10 research outputs found
Forward Quark Jets from Protons Shattering the Colored Glass
- Author
- A. Accardi
- A. Ayala
- A. Dumitru
- A. H. Mueller
- A. H. Mueller
- A. Hebecker
- A. Hebecker
- A. Kovner
- A. Kovner
- A. Kovner
- A. Kovner
- A. Kovner
- A. Krasnitz
- A. Krasnitz
- Adrian Dumitru
- C. Itzykson
- D. J. Gross
- D. J. Gross
- D. Kharzeev
- D. Kharzeev
- E. Iancu
- F. Gelis
- G. T. Bodwin
- G. T. Bodwin
- I. Balitsky
- J. Jalilian-Marian
- J. Jalilian-Marian
- J. Jalilian-Marian
- J. Jalilian-Marian
- J. Jalilian-Marian
- J. Jalilian-Marian
- Jamal Jalilian-Marian
- K. Golec-Biernat
- K. Golec-Biernat
- L. Frankfurt
- L. McLerran
- L. McLerran
- L. McLerran
- L. V. Gribov
- W. Buchmüller
- W. Buchmüller
- W. Buchmüller
- Y. V. Kovchegov
- Y. V. Kovchegov
- Y. V. Kovchegov
- Y. V. Kovchegov
- Y. V. Kovchegov
- Y. V. Kovchegov
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 02/04/2002
- Field of study
We consider the single-inclusive minijet cross section in pA at forward
rapidity within the Color Glass Condensate model of high energy collisions. We
show that the nucleus appears black to the incident quarks except for very
large impact parameters. A markedly flatter p_t distribution as compared to QCD
in the dilute perturbative limit is predicted for transverse momenta about the
saturation scale, which could be as large as Q_s^2 ~ 10 GeV^2 for a gold
nucleus boosted to rapidity ~10 (as at the BNL-RHIC).Comment: 9 pages, no figure
Giant ascending aortic aneurysm after aortic valve replacement
- Publication venue
- 'Wiley'
- Publication date
- Field of study
THE INITIAL STATE OF HEAVY ION COLLISIONS
- Author
- Publication venue
- 'World Scientific Pub Co Pte Lt'
- Publication date
- Field of study
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population
- Author
- A Sorour
- A Özcan
- Adrian P. Trifa
- Alina Bogliș
- Andrei Crauciuc
- C Schoch
- C Seedhouse
- Carmen Duicu
- Claudia Bănescu
- Cristina Skypnyk
- D Liu
- Erzsebeth Lazar
- F Wang
- Florin Tripon
- I Moreno
- J Topinka
- JC Hernández-Boluda
- JF Luo
- JM Allan
- JN Brewin
- JY Shi
- K Douzi
- K Döhner
- M Monzo
- Mihaela Iancu
- Minodora Dobreanu
- N Berhane
- N Kuptsova
- N Kuptsova-Clarkson
- P Xu
- PA Mehta
- R El-Zein
- S Benhamou
- SS Strom
- Valeriu G. Moldovan
- VM Guillem
- X-F He
- XM Xu
- Y Liu
- Y Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cryo-electron Microscopy of Membrane Proteins
- Author
- A Philippsen
- A Philippsen
- AD Schenk
- B Gipson
- B Gipson
- B Gipson
- BE Bammes
- BK Jap
- CV Iancu
- D Levy
- E Nogales
- FP Booy
- G Ren
- GA Signorell
- H Stahlberg
- H-J Butt
- HW Remigy
- I Iacovache
- J Dubochet
- J Vonck
- JA Mindell
- K Mitsuoka
- K Murata
- K Tani
- KA Taylor
- KA Taylor
- KH Downing
- KH Downing
- KH Downing
- L Hasler
- LA Amos
- LR Comolli
- M Adrian
- M Arheit
- M Arheit
- M Arheit
- M Hu
- MM Golas
- MM Golas
- N Coudray
- N Grigorieff
- N Gyobu
- PD Abeyrathne
- PD Abeyrathne
- PN Unwin
- R Crowther
- R Henderson
- R Henderson
- R Henderson
- R Henderson
- RM Glaeser
- RM Glaeser
- RM Glaeser
- RM Glaeser
- RM Glaeser
- RM Glaeser
- T Gonen
- T Walz
- U Aebi
- W Kühlbrandt
- W Kühlbrandt
- X Zeng
- X Zeng
- X Zhang
- Y Fujiyoshi
- Y Fujiyoshi
- Y Fujiyoshi
- Y Hiroaki
- Y Kimura
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Electron crystallography is used to study membrane proteins in the form of planar, two-dimensional (2D) crystals, or other crystalline arrays such as tubular crystals. This method has been used to determine the atomic resolution structures of bacteriorhodopsin, tubulin, aquaporins, and several other membrane proteins. In addition, a large number of membrane protein structures were studied at a slightly lower resolution, whereby at least secondary structure motifs could be identified.In order to conserve the structural details of delicate crystalline arrays, cryo-electron microscopy (cryo-EM) allows imaging and/or electron diffraction of membrane proteins in their close-to-native state within a lipid bilayer membrane.To achieve ultimate high-resolution structural information of 2D crystals, meticulous sample preparation for electron crystallography is of outmost importance. Beam-induced specimen drift and lack of specimen flatness can severely affect the attainable resolution of images for tilted samples. Sample preparations that sandwich the 2D crystals between symmetrical carbon films reduce the beam-induced specimen drift, and the flatness of the preparations can be optimized by the choice of the grid material and the preparation protocol.Data collection in the cryo-electron microscope using either the imaging or the electron diffraction mode has to be performed applying low-dose procedures. Spot-scanning further reduces the effects of beam-induced drift. Data collection using automated acquisition schemes, along with improved and user-friendlier data processing software, is increasingly being used and is likely to bring the technique to a wider user base
Poster session III * Friday 10 December 2010, 08:30-12:30
- Author
- A. Ahmed
- A. Ahmeti
- A. Alkhaldi
- A. Baltabaeva
- A. Barrera Cordero
- A. Bellouin
- A. Bertasiute
- A. Bhan
- A. Bouzas-Mosquera
- A. Brown
- A. Budaj
- A. C. Van Rossum
- A. Cacicedo
- A. Calin
- A. Castro-Beiras
- A. Ciobanu
- A. Clavell
- A. D'andrea
- A. Daponte
- A. De Roos
- A. Di Monaco
- A. Dipchand
- A. Duszanska
- A. Evangelista
- A. F. F. Osorio
- A. Garcia
- A. Gopal
- A. Hamilton
- A. Hayashida
- A. Holmgren
- A. Hvelplund
- A. Iniguez-Romo
- A. Iqbal
- A. Jijeh
- A. Kaczynska
- A. Kempny
- A. Kenny
- A. Kiotsekoglou
- A. Kiotsekoglou
- A. Kiotsekoglou
- A. Koprowski
- A. Krishnan
- A. Kuch-Wocial
- A. Kulach
- A. L. R. Saroute
- A. La Gerche
- A. Linde Estrella
- A. Lopez
- A. M. Anwar
- A. M. Duncan
- A. Margonato
- A. Meissner
- A. Morganti
- A. Morton
- A. Orda
- A. Perez-Perez
- A. Perkan
- A. Poniku
- A. Ripoli
- A. Rivera
- A. Roman-Pognuz
- A. Rosner
- A. Roy
- A. Rynkiewicz
- A. S. Gopal
- A. S. Gopal
- A. S. Jensen
- A. Sahlen
- A. Saino
- A. Salvi
- A. Saxena
- A. Sestito
- A. Sieders
- A. Staron
- A. Stoylen
- A. Sutandar
- A. Tomaszuk-Kazberuk
- A. Tuncez
- A. Zaidi
- B. A. Popescu
- B. A. Popescu
- B. Abdel Ghani
- B. B. Loegstrup
- B. B. Siswanto
- B. Bhargava
- B. Bijnens
- B. Bijnens
- B. Castaldi
- B. Cosyns
- B. Eika
- B. Essadiqi
- B. Essadiqi
- B. Fernstrom
- B. Garcia
- B. H. Amundsen
- B. J. Bouma
- B. Karolko
- B. Obrenovic-Kircanski
- B. Orbovic
- B. Petruzziello
- B. Pinamonti
- B. Roosens
- B. Sobkowicz
- B. Uygur
- B. Villari
- B. W. Mccrindle
- B. Zaborska
- C. A. Szmigielski
- C. A. Szmigielski
- C. Arsenescu Georgescu
- C. B. Terwee
- C. Caniggia
- C. Dedobbeleer
- C. Dedobbeleer
- C. Dussault
- C. Ferreira
- C. George
- C. Ginghina
- C. Ginghina
- C. H. Cadis Horatiu
- C. Hassager
- C. Iacono
- C. K. Lee
- C. Linden
- C. Lockhart
- C. M. Li
- C. M. Yu
- C. Maguire
- C. Manlhiot
- C. Manlhiot
- C. Mukherjee
- C. N. Lang
- C. Naruse
- C. Ober
- C. P. Lau
- C. Papadopoulos
- C. Plummer
- C. Porley
- C. Prinz
- C. Reverberi
- C. Revnic
- C. Ridard
- C. S. Park
- C. Slorach
- C. T. Fackoury
- C. Thebault
- C. W. Siu
- C. Y. Ma
- C. Z. Pan
- D. A. Samson
- D. Alexandru
- D. Avenarius
- D. Barbosa
- D. Blommaert
- D. Bokor
- D. Ciecwierz
- D. Garcia-Dorado
- D. Greentree
- D. Guldbrand
- D. H. Do
- D. H. Do
- D. H. Shin
- D. Harries
- D. Hayat
- D. Hildick Smith
- D. Kalimanovska Ostric
- D. Leong
- D. Lowenstein Haber
- D. Mesa Rubio
- D. Muraru
- D. Normandin
- D. Personeni
- D. Rogoz
- D. Sartorio
- D. Stella
- D. Tsiapras
- D. Vinereanu
- D. X. Zhou
- D. Zaliaduonyte-Peksiene
- E. Agricola
- E. Avramidou
- E. Bossone
- E. Caiani
- E. Colombo
- E. De Teresa Galvan
- E. Della Grazia
- E. Donal
- E. Eixarch
- E. Gerdts
- E. Golia
- E. Gratacos
- E. Haliti
- E. Haliti
- E. Ho
- E. Laraudogoitia Zaldumbide
- E. Leiballi
- E. Locantore
- E. M. Staal
- E. Mitry
- E. Nicolaides
- E. Paredes-Galan
- E. Picano
- E. Pociute
- E. T. Jaeggi
- E. Villanueva Fernandez
- F. Alhabshan
- F. Antonini-Canterin
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- F. Carrasco Chinchilla
- F. Cobelli
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- F. Crispi
- F. D. De Leo
- F. Dormal
- F. E. Calvo Iglesias
- F. F. Helvacioglu
- F. Figueras
- F. Giannini
- F. Gustafsson
- F. J. Alzueta Rodriguez
- F. J. Ten Cate
- F. Jander
- F. Le Noble
- F. P. Francesco Pollice
- F. Ridocci Soriano
- F. Rigo
- F. Toledano Delgado
- F. W. Mohr
- G. A. Lanza
- G. Arriba
- G. B. Antongiovanni
- G. Bajraktari
- G. Bajraktari
- G. Bajraktari
- G. C. Gaetano Contegiacomo
- G. Careri
- G. Di Salvo
- G. Domproglou
- G. Faden
- G. Feltes
- G. Gaio
- G. H. Yan
- G. Harimurti
- G. Isasti Aizpurua
- G. J. King
- G. Kaleschke
- G. Kerckhoff
- G. Kiss
- G. L. Nicolosi
- G. Lloyd
- G. Macgowan
- G. Manoharan
- G. Melissano
- G. Opolski
- G. P. Diller
- G. Pacileo
- G. Plehn
- G. R. Sutherland
- G. Romano
- G. Salerno
- G. Santoro
- G. Sinagra
- G. Styczynski
- G. Van Camp
- G. Veen
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- G. Whyte
- G. Zambrana
- H. A. C. M. Bruin De- Bon
- H. Abo Remsh
- H. Baumgartner
- H. Becher
- H. Becher
- H. Brun
- H. Chamsi-Pasha
- H. D. Tschernich
- H. E. Egeblad
- H. F. Tse
- H. Hironaka
- H. Ito
- H. J. Trappe
- H. J. Youn
- H. K. Chabane
- H. K. Jeon
- H. K. Najm
- H. Kisacik
- H. Lamb
- H. M. Eckmann
- H. M. Siebelink
- H. O. Jung
- H. Okura
- H. R. Andersen
- H. Skulstad
- H. Torp
- H. Villarraga
- H. Y. Sohn
- H. Yoshino
- I. A. Iancu Adrian
- I. Amuntaser
- I. C. Demiroglu
- I. Helland
- I. Hmila
- I. Ikonomidis
- I. Irmalita
- I. Kowatsch
- I. Lekuona
- I. Mcleod
- I. Otaegui
- I. Paraskevaidis
- I. S. Craciunescu
- I. S. Ramzy
- I. Solla-Ruiz
- I. Villanueva-Benito
- J. A. F. Ramires
- J. A. Lowenstein
- J. A. Noble
- J. Barbado
- J. Bartrons
- J. Berning
- J. C. Han
- J. C. Moggridge
- J. C. Moggridge
- J. C. N. Sbano
- J. Castillo
- J. Chen
- J. Chow
- J. D'hooge
- J. D. Kasprzak
- J. D. Kasprzak
- J. D. Kasprzak
- J. D. Newton
- J. D. Schuijf
- J. D. Somauroo
- J. E. Moller
- J. E. Nordrehaug
- J. Ender
- J. F. Rodriguez
- J. Fernandez Pastor
- J. Forster
- J. H. Kim
- J. Herrera
- J. Hyde
- J. J. Alarcon
- J. J. Bax
- J. J. Onaindia
- J. Jamart
- J. K. Jang
- J. Kochanowski
- J. L. Dubois Rande
- J. L. Pena Hernandez
- J. L. Perez Bosca
- J. Lopez Aguilera
- J. M. Mccomb
- J. M. Tsutsui
- J. Magne
- J. Malyszko
- J. Nahum
- J. Necas
- J. Nowak
- J. Paniagua
- J. Parissis
- J. Pemberton
- J. Peteiro
- J. R. Balaguer Malfagon
- J. R. Rumoroso
- J. Reiken
- J. Rieber
- J. S. Malyszko
- J. S. Uhm
- J. Seeburger
- J. Shrimpton
- J. Silberbauer
- J. Slikkerveer
- J. Suarez De Lezo Cruz Conde
- J. Torras
- J. U. Voigt
- J. Vaskelyte
- J. Vleugels
- J. Westenberg
- J. Yoshikawa
- J. Zumalde
- K. Adjei-Twum
- K. Baronaite-Dudoniene
- K. Bennet
- K. Dale
- K. E. Klaaborg
- K. Hristova
- K. Imai
- K. Ishii
- K. Iwakura
- K. Kupczynska
- K. L. Tong
- K. L. Williams
- K. Lee
- K. M. Li
- K. Mitrega
- K. O'connor
- K. Obase
- K. Ozawa
- K. P. George
- K. Rajpoot
- K. Saito
- K. Sakata
- K. Shahgaldi
- K. Simamonian
- K. Smarz
- K. Wierzbowska
- K. Wierzbowska-Drabik
- K. Wierzbowska-Drabik
- K. Yiangou
- K. Yoshida
- L. A. Brodin
- L. A. Pierard
- L. B. Andersen
- L. Bertoglio
- L. Brodin
- L. C. Chiappa
- L. Cejudo Diaz Del Campo
- L. Chrzanowski
- L. Chrzanowski
- L. De Roy
- L. Dei Cas
- L. Delfino
- L. Ghio
- L. Gianturco
- L. Gutierrez
- L. J. Soskic
- L. Koopman
- L. L. Dong
- L. L. Lee
- L. Lee
- L. Lewicki
- L. Mertens
- L. Mertens
- L. P. Koopman
- L. Pratali
- L. Riegler
- L. S. Magda
- L. S. Tam
- L. Szymanski
- L. Tomasoni
- L. Tomasoni
- M. Amor
- M. Anastasiou-Nana
- M. Ancona
- M. Andersen
- M. Antoine
- M. Baroni
- M. Bona
- M. Borger
- M. Bravo-Amaro
- M. C. Brochu
- M. C. Brochu
- M. C. Kontos
- M. Cattaneo
- M. Chmielecki
- M. Cocciolo
- M. Coutu
- M. De Giorgi
- M. Delgado Ortega
- M. Deljanin Ilic
- M. Della Porta
- M. Dencker
- M. Descalzo
- M. El-Omar
- M. F. A. A. Aly
- M. Fijalkowski
- M. Florescu
- M. Floria
- M. G. Russo
- M. Glauber
- M. Govindan
- M. Gudin Uriel
- M. Heatley
- M. Iancu
- M. Ioannides
- M. J. Daly
- M. J. Molina Mora
- M. J. Monaghan
- M. Jasinski
- M. K. Karlsson
- M. Kalinowski
- M. Kalinowski
- M. Kloeckner
- M. Lacrosse
- M. Lafuente
- M. Laurent
- M. Leung
- M. Luckie
- M. Mamas
- M. Mariani
- M. Merlo
- M. Monaghan
- M. Moonen
- M. Morillas
- M. Mueller
- M. Myrianthefs
- M. Mysliwiec
- M. Oppizzi
- M. Ozdemir
- M. Pan Alvarez-Ossorio
- M. Pandolfo
- M. Paul
- M. Pineiro
- M. Postula
- M. Przewlocka-Kosmala
- M. R. Perotti
- M. Remmelink
- M. Roik
- M. Rosca
- M. Ruiz Ortiz
- M. S. Spence
- M. Serban
- M. Shanks
- M. Sinski
- M. Skowerski
- M. Slavich
- M. Sosnowski
- M. Szulc
- M. Szulik
- M. T. Gonzalez
- M. T. Lonnebakken
- M. T. Palladino
- M. Taniguchi
- M. Tespili
- M. Triggiani
- M. Turiel
- M. Turiel
- M. W. Prull
- M. Wang
- M. Y. Henein
- M. Y. Henein
- M. Y. Henein
- M. Y. Henein
- M. Zdravkovic
- N. Ajmone Marsan
- N. Casso
- N. Chahal
- N. Gaibazzi
- N. Grubb
- N. H. Secher
- N. Herszkowicz
- N. Koide
- N. Mansencal
- N. Martinez Alzamora
- N. Mc Elhome
- N. R. Patel
- N. Rexhepaj
- N. Roszczyk
- N. Sulke
- N. Watanabe
- N. Watanabe
- O. Azevedo
- O. Baumann
- O. Catalano
- O. Dubourg
- O. Goetzsche
- O. Kamp
- O. Kamp
- O. M. Ober Mihai
- O. Quintana
- O. Thorsson
- O. Tufekcioglu
- O. Yildirimturk
- P. A. Andreea Parv
- P. A. Poole-Wilson
- P. A. Scopelliti
- P. Brassard
- P. Bresser
- P. Colonna
- P. Faggiano
- P. Farand
- P. Farand
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- P. I. O. Caso
- P. J. Tan
- P. Jung
- P. L. Madsen
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- P. Lancellotti
- P. Lim
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- P. Lindqvist
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- P. Misra
- P. P. Goh
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- P. Pazos
- P. Pearson
- P. Pruszczyk
- P. R. James
- P. Raju
- P. Rougier
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- P. Schneider
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- P. Tarzia
- P. Unger
- P. Unger
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- P. Wollmer
- Q. Ciampi
- Q. Shang
- Q. Zhang
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- R. E. Shave
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- R. T. Murphy
- R. Targonski
- R. Toole
- R. Toole
- R. Winter
- R. Yamada
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- S. C. Govind
- S. C. Govind
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- S. Elezi
- S. Elezi
- S. Frattini
- S. G. Priori
- S. Gianstefani
- S. Govind
- S. H. An
- S. H. Ong
- S. H. Poulsen
- S. Hernot
- S. I. Jung
- S. I. Seo
- S. I. Song
- S. Ilic
- S. K. Saha
- S. K. Saha
- S. K. Saha
- S. Kovalova
- S. Kyrzopoulos
- S. Lee
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- S. Lepage
- S. Longhi
- S. M. Seo
- S. Malm
- S. Muyldermans
- S. Nair
- S. Orwat
- S. Rakar
- S. Ramakrishnan
- S. Ristic
- S. S. Cheong
- S. S. Ramesh
- S. Sacchi
- S. Sano
- S. Santangelo
- S. Sitia
- S. Sitia
- S. Stella
- S. Storti
- S. Surie
- S. Truong
- S. V. Nair
- S. Velasco
- S. W. Lord
- S. Wos
- S. Y. Jung
- S. Y. Yoo
- S. Yurdakul
- S. Z. Abildstrom
- T. Akagi
- T. Bett
- T. Butz
- T. Christodoulides
- T. Dahlslett
- T. Edvardsen
- T. Hirnle
- T. J. Bradley
- T. Jaxa-Chamiec
- T. K. M. Cudjoe
- T. Kukulski
- T. Lahoutte
- T. Myrmel
- T. R. Porter
- T. Sakuma
- T. Sarkola
- T. Sen
- T. Tsuzuku
- T. Wang
- T. Z. Katova
- U. Gustafsson
- U. Trivedi
- V. Bistola
- V. Daru
- V. De Gennaro Colonna
- V. Delgado
- V. Gadiyaram
- V. Hyseni
- V. Klauss
- V. Kodali
- V. Kodoth
- V. Kostova
- V. Magagnin
- V. Mizariene
- V. Pineda
- V. Sachpekidis
- V. Serra
- V. Stasinos
- V. Stoickov
- V. Uscatescu
- V. Valverde
- V. Voudris
- V. Zilioli
- W. B. Chung
- W. Dubaniewicz
- W. Hui
- W. J. Musial
- W. K. Yip
- W. Mampuya
- W. Mampuya
- W. Mathias
- W. Puchalski
- W. S. Yue
- W. Streb
- X. Gu
- X. Gu
- X. H. Shu
- X. Y. Gu
- X. Y. Gu
- Y. E. A. Appelman
- Y. H. He
- Y. H. He
- Y. Miyamoto
- Y. Nosir
- Y. S. Goh
- Y. S. Wang
- Y. Simova
- Y. Tayyareci
- Y. Y. Lam
- Y. Y. Lam
- Z. A. Li
- Z. A. Li
- Z. Gasior
- Z. Gasior
- Z. Golbasi
- Z. Kalarus
- Z. Vela
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
A Survey of Empirical Results on Program Slicing
- Author
- ABAT MARC EVANS
- ABDUL RAHIM AIZAI AZAN
- ABE MITSUNORI
- ABIB JR EDUARDO
- ABOLA MARIA TERESA
- Aboyans Victor
- ABOYANS VICTOR
- ABRANTES JOSE ANTONIO
- ABU HASSAN MUHAMMAD RADZI
- ACCINI MENDOZA JOSE LUIS
- ADLER FREDRIC
- AHUAD GUERRERO RODOLFO ANDRES
- AKATSUKA YUTAKA
- AKO JUNYA
- AL-KHALILI FARIS
- AL-QOOFI FAISAL
- ALBERTSSON PER
- ALBISU DI GENNERO JUAN PABLO
- ALCARAZ JOHN DENNIS
- Alings Marco
- ALINGS MARCO
- ALMROTH HENRIK
- ALVAREZ MOIRA
- AMERENA JOHN
- Anand Sonia S
- ANDERSSON TOMMY
- ANDO KENJI
- ANONUEVO JOHN
- APPEL KARL-FRIEDRICH
- ARCOS EDGAR
- ARIMIE RALUCA
- AROCA GUSTAVO
- ARSENESCU CATALINA
- ATAR SHAUL
- AUSHEVA AZA
- AUSTIN DAVID
- AVERKOV OLEG
- Avezum Alvaro A
- BABAPULLE MOHAN
- BACHARACH J MICHAEL
- BAE JANG-HO
- BAI XIAO JUAN
- BAINEY KEVIN
- BAJNOK LASZLO
- BAKAEEN FAISAL
- BAKAI JUDIT
- BALDIN MARIA GRAZIA
- BANERJEE SUBHASH
- Bangdiwala Shrikant I
- BARBARASH OLGA
- BARBIERI MARIA
- BARTELS GERARD
- BARTOLACCI INES PALMIRA
- BARTON JOHN
- BAZYLEVYCH ANDRIY
- BEDWELL NOEL
- BENEDEK IMRE
- BENESOVA MIROSLAVA
- BERLINGIERI JOSEPH
- BERNARDINANGELI MARINO
- BHARGAVA RAKESH
- Bhatt Deepak L
- BIRDI INDERPAUL
- BITTNER VERA
- BLACK ROBERT
- BLOMBERY PETER
- BOBESCU ELENA
- BOCCARA FRANCK
- BODA ZOLTAN
- BOENELYKKE SOERENSEN VIBEKE
- BORDONAVA ANSELMO PAULINO
- Bosch Jackie
- BOSI STEFANO
- BOTELHO ROBERTO
- BOURGEOIS RONALD
- BOYLE ANDREW
- BRAILE MARIA
- Branch Kelley
- BRANCH KELLEY
- BRANNY MARIAN
- BRAT RADIM
- BRAUN-DULLAEUS RUEDIGER
- BREEDVELD ROB
- BRONCEL MARLENA
- BROWN CRAIG
- BRTKO MIROSLAV
- BRULOTTE STEEVE
- CACCAVO ALBERTO
- CALVERT JOHN
- CAMP ALAN
- CAMPEAU JEAN
- CANADYOVA JULIA
- CARDONA MARCELO
- CARMINE DE MATTEIS
- CARROLL PATRICK
- CARTASEGNA LUIS
- CARTER JUSTIN
- CASTILLO HENRY
- CAYLA GUILLAUME
- CHA JAMES
- CHACON CAROLINA
- CHANDRA LOKESH
- Chen Edmond
- CHEN XIAO PING
- CHEN XIN
- CHILTON ROBERT
- CHIONCEL OVIDIU
- CHUA PHILIP
- CINTEZA MIRCEA
- CIRRINCIONE VINCENZO
- COBOS JORGE LEONARDO
- COLQUHOUN DAVID
- COMAN IOAN
- COMEROTA ANTHONY
- COMMERFORD PATRICK
- Commerford Patrick J
- CONNOLLY DEREK
- Connolly Stuart J
- CORBALAN RAMON
- COSMI FRANCO
- COSTABEL JUAN PABLO
- COSTELLO FREDERICK
- COTTON JAMES
- COUFAL ZDENEK
- CREAN PETER
- CRUZ JOSEFINA
- CUADRADO JESUS
- CUERVO MILLAN FRANCISCO
- CUNEO CARLOS
- CURTIN RONAN
- CZARNECKA DANUTA
- CZARNECKI WLODZIMIERZ
- DAGENAIS FRANCOIS
- DAGENAIS GILLES R
- DAGHER GEORGE
- DAIDA HIROYUKI
- DARIUS HARALD
- DAVEY PATRICK
- DAVIERWALA PIROZE
- DE CARVALHO CANTARELLI MARCELO JOSE
- DE GROOT MARC ROBERT
- DE VRIES KEES-JAN
- DEBONNAIRE PHILIPPE
- DEL PILAR JOSE CARLO
- DELLA SIEGA ANTHONY
- DELLBORG MIKAEL
- DEMPSEY STEPHEN
- DEN HARTOG FRANK
- DI BIASE MATTEO
- DI PASQUALE GIUSEPPE
- DIAZ ARIEL
- Diaz Rafael
- DIMULESCU DOINA
- DINNEEN SEAN
- DIXEN ULRIK
- DOBREANU DAN
- DOMAE HIROSHI
- DONG YUGANG
- DONNELLY PATRICK
- DORSEL THOMAS
- DRAN RICARDO DARIO
- DROZDAKOVA ERIKA
- DUARTE YAN CARLOS
- DUENGEN HANS-DIRK
- DUJARDIN KARL
- DUTRA OSCAR
- EBO GERALDINE
- ECTOR BAVO
- EFREMUSHKINA ANNA
- Eikelboom John W
- ELEGEERT IVAN
- ENGELBRECHT JAN
- FAGGIANO POMPILIO
- FELL DAVID
- FERRARI EMILE
- FERRE PACORA FREDY ANTONI
- FIELDS RONALD
- FLORIAN JINDRICH
- FOLTYNOVA CAISOVA LENKA
- Fox Keith A A
- FREMES STEPHEN
- FRENCH WILLIAM
- FU GUOSHENG
- FUJII KENSHI
- GAITA DAN
- GAJOS GRZEGORZ
- GALVANI MARCELLO
- GARCIA DURAN RUBEN OMAR
- GARCIA HENRY
- GARCIA LUIS HERNANDO
- GARRIDO MARCELO
- GASPAR LUDOVIT
- GE JUNBO
- GIBSON KATHLEEN
- GILLESPIE EVE
- GISLASON GUNNAR
- GLANZ ANTHONY
- GOGIA HARINDER
- GOMEZ VILAMAJO OSCAR
- GOMEZ JUAN
- GONZALEZ COLASO PATRICIA DEL CARMEN
- GOSSELIN GILBERT
- GOSSELINK MARCEL
- GRENA PAUL
- GRINFELD DIEGO
- GROENEMEIJER BJORN
- GUEROCAK OSMAN
- GULIZIA MICHELE MASSIMO
- GURBEL PAUL
- GUZIK TOMASZ
- GUZMAN LUIS
- GUZMAN RANDOLPH
- HA JONG-WON
- HAKAS JOSEPH
- HALABI MAJDI
- HAMMETT CHRISTOPHER
- HAMROFF GLENN
- HARRISON ROBERT
- Hart Robert G
- HARTLEIB MICHAEL
- HASBANI EDUARDO
- HASHIMOTO TETSUO
- HATALOVA KATARINA
- HEFFERNAN MICHAEL
- HEIMAN MARK
- HERNANDES MAURO
- HERRMAN JEAN PAUL
- HIGASHINO YORIHIKO
- HIGASHIUE SHINICHI
- HIGUCHI YOSHIHARU
- HII CHRIS
- HILL LAURIE
- HILTON THOMAS
- HIMI TOSHIHARU
- HIRAYAMA ATSUSHI
- HIROKAMI MITSUGU
- HIRSCH GREGORY
- HISAMATSU YUJI
- HOEKSTRA EDUARD
- HOFFER ETIENNE
- HOMINAL MIGUEL ANGEL
- HOMZA MIROSLAV
- HOOGSLAG PIETER
- HORAK ADRIAN
- HOSOKAWA SHINOBU
- HOULIND KIM
- HRABAR ADRIAN
- HRANAI MARIAN
- HU TAO HONG
- HUANG WEIJIAN
- HUNTER JOHN J.
- HUYNH THAO
- I-HSUAN TSAI PETER
- IANCU ADRIAN
- IBANEZ SAGGIA LUZ MARIA
- ILIESIU ADRIANA
- IMAMAKI MIZUHO
- INDIO DO BRASIL CLARISSE
- INGARAMO ADRIAN
- INOKO MORIAKI
- IZUKAWA NILO
- JANION MARIANNA
- JANO GABRIEL
- JANSEN SHIRLEY
- JANSKY PETR
- JARAI ZOLTAN
- JARNERT CHRISTINA
- JESERICH MICHAEL
- JIA KAIYING
- JOHANSSON LARS
- JOHNSTON JAMES
- JOO SEUNGJAE
- JUNGMAIR WOLFGANG
- KADEL CHRISTOPH
- Kakkar Ajay K
- KALETOVA MARKETA
- KAMIYA HARUO
- KANNO TAKAYASU
- KANTOLA ILKKA
- KARPENKO OLEKSANDR
- KASIM SAZZLI
- KATZ AMOS
- KAWAKAMI HIDEO
- KE YUANNAN
- Keltai Katalin
- KEMENY VENDEL
- KHAYKIN YAARIV
- KIAII BOB
- KIM CHEOLHO
- KIM CHONG-JIN
- KIM DONG-SOO
- KIM JANG YOUNG
- KIM YONG JIN
- KIM YOUNG-KWON
- KIMURA KAZUO
- KINOSHITA NORIYUKI
- KIS ERNO
- KLAINMAN ELIEZER
- KLUG ERIC
- KOBAYASHI HIROO
- KOBER LARS
- KONG YE
- KONONENKO LYUDMYLA
- KORANYI LASZLO
- KORETSUNE YUKIHIRO
- KOSHY N. MATHEW
- KOSTIS JOHN B.
- KOVAL OLENA
- KOVAL VALENTYNA
- KRAGTEN HANS
- KRYZA RADIM
- KUKREJA NEVILLE
- KURAMOCHI TAKEHIKO
- LADER ELLIS
- LAM ANDY
- LAMY ANDRE
- LASZLO ZOLTAN
- LEAES PAULO
- LECLERCQ FLORENCE
- Leong Darryl P
- LEROY JEAN
- LEWIS BASIL
- Lewis Basil S
- LI CHUNJIAN
- LI JIANPING
- LI JUNXIA
- LIGHEZAN DANIEL
- LINDNER JAROSLAV
- LITVAK BRUNO MARCOS RAUL
- LIU BO
- LIU SHAO WEN
- LO WINGCHI
- LOK DIRK
- LONN EVA
- LOPEZ JOSE
- Lopez-Jaramillo Patricio
- LOYOLA ALDRIN
- LUBANDA JEAN-CLAUDE
- LUCIARDI HECTOR LUCAS
- LUPOVITCH STEVEN
- LUQUEZ HUGO
- MABIN THOMAS
- MACHIDA MASAHARU
- MACIN STELLA MARIS
- MACKINNON IGNACIO J.
- MACNEILL BRIAIN
- MAFFEI LAURA ELENA
- MAGA PAWEL
- Maggioni Aldo P
- MAHON NIALL
- MAIA LILIA
- MAJUL CLAUDIO RODOLFO
- MAKOTOKO ELLEN MAKONLI
- MALHOTRA VINAY
- MALY JIRI
- MALY MARTIN
- MALYNOVSKY YAROSLAV
- MANDORLA SARA
- MANENTI EULER
- MANITA MAMORU
- MANZUR J FERNANDO
- MARCIAN PAVEL
- MARCINEK GABRIEL
- MARMOL RICARDO
- MATUSKA JIRI
- MCADAM BRENDAN
- MCCORMICK MATTHEW
- MCGUINN WILLIAM
- MEDINA MARCELO
- MEHTA PRAVINSAGAR
- MEHTA RAJENDRA
- MERALI FATIMA
- MESSAS EMMANUEL
- MICHAELSON STEPHEN
- MILHOUS JOHANNES GERT-JAN
- MINELLI CESAR
- MISMETTI PATRICK
- Misselwitz Frank
- MITA TERUAKI
- MIYAMOTO NAOMASA
- MIZUTOMI KAZUAKI
- MOCCETTI TIZIANO
- MOHAMED ZAID
- MOHD ZAMRIN DIMON
- MOLINA DE SALAZAR DORA INES
- MONTANA OSCAR
- MOOE THOMAS
- MORALES DANTE
- MORAN MICHAEL
- MORENO SILGADO GUSTAVO ADOLFO
- MORIARTY ANDREW
- MOROCUTTI GIORGIO
- MOS LUCIO
- MOTOVSKA ZUZANA
- MOTREFF PASCAL
- MURPHY ANDREW
- NAHUELPAN LEONARDO
- NAKAMURA SHIGERU
- NAKANO AKIHIKO
- NALDI MONICA
- NANI SEBASTIAN
- NARASIMHAN SESHASAYEE
- NASI LUIZ ANTONIO
- NAWAZ SHAH
- NGUYEN MICHEL
- NICOLAU JOSE CARLOS
- NIELSEN HENRIK
- NIEROP PETER
- NIKOL SIGRID
- NIKOLSKY EUGENIA
- NISHINO YASUHIRO
- NODA TOSHIYUKI
- NOISEUX NICOLAS
- NOORI EBRAHIM
- NOVARETTO LEONARDO
- NOVIKOVA NINA
- O'Donnell Martin
- OEI FANNY
- OKUBO MUNENORI
- OKUDA HARUHITO
- OLIVEIRA LIVIA
- OLIVIERI CARLO
- OLTRONA VISCONTI LUIGI
- OMER SHUAB
- ONAKA HARUHIKO
- OPITZ CHRISTIAN
- OSIPOVA IRINA
- OZAKI YUKIO
- PALOMARES ELLEN
- PANDEY SHEKHAR
- PANTEV EMIL
- PARK CHUL SOO
- PARKHOMENKO ALEXANDER
- PEACE AARON
- PELAGAGGE MARIA JOSE
- PELLA DANIEL
- PEREZ LUIS
- PEREZ MARITZA
- PERNA GIAN PIERO
- PERUGACHI CARMITA
- PETRELLA ROBERT
- PETRESCU LUCIAN
- PICCINNI GIOVANNI CARLO
- PICHETTE FRANCIS
- PILON CLAUDE
- PINCETTI CHRISTIAN
- PIRK JAN
- PIRVU OCTAVIAN
- PITARGUE ARTHUR
- Pogosova Nana
- POLASEK ROSTISLAV
- POOR FERENC
- POPONINA TATIANA
- PORTNAY EDWARD
- POTTHOFF SERGIO
- POULTER ROHAN
- POW CHON LONG FREDDY
- POZDNYAKOV YURY
- PRECOMA DALTON
- PRETORIUS CATHARINA ELIZABETH
- PRINS F.J.
- PROKHOROV OLEKSANDR
- RAFFO CARLOS
- RANFT JURGEN
- RASMANIS GUNDARS
- RECH RAFAEL
- REFSGAARD JENS
- REIS GILMAR
- REPIN ALEXEY
- REY NANNETTE
- RHEAULT PAUL
- RICCI JOSEPH A
- RICHTER MAREK
- ROBBA DEBORA
- ROBERTS-THOMSON PHILIP
- ROGELIO GREGORIO
- ROGERS JAMES
- RONNER EELKO
- ROSSI DOS SANTOS FABIO
- ROSSI PAULO
- ROY ANNIE
- ROYSE ALISTAIR
- RUDENKO LEONID
- RUPKA DENNIS
- Ryden Lars
- RYNKIEWICZ ANDRZEJ
- SAKAMOTO TOMOHIRO
- SAKU KEIJIRO
- SALA JORGELINA
- SALACATA ABRAHAM
- SANCHEZ VALLEJO GREGORIO
- SANCHEZ MAYRA
- SANGRIGOLI RENEE
- SARAIVA JOSE
- SARJANOVICH RODOLFO JUAN
- SAUNDERS KEVIN
- SCHELLONG SEBASTIAN
- SCHIAVI LILIA BEATRIZ
- SCHNEIDER RICKY
- SCHROE HERMAN
- SCHYGIEL PABLO OMAR
- SEEDAT SAADIYA
- SEIWERT ANDREW
- SELVANAYAGAM JOSEPH
- SENIOR ROXY
- SEPULVEDA PABLO
- SEROTA HARVEY
- SERRANO JUNIOR CARLOS VICENTE
- SEVESTRE MARIE ANTOINETTE
- SHAMMAS NICOLAS
- SHAW JAMES
- SHIMOMURA HIDEKI
- SHUKLA DINKAR
- SHUKLE PRAVIN
- SINAGRA GIANFRANCO
- SINESCU CRINA
- SINGH BHUWAN
- SIZOVA ZHANNA
- SKALNIKOVA VLADIMIRA
- SLABY JOSEF
- SLOAN STEPHEN
- SOEGAARD PETER
- SONI ANAND
- SOTOMAYOR ARISTIDES
- SOUZA WEIMAR
- SPINAR JINDRICH
- SPINAROVA LENKA
- SRIVASTAVA SUNNY
- STEG GABRIEL
- STELLBRINK CHRISTOPH
- STOCKINS BENJAMIN
- STOERK STEFAN
- STOROZHUK BORYS
- STRAKA ZBYNEK
- STRAZHESKO IRINA
- Störk Stefan
- SULIT DENNIS JOSE
- SURESH DAMODHAR
- SWART HENK
- SZUBA ANDRZEJ
- TAKAHASHI AKIHIKO
- TANAJURA LUIZ FERNANDO
- TAO LIANG
- TENGMARK BENGT-OLOV
- TEODORESCU IULIA
- TERAN PABLO
- TESAK MARTIN
- TESLOIANU DAN
- THEW STEPHEN
- TIAN HONGYAN
- TIRADOR LOUIE
- TORSTENSSON INGEMAR
- TRETINA MARTIN
- TREVELYAN JASPER
- TRUJILLO DADA FREDY ALBERTO
- TRUJILLO FREDDY
- TSELUYKO VIRA
- TUOMILEHTO HENRI
- TUOMILEHTO HENRI
- TUOMILEHTO JAAKKO
- TUOMINEN MARJA-LEENA
- TURGEMAN YOAV
- TYTUS RICHARD
- UENO HIDEKI
- URINA MIGUEL
- UTSU NORIAKI
- VACANTE MICHAEL
- VAN BERGEN PAUL
- VAN DE BORNE PHILIPPE
- VAN DEN HEUVEL PAUL
- VAN DER BORGH ROGER
- VAN DER ZWAAN COEN
- VAN ECK JACOB
- VAN GORSELEN EDWIN
- VAN ZYL LOUIS
- Vanassche Thomas
- Varigos John D
- VASYUK YURY
- VDOVYCHENKO VALERIY
- VEJAR MARGARITA
- VENKATARAMAN ASOK
- VENSENTINI NATALIA
- VENTURI FLAVIO
- VERESS GABOR
- VERHAMME PETER
- VERTES ANDRAS
- VERTKIN ARKADIY
- VESGA BORIS
- VICO MARISA
- VIERGEVER ERIC
- Vinereanu Dragos
- VINEREANU DRAGOS
- VINTILA MARIUS MARCIAN
- VITA NESTOR ALEJANDRO
- VIZEL SAUL
- VIZIR VADYM
- VOEHRINGER HANS-FRIEDRICH
- VOEVODA MIKHAIL
- VOGEL DANIEL
- VOJTISEK PETR
- VOLKOV VOLODYMYR
- VORPAHL MARC
- VRANCKX PASCAL
- WAHLGREN CARL-MAGNUS
- WALSH RONALD
- WAN AHMAD WAN AZMAN
- WANG CHUNSHENG
- WANG ZHAOHUI
- WHELAN ALAN
- Widimsky Peter
- WIENDL MARTIN
- WIGGERS HENRIK
- WILLEMS FRANK
- WINKELMANN BERNHARD
- WU SHULIN
- WU XUESI
- WU ZONGQUI
- YAMADA TAKAHISA
- YAMADA YUTAKA
- YANG PING
- YANG YUN MEI
- YIN PENGFEI
- YOSHIDA TETSURO
- YU LITIAN
- YUSOFF KHALID
- Yusuf Salim
- ZABOWKA MACIEJ
- ZAIDMAN CESAR
- ZATEYSHCHIKOV DMITRY
- ZEGERS ERWIN
- ZELTSER DAVID
- ZEUTHEN ELISABETH
- ZHANG JIWEI
- ZHANG RUIYAN
- ZHENG YANG
- ZHENG ZHE
- ZHOU XINMIN
- Zhu Jun
- ZIDKOVA EVA
- ZIMLICHMAN REUVEN
- ZIMLICHMAN REUVEN
- ZIMMERMANN SERGIO LUIZ
- ZOET-NUGTEREN STIENEKE
- ZSARY ANDRAS
- Publication venue
- Publication date
- 01/01/2004
- Field of study
International audienceBACKGROUND:Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.METHODS:This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90. After a 30-day run-in period, patients were randomly assigned (1:1:1) to receive oral rivaroxaban (2·5 mg twice a day) plus aspirin (100 mg once a day), rivaroxaban twice a day (5 mg with aspirin placebo once a day), or to aspirin once a day (100 mg and rivaroxaban placebo twice a day). Randomisation was computer generated. Each treatment group was double dummy, and the patient, investigators, and central study staff were masked to treatment allocation. The primary outcome was cardiovascular death, myocardial infarction or stroke; the primary peripheral artery disease outcome was major adverse limb events including major amputation. This trial is registered with ClinicalTrials.gov, number NCT01776424, and is closed to new participants.FINDINGS:Between March 12, 2013, and May 10, 2016, we enrolled 7470 patients with peripheral artery disease from 558 centres. The combination of rivaroxaban plus aspirin compared with aspirin alone reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke (126 [5%] of 2492 vs 174 [7%] of 2504; hazard ratio [HR] 0·72, 95% CI 0·57-0·90, p=0·0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2%]; HR 0·54 95% CI 0·35-0·82, p=0·0037). Rivaroxaban 5 mg twice a day compared with aspirin alone did not significantly reduce the composite endpoint (149 [6%] of 2474 vs 174 [7%] of 2504; HR 0·86, 95% CI 0·69-1·08, p=0·19), but reduced major adverse limb events including major amputation (40 [2%] vs 60 [2%]; HR 0·67, 95% CI 0·45-1·00, p=0·05). The median duration of treatment was 21 months. The use of the rivaroxaban plus aspirin combination increased major bleeding compared with the aspirin alone group (77 [3%] of 2492 vs 48 [2%] of 2504; HR 1·61, 95% CI 1·12-2·31, p=0·0089), which was mainly gastrointestinal. Similarly, major bleeding occurred in 79 (3%) of 2474 patients with rivaroxaban 5 mg, and in 48 (2%) of 2504 in the aspirin alone group (HR 1·68, 95% CI 1·17-2·40; p=0·0043).INTERPRETATION:Low-dose rivaroxaban taken twice a day plus aspirin once a day reduced major adverse cardiovascular and limb events when compared with aspirin alone. Although major bleeding was increased, fatal or critical organ bleeding was not. This combination therapy represents an important advance in the management of patients with peripheral artery disease. Rivaroxaban alone did not significantly reduce major adverse cardiovascular events compared with asprin alone, but reduced major adverse limb events and increased major bleeding
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
- Author
- Abid Mohamed
- Accini Jose Luis
- Acuña Silvia
- Adawi Faiad
- Adenuga Babafemi
- Adina Pop-Moldovan
- Ageev Fail
- Aguilar David
- Aguilar-Orozco Raul
- Ahmad Zia
- Aimaretti Gianluca
- Aizenberg Diego
- Akahori Hiroshi
- Akhmedzhanov Nadir
- Akinboboye Olakunle
- Akright Laura
- Al Mahmeed Wael
- Alanko Juha
- Alappat Paul
- Alawad Mohamad
- Alfonso Teresa
- Alimard Ramin
- Allen Peter
- Alvarez Carlos
- Alvarisqueta Andres
- Alzohaili Opada
- Ambos Anu
- Amerena John
- Amolina Ildze
- Andjelic Jelic Marina
- Andrade Miguel
- Andrews Robert
- Antorrena Isabel
- Araneda Guillermo
- Arango Juan
- Ariani Mehrdad
- Arnold Susan
- Arora Chander
- Arteaga Juan Manuel
- Assaad Samir
- Atar Shaul
- Avram Rodica Ioana
- Azad Nasrin
- Azzam Samir
- Baccaro Claudia
- Bailey Gordon
- Bain Stephen
- Barbarash Olga
- Barbarich Vladimir
- Barkoudah Ebrahim
- Bartolacci Ines
- Bascil Tutuncu Neslihan
- Basu Ambar
- Bayram Edmundo
- Bednarski Janusz
- Belousov Yury
- Ben Abdallah Nejib
- Benjamin Sabrina
- Bentley-Lewis Rhonda
- Berns Svetlana
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- Sulit Dennis Jose
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- Suplotova Ludmila
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- Sy Rosa Allyn
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- Syan Rajinder
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- Synenko Volodymyr
- Szymkowiak Katarzyna
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- Takahashi Akihiko
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- Tanenberg Robert
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- Trotta Michael
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- Tsuboko Yusuke
- Tsujimoto Mitsuru
- Tsujino Motoyoshi
- Tsuzuki Masahiro
- Tuan Weiming
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- Twahirwa Marcel
- Tzekova Maria
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- Vaid Brij
- Vallejos Julio
- Van Gaal William
- Van Zyl Louis
- Vance Carl
- Vasko Peter
- Vazir Ali
- Vazquez-Garcia Abraham
- Velasco-Sanchez Raul
- Venter Tjaart
- Vico Marisa
- Vida Manuel
- Vides Hella
- Vidrio Maricela
- Viktorova Inna
- Villalobos Renato
- Vinereanu Dragos
- Vinhas Margarida
- Vishnevsky Alexander
- Vorokhobina Natalia
- Wainstein Julio
- Waisman Florencia
- Wang Thomas
- Wang Tzung-Dau
- Warner Alberta
- Warnica James Wayne
- Watanabe Shuichi
- Watson Henry
- Weber Sandra
- Webster Brian
- Weindorff Kathleen
- Weinrauch Larry
- Welch Michelle
- Welker James
- Westerberg Bernhard
- White Anthony
- White Lindsey
- Whitelaw Donald
- Wilczewski Przemyslaw
- Wilding John
- Wiles Philip
- Williams Marcus
- Wu Wen-Chih
- Wu Yujun
- Wynne Alan
- Wyss Fernando
- Xu Biao
- Yakusevich Vladimir
- Yakushin Sergey
- Yamada Takahisa
- Yang Jiefu
- Yang Jinkui
- Yang Yanmin
- Yañez Mario
- Yeap Bu
- Yigit Zerrin
- Yocono Mark
- Yordanov Viktor
- Yuen Kevin
- Yupanqui Hernan
- Zadionchenko Vladimir
- Zalevskaya Alsu
- Zalevsky Grigory
- Zarankiene Rima
- Zateyshchikova Anna
- Zavala Alejandro
- Zhuravleva Larisa
- Zidi Borni
- Zorkun Cafer
- Zubiate Carlos
- Zuraw Bruce L.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND:
Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.
METHODS:
ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy.
RESULTS:
Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m(2), and duration of T2DM was 9.3 ± 8.2 years. The qualifying ACS was a myocardial infarction in 83% and unstable angina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events.
CONCLUSION:
ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- A Nizarudeen
- Aalem Hajer Abd Alhamed
- Ababneh Hazim
- Abbas Ahmed
- Abbas Aram
- Abbas Hussain
- Abbasi Arezou
- Abbassi Fariba
- Abbasy Jibran
- Abbood Ali H
- Abboud Kirellos
- Abdallah Ahmed
- Abdalsalam Sabriya Juma Ali
- Abdelaal Abdelrahman
- Abdelalemm Mohamed
- Abdelhafez Mohammed Hisham Zayan
- Abdelhalim Karim
- Abdeljalil Mahmoud
- Abdelkarem Mohamed
- Abdelmageed Abdelfatah
- Abdelmageed Abdelfatah
- Abdelmaksoud Mohamed
- Abdelmawgoud Sherif
- Abdelmawla Mohamed
- Abdelmawla Mohamed Osama Mohammed Kamel
- Abdelmoneim Noha
- Abdelnoor Ahmad
- Abdelrahman Fatma
- Abdelrazek Hussein A
- Abdelrhman Reham
- Abdelzaher Abdurrahman
- Abdelzaher Abdurrahman Taha
- Abdou Khaled
- Abdoun Meriem
- Abdualqader Mahmmoud
- Abdualqader Mahmmoud Yehia Mohammed
- Abdulhaq Aram
- Abduljawad Heba
- Abdullaev Abakar
- Abdullah Nik Azim Nik
- Abdulmonem Aya
- Abdulwahed Eman
- Abebrese John
- Abiyere Henry
- Abobakr Abobakr Mahfoz
- Aboelfath Shiamaa
- Abosamak Nour Eldin
- Abu-Elfatth Ahmed Mohammed
- Abu-Ghazal Sara
- Abu-Ghazal Sara Yassir
- Abuali Ahmed S A M E
- Abuelazm Mohamed
- Abuelnaga Yasmeen
- Abuelnaga Yasmeen
- Abughazal Sara Yasser
- Abuleil Amro
- Abusannuga Malek
- Abuzaina Khalil
- Adam Islam
- Aday Ulaş
- Adeyeye Ademola
- Adeyeye Nigeria Ademola
- Adham Mustapha
- Adhikari Krishna Mohan
- Affary Anter Al
- Afzal Ameer
- Afzal Iqraa
- Aghdassi Ali
- Ahmed Emad Ali
- Ahmed Mohamed Bahaa Eldin
- Ahmed Randa
- Ahmeed Sultan
- Ajayi Peter
- Akahoshi Keiichi
- Akbar Ali
- Akhtar Naseem
- Al-Abdi Radfan
- Al-Abed Omar
- Al-Ameri Saba
- Al-Ameri Saba Ahmed Ahmed Saleh
- Al-Asadi Mohammed Abdulkhaleq Mohammed Mohsen
- Al-Dowsh Nagra Are
- Al-Eryani Fatima
- Al-Faiq Siham
- Al-Haj Ahmad
- Al-Hyari Abdelkareem
- Al-Isawi Ali
- Al-juaifari Maytham Aqeel
- Al-Khawlani Qaeid
- Al-Kubati Waheeb
- Al-Maadani Basma
- Al-Mallah Rozana
- Al-Markiz Eman
- Al-Mekhlafi Ayat
- Al-Melhani Watheeq
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Ogaili Mustafa
- Al-Qasrawi Shahd
- Al-Saban Rafat
- Al-saban Rafat Ameen Mohammed
- Al-Sader Maytham Al-Juaifari
- Al-Samawi Abdulaziz
- Al-Samawi Hytham
- Al-Sarireh Bilal
- Al-Shami Khayry
- Al-shami Manar
- Al-sharabi Ebrahim Ahmed Esmail
- Al-Shehari Mohammed
- Al-Tekreeti Sarah
- Alahmed Farouq
- Alahmed Hoor
- Alaimo Laura
- Alali Mahmoud Bilal
- Alannaz Omar
- Alansary Marwa Nasrelden
- Alatise Olusegun
- Alattas Zainab
- Alawna Reem
- Alazab Emad
- Albaba Safa'
- Albakry Rudaina
- Albar Aisha
- Albaraesi Mohammed N
- Albarouni Sofian
- Albishti Ahmed
- Alboridy Muneera
- Aldoescu Sorin
- AlDowsh Nagran Aref
- Aldressi Wafa
- Aldumaini Hamdan
- Alegria Cesar Rodriguez
- Alfano Marie Sophie
- Alfatah Maryam Abd
- Alfonso Cenon
- Alfurais Sarah
- Alghazo Heyam
- Alhaboob Nassir
- Alharthi Mohammed
- Alhashemi Mais
- Alhmaidi Riad
- Alhouri Ahmad
- Alhouri Ahmad Nabil
- Ali Ahmed Youssef Mohamed
- Ali Dina
- Ali Ramzi Abdullah Yahya
- Ali Ramzi Ali Abdullah Yahya
- Ali Suhil Ben
- Alissawi Subhi
- Alissawi Subhi Zahi
- Aliwy Marwan Al
- Aljaber Ahmad
- Aljamal Sarah
- Aljiffry Murad
- Alkhadem Maeen Ali
- Alkhaleel Wael
- Alkhateb Hossain
- Allah Mohamed Abd
- Allam Ahmed
- Allam Mohamed
- Allam Shrouq
- Allisiardi Fabrizio
- Alloush Ali
- Almarashi Hassan
- Almarkiz Eman
- Almasri Tabarak Abedlnaser
- Almassaudi Ali
- Almekhlafi Tofik
- Almiani Sari
- Almjersah Abdulrahman
- Alnammourah Walaa Mohammed
- Alnammourah Walaa Mohammed
- Alnimr Ahmed
- Aloulou Marwa
- Alowjali Fatoom
- Alsabah Mohamed
- Alsabbagh Feras
- AlSaffaf Mohamed
- Alsanany Ghadeer Mohammed
- Alsayadi Ramzi
- Alshaghel Mohammed
- Alsharabi Ebrahim
- Alshareea Entisar
- Alsharif Doaa
- Alsharif Doaa Sabry
- Alsharif Doaa Sabry
- Alsharif Doaa Sabry
- Alshatshat Abdulhadi
- Alsori Mohamed
- Alsoudani Ali
- Altatari Abdulrahman
- Altatari Ahmad Mohammad
- Alwafy Khaled
- Alwan Hussein Mohammed
- Alyasin Ismaeil
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- Fareed Ahmed M
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- Konstadoulakis Manousos
- Konstantinidis Konstantinos M
- Konstantinidis Michael K
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- Vougas Vasileios
- Vouros Dimitrios
- Vrakopoulou Gavriella Zoi
- Waechter Fábio Luiz
- Waffa Zuraiha
- Wagner Ki
- Wahib El Mahdi
- Wake Rudyard
- Wang Huaizhi
- Wang Jiping
- Waqar Usama
- Waqar Usama
- Wardeh Salah
- Wardeszkiewicz Aleksander
- Wassmer Charles-Henri
- Weber Markus
- Wei Alice
- Wei Kongyuan
- Wei Kongyuan
- Weitz Jürgen
- Wellner Ulrich
- Welsch Thilo
- Welsh Fraser
- Wen Daniel
- Wennerblom Johanna Hansson
- Wenning Anna Silvia
- Wicherts Dennis
- Wierzchowski Michał
- Wikar Tomasz
- Williamsson Caroline
- Windsor John
- Winslow Emily
- Wlazlak Michal
- Wolfgang Christopher
- Wu Chien Hui
- Wu Chien Hui
- Wüllenweber Hans-Peter
- Wyroślak-Najs Justyna
- Yadav Kaushal
- Yadev Induprabha
- Yadev Induprabha
- Yaghan Rami
- Yamamoto Tomohisa
- Yang Po-Chih
- Yassin Laya Moayyad Ahmed
- Yassin Raya
- Yegen Cumhur
- Yeo Charles
- Yesilyurt Degercan
- Yip Vincent
- Yoong Boon
- Yoong Boon Koon
- Younes Eman
- Younes Eman
- Young Alistair
- Yousef Amal
- Youssef Amal
- Yu Ming-Chin
- Zacharakis Emmanouil
- Zacharoulis Dimitrios
- Zachiotis Marinos
- Zagainov Vladimir
- Zaharie Florin
- Zahed Mohamed
- Zahed Mohamed Samir Mohamed
- Zakaria Andee Dzulkarnaen
- Zamri Fatimah Mardhiyyah Binti
- Zanatta Michela
- Zanello Matteo
- Zanini Nicola
- Zanus Giacomo
- Zanus Giacomo
- Zaruba Pavel
- Zawia Ali
- Zayed Ahmed
- Zdujic Predrag
- Zedelj Jurica
- Zeh Herbert J
- Zentar Aziz
- Zerbi Alessandro
- Zidan Taha
- Zidan Taha
- Zironda Andrea
- Zitawi Abdullah
- Zivanovic Marko
- Zogopoulos George
- Zonta Sandro
- Zonta Sandro
- Zorrilla Carlos Florez
- Zozaya Gabriel
- Zreqat Qusai
- Zuhdi Zamri
- Zuhdy Mohammad
- Zygomalas Apollon
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)