Fish Oil Supplementation During Late Pregnancy Does Not Influence Plasma Lipids or Lipoprotein Levels in Young Adult Offspring

Nutritional influences on cardiovascular disease operate throughout life. Studies in both experimental animals and humans have suggested that changes in the peri- and early post-natal nutrition can affect the development of the various components of the metabolic syndrome in adult life. This has lead to the hypothesis that n-3 fatty acid supplementation in pregnancy may have a beneficial effect on lipid profile in the offspring. The aim of the present study was to investigate the effect of supplementation with n-3 fatty acids during the third trimester of pregnancy on lipids and lipoproteins in the 19-year-old offspring. The study was based on the follow-up of a randomized controlled trial from 1990 where 533 pregnant women were randomized to fish oil (n = 266), olive oil (n = 136) or no oil (n = 131). In 2009, the offspring were invited to a physical examination including blood sampling. A total of 243 of the offspring participated. Lipid values did not differ between the fish oil and olive oil groups. The relative adjusted difference (95% confidence intervals) in lipid concentrations was −3% (−11; 7) for LDL cholesterol, 3% (−3; 10) for HDL cholesterol, −1% (−6; 5) for total cholesterol,−4% (−16; 10) for TAG concentrations, 2%(−2; 7) for apolipoprotein A1, −1% (−9; 7) for apolipoprotein B and 3% (−7; 15) in relative abundance of small dense LDL. In conclusion, there was no effect of fish oil supplementation during the third trimester of pregnancy on offspring plasma lipids and lipoproteins in adolescence

Glucocorticoid Effects on the Programming of AT1b Angiotensin Receptor Gene Methylation and Expression in the Rat

Adverse events in pregnancy may ‘programme’ offspring for the later development of cardiovascular disease and hypertension. Previously, using a rodent model of programmed hypertension we have demonstrated the role of the renin-angiotensin system in this process. More recently we showed that a maternal low protein diet resulted in undermethylation of the At1b angiotensin receptor promoter and the early overexpression of this gene in the adrenal of offspring. Here, we investigate the hypothesis that maternal glucocorticoid modulates this effect on fetal DNA methylation and gene expression. We investigated whether treatment of rat dams with the 11β-hydroxylase inhibitor metyrapone, could prevent the epigenetic and gene expression changes we observed. Offspring of mothers subjected to a low protein diet in pregnancy showed reduced adrenal Agtr1b methylation and increased adrenal gene expression as we observed previously. Treatment of mothers with metyrapone for the first 14 days of pregnancy reversed these changes and prevented the appearance of hypertension in the offspring at 4 weeks of age. As a control for non-specific effects of programmed hypertension we studied offspring of mothers treated with dexamethasone from day 15 of pregnancy and showed that, whilst they had raised blood pressure, they failed to show any evidence of Agtr1b methylation or increase in gene expression. We conclude that maternal glucocorticoid in early pregnancy may induce changes in methylation and expression of the Agtr1b gene as these are clearly reversed by an 11 beta-hydroxylase inhibitor. However in later pregnancy a converse effect with dexamethasone could not be demonstrated and this may reflect either an alternative mechanism of this glucocorticoid or a stage-specific influence

A population of dust-rich quasars at z ∼ 1.5

We report Herschel SPIRE (250, 350, and 500 μm) detections of 32 quasars with redshifts 0.5 ≤z < 3.6 from the Herschel Multi-tiered Extragalactic Survey (HerMES). These sources are from a MIPS 24 μm flux-limited sample of 326 quasars in the Lockman Hole Field. The extensive multi-wavelength data available in the field permit construction of the rest-frame spectral energy distributions (SEDs) from ultraviolet to the mid-infrared for all sources, and to the far-infrared (FIR) for the 32 objects. Most quasars with Herschel FIR detections show dust temperatures in the range of 25-60K, with a mean of 34K. The FIR luminosities range from 1011.3 to 1013.5 L, qualifying most of their hosts as ultra- or hyper-luminous infrared galaxies. These FIR-detected quasars may represent a dust-rich population, but with lower redshifts and fainter luminosities than quasars observed at 1mm. However, their FIR properties cannot be predicted from shorter wavelengths (0.3-20 μm, rest frame), and the bolometric luminosities derived using the 5100Å index may be underestimated for these FIR-detected quasars. Regardless of redshift, we observed a decline in the relative strength of FIR luminosities for quasars with higher near-infrared luminosities. © 2012. The American Astronomical Society. All rights reserved

A POPULATION OF DUST-RICH QUASARS AT z similar to 1.5

We report Herschel SPIRE (250, 350, and 500 μm) detections of 32 quasars with redshifts 0.5 ≤z < 3.6 from the Herschel Multi-tiered Extragalactic Survey (HerMES). These sources are from a MIPS 24 μm flux-limited sample of 326 quasars in the Lockman Hole Field. The extensive multi-wavelength data available in the field permit construction of the rest-frame spectral energy distributions (SEDs) from ultraviolet to the mid-infrared for all sources, and to the far-infrared (FIR) for the 32 objects. Most quasars with Herschel FIR detections show dust temperatures in the range of 25-60K, with a mean of 34K. The FIR luminosities range from 1011.3 to 1013.5 L, qualifying most of their hosts as ultra- or hyper-luminous infrared galaxies. These FIR-detected quasars may represent a dust-rich population, but with lower redshifts and fainter luminosities than quasars observed at 1mm. However, their FIR properties cannot be predicted from shorter wavelengths (0.3-20 μm, rest frame), and the bolometric luminosities derived using the 5100Å index may be underestimated for these FIR-detected quasars. Regardless of redshift, we observed a decline in the relative strength of FIR luminosities for quasars with higher near-infrared luminosities. © 2012. The American Astronomical Society. All rights reserved

Herschel multitiered extragalactic survey: Clusters of dusty galaxies uncovered by Herschel and Planck

The potential for Planck to detect clusters of dusty, star-forming galaxies at z > 1 is tested by examining the Herschel-SPIRE images of Planck Early Release Compact Source Catalog sources lying in fields observed by the Herschel Multitiered Extragalactic Survey. Of the 16 Planck sources that lie in the ~90 sq. deg. examined, we find that 12 are associated with single bright Herschel sources. The remaining four are associated with overdensities of Herschel sources, making them candidate clusters of dusty, star-forming galaxies. We use complementary optical/near-IR data for these 'clumps' to test this idea, and find evidence for the presence of galaxy clusters in all four cases. We use photometric redshiftsand red sequence galaxies to estimate the redshifts of these clusters, finding that they range from 0.8 to 2.3. These redshifts imply that the Herschel sources in these clusters, which contribute to the detected Planck flux, are forming stars very rapidly, with typical total cluster star formation rates > 1000M⊙ yr-1. The high-redshift clusters discovered inthese observations are used to constrain the epoch of cluster galaxy formation, finding that the galaxies in our clusters are 1-1.5 Gyr old at z ~ 1-2. Prospects for the discovery of further clusters of dusty galaxies are discussed, using not only all sky Planck surveys, but also deeper, smaller area, Herschel surveys. © 2014 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society

HerMES: detection of cosmic magnification of submillimetre galaxies using angular cross-correlation

Cosmic magnification is due to the weak gravitational lensing of sources in the distant Universe by foreground large-scale structure leading to coherent changes in the observed number density of the background sources. Depending on the slope of the background source number counts, cosmic magnification causes a correlation between the background and foreground galaxies, which is unexpected in the absence of lensing if the two populations are spatially disjoint. Previous attempts using submillimetre (sub-mm) sources have been hampered by small number statistics. The large number of sources detected in the {\it Herschel} Multi-tiered Extra-galactic Survey (HerMES) Lockman-SWIRE field enables us to carry out the first robust study of the cross-correlation between sub-mm sources and sources at lower redshifts. Using ancillary data we compile two low-redshift samples from SDSS and SWIRE with ~ 0.2 and 0.4, respectively, and cross-correlate with two sub-mm samples based on flux density and colour criteria, selecting galaxies preferentially at z ~ 2. We detect cross-correlation on angular scales between ~1 and 50 arcmin and find clear evidence that this is primarily due to cosmic magnification. A small, but non-negligible signal from intrinsic clustering is likely to be present due to the tails of the redshift distribution of the sub-mm sources overlapping with those of the foreground samples.Comment: 7 pages, 2 figues, accepted for publication in MNRA

HerMES: LYMAN BREAK GALAXIES INDIVIDUALLY DETECTED AT 0.7 <= z <= 2.0 IN GOODS-N WITH HERSCHEL/SPIRE

As part of the Herschel Multi-tiered Extragalactic Survey we have investigated the rest-frame far-infrared (FIR) properties of a sample of more than 4800 Lyman break galaxies (LBGs) in the Great Observatories Origins Deep Survey North field. Most LBGs are not detected individually, but we do detect a sub-sample of 12 objects at 0.7 2.5. The UV-to-FIR spectral energy distributions of the objects detected in the rest-frame FIR are investigated using the code CIGALE to estimate physical parameters. We find that LBGs detected by SPIRE are high-mass, luminous infrared galaxies. It appears that LBGs are located in a triangle-shaped region in the A(FUV) versus log L-FUV = 0 diagram limited by A(FUV) = 0 at the bottom and by a diagonal following the temporal evolution of the most massive galaxies from the bottom right to the top left of the diagram. This upper envelop can be used as upper limits for the UV dust attenuation as a function of L-FUV. The limits of this region are well explained using a closed-box model, where the chemical evolution of galaxies produces metals, which in turn lead to higher dust attenuation when the galaxies age