The Young Man Four-Square

In this book, ...dedicated to every young man who has an ambition to make the most of himself and his opportunities, James Vance discusses the four roles of men: business, society, politics, and religion. Vance emphasizes the importance and benefits of diligence for men in business and at work, giving advice on choosing a vocation, balancing work and other duties, and important traits for the businessman. For the young man in society, Vance warns against becoming certain types of society men, such as the blasé young man or the dishonest young man, and gives advice concerning how to take part in society. The young man in politics is to stay informed on current issues, obey the law, and vote. Finally, the young man in religion is to live like Christ and take an active role in the religious community even if he does not become a priest.https://openworks.wooster.edu/motherhomeheaven/1054/thumbnail.jp

Patient-reported outcomes following flexible sigmoidoscopy screening for colorectal cancer in a demonstration screening programme in the UK

<p>OBJECTIVES: Flexible sigmoidoscopy (FS) screening for colorectal cancer will be introduced into the National Cancer Screening Programmes in England in 2013. Patient-reported outcome measures (PROMs) from trial participants indicate high acceptability and no adverse physical or psychological consequences, but this may not generalize to routine screening in the community. This study examined PROMs in a community-based FS screening programme.</p> <p>METHODS: Eligible adults aged 58-59 (n = 2016) registered at 34 London general practices were mailed a National Health Service-endorsed invitation to attend FS screening. Pain and side-effects were assessed in a 'morning-after' questionnaire, and satisfaction was assessed in a three-month follow-up questionnaire. Anxiety, self-rated health and colorectal symptoms were assessed at prescreening and follow-up.</p> <p>RESULTS: In total, 1020 people attended screening and were included in the current analyses, of whom 913 (90%) returned the morning-after questionnaire, and 674 (66%) the follow-up questionnaire. The prescreening questionnaire had been completed by 751 (74%) of those who attended. The majority (87%) of respondents reported no pain or mild pain, and the most frequent side-effect (wind) was only experienced more than mildly by 16%. Satisfaction was extremely high, with 98% glad they had the test; 97% would encourage a friend to have it. From prescreening to follow-up there were no changes in anxiety or self-rated health, and the number of colorectal symptoms declined. Satisfaction and changes in wellbeing were not moderated by gender, deprivation, ethnicity or screening outcome.</p> <p>CONCLUSIONS: PROMs indicate high acceptability of FS screening in 58-59 year olds, with no adverse effects on colorectal symptoms, health status or psychological wellbeing.</p&gt

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.

NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity. NAIPs (NLR family, apoptosis inhibitory proteins) are NLRs that appear to function as cytosolic immunoreceptors for specific bacterial proteins, including flagellin and the inner rod and needle proteins of bacterial type III secretion systems (T3SSs). Despite strong biochemical evidence implicating NAIPs in specific detection of bacterial ligands, genetic evidence has been lacking. Here we report the use of CRISPR/Cas9 to generate Naip1(-/-) and Naip2(-/-) mice, as well as Naip1-6(Δ/Δ) mice lacking all functional Naip genes. By challenging Naip1(-/-) or Naip2(-/-) mice with specific bacterial ligands in vivo, we demonstrate that Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin. Previously generated Naip5(-/-) mice retain some residual responsiveness to flagellin in vivo, whereas Naip1-6(Δ/Δ) mice fail to respond to cytosolic flagellin, consistent with previous biochemical data implicating NAIP6 in flagellin detection. Our results provide genetic evidence that specific NAIP proteins function to detect specific bacterial proteins in vivo

Predictive modelling of student reviewing behaviors in an introductory programming course

In this paper, we developed predictive models based on students’ reviewing behaviors in an Introductory Programming course. These patterns were captured using an educational technology that students used to review their graded paper- based assessments. Models were trained and tested with the goal of identifying students’ academic performance and those who might be in need of assistance. The results of the retrospective analysis show a reasonable accuracy. This suggests the possibility of developing interventions for students, such as providing feedback in the form of effective reviewing strategies

Domain Wall Bubbles in High Energy Heavy Ion Collisions

It has been recently shown that meta-stable domain walls exist in high-density QCD ($\mu\neq 0$) as well as in QCD with large number of colors ($N_c\to\infty$), with the lifetime being exponentially long in both cases. Such metastable domain walls may exist in our world as well, especially in hot hadronic matter with temperature close to critical. In this paper we discuss what happens if a bubble made of such wall is created in heavy ion collisions, in the mixed phase between QGP and hadronic matter. We show it will further be expanded to larger volume $\sim 20 fm^3$ by the pion pressure, before it disappears, either by puncture or contraction. Both scenarios leave distinctive experimental signatures of such events, negatively affecting the interference correlations between the outgoing pions.Comment: 6 pages, 1 fi

A method of eta' decay product selection to study partial chiral symmetry restoration

In case of chiral U_A(1) symmetry restoration the mass of the eta' boson (the ninth, would-be Goldstone boson) is decreased, thus its production cross section is heavily enhanced. The eta' decays (through one of its decay channels) into five pions. These pions will not be correlated in terms of Bose-Einsten correlations, thus the production enhancement changes the strength of two-pion correlation functions at low momentum. Preliminary results strongly support the mass decrease of the eta' boson. In this paper we propose a method to select pions coming from eta' decays. We investigate the efficiency of the proposed kinematical cut in several collision systems and energies with several simulators. We prove that our method can be used in all investigeted collision systems.Comment: Talk at the VI Workshop on Particle Correlations and Femtoscopy, Kiev, September 14-18, 2010. 6 pages, 3 figures. This work was supported by the OTKA grant NK73143 and M. Csanad's Bolyai scholarshi

Chaotic Diffusion on Periodic Orbits: The Perturbed Arnol'd Cat Map

Chaotic diffusion on periodic orbits (POs) is studied for the perturbed Arnol'd cat map on a cylinder, in a range of perturbation parameters corresponding to an extended structural-stability regime of the system on the torus. The diffusion coefficient is calculated using the following PO formulas: (a) The curvature expansion of the Ruelle zeta function. (b) The average of the PO winding-number squared, $w^{2}$, weighted by a stability factor. (c) The uniform (nonweighted) average of $w^{2}$. The results from formulas (a) and (b) agree very well with those obtained by standard methods, for all the perturbation parameters considered. Formula (c) gives reasonably accurate results for sufficiently small parameters corresponding also to cases of a considerably nonuniform hyperbolicity. This is due to {\em uniformity sum rules} satisfied by the PO Lyapunov eigenvalues at {\em fixed} $w$. These sum rules follow from general arguments and are supported by much numerical evidence.Comment: 6 Tables, 2 Figures (postscript); To appear in Physical Review

Controlled Irradiative Formation of Penitentes

Spike-shaped structures are produced by light-driven ablation in very different contexts. Penitentes 1-4 m high are common on Andean glaciers, where their formation changes glacier dynamics and hydrology. Laser ablation can produce cones 10-100 microns high with a variety of proposed applications in materials science. We report the first laboratory generation of centimeter-scale snow and ice penitentes. Systematically varying conditions allows identification of the essential parameters controlling the formation of ablation structures. We demonstrate that penitente initiation and coarsening requires cold temperatures, so that ablation leads to sublimation rather than melting. Once penitentes have formed, further growth of height can occur by melting. The penitentes intially appear as small structures (3 mm high) and grow by coarsening to 1-5 cm high. Our results are an important step towards understanding and controlling ablation morphologies.Comment: Accepted for publication in Physical Review Letter

Strange hyperon and antihyperon production from quark and string-rope matter

Hyperon and antihyperon production is investigated using two microscopical models: {\bf (1)} the fast hadronization of quark matter as given by the ALCOR model; {\bf (2)} string formation and fragmentation as in the HIJING/B model. We calculate the particle numbers and momentum distributions for Pb+Pb collisions at CERN SPS energies in order to compare the two models with each other and with the available experimental data. We show that these two theoretical approaches give similar yields for the hyperons, but strongly differ for antihyperons.Comment: 11 pages, Latex, 3 EPS figures, contribution to the Proceedings of the 4th International Conference on Strangeness in Quark Matter (SQM'98), Padova, Italy, 20-24 July 199