are < 2wt％ Pb), Pb contents are extremely high in high-Pb bronze group. Such objects with various Sn-ratios with As and Sb might suggest recycling work of metal in ancient societies. Thus, chemical signature might not always be related to their origins of ore minerals in the objects

キムラ ブザン コレクション ニオケル チュウゴク ホッポウケイ セイドウキ キムラ ブザン ト チュウゴク ビジュツ コレクション

学習院大学東洋文化研究所一般研究プロジェクト「木村武山と中国美術コレクション」（研究代表者 鶴間和幸（文学部教授）、2017 ～ 2018年度）の研究成

Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization

RBM20 is a major regulator of heart-specific alternative pre-mRNA splicing of TTN encoding a giant sarcomeric protein titin. Mutation in RBM20 is linked to autosomal-dominant familial dilated cardiomyopathy (DCM), yet most of the RBM20 missense mutations in familial and sporadic cases were mapped to an RSRSP stretch in an arginine/serine-rich region of which function remains unknown. In the present study, we identified an R634W missense mutation within the stretch and a G1031X nonsense mutation in cohorts of DCM patients. We demonstrate that the two serine residues in the RSRSP stretch are constitutively phosphorylated and mutations in the stretch disturb nuclear localization of RBM20. Rbm20 S637A knock-in mouse mimicking an S635A mutation reported in a familial case showed a remarkable effect on titin isoform expression like in a patient carrying the mutation. These results revealed the function of the RSRSP stretch as a critical part of a nuclear localization signal and offer the Rbm20 S637A mouse as a good model for in vivo study

Treatment algorithm of ACTH deficiency

Objective : To examine diagnostic performance of corticotropin-releasing hormone (CRH) test combined with baseline dehydroepiandrosterone sulfate (DHEA-S) in patients with a suspect of central adrenal insufficiency. Methods : Patients (n=215) requiring daily or intermittent hydrocortisone replacement, or no replacement were retrospectively checked with their peak cortisol after CRH test and baseline DHEA-S. Results : None of 106 patients with the peak cortisol ≥ 17.5 μg / dL after CRH test required replacement, and all 64 patients with the peak cortisol < 10.0 μg / dL required daily replacement. Among 8 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S below the reference range, 6 patients required daily replacement and 1 patient was under intermittent replacement. Among 37 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S within the reference range, 10 and 6 patients were under intermittent and daily replacement, respectively. Conclusions : No patients with the peak cortisol ≥ 17.5 μg / dL required hydrocortisone replacement, and all patients with the peak cortisol below 10.0 μg / dL required daily replacement. Careful clinical evaluation was required to determine requirement for replacement in patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL even in combination with baseline DHEA-S

Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?

Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and actions of FGF21 in humans remain unclear. Here we have investigated the regulatory mechanisms of the human FGF21 gene at the transcriptional level. A deletion study of the human FGF21 promoter (−1672 to +230 bp) revealed two fasting signals, including peroxisome proliferator-activated receptor α (PPARα) and glucagon signals, that independently induced human FGF21 gene transcription in mouse primary hepatocytes. In addition, two feeding signals, glucose and xylitol, also dose-dependently induced human FGF21 gene transcription and mRNA expression in both human HepG2 cells and mouse primary hepatocytes. FGF21 protein expression and secretion were also induced by high glucose stimulation. The human FGF21 promoter (−1672 to +230 bp) was found to have a carbohydrate-responsive element at −380 to −366 bp, which is distinct from the PPAR response element (PPRE). Knock-down of the carbohydrate response element binding protein by RNAi diminished glucose-induced human FGF21 transcription. Moreover, we found that a region from −555 to −443 bp of the human FGF21 promoter region exerts an important role in the activation of basic transcription. In conclusion, human FGF21 gene expression is paradoxically and independently regulated by both fasting and feeding signals. These regulatory mechanisms suggest that human FGF21 is increased with nutritional crisis, including starvation and overfeeding

Boronate Based Metal-Free Platform for Diphosphate-Specific Molecular Recognitions

A reversible boronate–diol interaction provides a versatile synthetic platform for molecular recognitions whose binding specificity can be molecularly tailored. We found that boronate derivatives with relatively strong acidity generally undergo a diphosphate-specific recognition among other phosphates under weakly acidic pH conditions, a feature relevant to DNA sequencing. ¹¹B and ³¹P NMR studies identified “tetrahedral boronate and divalent diphosphate” as a pair responsible for forming a 1:1 stoichiometric complex, which manifests as a unique pH-dependent stability