34 research outputs found

    Un bosque de malas hierbas

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    [Inicio] Esta propuesta visual se conforma a partir de fragmentos de fotografías extraídos de la investigación doctoral Ecosistemas gráficos: una investigación científico-artística sobre el devenir del residuo vegetal de especies exóticas [invasoras], realizada en el programa de doctorado Creatividad e Innovación Social y Sostenible, de la Universidade de Vigo, España, bajo la co-dirección de Anne Heyvaert y Ángeles Cancela Carral. El proyecto se centra en cuatro especies de plantas exóticoinvasoras, localizadas en la zona de bosque de ribera del río Umia, en Ribadumia, Galicia. Estas especies son Eucalyptus globulus (exótica i ecológicamente invasora), Arundo donax, Phytolacca americana y Tradescantia fluminensis. [...

    La multidimensionalidad de la planta. Siete especies de árboles tropicales de Guayana Francesa a través del prisma del arte y la ciencia

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    Arte y Ciencia. Grandes compañeras en la batalla por la difusión y comunicación de nuestro medio ambiente y entorno natural. Dos estudiantes de doctorado, Antía Iglesias y Marion Boisseaux han decidido entrelazar sus disciplinas para desarrollar una imagen más completa de lo que es una planta. Ambas investigan explorando e integrando las múltiples perspectivas de sus respectivos campos de especialización para comprender mejor la naturaleza de los árboles guayaneses y cómo harán frente al cambio climático.Centro de Estudios de la Biodiversidad Amazónic

    Focus on progressive myoclonic epilepsy in Berardinelli-Seip syndrome

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    This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10072-020-04780-0S

    Micro-visualización del residuo vegetal de Especies Exótico Invasoras (EEI) como materia papelera y su aplicación en la estampación artístico-gráfica

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    Este estudio reflexiona sobre la práctica consciente del arte gráfico proponiendo el aprovechamiento del residuo vegetal de especies exótico-invasoras para la elaboración descentralizada de papel. Se investigan sus propiedades técnicas y su aplicabilidad en la estampación artística. Se ha empleado un enfoque teórico-práctico que visualiza el potencial de la imagen microscópica. El estudio se centra en el análisis de tres EEI cuyo residuo se utiliza como fuente de celulosa. Las tres EEI seleccionadas fueron recolectadas en el bosque de ribera del río Umia, Pontevedra. Estos soportes fueron sometidos a tres pruebas gráficas: corte láser, estampación xilográfica y de fotograbado. Lo resultados, visuales y técnicos, permiten comprender sus características físico-mecánicas e idoneidad para la elaboración de imágenes artísticas

    The book in white. Liminal spaces of contemporary graphics: A proposal of creative methodology for the application of research to teaching through the artist's book

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    [EN] The project 'Libro en blanco: Espacios Liminales de la Gráfica Contemporánea (Blank Book: Liminal Spaces of Contemporary Graphics), proposed by the group Dx5, focuses on understanding the complexity of contemporary graphics and the emerging synergies in new liminal spaces through white as a common thread. Through mixed research and practice: theoretical, artistic, scientific and technical; the group has delved for more than two decades in the interrelational principles of contemporary graphics and, on this occasion, proposes a review of the fundamental bases of it. The main objective of this proposal is to reveal the apparently invisible principles of contemporary graphics; exploring its changing forms through a proposal that combines graphics itself, editorial design, theoretical-conceptual reflection and the format of the artist s book. In this way, it seeks to connect traditional graphics with contemporary creations and proposals and to reexamine the basic concepts. The project focuses on five key themes, synthesized in codes that generate, throughout the book, a network of interconnections. Through these themes, the philosophy behind contemporary graphic practice is deepened and the in-between, liminal, ignored or invisible spaces of expanded field graphics are developed. The tangible result is the limited edition artist s book Libro en Blanco (Blank Book), which gathers the reflections and visual and conceptual works of Dx5 members and colla-borators, deepening in the principles set out in the bases of the project. In this way we seek to broaden the understanding of contemporary graphics and propose the application of these concepts and the artist s book format as an educational tool, promoting artistic research as a creative methodology for education in the fine arts, graphic design and publishing.[ES] El proyecto Libro en blanco: Espacios Liminales de la Gráfica Contemporánea' planteado por el grupo Dx5, se enfoca en comprender la complejidad de la gráfica contemporánea y las sinergias emergentes en nuevos espacios liminales a través del blanco como hilo conductor. Mediante la investigación y práctica mixtas: teórica, artística, científica y técnica; el grupo ha profundizado durante más de dos décadas en los principios interrelaciónales de la gráfica contemporánea y, en esta ocasión, propone una revisión de las bases fundamentales de la misma. El objetivo principal de esta propuesta es revelar los principios, aparentemente invisibles, de la gráfica contemporánea; explorando sus formas cambiantes  a través de una propuesta que combina la propia gráfica, el diseño editorial, la reflexión teórico-conceptual y el formato del libro de artista. De esta manera se busca conectar la gráfica tradicional con las creaciones y propuestas contemporáneas y re-examinar los conceptos base. El proyecto se centra en cinco temas clave, sintetizados en códigos que  generan, a lo largo del libro, una red de interconexiones. A través de estos temas se profundiza en la filosofía detrás de práctica gráfica contemporánea y se desarrollan los espacios intermedios, liminales, ignorados o invisibles de la gráfica de campo expandido. El resultado tangible es el libro de artista "Libro en Blanco", de edición limitada, que recoge las reflexiones y obras visuales y conceptuales de miembros y colaboradores del Dx5, profundizando en los principios planteados en las bases del proyecto. De esta manera se busca ampliar la comprensión de la gráfica contemporánea y proponer la aplicación de estos conceptos y del formato de libro de artista como herramienta educativa, promoviendo la investigación artística como metodología creativa de educación en las Bellas Artes, el diseño gráfico y la edición.Soler Baena, A.; Iglesias Fernández, A. (2024). "Libro en Blanco". Espacios liminales de la gráfica contemporánea: Una propuesta de metodología creativa de aplicación de la investigación a la docencia a través del libro de artista. Revista Sonda. Investigación en Artes y Letras. 13:66-80. https://doi.org/10.4995/sonda.2024.2028866801

    Effect of β-estradiol on adipogenesis in a 3T3-L1 cell model of prelamin A accumulation

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    The accumulation of farnesylated prelamin A has been suggested as one of the mechanisms responsible for the loss of fat in type 2 familial partial lipodystrophy due to variants in the LMNA gene. In this rare disease, fat loss appears in women after puberty, affecting sex-hormone-dependent anatomical areas. This study investigated the impact of 17-β-estradiol on adipogenesis in murine preadipocytes subjected to a pharmacologically induced accumulation of farnesylated and non-farnesylated prelamin A. To induce the accumulation of non-farnesylated or farnesylated prelamin A, 3T3-L1 cells were treated with the farnesyltransferase inhibitor 277 or the methyltransferase inhibitor N-acetyl-S-farnesyl-l-cysteine methylester. Subsequently, the cells were induced to undergo adipocyte differentiation in the presence or absence of 17-β-estradiol. Prelamin A accumulation was assessed through immunofluorescence, while real-time PCR and Western blot techniques were used to quantify several adipogenic genes and evaluate protein levels, respectively. The results showed that 17-β-estradiol increased adipogenesis, although the combination of this hormone plus farnesylated prelamin A led to a reduction in the number of mature adipocytes and the expression of the different genes involved in adipogenesis. In conclusion, the influence of farnesylated prelamin A accumulation on adipogenesis manifested only in the presence of estradiol. These in vitro findings suggest a potential mechanism that could explain the characteristic phenotype in women suffering type 2 familial partial lipodystrophyThis research was funded by the Instituto de Salud Carlos III, ISCIII and the European Regional Development Fund, ERDF (grant number PI081449), an intramural grant from the Xunta de Galicia (GPC2014/036, ED341b 2017/19, ED431B 2020/37) and a research grant from the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP). A.F.-P. receives funding from the Fundación Alfonso Martín EscuderoS

    Lipodystrophy-associated progeroid syndromes

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    This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s42000-022-00386-7With the exception of HIV-associated lipodystrophy, lipodystrophy syndromes are rare conditions characterized by a lack of adipose tissue, which is not generally recovered. As a consequence, an ectopic deposition of lipids frequently occurs, which usually leads to insulin resistance, atherogenic dyslipidemia, and hepatic steatosis. These disorders include certain accelerated aging syndromes or progeroid syndromes. Even though each of them has unique clinical features, most show common clinical characteristics that affect growth, skin and appendages, adipose tissue, muscle, and bone and, in some of them, life expectancy is reduced. Although the molecular bases of these Mendelian disorders are very diverse and not well known, genomic instability is frequent as a consequence of impairment of nuclear organization, chromatin structure, and DNA repair, as well as epigenetic dysregulation and mitochondrial dysfunction. In this review, the main clinical features of the lipodystrophy-associated progeroid syndromes will be described along with their causes and pathogenic mechanisms, and an attempt will be made to identify which of López-Otín’s hallmarks of aging are present.This work was supported by the Instituto de Salud Carlos III and the European Regional Development Fund (ERDF (grant number PI081449), and an intramural grant from the Xunta de Galicia (GPC2014/036, ED341b 2017/19, ED431B 2020/37). A.F.-P. is a Rio Hortega researcher (ISCIII; CM20/00155). S.S.-I. was awarded a Research Fellowship from the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP).S

    Familial partial lipodystrophy syndromes

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    Lipodystrophies are a heterogeneous group of rare conditions characterised by the loss of adipose tissue. The most common forms are the familial partial lipodystrophy (FPLD) syndromes, which include a set of disorders, usually autosomal dominant, due to different pathogenetic mechanisms leading to improper fat distribution (loss of fat in the limbs and gluteal region and variable regional fat accumulation). Affected patients are prone to suffering serious morbidity via the development of metabolic complications associated to insulin resistance and an inability to properly store lipids. Although no well-defined diagnostic criteria have been established for lipodystrophy, there are certain clues related to medical history, physical examination and body composition evaluation that may suggest FPLD prior to confirmatory genetic analysis. Its treatment must be fundamentally oriented towards the control of the metabolic abnormalities. In this sense, metreleptin therapy, the newer classes of hypoglycaemic agents and other investigational drugs are showing promising results. This review aims to summarise the current knowledge of FPLD syndromes and to describe their clinical and molecular picture, diagnostic approaches and recent treatment modalities.This study was supported by the Instituto de Salud Carlos III and the European Regional Development Fund, ERDF (Grant No. PI081449), and an intramural grant from the Xunta de Galicia (GPC2014/036, ED341b 2017/19, ED431B 2020/37). A.F.-P. is a Rio Hortega researcher (ISCIII; CM20/00155). S.S.I. was awarded a Research Fellowship, granted by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP).S

    Anthocyanins and total phenolic compounds from pigment extractions of non-native species from the Umia river basin: Eucalyptus globulus, Tradescantia fluminensis, and Arundo donax

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    Alien invasive species (AIS) and non-native species are a prominent and extended problem in a wide range of areas in Europe and around the world. Centered in the Umia’s riparian forest, in Galicia, we found at least three main AIS needing to be controlled and harvested to preserve the biodiversity of the area. Previous studies probed that leaves and bark of selected species—Tradescantia fluminensis, Arundo donax, and Eucalyptus globulus—have important antioxidant properties, suitable for use in pharmaceutical and industrial contexts. A comparison of four solid-liquid extraction methods—Soxhlet extraction, ultrasound assisted extraction, thermal agitator, and infusion—was conducted in order to define the most efficient method in correlation within antioxidant (anthocyanins and total phenols) extraction. Water was selected as solvent, providing a sustainable research background without implying any chemical additives. The best extraction yields were obtained with Soxhlet extraction for all raw matter, with best results for Tradescantia fluminensis (41.89%) and Eucalyptus globulus leaves (39.35%); followed by the ultrasonic assisted extraction method, with better yield performed with Eucalyptus leaves (27.07%). On the contrary, Tradescantia fluminensis showed better efficiency with thermal agitator (35.07% compared to 23.19% from ultrasound extraction). After extractions, identification and quantification of total phenolic compounds and anthocyanins were carried out using spectrophotometric determination and acid hydrolysis in butanol method. In general, the best extraction yield in correlation with higher antioxidant content was performed by thermal agitator method, and Eucalyptus globulus leaves were demonstrated to be the better anthocyanins (6.18 ± 0.82 mg CC/g) and total phenols containers (172.40 ± 44.53 mg GAE/g). Studies provided promising possibilities for the residues of the three non-native species analyzed, as a source of antioxidants, favoring circular economy systems, as well as taking care of biodiversity in affected environments.Xunta de Galicia | Ref. Becas predoctorales 29

    Characterization of cellulose derived from invasive alien species plant waste for application in the papermaking industry: physic-mechanical, optical, and chemical property analysis

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    This study examines the potential of four invasive plant species, both arboreal and herbaceous, within the riparian forest of the Umia River in Galicia, a common ecosystem in northern Spain. These invasive species (Arundo donax, Phytolacca americana, Eucalyptus globulus, and Tradescantia fluminensis) were collected and assessed for their suitability as an alternative source of pulp and paper materials for the paper industry to mitigate the environmental impacts associated with conventional cellulose fiber production from harmful monocultures. Cellulosic material from leaves, bark, and/or stems of each of the selected species was isolated from lignin and hemicelluloses through kraft pulping processes. Resulted fibers and pulps were analyzed visually, morphologically, chemically, and mechanically to evaluate their papermaking properties. To compare these properties with those of commercially available pulp, test sheets were concurrently produced using commercial bleached Eucalyptus cellulose. The findings reveal that the employed fibers exhibit promising characteristics for artistic paper production. Regarding the pulp, two refining times were tested in a PFI machine, and the Schopper–Riegler degree was measured. Paper sheets underwent various tests to determine thickness, basis weight, apparent volume, apparent density, permeability, and chemical composition, as well as microscopic optical and morphological properties. The fibers obtained from the waste derived from the removal of invasive exotic species and biodiversity control present a viable and intriguing alternative for decentralized paper production, yielding noteworthy results for the creative sector. This research highlights the potential of harnessing invasive species for sustainable and innovative paper manufacturing practices.Universidade de Vig
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