Instanton induced charged fermion and neutrino masses in a minimal Standard Model scenario from intersecting D-branes

String instanton Yukawa corrections from Euclidean D-branes are investigated in an effective Standard Model theory obtained from the minimal U(3)xU(2)xU(1) D-brane configuration. In the case of the minimal chiral and Higgs spectrum, it is found that superpotential contributions are induced by string instantons for the perturbatively forbidden entries of the up and down quark mass matrices. Analogous non-perturbative effects generate heavy Majorana neutrino masses and a Dirac neutrino texture with factorizable Yukawa couplings. For this latter case, a specific example is worked out where it is shown how this texture can reconcile the neutrino data.Comment: 17 pages, 3 figure

Providing structural modules with self-integrity monitoring

With the advent of complex space structures (i.e., U.S. Space Station), the need for methods for remotely detecting structural damage will become greater. Some of these structures will have hundreds of individual structural elements (i.e., strut members). Should some of them become damaged, it could be virtually impossible to detect it using visual or similar inspection techniques. The damage of only a few individual members may or may not be a serious problem. However, should a significant number of the members be damaged, a significant problem could be created. The implementation of an appropriate remote damage detection scheme would greatly reduce the likelihood of a serious problem related to structural damage ever occurring. This report presents the results of the research conducted on remote structural damage detection approaches and the related mathematical algorithms. The research was conducted for the Small Business Innovation and Research (SBIR) Phase 2 National Aeronautics and Space Administration (NASA) Contract NAS7-961

More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions.

© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the coagulation cascade.1 To attenuate the risk of future thrombotic events, patients with ACS are treated with dual antiplatelet therapy (DAPT), namely, the combination of aspirin with a P2Y12 inhibitor, such as clopidogrel, ticagrelor, or prasugrel. Despite DAPT, some ≈10% of ACS patients experience recurrent major adverse cardiovascular events over the subsequent 30 days,2 driving the quest for more effective inhibition of thrombotic pathways. In this review, we provide an overview of studies to date and those ongoing that aim to deliver more effective combinations of antithrombotic agents to patients with recent ACS. We have chosen to confine the review to ACS patients without atrial fibrillation because those with atrial fibrillation have a clear indication for combination therapy that includes oral anticoagulation and should, we feel, be treated as a separate cohort. In this article, we discuss the limitations of the currently available clinical trial data and future directions, with suggestions for how practice might change to reduce the risk of coronary thrombosis in those at greatest risk, with minimal impact on bleeding.Peer reviewedFinal Published versio

Magneto-Acoustic Waves of Small Amplitude in Optically Thin Quasi-Isentropic Plasmas

The evolution of quasi-isentropic magnetohydrodynamic waves of small but finite amplitude in an optically thin plasma is analyzed. The plasma is assumed to be initially homogeneous, in thermal equilibrium and with a straight and homogeneous magnetic field frozen in. Depending on the particular form of the heating/cooling function, the plasma may act as a dissipative or active medium for magnetoacoustic waves, while Alfven waves are not directly affected. An evolutionary equation for fast and slow magnetoacoustic waves in the single wave limit, has been derived and solved, allowing us to analyse the wave modification by competition of weakly nonlinear and quasi-isentropic effects. It was shown that the sign of the quasi-isentropic term determines the scenario of the evolution, either dissipative or active. In the dissipative case, when the plasma is first order isentropically stable the magnetoacoustic waves are damped and the time for shock wave formation is delayed. However, in the active case when the plasma is isentropically overstable, the wave amplitude grows, the strength of the shock increases and the breaking time decreases. The magnitude of the above effects depends upon the angle between the wave vector and the magnetic field. For hot (T > 10^4 K) atomic plasmas with solar abundances either in the interstellar medium or in the solar atmosphere, as well as for the cold (T < 10^3 K) ISM molecular gas, the range of temperature where the plasma is isentropically unstable and the corresponding time and length-scale for wave breaking have been found.Comment: 14 pages, 10 figures. To appear in ApJ January 200

Massive Neutrinos and (Heterotic) String Theory

String theories in principle address the origin and values of the quark and lepton masses. Perhaps the small values of neutrino masses could be explained generically in string theory even if it is more difficult to calculate individual values, or perhaps some string constructions could be favored by generating small neutrino masses. We examine this issue in the context of the well-known three-family standard-like Z_3 heterotic orbifolds, where the theory is well enough known to construct the corresponding operators allowed by string selection rules, and analyze the D- and F-flatness conditions. Surprisingly, we find that a simple see-saw mechanism does not arise. It is not clear whether this is a property of this construction, or of orbifolds more generally, or of string theory itself. Extended see-saw mechanisms may be allowed; more analysis will be needed to settle that issue. We briefly speculate on their form if allowed and on the possibility of alternatives, such as small Dirac masses and triplet see-saws. The smallness of neutrino masses may be a powerful probe of string constructions in general. We also find further evidence that there are only 20 inequivalent models in this class, which affects the counting of string vacua.Comment: 18 pages in RevTeX format. Single-column postscript version available at http://sage.hep.upenn.edu/~bnelson/singpre.p

Minimal Family Unification

Absract It is proposed that there exist, within a new $SU(2)^{'}$, a gauged discrete group $Q_6$ (the order 12 double dihedral group) acting as a family symmetry. This nonabelian finite group can explain hierarchical features of families, using an assignment for quarks and leptons dictated by the requirements of anomaly cancellation and of no additional quarks.Comment: 10 pages, IFP-701-UNC;VAND-TH-94-

Strategies Employed by Community-Based Service Providers to Address HIV-Associated Neurocognitive Challenges: A Qualitative Study

Background: HIV-associated neurocognitive disorders and other causes of neurocognitive challenges experienced by people living with HIV (PLWH) persist as public health concerns in developed countries. Consequently, PLWH who experience neurocognitive challenges increasingly require social support and mental health services from community-based providers in the HIV sector. Methods: Thirty-three providers from 22 AIDS service organizations across Ontario, Canada, were interviewed to determine the strategies they used to support PLWH experiencing neurocognitive difficulties. Thematic analysis was conducted to determine key themes from the interview data. Results: Three types of strategies were identified: (a) intrapersonal, (b) interpersonal, and (c) organizational. Intrapersonal strategies involved learning and staying informed about causes of neurocognitive challenges. Interpersonal strategies included providing practical assistance, information, counseling, and/or referrals to PLWH. Organizational strategies included creating dedicated support groups for PLWH experiencing neurocognitive challenges, partnering with other organizations with services not available within their own organization, and advocating for greater access to services with expertise and experience working with PLWH. Conclusion: Through concerted efforts in the future, it is likely that empirically investigating, developing, and customizing these strategies specifically to address HIV-associated neurocognitive challenges will yield improved social support and mental health outcomes for PLWH