Amplificador de potencia en banda ka

Peer ReviewedPostprint (published version

An Intelligent Radiomic Approach for Lung Cancer Screening

Funding: This project is supported by the Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER), RTI2018-095209-B-C21 (MCI/AEI/FEDER, UE), Generalitat de Catalunya, 2017-SGR-1624 and CERCA-Programme. Debora Gil is supported by Serra Hunter Fellow.This project is supported by the Ministerio de Ciencia e Innovaci?n (MCI), Agencia Estatal de Investigaci?n (AEI) and Fondo Europeo de Desarrollo Regional (FEDER), RTI2018-095209-B-C21 (MCI/AEI/FEDER, UE), Generalitat de Catalunya, 2017-SGR-1624 and CERCA-Programme. Debora Gil is supported by Serra Hunter Fellow. Barcelona Respiratory Network (BRN), Acad?mia de Ci?ncies M?diques de Catalunya i Balears, i Fundaci? Ramon Pla i Armengol.The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection

Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization

A limited repertoire of PPP family of serine/threonine phosphatases with a highly conserved catalytic domain acts on thousands of protein targets to orchestrate myriad central biological roles. A major structural reorganization of human calcineurin, a ubiquitous Ser/Thr PPP regulated by calcium and calmodulin and targeted by immunosuppressant drugs cyclosporin A and FK506, is unveiled here. The new conformation involves trans- to cis- isomerization of proline in the SAPNY sequence, highly conserved across PPPs, and remodels the main regulatory site where NFATc transcription factors bind. Transitions between cis- and trans- conformations may involve peptidyl prolyl isomerases such as cyclophilin A and FKBP12, which are known to physically interact with and modulate calcineurin even in the absence of immunosuppressant drugs. Alternative conformations in PPPs provide a new perspective on interactions with substrates and other protein partners and may foster development of more specific inhibitors as drug candidates

Pleuroparenchymal Fibroelastosis : a New Entity within the Spectrum of Rare Idiopathic Interstitial Pneumonias

Pleuroparenchymal fibroelastosis (PPFE) is a rare entity that has been recently included in the official American Thoracic Society/European Respiratory Society (ATS/ERS) statement in 2013 as a group of rare idiopathic interstitial pneumonias (IIPs). PPFE is characterized by pleural and subpleural parenchymal thickening due to elastic fiber proliferation, mainly in the upper lobes. The etiology of the disease is unclear, although some cases have been associated as a complication after bone marrow transplantation, lung transplantation (LT), chemotherapy, and recurrent respiratory infections. The patients usually report progressive dyspnea and dry cough and are predisposed to develop spontaneous or iatrogenic pneumothoraces after surgical lung biopsy (SLB) for its diagnosis. That is why better awareness with the clinical and radiologic features can help optimal management by the multidisciplinary team. Novel invasive techniques such as cryobiopsy may become useful tools in these patients as it could spare SLB. We present the first reported cases in Spain

Long-term strenuous exercise promotes vascular injury by selectively damaging the tunica media: experimental evidence

Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise

Transversalitat en el disseny curricular del Màster Universitari d'Enginyeria en Organització a l'ETSEIAT

Mitjançant aquest projecte hem creat punts de connexió entre diferents assignatures per augmentar la transversalitat dins el pla d'estudis del Màster Universitari en Enginyeria d’Organització. D’aquesta manera, oferim als estudiants/es la possibilitat de tractar problemes propers a les situacions reals de l'exercici de la seva professió, integrant àmbits i metodologies que prèviament es trobaven dispersos en les diferents assignatures. Com a resultat, hem creat una col·lecció de 18 casos transversals que acompanyen els estudiants/es durant més d’una assignatura. Així, poden analitzar una situació complexa amb diferents metodologies tractades al llarg dels seus estudis i integrar-les tot formant un portafoli docent. Els resultats del projecte faciliten que les assignatures deixin de ser contenidors aïllats (propi de la divisió del coneixement en especialitzats o departaments) per convertir-se en un procés continu i interconnectat de coneixements que els estudiants/es han d’aplicar en diferents moments durant els seus estudis. Els materials didàctics desenvolupats conjuntament per l’equip del projecte, són accessibles a cada assignatura involucrada mitjançant la plataforma docent atenea i estaran publicats al dipòsit UPC Commons a partir de febrer de 2013.Peer Reviewe

Guía de actividades docentes para la formación en integración e igualdad de oportunidades por razón de discapacidad en las enseñanzas técnicas: accesibilidad universal y diseño para todos

Esta guía se ha promovido desde la Universidad Politécnica de Cataluña (UPC) en un momento caracterizado por la transición a los nuevos grados y másteres. Elaborada con un enfoque práctico y didáctico, quiere ser una herramienta de fácil uso y lectura para el profesorado de las carreras técnicas de cualquier universidad española, aportando ejemplos de aplicación de los principios de diseño para todos y criterios de accesibilidad universal en su práctica docente

Guía de actividades docentes para la formación en integración e igualdad de oportunidades por razón de discapacidad en las enseñanzas técnicas: accesibilidad universal y diseño para todos

Estudio financiado por el MEC, Programa Estudio y AnálisisPostprint (published version

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery