199 research outputs found

    Spectral conservation laws for periodic nonlinear equations of the Melnikov type

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    We consider the nonlinear equations obtained from soliton equations by adding self-consistent sources. We demonstrate by using as an example the Kadomtsev-Petviashvili equation that such equations on periodic functions are not isospectral. They deform the spectral curve but preserve the multipliers of the Floquet functions. The latter property implies that the conservation laws, for soliton equations, which may be described in terms of the Floquet multipliers give rise to conservation laws for the corresponding equations with self-consistent sources. Such a property was first observed by us for some geometrical flow which appears in the conformal geometry of tori in three- and four-dimensional Euclidean spaces (math/0611215).Comment: 16 page

    Faddeev eigenfunctions for two-dimensional Schrodinger operators via the Moutard transformation

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    We demonstrate how the Moutard transformation of two-dimensional Schrodinger operators acts on the Faddeev eigenfunctions on the zero energy level and present some explicitly computed examples of such eigenfunctions for smooth fast decaying potentials of operators with non-trivial kernel and for deformed potentials which correspond to blowing up solutions of the Novikov-Veselov equation.Comment: 11 pages, final remarks are adde

    A large time asymptotics for transparent potentials for the Novikov-Veselov equation at positive energy

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    In the present paper we begin studies on the large time asymptotic behavior for solutions of the Cauchy problem for the Novikov--Veselov equation (an analog of KdV in 2 + 1 dimensions) at positive energy. In addition, we are focused on a family of reflectionless (transparent) potentials parameterized by a function of two variables. In particular, we show that there are no isolated soliton type waves in the large time asymptotics for these solutions in contrast with well-known large time asymptotics for solutions of the KdV equation with reflectionless initial data

    Π‘ΠΈΠ½Ρ‚Π΅Π· Ρ‚Π° Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΎΠΌΠ΅Ρ‚ΠΈΠ»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… Π°Π½Ρ–Π»Ρ–Π΄Ρ–Π² 4-гідрокси-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΈΡ… кислот

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    In order to reveal the regularities of the β€œstructure – biological activity” relationship by interaction of esters of 1-R-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxylic acids and trifluoromethyl substituted anilines in boiling xylene with good yields and purity the corresponding N-aryl-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides have been synthesized. The structure of the compounds obtained has been confirmed by the data of elemental analysis and NMR 1Hspectroscopy. It has been shown that the presence of trifluoromethyl groups having the powerful electron-withdrawing properties affects the position of signals of the aniline moiety protons: comparing to the spectra of the model methyl derivatives they undergo a significant paramagnetic shift. According to the results of the pharmacological studies conducted it has been found that the replacement of methyl groups in the anilide moiety of 1-R-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides to trifluoromethyl has a different effect on their analgesic activity, which can remain at the original level, be completely lost or significantly increase. However, N-aryl-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides definitely lose the ability to influence in any way on the excretory renal function after this chemical modification.Π‘ Ρ†Π΅Π»ΡŒΡŽ выявлСния закономСрностСй связи «структура – биологичСская Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΒ» взаимодСйствиСм слоТных эфиров 1-R-4-гидрокси-2,2-диоксо-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²Ρ‹Ρ… кислот ΠΈ Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΌΠ΅Ρ‚ΠΈΠ»Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ² Π² кипящСм ксилолС с Ρ…ΠΎΡ€ΠΎΡˆΠΈΠΌΠΈ Π²Ρ‹Ρ…ΠΎΠ΄Π°ΠΌΠΈ ΠΈ чистотой синтСзированы ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ N-Π°Ρ€ΠΈΠ»-4-гидрокси-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамиды. Π‘Ρ‚Ρ€ΠΎΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… соСдинСний ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½Ρ‹ΠΌΠΈ элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ спСктроскопии ЯМР 1Н. Показано, Ρ‡Ρ‚ΠΎ присутствиС ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΡ… ΠΌΠΎΡ‰Π½Ρ‹ΠΌΠΈ элСктроноакцСпторными свойствами Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½Ρ‹Ρ… Π³Ρ€ΡƒΠΏΠΏ сказываСтся Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ сигналов ΠΏΡ€ΠΎΡ‚ΠΎΠ½ΠΎΠ² Π°Π½ΠΈΠ»ΠΈΠ΄Π½Ρ‹Ρ… Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ΠΎΠ² – ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ со спСктрами ΠΌΠΎΠ΄Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Ρ… ΠΎΠ½ΠΈ ΠΏΡ€Π΅Ρ‚Π΅Ρ€ΠΏΠ΅Π²Π°ΡŽΡ‚ сущСствСнный ΠΏΠ°Ρ€Π°ΠΌΠ°Π³Π½ΠΈΡ‚Π½Ρ‹ΠΉ сдвиг. По Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Ρ… фармакологичСских испытаний Π½Π°ΠΉΠ΄Π΅Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π·Π°ΠΌΠ΅Π½Π° ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½Ρ‹Ρ… Π³Ρ€ΡƒΠΏΠΏ Π² Π°Π½ΠΈΠ»ΠΈΠ΄Π½ΠΎΠΌ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Π΅ 1-R-4-гидрокси-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамидов Π½Π° Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€-ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½Ρ‹Π΅ ΠΏΠΎ-Ρ€Π°Π·Π½ΠΎΠΌΡƒ влияСт Π½Π° ΠΈΡ… Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, которая ΠΌΠΎΠΆΠ΅Ρ‚ ΠΎΡΡ‚Π°Π²Π°Ρ‚ΡŒΡΡ Π½Π° исходном ΡƒΡ€ΠΎΠ²Π½Π΅, ΠΏΠΎΠ»Π½ΠΎΡΡ‚ΡŒΡŽ Ρ‚Π΅Ρ€ΡΡ‚ΡŒΡΡ ΠΈΠ»ΠΈ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΡƒΡΠΈΠ»ΠΈΠ²Π°Ρ‚ΡŒΡΡ. А Π²ΠΎΡ‚ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ Π²Π»ΠΈΡΡ‚ΡŒ ΠΊΠ°ΠΊΠΈΠΌ-Π»ΠΈΠ±ΠΎ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ Π½Π° ΠΌΠΎΡ‡Π΅Π²Ρ‹Π΄Π΅Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΡƒΡŽ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΡŽ ΠΏΠΎΡ‡Π΅ΠΊ N-Π°Ρ€ΠΈΠ»-4-гидрокси-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамиды послС ΡƒΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ химичСской ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ ΠΎΠ΄Π½ΠΎΠ·Π½Π°Ρ‡Π½ΠΎ ΡƒΡ‚Ρ€Π°Ρ‡ΠΈΠ²Π°ΡŽΡ‚.Π— ΠΌΠ΅Ρ‚ΠΎΡŽ виявлСння закономірностСй зв’язку «структура – Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒΒ» Π²Π·Π°Ρ”ΠΌΠΎΠ΄Ρ–Ρ”ΡŽ СстСрів 1-R-4-гідрокси-2,2-діоксо-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΈΡ… кислот Ρ‚Π° Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΎΠΌΠ΅Ρ‚ΠΈΠ»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… Π°Π½Ρ–Π»Ρ–Π½Ρ–Π² Ρƒ киплячому ксилолі Π· Π΄ΠΎΠ±Ρ€ΠΈΠΌΠΈ Π²ΠΈΡ…ΠΎΠ΄Π°ΠΌΠΈ Ρ– Ρ‡ΠΈΡΡ‚ΠΎΡ‚ΠΎΡŽ синтСзовані Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½Ρ– N-Π°Ρ€ΠΈΠ»-4-гідрокси- 2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксаміди. Π‘ΡƒΠ΄ΠΎΠ²Π° ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΡ… сполук Π΄ΠΎΠ²Π΅Π΄Π΅Π½Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»Ρ–Π·Ρƒ Ρ‚Π° спСктроскопії ЯМР 1Н. Показано, Ρ‰ΠΎ ΠΏΡ€ΠΈΡΡƒΡ‚Π½Ρ–ΡΡ‚ΡŒ Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΎΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½ΠΈΡ… Π³Ρ€ΡƒΠΏ, які Π²ΠΈΡΠ²Π»ΡΡŽΡ‚ΡŒ ΡΠΈΠ»ΡŒΠ½Ρ– Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΎΠ½ΠΎΠ°ΠΊΡ†Π΅ΠΏΡ‚ΠΎΡ€Π½Ρ– властивості, ΠΏΠΎΠ·Π½Π°Ρ‡Π°Ρ”Ρ‚ΡŒΡΡ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ– сигналів ΠΏΡ€ΠΎΡ‚ΠΎΠ½Ρ–Π² Π°Π½Ρ–Π»Ρ–Π΄Π½ΠΈΡ… Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Ρ–Π² – порівняно Π·Ρ– спСктрами ΠΌΠΎΠ΄Π΅Π»ΡŒΠ½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½ΠΈΡ… ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ… Π²ΠΎΠ½ΠΈ ΠΏΡ–Π΄Π΄Π°ΡŽΡ‚ΡŒΡΡ суттєвому ΠΏΠ°Ρ€Π°ΠΌΠ°Π³Π½Ρ–Ρ‚Π½ΠΎΠΌΡƒ зсуву. Π—Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ… Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΈΡ… Π²ΠΈΠΏΡ€ΠΎΠ±ΠΎΠ²ΡƒΠ²Π°Π½ΡŒ Π·Π½Π°ΠΉΠ΄Π΅Π½ΠΎ, Ρ‰ΠΎ Π·Π°ΠΌΡ–Π½Π° ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½ΠΈΡ… Π³Ρ€ΡƒΠΏ Π² Π°Π½Ρ–Π»Ρ–Π΄Π½ΠΎΠΌΡƒ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Ρ– 1-R-4-гідрокси-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксамідів Π½Π° Ρ‚Ρ€ΠΈΡ„Ρ‚ΠΎΡ€ΠΎΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½Ρ– ΠΏΠΎ-Ρ€Ρ–Π·Π½ΠΎΠΌΡƒ Π²ΠΏΠ»ΠΈΠ²Π°Ρ” Π½Π° Ρ—Ρ… Π°Π½Π°Π»Π³Π΅Ρ‚ΠΈΡ‡Π½Ρƒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ, яка ΠΌΠΎΠΆΠ΅ Π·Π°Π»ΠΈΡˆΠ°Ρ‚ΠΈΡΡ Π½Π° Π²ΠΈΡ…Ρ–Π΄Π½ΠΎΠΌΡƒ Ρ€Ρ–Π²Π½Ρ–, ΠΏΠΎΠ²Π½Ρ–ΡΡ‚ΡŽ втрачатися Π°Π±ΠΎ ΠΆ Π·Π½Π°Ρ‡Π½ΠΎ ΠΏΠΎΡΠΈΠ»ΡŽΠ²Π°Ρ‚ΠΈΡΡ. А ось Π·Π΄Π°Ρ‚Π½Ρ–ΡΡ‚ΡŒ Π²ΠΏΠ»ΠΈΠ²Π°Ρ‚ΠΈ Π±ΡƒΠ΄ΡŒ-яким Ρ‡ΠΈΠ½ΠΎΠΌ Π½Π° ΡΠ΅Ρ‡ΠΎΠ²ΠΈΠ΄Ρ–Π»ΡŒΠ½Ρƒ Ρ„ΡƒΠ½ΠΊΡ†Ρ–ΡŽ Π½ΠΈΡ€ΠΎΠΊ N-Π°Ρ€ΠΈΠ»-4-гідрокси-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксаміди після Π·Π°Π·Π½Π°Ρ‡Π΅Π½ΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΎΡ— ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ— ΠΎΠ΄Π½ΠΎΠ·Π½Π°Ρ‡Π½ΠΎ Π²Ρ‚Ρ€Π°Ρ‡Π°ΡŽΡ‚ΡŒ

    A RARE CASE OF ALVEOLAR SARCOMA OF THE PARAPHARYNGEAL SPACE

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    The paper describes the rare malignancy alveolar soft tissue sarcoma. The tumor was located in the parapharyngeal space; it was detected during pregnancy. The authors give the data available in the literature on the clinical manifestations of this disease, the specific features of morphological diagnosis, and treatment policy. The described case focuses on the complexities of diagnosis and preoperative preparation and surgical techniques

    Isoperiodic deformations of the acoustic operator and periodic solutions of the Harry Dym equation

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    We consider the problem of describing the possible spectra of an acoustic operator with a periodic finite-gap density. We construct flows on the moduli space of algebraic Riemann surfaces that preserve the periods of the corresponding operator. By a suitable extension of the phase space, these equations can be written with quadratic irrationalities.Comment: 15 page

    Topological Phenomena in the Real Periodic Sine-Gordon Theory

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    The set of real finite-gap Sine-Gordon solutions corresponding to a fixed spectral curve consists of several connected components. A simple explicit description of these components obtained by the authors recently is used to study the consequences of this property. In particular this description allows to calculate the topological charge of solutions (the averaging of the xx-derivative of the potential) and to show that the averaging of other standard conservation laws is the same for all components.Comment: LaTeX, 18 pages, 3 figure

    Finite-gap Solutions of the Vortex Filament Equation: Isoperiodic Deformations

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    We study the topology of quasiperiodic solutions of the vortex filament equation in a neighborhood of multiply covered circles. We construct these solutions by means of a sequence of isoperiodic deformations, at each step of which a real double point is "unpinched" to produce a new pair of branch points and therefore a solution of higher genus. We prove that every step in this process corresponds to a cabling operation on the previous curve, and we provide a labelling scheme that matches the deformation data with the knot type of the resulting filament.Comment: 33 pages, 5 figures; submitted to Journal of Nonlinear Scienc

    Π‘ΠΈΠ½Ρ‚Π΅Π· Ρ‚Π° Π°Π½Π°Π»Π³Π΅Ρ‚ΠΈΡ‡Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ N-(Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»-2-Ρ–Π»)-4-гідрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксамідів

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    Continuing the search of new effective analgesics with improved properties the corresponding N-(benzothiazol- 2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamides have been synthesized in boiling xylene by the interaction of methyl ester of 4-hydroxy-1-methyl-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxylic acid with 2-aminobenzothiazoles. The structure of the substances synthesized has been confirmed by the data of elemental analysis, NMR 1H spectroscopy and mass-spectrometry. The peculiarities of the aromatic region interpretation in NMR 1H spectra of the structural class studied have been discussed. It has been shown that in ionization by electron impact the primary fragmentation of molecular ions of N-(benzothiazol-2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamides surprisingly occurs in a variety of ways. It starts with SO2 release in amide unsubstituted in the benzothiazole moiety of the molecule and its 6-methyl analogue, while for halogenated products the primary breaking of the terminal carbamide bond or the loss of halogen are characteristic. According to the results of the pharmacological research performed on the model of tail-flick procedure, N-(6-bromobenzothiazol-2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamide has been determined; it exhibits the analgesic effect at the level of Meloxicam.ΠŸΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠ°Ρ поиск Π½ΠΎΠ²Ρ‹Ρ… эффСктивных Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΡ… срСдств с ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½Π½Ρ‹ΠΌΠΈ свойствами, взаимодСйствиСм ΠΌΠ΅Ρ‚ΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ эфира 4-гидрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-диоксо-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты с 2-Π°ΠΌΠΈΠ½ΠΎΠ±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»Π°ΠΌΠΈ Π² кипящСм ксилолС синтСзированы ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ N-Π±Π΅Π½Π·ΠΎ-Ρ‚ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-гидрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамиды. Π‘Ρ‚Ρ€ΠΎΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½- Π½Ρ‹Ρ… вСщСств ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½Ρ‹ΠΌΠΈ элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π°, спСктроскопии ЯМР 1Н ΠΈ масс-спСктромСтрии. ΠžΠ±ΡΡƒΠΆΠ΄Π°ΡŽΡ‚ΡΡ особСнности ΠΈΠ½Ρ‚Π΅Ρ€ΠΏΡ€Π΅Ρ‚Π°Ρ†ΠΈΠΈ ароматичСской области Π² спСктрах ЯМР 1Н ΠΈΠ·ΡƒΡ‡Π°Π΅ΠΌΠΎΠ³ΠΎ класса химичСских соСдинСний. Показано, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈ ΠΈΠΎΠ½ΠΈΠ·Π°Ρ†ΠΈΠΈ элСктронным ΡƒΠ΄Π°Ρ€ΠΎΠΌ пСрвичная фрагмСнтация молСкулярных ΠΈΠΎΠ½ΠΎΠ² N-(Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-гидрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамидов Π½Π΅ΠΎΠΆΠΈΠ΄Π°Π½Π½ΠΎ происходит Ρ€Π°Π·Π½Ρ‹ΠΌΠΈ путями. Π£ Π½Π΅Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½ΠΎΠ³ΠΎ Π² Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»ΡŒΠ½ΠΎΠΉ части ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Ρ‹ Π°ΠΌΠΈΠ΄Π° ΠΈ Π΅Π³ΠΎ 6-ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° ΠΎΠ½Π° начинаСтся с выброса SO2, Ρ‚ΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ для Π³Π°Π»ΠΎΠ³Π΅Π½Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π΅Π½ ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½Ρ‹ΠΉ Ρ€Π°Π·Ρ€Ρ‹Π² Ρ‚Π΅Ρ€ΠΌΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΊΠ°Ρ€Π±Π°ΠΌΠΈΠ΄Π½ΠΎΠΉ связи ΠΈΠ»ΠΈ ΡƒΡ‚Ρ€Π°Ρ‚Π° Π³Π°Π»ΠΎΠ³Π΅Π½Π°. По Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ фармакологичСских испытаний, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Ρ… Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ тСрмичСского раздраТСния ΠΊΠΎΠ½Ρ‡ΠΈΠΊΠ° хвоста (tail-flick), выявлСн N-(6-Π±Ρ€ΠΎΠΌΠ±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-гидрокси- 1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-диоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚ΠΈΠ°Π·ΠΈΠ½-3-карбоксамид, ΠΏΡ€ΠΎΡΠ²Π»ΡΡŽΡ‰ΠΈΠΉ Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΠΉ эффСкт Π½Π° ΡƒΡ€ΠΎΠ²Π½Π΅ мСлоксикама.ΠŸΡ€ΠΎΠ΄ΠΎΠ²ΠΆΡƒΡŽΡ‡ΠΈ ΠΏΠΎΡˆΡƒΠΊ Π½ΠΎΠ²ΠΈΡ… Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π½ΠΈΡ… засобів Π· ΠΏΠΎΠΊΡ€Π°Ρ‰Π΅Π½ΠΈΠΌΠΈ властивостями, Π²Π·Π°Ρ”ΠΌΠΎΠ΄Ρ–Ρ”ΡŽ ΠΌΠ΅Ρ‚ΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ СстСру 4-гідрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Π· 2-Π°ΠΌΡ–Π½ΠΎΠ±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»Π°ΠΌΠΈ Ρƒ киплячому ксилолі синтСзовані Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½Ρ– N-(Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»-2-Ρ–Π»)-4-гідрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксаміди. Π‘ΡƒΠ΄ΠΎΠ²Π° ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»Ρ–Π·Ρƒ, спСктроскопії ЯМР 1Н Ρ‚Π° мас-спСктромСтрії. ΠžΠ±Π³ΠΎΠ²ΠΎΡ€ΡŽΡŽΡ‚ΡŒΡΡ особливості Ρ–Π½Ρ‚Π΅Ρ€ΠΏΡ€Π΅Ρ‚Π°Ρ†Ρ–Ρ— Π°Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΡ‡Π½ΠΎΡ— області Π² спСктрах ЯМР 1Н дослідТуваного класу Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… сполук. Показано, Ρ‰ΠΎ ΠΏΡ€ΠΈ Ρ–ΠΎΠ½Ρ–Π·Π°Ρ†Ρ–Ρ— Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΎΠ½Π½ΠΈΠΌ ΡƒΠ΄Π°Ρ€ΠΎΠΌ ΠΏΠ΅Ρ€Π²ΠΈΠ½Π½Π° фрагмСнтація молСкулярних Ρ–ΠΎΠ½Ρ–Π² N-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»-2-Ρ–Π»)-4-гідрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксамідів нСсподівано ΠΏΠ΅Ρ€Π΅Π±Ρ–Π³Π°Ρ” Ρ€Ρ–Π·Π½ΠΈΠΌΠΈ ΡˆΠ»ΡΡ…Π°ΠΌΠΈ. Π£ Π½Π΅Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΎΠ³ΠΎ Π² Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»ΡŒΠ½Ρ–ΠΉ частині ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»ΠΈ Π°ΠΌΡ–Π΄Ρƒ Ρ‚Π° ΠΉΠΎΠ³ΠΎ 6-ΠΌΠ΅Ρ‚ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° Π²ΠΎΠ½Π° ΠΏΠΎΡ‡ΠΈΠ½Π°Ρ”Ρ‚ΡŒΡΡ Π· Π²ΠΈΠΊΠΈΠ΄Ρƒ SO2, Ρ‚ΠΎΠ΄Ρ– як для Π³Π°Π»ΠΎΠ³Π΅Π½Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ–Π² Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½ΠΈΠΉ ΠΏΠ΅Ρ€Π²ΠΈΠ½Π½ΠΈΠΉ Ρ€ΠΎΠ·Ρ€ΠΈΠ² Ρ‚Π΅Ρ€ΠΌΡ–Π½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΊΠ°Ρ€Π±Π°ΠΌΡ–Π΄Π½ΠΎΠ³ΠΎ зв’язку Π°Π±ΠΎ Π²Ρ‚Ρ€Π°Ρ‚Π° Π³Π°Π»ΠΎΠ³Π΅Π½Ρƒ. Π—Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌΠΈ Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΈΡ… Π²ΠΈΠΏΡ€ΠΎΠ±ΠΎΠ²ΡƒΠ²Π°Π½ΡŒ, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ… Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– Ρ‚Π΅Ρ€ΠΌΡ–Ρ‡Π½ΠΎΠ³ΠΎ подразнСння ΠΊΡ–Π½Ρ‡ΠΈΠΊΠ° хвоста (tail-flick), виявлСно N-(6-Π±Ρ€ΠΎΠΌΠ±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΎΠ»-2-Ρ–Π»)-4-гідрокси-1-ΠΌΠ΅Ρ‚ΠΈΠ»-2,2-діоксо-1Н-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡ‚Ρ–Π°Π·ΠΈΠ½-3-карбоксамід, який проявляє Π°Π½Π°Π»Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΈΠΉ Π΅Ρ„Π΅ΠΊΡ‚ Π½Π° Ρ€Ρ–Π²Π½Ρ– мСлоксикаму
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