Cherenkov radiation by particles traversing the background radiatio n

High energy particles traversing the Universe through the cosmic microwave backgroung radiation can, in principle, emit Cherenkov radiation. It is shown that the energy threshold for this radiation is extremely high and its intensity would be too low due to the low density of the "relic photons gas" and very weak interaction of two photons.Comment: 6 pages, LATEX, no Figs.; to be published in JETP Lett. 75 (N4) (2002

On labeling in graph visualization

Cataloged from PDF version of article.When visualizing graphs, it is essential to communicate the meaning of each graph object via text or graphical labels. Automatic placement of labels in a graph is an NP-Hard problem, for which efficient heuristic solutions have been recently developed. In this paper, we describe a general framework for modeling, drawing, editing, and automatic placement of labels respecting user constraints. In addition, we present the interface and the basic engine of the Graph Editor Toolkit – a family of portable graph visualization libraries designed for integration into graphical user interface application programs. This toolkit produces a high quality automated placement of labels in a graph using our framework. A brief survey of automatic label placement algorithms is also presented. Finally we describe extensions to certain existing automatic label placement algorithms, allowing their integration into this visualization tool. (C) 2007 Elsevier Inc. All rights reserved

Field induced superconductivity with enhanced and tunable paramagnetic limit

We demonstrate that in a superconducting multilayered system with alternating interlayer coupling a new type of nonuniform superconducting state can be realized under in-plane magnetic field. The Zeeman effect in this state is compensated by the energy splitting between bonding and antibonding levels. Such compensation mechanism at low temperature leads to the field-induced superconductivity. We discuss the conditions for the experimental observation of the predicted phenomena.Comment: 5 pages, 4 figures include

Josephson current in a superconductor-ferromagnet junction with two non-collinear magnetic domains

We study the Josephson effect in a superconductor--ferromagnet--superconductor (SFS) junction with ferromagnetic domains of non-collinear magnetization. As a model for our study we consider a diffusive junction with two ferromagnetic domains along the junction. The superconductor is assumed to be close to the critical temperature $T_c$, and the linearized Usadel equations predict a sinusoidal current-phase relation. We find analytically the critical current as a function of domain lengths and of the angle between the orientations of their magnetizations. As a function of those parameters, the junction may undergo transitions between 0 and $\pi$ phases. We find that the presence of domains reduces the range of junction lengths at which the $\pi$ phase is observed. For the junction with two domains of the same length, the $\pi$ phase totally disappears as soon as the misorientation angle exceeds $\pi/2$. We further comment on possible implication of our results for experimentally observable 0--$\pi$ transitions in SFS junctions.Comment: 9 pages, 4 figures, minor changes, references adde

Elastic and Raman scattering of 9.0 and 11.4 MeV photons from Au, Dy and In

Monoenergetic photons between 8.8 and 11.4 MeV were scattered elastically and in elastically (Raman) from natural targets of Au, Dy and In.15 new cross sections were measured. Evidence is presented for a slight deformation in the 197Au nucleus, generally believed to be spherical. It is predicted, on the basis of these measurements, that the Giant Dipole Resonance of Dy is very similar to that of 160Gd. A narrow isolated resonance at 9.0 MeV is observed in In.Comment: 31 pages, 11 figure

Comparison of four diagnostic methods for detecting rabies viruses circulating in Korea

It is essential to rapidly and precisely diagnose rabies. In this study, we evaluated four diagnostic methods, indirect fluorescent antibody test (FAT), virus isolation (VI), reverse transcriptase polymerase chain reaction (RT-PCR), and rapid immunodiagnostic assay (RIDA), to detect rabies in animal brain homogenates. Out of the 110 animal brain samples tested, 20 (18.2%) were positive for rabies according to the FAT. Compared to the FAT, the sensitivities of VI, RT-PCR, and RIDA were 100, 100, and 95%, respectively. The specificities of VI, RT-PCR and RIDA were found to be 100, 100, and 98.9%, respectively. Rabies viruses circulating in Korea were isolated and propagated in murine neuroblastoma (NG108-15) cells with titers ranging from 101.5 to 104.5 TCID50/mL. Although the RIDA findings did not completely coincide with results obtained from FAT, VI, and RT-PCR, RIDA appears to be a fast and reliable assay that can be used to analyze brain samples. In summary, the results from our study showed that VI, RT-PCR, and RIDA can be used as supplementary diagnostic tools for detecting rabies viruses in both laboratory and field settings

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Purpose: To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). Design: RESCUE is a multicenter, randomized, double-masked, sham-controlled, phase 3 clinical trial. Participants: Subjects with the m.11778G>A mitochondrial DNA mutation and vision loss ≤6 months from onset in 1 or both eyes were included. Methods: Each subject's right eye was randomly assigned (1:1) to treatment with rAAV2/2-ND4 (single injection of 9 × 1010 viral genomes in 90 μl) or to sham injection. The left eye received the treatment not allocated to the right eye. Main Outcome Measures: The primary end point was the difference of the change from baseline in best-corrected visual acuity (BCVA) between rAAV2/2-ND4–treated and sham-treated eyes at week 48. Other outcome measures included contrast sensitivity, Humphrey visual field perimetry, retinal anatomic measures, and quality of life. Follow-up extended to week 96. Results: Efficacy analysis included 38 subjects. Mean age was 36.8 years, and 82% were male. Mean duration of vision loss at time of treatment was 3.6 months and 3.9 months in the rAAV2/2-ND4–treated eyes and sham-treated eyes, respectively. Mean baseline logarithm of the minimum angle of resolution (logMAR) BCVA (standard deviation) was 1.31 (0.52) in rAAV2/2-ND4–treated eyes and 1.26 (0.62) in sham-treated eyes, with a range from −0.20 to 2.51. At week 48, the difference of the change in BCVA from baseline between rAAV2/2-ND4–treated and sham-treated eyes was −0.01 logMAR (P = 0.89); the primary end point of a −0.3 logMAR (15-letter) difference was not met. The mean BCVA for both groups deteriorated over the initial weeks, reaching the worst levels at week 24, followed by a plateau phase until week 48, and then an improvement of +10 and +9 Early Treatment Diabetic Retinopathy Study letters equivalent from the plateau level in the rAAV2/2-ND4–treated and sham-treated eyes, respectively. Conclusions: At 96 weeks after unilateral injection of rAAV2/2-ND4, LHON subjects carrying the m.11778G>A mutation treated within 6 months after vision loss achieved comparable visual outcomes in the injected and uninjected eyes

Uncovering spatial topology represented by rat hippocampal population neuronal codes

Hippocampal population codes play an important role in representation of spatial environment and spatial navigation. Uncovering the internal representation of hippocampal population codes will help understand neural mechanisms of the hippocampus. For instance, uncovering the patterns represented by rat hippocampus (CA1) pyramidal cells during periods of either navigation or sleep has been an active research topic over the past decades. However, previous approaches to analyze or decode firing patterns of population neurons all assume the knowledge of the place fields, which are estimated from training data a priori. The question still remains unclear how can we extract information from population neuronal responses either without a priori knowledge or in the presence of finite sampling constraint. Finding the answer to this question would leverage our ability to examine the population neuronal codes under different experimental conditions. Using rat hippocampus as a model system, we attempt to uncover the hidden “spatial topology” represented by the hippocampal population codes. We develop a hidden Markov model (HMM) and a variational Bayesian (VB) inference algorithm to achieve this computational goal, and we apply the analysis to extensive simulation and experimental data. Our empirical results show promising direction for discovering structural patterns of ensemble spike activity during periods of active navigation. This study would also provide useful insights for future exploratory data analysis of population neuronal codes during periods of sleep.National Institutes of Health (U.S.) (NIH Grant DP1-OD003646)National Institutes of Health (U.S.) (Grant MH061976