413 research outputs found
Secretory activity of gastroduodenal zone before and after cholecystectomia
Вивчено функціональні особливості секреторної активності гастродуоденальної зони до та після холецистектомії. Встановлено пригнічення ферментовидільної функції шлунка у хворих із постхолецистектомічним синдромом. З’ясовано, що наявність дуодено-гастрального рефлюксу свідчить про дуоденостаз і недостатність замикальної функції пілоричного сфінктера. У хворих видалення жовчного міхура призводить до аритмії циркадних і ультрадіадних ритмів усієї травної системи й, у тому числі, до порушень активності секреторних залоз шлунка.Изучены функциональные особенности секреторной активности гастродуоденальной зоны до и пис¬ля холецистэктомии. Установлено угнетение ферментовыводящей функции желудка у больных с постхолецистэктомический синдромом. Выяснено, что наличие дуодено- гастральной рефлюкса свидетельствует о дуоденостаз и недостаточность замыкательной функции пилорического сфинктера. У больных удаление желчного пузыря приводит к аритмии циркадных и ультрадиадних ритмов всей пищеварительной системы и, в том числе, к нарушениям активности секреторных желез желудка.Functional features of the gastroduodenal zone secretory activity before and after cholecystectomia were studied. The oppression of the stomach enzymatic secretion in patients with postcholecystectomia syndrome was established. The presence of duodeno-gastral reflux testifies to the duodenostasis and incompetence of closing function of the pyloric sphincter. Cholecystectomia entails the arrhythmia of circadian and ultradian rhythms of the whole digestive apparatus, including the derangements of the stomach secretory glands
Conformational changes in matrix-isolated 6-methoxyindole: Effects of the thermal and infrared light excitations
Conformational changes induced thermally or upon infrared excitation of matrix-isolated
6-methoxyindole were investigated. Narrowband near-infrared excitation of the first overtone of
the N–H stretching vibration of each one of the two identified conformers is found to induce a
selective large-scale conversion of the pumped conformer into the other one. This easily controllable
bidirectional process consists in the intramolecular reorientation of the methoxy group and allowed a
full assignment of the infrared spectra of the two conformers. Matrices with different conformational
compositions prepared by narrow-band irradiations were subsequently used to investigate the effects
of both thermal and broadband infrared excitations on the conformational mixtures. Particular
attention is given to the influence of the matrix medium (Ar vs. Xe) and conformational effects of
exposition of the sample to the spectrometer light source during the measurements.Peer ReviewedPostprint (author's final draft
New treatment options for bladder cancer patients: based on ASCO 2022 materials and beyond
Bladder cancer is the fourth most common cancer worldwide and the eighth leading cause of cancer mortality in men. The advent of new systemic therapies, including PD-1 and PD-L1 inhibitors, and advances in biomarker development have revolutionized the treatment of this disease. The current guidelines of the National Comprehensive Cancer Network (NCCN) support the inclusion of some new therapies in clinical practice. Over the past decade, many approvals for immuno-therapeutic agents have been obtained. Since bladder cancer is characterized by a high frequency of mutations, there has been a widespread introduction of medicines from the group of immune checkpoint inhibitors. All studies from this review were presented at a recent meeting of the American Society of Clinical Oncology (ASCO) and published in reputable journals
Structural-chemical features and morphology of glauconites in sedimentary iron ore of Bakchar prospect (Western Siberia)
The research embraces the investigation results of glauconites in Bakchar iron ore occurrences to evaluate the potential diversified commercial application of this mineral. The following lab methods were used to analyze the morphology, chemical composition and structure of glauconites: granulometric analysis, optical microscopy, electron microscopy, X-ray fluorescence analysis, atomic arc-emission analysis and infrared spectroscopy. Glauconite was classified according to morphology and grain color and chemical composition and some specific characteristics were also determined (relative content of absorbed water, random distribution of smectite flakes within the grain structures). The research results showed that pistacho-green glauconite grains are less subjected to alteration than greenish-yellow grains due to the content of potassium, iron, absorbed water and organic impurities
Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members
High resolution protein folding with a transferable potential
A generalized computational method for folding proteins with a fully
transferable potential and geometrically realistic all-atom model is presented
and tested on seven different helix bundle proteins. The protocol, which
includes graph-theoretical analysis of the ensemble of resulting folded
conformations, was systematically applied and consistently produced structure
predictions of approximately 3 Angstroms without any knowledge of the native
state. To measure and understand the significance of the results, extensive
control simulations were conducted. Graph theoretic analysis provides a means
for systematically identifying the native fold and provides physical insight,
conceptually linking the results to modern theoretical views of protein
folding. In addition to presenting a method for prediction of structure and
folding mechanism, our model suggests that a accurate all-atom amino acid
representation coupled with a physically reasonable atomic interaction
potential (that does not require optimization to the test set) and hydrogen
bonding are essential features for a realistic protein model.Comment: submitted to PNAS 2005-03-1
BEAM POSITION MONITOR SYSTEM FOR 2 MEV ELECTRON COOLER FOR COSY
Abstract The 2 MEV electron cooler for COSY storage ring FZJ is assembling in BINP. Beam position monitor (BPM) system for orbit measurements has been developed and fabricated at BINP. The system contains 2 BPMs inside the cooling section and 10 BPMs in transport channels. Continuous electron beam is modulated with a 3 MHz signal for capability to get signals from pickup electrodes. The beam current modulation can be varied in the range of 0.3-1.5 mA. The BPMs inside the cooling section can measure both electron and proton beams. It is achieved by means of switching the reference signals inside the BPM electronics. The BPM electronics provides highly precise beam position measurements. Position measurement error doesn't exceed 1 micron. Design features of the BPM system, its parameters and testing results are presented in this paper
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