An AI-Based Feedback Visualisation System for Speech Training

This paper proposes providing automatic feedback to support public speech training. For the first time, speech feedback is provided on a visual dashboard including not only the transcription and pitch information, but also emotion information. A method is proposed to perform emotion classification using state-of-the-art convolutional neural networks (CNNs). Moreover, this approach can be used for speech analysis purposes. A case study exploring pitch in Japanese speech is presented in this paper

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF of wild-type mice, suggesting that tau is released in the absence of neurodegeneration. ISF tau was significantly higher than CSF tau and their concentrations were not significantly correlated. Using P301S human tau transgenic mice (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent with its elevated levels of expression. However, following the onset of tau aggregation, monomeric ISF tau decreased markedly. Biochemical analysis demonstrated that soluble tau in brain homogenates decreased along with the deposition of insoluble tau. Tau fibrils injected into the hippocampus decreased ISF tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. This technique should facilitate further studies of tau secretion, spread of tau pathology, the effects of different disease states on ISF tau, and the efficacy of experimental treatments

Solving the degeneracy of the lepton-flavor mixing angle theta_atm by the T2KK two detector neutrino oscillation experiment

If the atmospheric neutrino oscillation amplitude, sin^2 2theta_atm is not maximal, there is a two fold ambiguity in the neutrino parameter space: sin^2 theta_atm>0.5 or sin^2 theta_atm<0.5. In this article, we study the impact of this degeneracy, the so-called octant degeneracy, on the T2KK experiment, which is a proposed extension of the T2K (Tokai-to-Kaimoka) neutrino oscillation experiment with an additional water cherenkov detector placed in Korea. We find that the degeneracy between sin^2 theta_atm= 0.40 and 0.60 can be resolved at the 3sigma level for sin^2 2theta_rct>0.12 (0.08) for the optimal combination of a 3.0^circ off-axis beam (OAB) at SK (L=295km) and a 0.5^circ OAB at L=1000km with a far detector of 100kton volume, after 5 years of exposure with 1.0(5.0) time 10^21 POT/year, if the hierarchy is normal. We also study the influence of the octant degeneracy on the capability of T2KK experiment to determine the mass hierarchy and the leptonic CP phase. The capability of rejecting the wrong mass hierarchy grows with increasing sin^2 theta_atm when the hierarchy is normal, whereas it is rather insensitive to sin^2 theta_atm for the inverted hierarchy. We also find that the 1sigma allowed region of the CP phase is not affected significantly even when the octant degeneracy is not resolved. All our results are obtained for the 22.5 kton Super-Kamiokande as a near detector and without an anti-neutrino beam.Comment: 23 pages, 9 figure

Jet angular correlation in vector-boson fusion processes at hadron colliders

Higgs boson and massive-graviton productions in association with two jets via vector-boson fusion (VBF) processes and their decays into a vector-boson pair at hadron colliders are studied. They include scalar and tensor boson production processes via weak-boson fusion in quark-quark collisions, gluon fusion in quark-quark, quark-gluon and gluon-gluon collisions, as well as their decays into a pair of weak bosons or virtual gluons which subsequently decay into $\ell\bar\ell$, $q\bar q$ or $gg$. We give the helicity amplitudes explicitly for all the VBF subprocesses, and show that the VBF amplitudes dominate the exact matrix elements not only for the weak-boson fusion processes but also for all the gluon fusion processes when appropriate selection cuts are applied, such as a large rapidity separation between two jets and a slicing cut for the transverse momenta of the jets. We also show that our off-shell vector-boson current amplitudes reduce to the standard quark and gluon splitting amplitudes with appropriate gluon-polarization phases in the collinear limit. Nontrivial azimuthal angle correlations of the jets in the production and in the decay of massive spin-0 and -2 bosons are manifestly expressed as the quantum interference among different helicity states of the intermediate vector-bosons. Those correlations reflect the spin and the CP nature of the Higgs bosons and the massive gravitons.Comment: 47 pages, 7 figures, 10 tables; references added, version to appear in JHE

Expression analysis of G Protein-coupled receptors in mouse macrophages

Background. Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic micro-array analysis of GPCR expression in primary mouse macrophages to identify family members that are either enriched in macrophages compared to a panel of other cell types, or are regulated by an inflammatory stimulus, the bacterial product lipopolysaccharide (LPS). Results. Several members of the P2RY family had striking expression patterns in macrophages; P2ry6 mRNA was essentially expressed in a macrophage-specific fashion, whilst P2ry1 and P2ry5 mRNA levels were strongly down-regulated by LPS. Expression of several other GPCRs was either restricted to macrophages (e.g. Gpr84) or to both macrophages and neural tissues (e.g. P2ry12, Gpr85). The GPCR repertoire expressed by bone marrow-derived macrophages and thioglycollate- elicited peritoneal macrophages had some commonality, but there were also several GPCRs preferentially expressed by either cell population. Conclusion. The constitutive or regulated expression in macrophages of several GPCRs identified in this study has not previously been described. Future studies on such GPCRs and their agonists are likely to provide important insights into macrophage biology, as well as novel inflammatory pathways that could be future targets for drug discovery

Neutrino Electron Scattering and Electroweak Gauge Structure: Future Tests

Low-energy high-resolution neutrino-electron scattering experiments may play an important role in testing the gauge structure of the electroweak interaction. We propose the use of radioactive neutrino sources (e.g. $^{51}$Cr) in underground experiments such as BOREXINO, HELLAZ and LAMA. As an illustration, we display the sensitivity of these detectors in testing the possible existence of extra neutral gauge bosons, both in the framework of E_6 models and of models with left-right symmetry.Comment: 22 pages, revtex, 4 figures included, accepted for publication in Phys. Rev.

100 years of progress in understanding the stratosphere and mesosphere

The stratosphere contains ~17% of Earth’s atmospheric mass, but its existence was unknown until 1902. In the following decades our knowledge grew gradually as more observations of the stratosphere were made. In 1913 the ozone layer, which protects life from harmful ultraviolet radiation, was discovered. From ozone and water vapor observations, a first basic idea of a stratospheric general circulation was put forward. Since the 1950s our knowledge of the stratosphere and mesosphere has expanded rapidly, and the importance of this region in the climate system has become clear. With more observations, several new stratospheric phenomena have been discovered: the quasi-biennial oscillation, sudden stratospheric warmings, the Southern Hemisphere ozone hole, and surface weather impacts of stratospheric variability. None of these phenomena were anticipated by theory. Advances in theory have more often than not been prompted by unexplained phenomena seen in new stratospheric observations. From the 1960s onward, the importance of dynamical processes and the coupled stratosphere–troposphere circulation was realized. Since approximately 2000, better representations of the stratosphere—and even the mesosphere—have been included in climate and weather forecasting models. We now know that in order to produce accurate seasonal weather forecasts, and to predict long-term changes in climate and the future evolution of the ozone layer, models with a well-resolved stratosphere with realistic dynamics and chemistry are necessary

Observations of the middle and upper atmosphere over Syowa station, Antarctica by JARE VIII-th term prioritized research project

第2回極域科学シンポジウム/第35回極域宙空圏シンポジウム 11月15日（火） 国立極地研究所 2階大会議