Neuronavigation in the Percutaneous Treatment of Trigeminal Neuralgia: Technical note

Objective: To describe neuronavigation-guided percutaneous radiofrequency thermocoagulation in the treatment of trigeminal neuralgia.Methods: Neuronavigation guided percutaneous radiofrequency thermocoagulation of the Gasser ganglion was used in nine patients with trigeminal neuralgia who developed resistance to drugs used in the treatment of TN or have had adverse effects due to drug toxicity. The age of the patients was between 62 and 78 years. Results: All patients had immediate pain relief after thermocoagulation guided by neuronavigation. Neuronavigation allowed visualization of instrument position in relation to target and the related anatomical structures. The technique helped preoperative planning of the optimal trajectory for needle insertion. There were no complications of the procedure.Conclusion: Image guided percutaneous thermocoagulation in the treatment of trigeminal neuralgia is a safe and promising procedure. The technique has reduced the risk of postoperative complications caused by “hunting” of the foramen ovale.&nbsp

Airborne Alternaria and Cladosporium Fungal Spores in Europe: Forecasting Possibilities and Relationships with Meteorological Parameters

Airborne fungal spores are prevalent components of bioaerosols with a large impact on ecology, economy and health. Their major socioeconomic effects could be reduced by accurate and timely prediction of airborne spore concentrations. The main aim of this study was to create and evaluate models of Alternaria and Cladosporium spore concentrations based on data on a continental scale. Additional goals included assessment of the level of generalization of the models in space and description of the main meteorological factors influencing fungal spore concentrations. Aerobiological monitoring was carried out at 18 sites in six countries across Europe over 3 to 21 years depending on site. Quantile random forest modelling was used to predict spore concentrations values. Generalization of the Alternaria and Cladosporium models was tested using (i) one model for all the sites, (ii) models for groups of sites, and (iii) models for individual sites. The study revealed the possibility of reliable prediction of fungal spore levels using gridded meteorological data. The classification models also showed the capacity for providing larger scale predictions of fungal spore concentrations. Regression models were distinctly less accurate than classification models due to several factors, including measurement errors and distinct day-to-day changes of concentrations. Temperature and vapour pressure proved to be the most important variables in the regression and classification models of Alternaria and Cladosporium spore concentrations. Accurate and operational daily-scale predictive models of bioaerosol abundances contribute to the assessment and evaluation of relevant exposure and consequently more timely and efficient management of phytopathogenic and of human allergic diseases

Airborne Alternaria and Cladosporium Fungal Spores in Europe: Forecasting Possibilities and Relationships with Meteorological Parameters

Airborne fungal spores are prevalent components of bioaerosols with a large impact on ecology, economy and health. Their major socioeconomic effects could be reduced by accurate and timely prediction of airborne spore concentrations. The main aim of this study was to create and evaluate models of Alternaria and Cladosporium spore concentrations based on data on a continental scale. Additional goals included assessment of the level of generalization of the models in space and description of the main meteorological factors influencing fungal spore concentrations. Aerobiological monitoring was carried out at 18 sites in six countries across Europe over 3 to 21 years depending on site. Quantile random forest modelling was used to predict spore concentrations values. Generalization of the Alternaria and Cladosporium models was tested using (i) one model for all the sites, (ii) models for groups of sites, and (iii) models for individual sites. The study revealed the possibility of reliable prediction of fungal spore levels using gridded meteorological data. The classification models also showed the capacity for providing larger scale predictions of fungal spore concentrations. Regression models were distinctly less accurate than classification models due to several factors, including measurement errors and distinct day-to-day changes of concentrations. Temperature and vapour pressure proved to be the most important variables in the regression and classification models of Alternaria and Cladosporium spore concentrations. Accurate and operational daily-scale predictive models of bioaerosol abundances contribute to the assessment and evaluation of relevant exposure and consequently more timely and efficient management of phytopathogenic and of human allergic diseases

Izloženost alergenima plijesni u unutarnjem okolišu

Humid indoor environments may be colonised by allergenic fi lamentous microfungi (moulds), Aspergillus spp., Penicillium spp., Cladosporium spp., and Alternaria spp. in particular. Mould-induced respiratory diseases are a worldwide problem. In the last two decades, mould allergens and glucans have been used as markers of indoor exposure to moulds. Recently, mould allergens Alt a 1 (Alternaria alternata) and Asp f 1 (Aspergillus fumigatus) have been analysed in various environments (residential and occupational) with enzyme-linked immunosorbent assays, which use monoclonal or polyclonal antibodies. Household Alt a 1 and Asp f 1 levels were usually under the limit of the method detection. By contrast, higher levels of mould allergens were found in environments with high levels of bioaerosols such as poultry farms and sawmills. Data on allergen Alt a 1 and Asp f 1 levels in agricultural settings may provide information on possible colonisation of respective moulds and point out to mould-related diseases in occupants.Vlažni, unutarnji prostori mogu biti kolonizirani alergogenim, filamentoznim mikrogljivicama (plijesni) uglavnom rodova Aspergillus, Penicillium, Cladosporium i Alternaria. Respiratorne bolesti uzrokovane plijesnima zdravstveni su problem diljem svijeta. U posljednja dva desetljeća, neki sastavni dijelovi plijesni kao alergeni i glukan rabe se kao pokazatelji izloženosti plijesni u unutarnjem okolišu. Nedavno su alergeni plijesni Alt a 1 (Alternaria alternata) i Asp f 1 (Aspergillus fumigatus) određivani u različitom okolišu (kućnom i profesionalnom) enzim-imunokemijskom metodom koja rabi monoklonska ili poliklonska antitijela. Razina Alt a 1 i Asp f 1 u kućnoj prašini ispod je granice detekcije. Nasuprot tomu, alergeni plijesni su određeni u okolišu s visokom razinom bioaerosola kao peradarnici i pilane. Razine alergena Alt a 1 i Asp f 1 u nekim poljoprivrednim objektima pružaju informaciju o mogućoj kolonizaciji plijesnima, što upućuje na moguće zdravstvene učinke kod zaposlenika

Noble gas and carbon isotope systematics at the seemingly inactive Ciomadul volcano (Eastern‐Central Europe, Romania): evidence for volcanic degassing

Ciomadul is the youngest volcano in the Carpathian-Pannonian Region, Eastern-Central Europe, which last erupted 30 ka. This volcano is considered to be inactive, however, combined evidence from petrologic and magnetotelluric data, as well as seismic tomography studies suggest the existence of a subvolcanic crystal mush with variable melt content. The volcanic area is characterized by high CO2 gas output rate, with a minimum of 8.7 × 103 t yr-1. We investigated 31 gas emissions at Ciomadul to constrain the origin of the volatiles. The δ13C-CO2 and 3He/4He compositions suggest the outgassing of a significant component of mantle-derived fluids. The He isotope signature in the outgassing fluids (up to 3.10 Ra) is lower than the values in the peridotite xenoliths of the nearby alkaline basalt volcanic field (R/Ra 5.95Ra±0.01) which are representative of a continental lithospheric mantle and significantly lower than MORB values. Considering the chemical characteristics of the Ciomadul dacite, including trace element and Sr- Nd and O isotope compositions, an upper crustal contamination is less probable, whereas the primary magmas could have been derived from an enriched mantle source. The low He isotopic ratios could indicate a strongly metasomatized mantle lithosphere. This could be due to infiltration of subduction-related fluids and postmetasomatic ingrowth of radiogenic He. The metasomatic fluids are inferred to have contained subducted carbonate material resulting in a heavier carbon isotope composition (13C is in the range of -1.4 to -4.6 ‰) and an increase of CO2/3He ratio. Our study shows the magmatic contribution to the emitted gases

Intracranial pressure monitoring study in severe traumatic brain injury and post-traumatic hydrocephalus

Objective. To evaluate patients who developed hydrocephalus following a severe traumatic brain injury in connection with the monitoring of intracranial pressure (ICP) during the acute stage of brain trauma. Methods. There were studied 25 patients with severe head injuries and GCS score of 7 to 4, age between 20 and 60 years, who underwent ICP monitoring and cerebral perfusion pressure (CPP) monitoring. Sixteen surviving patients were followed for 12 months and the development of the post–traumatic hydrocephalus was found at five patients. Conclusions. The analysis of the data of this study shows some observations: Mortality in severe traumatic brain injuries is correlated with a low GCS score, high ICP values and arterial hypotension. The favorable outcome is in connection with a high initial GCS score, a decrease of ICP and normal values of cerebral perfusion pressure. There were five cases of moderate post-traumatic hydrocephalus and these cases of hydrocephalus have stabilized and did not need a surgical intervention

Progressive parenchymatous intracranial hypertension: Review

The parenchymatous intracranial hypertension is the intracranial pressure increase caused by the intracranial volume modifications due to an intrinsic parenchymatous lesion (expansive intra-parenchymatous lesion, brain edema, etc.) or an extrinsic lesion (tumor, traumatic, infectious extra-parenchymatous compression, etc.). Depending on the location and the development manner, intracranial expansive processes cause the progressive increase in the intracranial pressure and then the occurrence of the ICH syndrome by the development of a supplementary volume. Benign intracranial tumors have a slow volume increasing rate and the neurological syndrome is installed progressively, while the ICH syndrome may occur late. Malign tumors have a rapid development rate and the neurological syndrome occurs precociously. The clinical decompensation represents the aggravation of the symptomatology by the tumor extension or by exceeding the compensating capacities of the intracranial pressure increase

Olfactory ensheathing cells in the treatment of the tethered cord syndrome: Case report

There are several data and commentaries regarding the role of the stem cells as effective therapies in the treatment of the central nervous system’s lesions. Even if at the experimental level there have been reported very promising results, when these methods have been applied in clinical field the results were not very successful. In this context, the numerous reports about patients with significant improvement of the neurological status after stem cells inoculation or olfactory ensheathing cells (OECs) inoculation performed by the researchers from Beijing Xishan Hospital, Beijing, China, adds a discordant note in this general pessimist background. Therefore, we will present the original discharge letter from the Beijing Xishan Hospital, Beijing, China then we will make some commentaries and will draw the final conclusions