99 research outputs found
Risk factors for obstructive sleep apnea syndrome in children: state of the art
The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS). Although the etiopathogenesis of adult OSAS is well known, many aspects of this syndrome in children are still debated. Its prevalence is about 2% in children from 2 to 8 years of age, mostly related to the size of the upper airways adenoid tissue. Several risk factors linked to the development of OSAS are typical of the pediatric age. The object of this paper is to analyze the state of the art on this specific topic, discussing its implications in terms of diagnosis and management
Trans-oral robotic surgery for the management of oropharyngeal carcinomas: A 9-year institutional experience
Trans-oral robotic surgery (TORS) has changed surgical management of patients with oropharyngeal squamous cell carcinomas (OPSCC). In this study we present surgical and oncologic outcomes of patients with oropharyngeal squamous cell carcinomas, treated using TORS, with and without an adjuvant therapy. Sixty patients with oropharyngeal squamous cell carcinomas treated with TORS between January 2008 and December 2017 have been retrospectively evaluated considering clinicopathologic features, disease characteristics, adjuvant treatments and oncological outcomes. TORS was performed for OPSCC to the base of tongue in 41.7%, tonsils in 46.7%, soft palate and posterior pharyngeal wall in 3.3% and 5%, respectively. Neck dissection was performed in 43.3% of patients. Management strategies included surgery alone in 30%, TORS and adjuvant radiotherapy in 33.3%, and TORS plus adjuvant chemotherapy in 36.7%. The 5-year overall survival of the total group was 77.6%, the 5-year disease-free survival rate was 85.2%, and the 5-year local recurrence-free survival rate was 90.6%. Finally, in selected patients TORS appears to yield similar oncologic outcomes and functional outcomes to traditional techniques and non-operative treatment with a possible benefit on long-term quality of life. The future offers exciting opportunities to combine TORS and radiotherapy in unique ways. However, further research is urgently needed to clarify the indications for adjuvant therapy following TORS resections
Revisiting special relativity: A natural algebraic alternative to Minkowski spacetime
Minkowski famously introduced the concept of a space-time continuum in 1908,
merging the three dimensions of space with an imaginary time dimension , with the unit imaginary producing the correct spacetime distance , and the results of Einstein's then recently developed theory of special
relativity, thus providing an explanation for Einstein's theory in terms of the
structure of space and time. As an alternative to a planar Minkowski space-time
of two space dimensions and one time dimension, we replace the unit imaginary , with the Clifford bivector for the plane
that also squares to minus one, but which can be included without the addition
of an extra dimension, as it is an integral part of the real Cartesian plane
with the orthonormal basis and . We find that with this model of
planar spacetime, using a two-dimensional Clifford multivector, the spacetime
metric and the Lorentz transformations follow immediately as properties of the
algebra. This also leads to momentum and energy being represented as components
of a multivector and we give a new efficient derivation of Compton's scattering
formula, and a simple formulation of Dirac's and Maxwell's equations. Based on
the mathematical structure of the multivector, we produce a semi-classical
model of massive particles, which can then be viewed as the origin of the
Minkowski spacetime structure and thus a deeper explanation for relativistic
effects. We also find a new perspective on the nature of time, which is now
given a precise mathematical definition as the bivector of the plane.Comment: 29 pages, 2 figure
pi-pi scattering in a QCD based model field theory
A model field theory, in which the interaction between quarks is mediated by
dressed vector boson exchange, is used to analyse the pionic sector of QCD. It
is shown that this model, which incorporates dynamical chiral symmetry
breaking, asymptotic freedom and quark confinement, allows one to calculate
, , and the partial wave amplitudes in -
scattering and obtain good agreement with the experimental data, with the
latter being well described up to energies \mbox{ MeV}.Comment: 23 Pages, 4 figures in PostScript format, PHY-7512-TH-93, REVTEX
Available via anonymous ftp in /pub: login anonymou get pipi93.tex Fig1.ps
Fig2.ps Fig3.ps Fig4.p
High-precision multiband time series photometry of exoplanets Qatar-1b and TrES-5b
We present an analysis of the Qatar-1 and TrES-5 transiting exoplanetary systems, which contain Jupiter-like planets on short-period orbits around K-dwarf stars. Our data comprise a total of 20 transit light curves obtained using five medium-class telescopes, operated using the defocusing technique. The average precision we reach in all our data is RMSQ = 1.1 mmag for Qatar-1 (V = 12.8) and RMST = 1.0 mmag for TrES-5 (V = 13.7). We use these data to refine the orbital ephemeris, photometric parameters, and measured physical properties of the two systems. One transit event for each object was observed simultaneously in three passbands (gri) using the BUSCA imager. The QES survey light curve of Qatar-1 has a clear sinusoidal variation on a period of P? = 23.697 ± 0.123 d, implying significant star-spot activity. We searched for star-spot crossing events in our light curves, but did not find clear evidence in any of the new data sets. The planet in the Qatar-1 system did not transit the active latitudes on the surfaces of its host star. Under the assumption that P? corresponds to the rotation period of Qatar-1A, the rotational velocity of this star is very close to the vsin?i? value found from observations of the RossiterâMcLaughlin effect. The low projected orbital obliquity found in this system thus implies a low absolute orbital obliquity, which is also a necessary condition for the transit chord of the planet to avoid active latitudes on the stellar surface
Unrelated cord blood transplant in children with high-risk acute lymphoblastic leukemia: a long-term follow-up
Recent Advances in the Diagnosis and Treatment of Influenza Pneumonia
A potentially fatal complication of influenza infection is the development of pneumonia, caused either directly by the influenza virus, or by secondary bacterial infection. Pneumonia related to the 2009 influenza A pandemic was found to be underestimated by commonly used pneumonia severity scores in many cases, and to be rapidly progressive, leading to respiratory failure. Confirmation of etiology by laboratory testing is warranted in such cases. Rapid antigen and immunofluorescence testing are useful screening tests, but have limited sensitivity. Confirmation of pandemic H1N1 influenza A infection can only be made by real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) or viral culture. The most effective preventive measure is annual influenza vaccination in selected individuals. Decisions to administer antiviral medications for influenza treatment or chemoprophylaxis should be based upon clinical and epidemiological factors, and should not be delayed by confirmatory laboratory testing results. Neuraminidase inhibitors (NI) are the agents of choice
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
25th Annual Computational Neuroscience Meeting: CNS-2016
Abstracts of the 25th Annual Computational Neuroscience
Meeting: CNS-2016
Seogwipo City, Jeju-do, South Korea. 2â7 July 201
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