2,144 research outputs found
A study of cytokine content in the blood serum of patients with lichen ruber planus
Introduction. Lichen ruber planus (LRP) is a chronic multifactorial dermatosis characterized by skin deterioration, intensive itchiness, and resistance to therapy. It leads to long term patient disability, therefore the main objective of the management is to define the pathogenetic factors of LRP, with the purpose of treatment optimization.
The objective of this study was to determine and analyze the level of individual cytokines in blood serum of patients with lichen ruber planus with different clinical symptoms of dermatosis.
Material and methods. The study involved 37 patients with lichen ruber planus. In 20 patients with LRP the pathology of the skin was widespread, and in 17 patients it was limited and localized. In 19 patients the dermatosis lasted for up to 6 months, in the remaining 18 patients – for more than 6 months. In patients with LRP, blood serum concentrations of individual cytokines – tumor necrotic factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-4 (IL-4) and interleukin-10 (IL-10) were determined by immunoassay analysis.
Results. It has been found that in blood serum of patients with LRP there is a significant increase of TNF-α and IL-1β, a mild increase of IL-4 and a tendency to decrease in IL-10 comparing to the control group. Significant changes in the content of the cytokines in the blood serum were observed for the patients with a widespread form of lichen ruber planus and the duration of the disease for more than 6 months, comparing to those with limited forms of the dermatosis and duration of the disease for up to 6 months.
Conclusions. In patients with LRP, changes of the indicators of cytokine profile in the peripheral blood were observed. There was a significant increase in the level of proinflammatory cytokines (TNF-α, IL-1β), and only a a mild increase or the tendency to decrease in the levels of anti-inflammatory cytokines IL-4 and IL-10, respectively. The magnitude of these changes of cytokines was dependent on the nature of the clinical progression of the LRP. This finding indicates the significance of the cytokines in the regulation of inflammatory processes in the pathogenesis of LRP. These findings report the importance in examining levels of pro- and anti-inflammatory cytokines, as a criteria in the clinical evaluation of LRP and the effectiveness of its treatment
Diagnostics and two-dimensional simulation of low-frequency inductively coupled plasmas with neutral gas heating and electron heat flares
This article presents the results on the diagnostics and numerical modeling of low-frequency (∼460 KHz) inductively coupled plasmas generated in a cylindrical metal chamber by an external flat spiral coil. Experimental data on the electron number densities and temperatures, electron energy distribution functions, and optical emission intensities of the abundant plasma species in low/intermediate pressure argon discharges are included. The spatial profiles of the plasma density, electron temperature, and excited argon species are computed, for different rf powers and working gas pressures, using the two-dimensional fluid approach. The model allows one to achieve a reasonable agreement between the computed and experimental data. The effect of the neutral gas temperature on the plasma parameters is also investigated. It is shown that neutral gas heating (at rf powers⩾0.55 kW) is one of the key factors that control the electron number density and temperature. The dependence of the average rf power loss, per electron–ion pair created, on the working gas pressure shows that the electron heat flux to the walls appears to be a critical factor in the total power loss in the discharge
Nanopowder management and control of plasma parameters in electronegative SiH4 plasmas
Management of nanosize powder particles via control of plasma parameters in a low-pressure SiH4
discharge for silicon microfabrication technologies is considered. The spatial profiles of electron and
positive/negative ion number densities, electron temperature, and charge of the fine particles are
obtained using a self-consistent fluid model of the electronegative plasmas in the parallel plate
reactor geometry. The model accounts for variable powder size and number density, powder-charge
distribution, local plasma nonuniformity, as well as UV photodetachment of electrons from the
nanoparticles. The relations between the equilibrium discharge state and powder properties and the
input power and neutral gas pressure are studied. Methods for controlling the electron temperature
and SiH3- anion (here assumed to be the powder precursor) density, and hence the powder growth
process, are proposed. It is shown that by controlling the neutral gas pressure, input power, and
powder size and density, plasma density profiles with high levels of uniformity can be achieved.
Management of powder charge distribution is also possible through control of the external
parameters
Markov Properties of Electrical Discharge Current Fluctuations in Plasma
Using the Markovian method, we study the stochastic nature of electrical
discharge current fluctuations in the Helium plasma. Sinusoidal trends are
extracted from the data set by the Fourier-Detrended Fluctuation analysis and
consequently cleaned data is retrieved. We determine the Markov time scale of
the detrended data set by using likelihood analysis. We also estimate the
Kramers-Moyal's coefficients of the discharge current fluctuations and derive
the corresponding Fokker-Planck equation. In addition, the obtained Langevin
equation enables us to reconstruct discharge time series with similar
statistical properties compared with the observed in the experiment. We also
provide an exact decomposition of temporal correlation function by using
Kramers-Moyal's coefficients. We show that for the stationary time series, the
two point temporal correlation function has an exponential decaying behavior
with a characteristic correlation time scale. Our results confirm that, there
is no definite relation between correlation and Markov time scales. However
both of them behave as monotonic increasing function of discharge current
intensity. Finally to complete our analysis, the multifractal behavior of
reconstructed time series using its Keramers-Moyal's coefficients and original
data set are investigated. Extended self similarity analysis demonstrates that
fluctuations in our experimental setup deviates from Kolmogorov (K41) theory
for fully developed turbulence regime.Comment: 25 pages, 9 figures and 4 tables. V3: Added comments, references,
figures and major correction
Measurement of azimuthal asymmetries in inclusive charged dipion production in annihilations at = 3.65 GeV
We present a measurement of the azimuthal asymmetries of two charged pions in
the inclusive process based on a data set of 62
at the center-of-mass energy GeV collected with
the BESIII detector. These asymmetries can be attributed to the Collins
fragmentation function. We observe a nonzero asymmetry, which increases with
increasing pion momentum. As our energy scale is close to that of the existing
semi-inclusive deep inelastic scattering experimental data, the measured
asymmetries are important inputs for the global analysis of extracting the
quark transversity distribution inside the nucleon and are valuable to explore
the energy evolution of the spin-dependent fragmentation function.Comment: 7 pages, 5 figure
Measurement of the Cross Section between 600 and 900 MeV Using Initial State Radiation
We extract the cross section in the energy
range between 600 and 900 MeV, exploiting the method of initial state
radiation. A data set with an integrated luminosity of 2.93 fb taken at
a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII
collider is used. The cross section is measured with a systematic uncertainty
of 0.9%. We extract the pion form factor as well as the
contribution of the measured cross section to the leading order hadronic vacuum
polarization contribution to . We find this value to be
.Comment: 14 pages, 7 figures, accepted by PL
Study of and and
We study the decays of and to the final states
and based on a single
baryon tag method using data samples of
and events collected with
the BESIII detector at the BEPCII collider. The decays to
are observed for the first time. The
measured branching fractions of and
are in good agreement with, and much
more precise, than the previously published results. The angular parameters for
these decays are also measured for the first time. The measured angular decay
parameter for , , is found to be negative, different to the other
decay processes in this measurement. In addition, the "12\% rule" and isospin
symmetry in the and and
systems are tested.Comment: 11 pages, 7 figures. This version is consistent with paper published
in Phys.Lett. B770 (2017) 217-22
Search for C-parity violation in and
Using events recorded in
collisions at 3.686 GeV with the BESIII at the BEPCII collider, we
present searches for C-parity violation in and decays via . No significant
signals are observed in either channel. Upper limits on the branching fractions
are set to be and
at the 90\%
confidence level. The former is one order of magnitude more stringent than the
previous upper limit, and the latter represents the first limit on this decay
channel.Comment: 7 pages, 2 figure
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