199 research outputs found
Spectral conservation laws for periodic nonlinear equations of the Melnikov type
We consider the nonlinear equations obtained from soliton equations by adding
self-consistent sources. We demonstrate by using as an example the
Kadomtsev-Petviashvili equation that such equations on periodic functions are
not isospectral. They deform the spectral curve but preserve the multipliers of
the Floquet functions. The latter property implies that the conservation laws,
for soliton equations, which may be described in terms of the Floquet
multipliers give rise to conservation laws for the corresponding equations with
self-consistent sources. Such a property was first observed by us for some
geometrical flow which appears in the conformal geometry of tori in three- and
four-dimensional Euclidean spaces (math/0611215).Comment: 16 page
Faddeev eigenfunctions for two-dimensional Schrodinger operators via the Moutard transformation
We demonstrate how the Moutard transformation of two-dimensional Schrodinger
operators acts on the Faddeev eigenfunctions on the zero energy level and
present some explicitly computed examples of such eigenfunctions for smooth
fast decaying potentials of operators with non-trivial kernel and for deformed
potentials which correspond to blowing up solutions of the Novikov-Veselov
equation.Comment: 11 pages, final remarks are adde
A large time asymptotics for transparent potentials for the Novikov-Veselov equation at positive energy
In the present paper we begin studies on the large time asymptotic behavior
for solutions of the Cauchy problem for the Novikov--Veselov equation (an
analog of KdV in 2 + 1 dimensions) at positive energy. In addition, we are
focused on a family of reflectionless (transparent) potentials parameterized by
a function of two variables. In particular, we show that there are no isolated
soliton type waves in the large time asymptotics for these solutions in
contrast with well-known large time asymptotics for solutions of the KdV
equation with reflectionless initial data
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΡΠΈΡΡΠΎΡΠΎΠΌΠ΅ΡΠΈΠ»Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ Π°Π½ΡΠ»ΡΠ΄ΡΠ² 4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡ
In order to reveal the regularities of the βstructure β biological activityβ relationship by interaction of esters of 1-R-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxylic acids and trifluoromethyl substituted anilines in boiling xylene with good yields and purity the corresponding N-aryl-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides have been synthesized. The structure of the compounds obtained has been confirmed by the data of elemental analysis and NMR 1Hspectroscopy. It has been shown that the presence of trifluoromethyl groups having the powerful electron-withdrawing properties affects the position of signals of the aniline moiety protons: comparing to the spectra of the model methyl derivatives they undergo a significant paramagnetic shift. According to the results of the pharmacological studies conducted it has been found that the replacement of methyl groups in the anilide moiety of 1-R-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides to trifluoromethyl has a different effect on their analgesic activity, which can remain at the original level, be completely lost or significantly increase. However, N-aryl-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazin-3-carboxamides definitely lose the ability to influence in any way on the excretory renal function after this chemical modification.Π‘ ΡΠ΅Π»ΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠ΅ΠΉ ΡΠ²ΡΠ·ΠΈ Β«ΡΡΡΡΠΊΡΡΡΠ° β Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΒ» Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠΈΡΠΎΠ² 1-R-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΡΡΠΈΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ² Π² ΠΊΠΈΠΏΡΡΠ΅ΠΌ ΠΊΡΠΈΠ»ΠΎΠ»Π΅ Ρ Ρ
ΠΎΡΠΎΡΠΈΠΌΠΈ Π²ΡΡ
ΠΎΠ΄Π°ΠΌΠΈ ΠΈ ΡΠΈΡΡΠΎΡΠΎΠΉ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ N-Π°ΡΠΈΠ»-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄Ρ. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π―ΠΠ 1Π. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
ΠΌΠΎΡΠ½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΎΠ°ΠΊΡΠ΅ΠΏΡΠΎΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΡΡΠΈΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΡΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΏΡΠΎΡΠΎΠ½ΠΎΠ² Π°Π½ΠΈΠ»ΠΈΠ΄Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² β ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ ΡΠΏΠ΅ΠΊΡΡΠ°ΠΌΠΈ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
ΠΎΠ½ΠΈ ΠΏΡΠ΅ΡΠ΅ΡΠΏΠ΅Π²Π°ΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΉ ΡΠ΄Π²ΠΈΠ³. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ Π½Π°ΠΉΠ΄Π΅Π½ΠΎ, ΡΡΠΎ Π·Π°ΠΌΠ΅Π½Π° ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ Π² Π°Π½ΠΈΠ»ΠΈΠ΄Π½ΠΎΠΌ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ΅ 1-R-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄ΠΎΠ² Π½Π° ΡΡΠΈΡΡΠΎΡ-ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΠ΅ ΠΏΠΎ-ΡΠ°Π·Π½ΠΎΠΌΡ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΈΡ
Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ ΠΎΡΡΠ°Π²Π°ΡΡΡΡ Π½Π° ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅, ΠΏΠΎΠ»Π½ΠΎΡΡΡΡ ΡΠ΅ΡΡΡΡΡΡ ΠΈΠ»ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡΠΈΠ»ΠΈΠ²Π°ΡΡΡΡ. Π Π²ΠΎΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π²Π»ΠΈΡΡΡ ΠΊΠ°ΠΊΠΈΠΌ-Π»ΠΈΠ±ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ Π½Π° ΠΌΠΎΡΠ΅Π²ΡΠ΄Π΅Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΡΠ½ΠΊΡΠΈΡ ΠΏΠΎΡΠ΅ΠΊ N-Π°ΡΠΈΠ»-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄Ρ ΠΏΠΎΡΠ»Π΅ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΎΠ΄Π½ΠΎΠ·Π½Π°ΡΠ½ΠΎ ΡΡΡΠ°ΡΠΈΠ²Π°ΡΡ.Π ΠΌΠ΅ΡΠΎΡ Π²ΠΈΡΠ²Π»Π΅Π½Π½Ρ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΡΡΠ½ΠΎΡΡΠ΅ΠΉ Π·Π²βΡΠ·ΠΊΡ Β«ΡΡΡΡΠΊΡΡΡΠ° β Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡΒ» Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡΡ Π΅ΡΡΠ΅ΡΡΠ² 1-R-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΡΠΎΠΊΡΠΎ-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ ΡΠ° ΡΡΠΈΡΡΠΎΡΠΎΠΌΠ΅ΡΠΈΠ»Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
Π°Π½ΡΠ»ΡΠ½ΡΠ² Ρ ΠΊΠΈΠΏΠ»ΡΡΠΎΠΌΡ ΠΊΡΠΈΠ»ΠΎΠ»Ρ Π· Π΄ΠΎΠ±ΡΠΈΠΌΠΈ Π²ΠΈΡ
ΠΎΠ΄Π°ΠΌΠΈ Ρ ΡΠΈΡΡΠΎΡΠΎΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½Ρ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½Ρ N-Π°ΡΠΈΠ»-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ- 2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΠΈ. ΠΡΠ΄ΠΎΠ²Π° ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Π΄ΠΎΠ²Π΅Π΄Π΅Π½Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ ΡΠ° ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ Π―ΠΠ 1Π. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΠΏΡΠΈΡΡΡΠ½ΡΡΡΡ ΡΡΠΈΡΡΠΎΡΠΎΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΈΡ
Π³ΡΡΠΏ, ΡΠΊΡ Π²ΠΈΡΠ²Π»ΡΡΡΡ ΡΠΈΠ»ΡΠ½Ρ Π΅Π»Π΅ΠΊΡΡΠΎΠ½ΠΎΠ°ΠΊΡΠ΅ΠΏΡΠΎΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ, ΠΏΠΎΠ·Π½Π°ΡΠ°ΡΡΡΡΡ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ ΡΠΈΠ³Π½Π°Π»ΡΠ² ΠΏΡΠΎΡΠΎΠ½ΡΠ² Π°Π½ΡΠ»ΡΠ΄Π½ΠΈΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡΠ² β ΠΏΠΎΡΡΠ²Π½ΡΠ½ΠΎ Π·Ρ ΡΠΏΠ΅ΠΊΡΡΠ°ΠΌΠΈ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
Π²ΠΎΠ½ΠΈ ΠΏΡΠ΄Π΄Π°ΡΡΡΡΡ ΡΡΡΡΡΠ²ΠΎΠΌΡ ΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΡΡΠ½ΠΎΠΌΡ Π·ΡΡΠ²Ρ. ΠΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π²ΠΈΠΏΡΠΎΠ±ΠΎΠ²ΡΠ²Π°Π½Ρ Π·Π½Π°ΠΉΠ΄Π΅Π½ΠΎ, ΡΠΎ Π·Π°ΠΌΡΠ½Π° ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΈΡ
Π³ΡΡΠΏ Π² Π°Π½ΡΠ»ΡΠ΄Π½ΠΎΠΌΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ 1-R-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ² Π½Π° ΡΡΠΈΡΡΠΎΡΠΎΠΌΠ΅ΡΠΈΠ»ΡΠ½Ρ ΠΏΠΎ-ΡΡΠ·Π½ΠΎΠΌΡ Π²ΠΏΠ»ΠΈΠ²Π°Ρ Π½Π° ΡΡ
Π°Π½Π°Π»Π³Π΅ΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ, ΡΠΊΠ° ΠΌΠΎΠΆΠ΅ Π·Π°Π»ΠΈΡΠ°ΡΠΈΡΡ Π½Π° Π²ΠΈΡ
ΡΠ΄Π½ΠΎΠΌΡ ΡΡΠ²Π½Ρ, ΠΏΠΎΠ²Π½ΡΡΡΡ Π²ΡΡΠ°ΡΠ°ΡΠΈΡΡ Π°Π±ΠΎ ΠΆ Π·Π½Π°ΡΠ½ΠΎ ΠΏΠΎΡΠΈΠ»ΡΠ²Π°ΡΠΈΡΡ. Π ΠΎΡΡ Π·Π΄Π°ΡΠ½ΡΡΡΡ Π²ΠΏΠ»ΠΈΠ²Π°ΡΠΈ Π±ΡΠ΄Ρ-ΡΠΊΠΈΠΌ ΡΠΈΠ½ΠΎΠΌ Π½Π° ΡΠ΅ΡΠΎΠ²ΠΈΠ΄ΡΠ»ΡΠ½Ρ ΡΡΠ½ΠΊΡΡΡ Π½ΠΈΡΠΎΠΊ N-Π°ΡΠΈΠ»-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΠΈ ΠΏΡΡΠ»Ρ Π·Π°Π·Π½Π°ΡΠ΅Π½ΠΎΡ Ρ
ΡΠΌΡΡΠ½ΠΎΡ ΠΌΠΎΠ΄ΠΈΡΡΠΊΠ°ΡΡΡ ΠΎΠ΄Π½ΠΎΠ·Π½Π°ΡΠ½ΠΎ Π²ΡΡΠ°ΡΠ°ΡΡΡ
A RARE CASE OF ALVEOLAR SARCOMA OF THE PARAPHARYNGEAL SPACE
The paper describes the rare malignancy alveolar soft tissue sarcoma. The tumor was located in the parapharyngeal space; it was detected during pregnancy. The authors give the data available in the literature on the clinical manifestations of this disease, the specific features of morphological diagnosis, and treatment policy. The described case focuses on the complexities of diagnosis and preoperative preparation and surgical techniques
Isoperiodic deformations of the acoustic operator and periodic solutions of the Harry Dym equation
We consider the problem of describing the possible spectra of an acoustic
operator with a periodic finite-gap density. We construct flows on the moduli
space of algebraic Riemann surfaces that preserve the periods of the
corresponding operator. By a suitable extension of the phase space, these
equations can be written with quadratic irrationalities.Comment: 15 page
Topological Phenomena in the Real Periodic Sine-Gordon Theory
The set of real finite-gap Sine-Gordon solutions corresponding to a fixed
spectral curve consists of several connected components. A simple explicit
description of these components obtained by the authors recently is used to
study the consequences of this property. In particular this description allows
to calculate the topological charge of solutions (the averaging of the
-derivative of the potential) and to show that the averaging of other
standard conservation laws is the same for all components.Comment: LaTeX, 18 pages, 3 figure
Finite-gap Solutions of the Vortex Filament Equation: Isoperiodic Deformations
We study the topology of quasiperiodic solutions of the vortex filament
equation in a neighborhood of multiply covered circles. We construct these
solutions by means of a sequence of isoperiodic deformations, at each step of
which a real double point is "unpinched" to produce a new pair of branch points
and therefore a solution of higher genus. We prove that every step in this
process corresponds to a cabling operation on the previous curve, and we
provide a labelling scheme that matches the deformation data with the knot type
of the resulting filament.Comment: 33 pages, 5 figures; submitted to Journal of Nonlinear Scienc
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π°Π½Π°Π»Π³Π΅ΡΠΈΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ N-(Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»-2-ΡΠ»)-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ²
Continuing the search of new effective analgesics with improved properties the corresponding N-(benzothiazol- 2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamides have been synthesized in boiling xylene by the interaction of methyl ester of 4-hydroxy-1-methyl-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxylic acid with 2-aminobenzothiazoles. The structure of the substances synthesized has been confirmed by the data of elemental analysis, NMR 1H spectroscopy and mass-spectrometry. The peculiarities of the aromatic region interpretation in NMR 1H spectra of the structural class studied have been discussed. It has been shown that in ionization by electron impact the primary fragmentation of molecular ions of N-(benzothiazol-2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamides surprisingly occurs in a variety of ways. It starts with SO2 release in amide unsubstituted in the benzothiazole moiety of the molecule and its 6-methyl analogue, while for halogenated products the primary breaking of the terminal carbamide bond or the loss of halogen are characteristic. According to the results of the pharmacological research performed on the model of tail-flick procedure, N-(6-bromobenzothiazol-2-yl)-4-hydroxy-2,2-dioxo-1H-2Ξ»6,1-benzothiazine-3-carboxamide has been determined; it exhibits the analgesic effect at the level of Meloxicam.ΠΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Ρ ΠΏΠΎΠΈΡΠΊ Π½ΠΎΠ²ΡΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΈΡΠ° 4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1H-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ 2-Π°ΠΌΠΈΠ½ΠΎΠ±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΎΠ»Π°ΠΌΠΈ Π² ΠΊΠΈΠΏΡΡΠ΅ΠΌ ΠΊΡΠΈΠ»ΠΎΠ»Π΅ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ N-Π±Π΅Π½Π·ΠΎ-ΡΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄Ρ. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½- Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π―ΠΠ 1Π ΠΈ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΠΈ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π² ΡΠΏΠ΅ΠΊΡΡΠ°Ρ
Π―ΠΠ 1Π ΠΈΠ·ΡΡΠ°Π΅ΠΌΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΈΠΎΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΌ ΡΠ΄Π°ΡΠΎΠΌ ΠΏΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΈΠΎΠ½ΠΎΠ² N-(Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄ΠΎΠ² Π½Π΅ΠΎΠΆΠΈΠ΄Π°Π½Π½ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΡΡΡΠΌΠΈ. Π£ Π½Π΅Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π² Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΠΎΠΉ ΡΠ°ΡΡΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Π°ΠΌΠΈΠ΄Π° ΠΈ Π΅Π³ΠΎ 6-ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° ΠΎΠ½Π° Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ Ρ Π²ΡΠ±ΡΠΎΡΠ° SO2, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Π΄Π»Ρ Π³Π°Π»ΠΎΠ³Π΅Π½Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ΅Π½ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΉ ΡΠ°Π·ΡΡΠ² ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΈΠ»ΠΈ ΡΡΡΠ°ΡΠ° Π³Π°Π»ΠΎΠ³Π΅Π½Π°. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠΈΠΊΠ° Ρ
Π²ΠΎΡΡΠ° (tail-flick), Π²ΡΡΠ²Π»Π΅Π½ N-(6-Π±ΡΠΎΠΌΠ±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ- 1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΠΈΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄, ΠΏΡΠΎΡΠ²Π»ΡΡΡΠΈΠΉ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΠΌΠ΅Π»ΠΎΠΊΡΠΈΠΊΠ°ΠΌΠ°.ΠΡΠΎΠ΄ΠΎΠ²ΠΆΡΡΡΠΈ ΠΏΠΎΡΡΠΊ Π½ΠΎΠ²ΠΈΡ
Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΡ
Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ½ΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² Π· ΠΏΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΌΠΈ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡΠΌΠΈ, Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡΡ ΠΌΠ΅ΡΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ Π΅ΡΡΠ΅ΡΡ 4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π· 2-Π°ΠΌΡΠ½ΠΎΠ±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»Π°ΠΌΠΈ Ρ ΠΊΠΈΠΏΠ»ΡΡΠΎΠΌΡ ΠΊΡΠΈΠ»ΠΎΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½Ρ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½Ρ N-(Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»-2-ΡΠ»)-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΠΈ. ΠΡΠ΄ΠΎΠ²Π° ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ, ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ Π―ΠΠ 1Π ΡΠ° ΠΌΠ°Ρ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΡΡ. ΠΠ±Π³ΠΎΠ²ΠΎΡΡΡΡΡΡΡ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΡΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΡΡ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ½ΠΎΡ ΠΎΠ±Π»Π°ΡΡΡ Π² ΡΠΏΠ΅ΠΊΡΡΠ°Ρ
Π―ΠΠ 1Π Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡ Ρ
ΡΠΌΡΡΠ½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΠΏΡΠΈ ΡΠΎΠ½ΡΠ·Π°ΡΡΡ Π΅Π»Π΅ΠΊΡΡΠΎΠ½Π½ΠΈΠΌ ΡΠ΄Π°ΡΠΎΠΌ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½Π° ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΈΡ
ΡΠΎΠ½ΡΠ² N-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»-2-ΡΠ»)-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ² Π½Π΅ΡΠΏΠΎΠ΄ΡΠ²Π°Π½ΠΎ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Π°Ρ ΡΡΠ·Π½ΠΈΠΌΠΈ ΡΠ»ΡΡ
Π°ΠΌΠΈ. Π£ Π½Π΅Π·Π°ΠΌΡΡΠ΅Π½ΠΎΠ³ΠΎ Π² Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»ΡΠ½ΡΠΉ ΡΠ°ΡΡΠΈΠ½Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ Π°ΠΌΡΠ΄Ρ ΡΠ° ΠΉΠΎΠ³ΠΎ 6-ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° Π²ΠΎΠ½Π° ΠΏΠΎΡΠΈΠ½Π°ΡΡΡΡΡ Π· Π²ΠΈΠΊΠΈΠ΄Ρ SO2, ΡΠΎΠ΄Ρ ΡΠΊ Π΄Π»Ρ Π³Π°Π»ΠΎΠ³Π΅Π½Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ² Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΈΠΉ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΈΠΉ ΡΠΎΠ·ΡΠΈΠ² ΡΠ΅ΡΠΌΡΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ±Π°ΠΌΡΠ΄Π½ΠΎΠ³ΠΎ Π·Π²βΡΠ·ΠΊΡ Π°Π±ΠΎ Π²ΡΡΠ°ΡΠ° Π³Π°Π»ΠΎΠ³Π΅Π½Ρ. ΠΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π²ΠΈΠΏΡΠΎΠ±ΠΎΠ²ΡΠ²Π°Π½Ρ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ΅ΡΠΌΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄ΡΠ°Π·Π½Π΅Π½Π½Ρ ΠΊΡΠ½ΡΠΈΠΊΠ° Ρ
Π²ΠΎΡΡΠ° (tail-flick), Π²ΠΈΡΠ²Π»Π΅Π½ΠΎ N-(6-Π±ΡΠΎΠΌΠ±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΎΠ»-2-ΡΠ»)-4-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-1-ΠΌΠ΅ΡΠΈΠ»-2,2-Π΄ΡΠΎΠΊΡΠΎ-1Π-2Ξ»6,1-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄, ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠ²Π»ΡΡ Π°Π½Π°Π»Π³Π΅ΡΠΈΡΠ½ΠΈΠΉ Π΅ΡΠ΅ΠΊΡ Π½Π° ΡΡΠ²Π½Ρ ΠΌΠ΅Π»ΠΎΠΊΡΠΈΠΊΠ°ΠΌΡ
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