Polimorfisme Gen Terkait Dengan Peningkatan Lipolisis Adiposum

Berbagai variasi genetik mempengaruhi lipolisis jaringan adiposum, suatu polimorfisme yang relatif umum seperti pada gen USF-1 dan gen AR (adrenoseptor). Polimorfisme gen USF-1 terkait dengan peningkatan kemampuan katekolamin untuk menstimulasi lipolisis pada sel-sel lemak, karena adanya peningkatan fungsi post-reseptor yang kemungkinan terjadi pada level protein kinase A yang melibatkan sub unit tipe 1 regulatori, sedangkan polimorfisme gen AR (adrenoseptor) ß2 dan ß3 terkait dengan sensitivitas reseptor yang berubah terhadap stimulasi agonis dan terhadap pengulangan (repeat) dinukleotida pada gen HSL (hormon-sensitive lipase) yang secara nyata menurunkan kemampuan katekolamin menstimulasi lipolisis

Low delta-V near-Earth asteroids: A survey of suitable targets for space missions

In the last decades Near-Earth Objects (NEOs) have become very important targets to study, since they can give us clues to the formation, evolution and composition of the Solar System. In addition, they may represent either a threat to humankind, or a repository of extraterrestrial resources for suitable space-borne missions. Within this framework, the choice of next-generation mission targets and the characterisation of a potential threat to our planet deserve special attention. To date, only a small part of the 11,000 discovered NEOs have been physically characterised. From ground and space-based observations one can determine some basic physical properties of these objects using visible and infrared spectroscopy. We present data for 13 objects observed with different telescopes around the world (NASA-IRTF, ESO-NTT, TNG) in the 0.4 - 2.5 um spectral range, within the NEOSURFACE survey (http://www.oa-roma.inaf.it/planet/NEOSurface.html). Objects are chosen from among the more accessible for a rendez-vous mission. All of them are characterised by a delta-V (the change in velocity needed for transferring a spacecraft from low-Earth orbit to rendez-vous with NEOs) lower than 10.5 km/s, well below the Solar System escape velocity (12.3 km/s). We taxonomically classify 9 of these objects for the first time. 11 objects belong to the S-complex taxonomy; the other 2 belong to the C-complex. We constrain the surface composition of these objects by comparing their spectra with meteorites from the RELAB database. We also compute olivine and pyroxene mineralogy for asteroids with a clear evidence of pyroxene bands. Mineralogy confirms the similarity with the already found H, L or LL ordinary chondrite analogues.Comment: 9 pages, 7 figures, to be published in A&A Minor changes by language edito

Versatile hybrid acoustic micromixer with demonstration of circulating cell-free DNA extraction from sub-ml plasma samples

A low-cost and easy to implement acoustic micromixer compatible with multiple fabrication technologies that can provide efficient and vigorous mixing

Liberatory School Counseling Practices to Promote Freedom Dreaming for Black Youth

The American School Counseling Association calls for professional school counselors to support the holistic development and success of all students. However, the field of school counseling is riddled with practices that have harmed and dehumanized Black students. For example, school counselors engage in practices (e.g., social–emotional learning and vocational guidance), which work to reinforce white supremacy and dehumanize Black students. Further, school counselors may also contribute to the ways that the basic and unique needs of Black students are overlooked, leading to the continued systemic adultification of Black students. What is needed is a radical imagination of school counseling, which centers on homeplace as the foundation in order to engage in freedom dreaming. In this article, the authors engage this radical imagination to detail an antiracist view of school counseling practice that embraces freedom dreaming and homeplace through healing and Indigenous educational practices, youth-led school counseling, and critical hip-hop practices to promote joy, creativity, power, love, resistance, and liberation

A Semiparametric Bayesian Multivariate Model for Survival Probabilities After Acute Myocardial Infarction

In this work, a Bayesian semiparametric multivariate model is fitted to study data related to in-hospital and 60-day survival probabilities of patients admitted to a hospital with ST-elevation myocardial infarction diagnosis. We consider a hierarchical generalized linear model to predict survival probabilities and a process indicator (time of intervention). Poisson-Dirichlet process priors, generalizing the well-known Dirichlet process, are considered for modeling the random-effect distribution of the grouping factor which is the hospital of admission

The NEOShield-2 EU project: The Italian contribution

The NEOShield-2 (2015-2017) project has been recently approved by the European Commission in the framework of the Horizon 2020 programme with the aim i) to study specific technologies and instruments to conduct close approach missions to NEOs or to undertake mitigation demonstration, and ii) to acquire in-depth information of physical properties of the population of small NEOs (50-300 m), in order to design mitigation missions and assess the consequences of an impact on Earth. The Italian scientific community is widely involved in this project

Photometric survey of 67 near-Earth objects

Context. The near-Earth object (NEO) population is a window into the original conditions of the protosolar nebula, and has the potential to provide a key pathway for the delivery of water and organics to the early Earth. In addition to delivering the crucial ingredients for life, NEOs can pose a serious hazard to humanity since they can impact the Earth. To properly quantify the impact risk, physical properties of the NEO population need to be studied. Unfortunately, NEOs have a great variation in terms of mitigation-relevant quantities (size, albedo, composition, etc.) and less than 15% of them have been characterized to date. Aims. There is an urgent need to undertake a comprehensive characterization of smaller NEOs (D < 300 m) given that there are many more of them than larger objects; their small sizes make them intrinsically fainter and therefore harder to study. One of the main aims of the NEOShield-2 project (2015-2017), financed by the European Community in the framework of the Horizon 2020 program, is therefore to retrieve physical properties of a wide number of NEOs in order to design impact mitigation missions and assess the consequences of an impact on Earth. Methods. We carried out visible photometry of NEOs, making use of the DOLORES instrument at the Telescopio Nazionale Galileo (TNG, La Palma, Spain) in order to derive visible color indexes and the taxonomic classification for each target in our sample. Results. We attributed for the first time the taxonomical complex of 67 objects obtained during the first year of the project. While the majority of our sample belong to the S-complex, carbonaceous C-complex NEOs deserve particular attention. These NEOs can be located in orbits that are challenging from a mitigation point of view, with high inclination and low minimum orbit intersection distance (MOID). In addition, the lack of carbonaceous material we see in the small NEO population might not be due to an observational bias alone

Quantum chemistry simulation of ground- and excited-state properties of the sulfonium cation on a superconducting quantum processor

The computational description of correlated electronic structure, and particularly of excited states of many-electron systems, is an anticipated application for quantum devices. An important ramification is to determine the dominant molecular fragmentation pathways in photo-dissociation experiments of light-sensitive compounds, like sulfonium-based photo-acid generators used in photolithography. Here we simulate the static and dynamical electronic structure of the H$_3$S$^+$ molecule, taken as a minimal model of a triply-bonded sulfur cation, on a superconducting quantum processor of the IBM Falcon architecture. To this end, we combine a qubit reduction technique with variational and diagonalization quantum algorithms, and use a sequence of error-mitigation techniques. We compute dipole structure factors and partial atomic charges along ground- and excited-state potential energy curves, revealing the occurrence of homo- and heterolytic fragmentation. To the best of our knowledge, this is the first simulation of a photo-dissociation reaction on a superconducting quantum device, and an important step towards the computational description of photo-dissociation by quantum computing algorithms.Comment: 12 pages, 7 figure

Osteocalcin does not influence acute or chronic inflammation in human vascular cells

Some human observational studies have suggested an anti-inflammatory role of osteocalcin (OCN). An inflammatory protocol using IFN-γ and TNF-α (10 ng/mL) was employed to examine the acute (24 hr) and chronic (144 hr) effects of uncarboxylated OCN (ucOCN) in commercial, primary, sub-cultured human aortic endothelial (HAEC) and smooth muscle cells (HASMCs). The inflammatory protocol increased phosphorylation of intracellular signalling proteins (CREB, JNK, p38, ERK, AKT, STAT3, STAT5) and increased secretion of adhesion markers (VCAM-1, ICAM-1, MCP-1) and pro-inflammatory cytokines (IL-6, IL-8). After acute inflammation, there were no additive or reductive effects of ucOCN in either cell type. Following chronic inflammation, ucOCN did not affect cell responses, nor did it appear to have any pro- or anti-inflammatory effects when administered acutely or chronically on its own in either cell type. Additionally, ucOCN did not affect lipopolysaccharide (LPS) induced acute inflammation in HAECs or HASMCs. The findings of this study do not support a causal role for OCN within the models of vascular inflammation chosen. Further confirmatory studies are warranted

The Milano Network for Acute Coronary Syndromes and Emergency Services

Cardiologic emergences need specific equipment, a specific organization and operative networks connecting every single loop of the intervention chaim. The Authors' experience confirm the extreme usefulness of the ECG transmission in supporting the emergency system, the Milan network is trying to expand the use of thus technique also to the MSB as experimental. This study showed also big importance for the evaluation of quality standards, as the simple knowledge of our performances for treatments appeared a strong incentive to monitor and improve decisional strategies