Erythrocytes and their value in pathogenesis of parodontium inflammatory diseases

Cheremisina V. F., Bereznyakova A. I. Erythrocytes and their value in pathogenesis of parodontium inflammatory diseases. Journal of Education, Health and Sport. 2019;9(4):611-617. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3240160 http://ojs.ukw.edu.pl/index.php/johs/article/view/7005 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.04.2019. Revised: 15.04.2019. Accepted: 29.04.2019. ERYTHROCYTES AND THEIR VALUE IN PATHOGENESIS OF PARODONTIUM INFLAMMATORY DISEASES V. F. Cheremisina, A. I. Bereznyakova National University of Pharmacy, Kharkiv, Ukraine; [email protected] Abstract The value of experimental animals (white rats) erythrocytes in pathogenesis of parodontium inflammatory disease was searched. The dynamics of Hb changes, erythrocytes number and hematocrit were surveyed. Periodontitis was moulded by special diet. When periodontitis developed oxidative stress and enhanced generation of reactive oxygen species were observed as well as changes in the number of erythrocytes, hemoglobin and erythrocyte indices. The latter were caused by membrane destructive processes in erythrocytes, decrease in their absolute number due to hemolysis, and changes in hematocrit due to blood redistribution. Key words: erythrocytes, hemoglobin, hematocrit, periodontitis

O narzędziach i wynikach badań = About the tools and the results of the research

Mrozkowiak M., Bereznyakova A. I., Cheremisina V. F., Zukow W. O narzędziach i wynikach badań = About the tools and the results of the research. Journal of Education, Health and Sport. 2015;5(11):245-260. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.33965http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A245-260https://pbn.nauka.gov.pl/works/670087Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.09.2015. Revised 25.10.2015. Accepted: 10.11.2015. O narzędziach i wynikach badańAbout the tools and the results of the research M. Mrozkowiak1, А. И. Березнякова2, В. Ф. Черемисина2, W. Zukow1M. Mrozkowiak1, A. I. Bereznyakova2, V. F. Cheremisina2, W. Zukow1 1Uniwersytet Kazimierza Wielkiego, Bydgoszcz1Kazimierz Wielki University, Bydgoszcz2Национальный фармацевтический университет, г. Харьков2National University of Pharmacy, Kharkiv  Słowa kluczowe: postawa ciała, cechy krwi, narzędzia badawcze, wyniki badań.Keywords: posture, blood, research tools, the results of the research. Streszczenie Pomimo wielu opracowanych koncepcji oceny postawy ciała, prześwietlenie promieniami Roentgena jest nadal metodą najbardziej popularną. Ortopedzi, porównując różne metody leczenia, mają tendencję do formułowania wniosków tylko na podstawie zdjęcia rtg. Należy zauważyć, że badanie z wykorzystaniem mory projekcyjnej nie zastępuje diagnostyki postawy rtg. Bowiem oparta jest na innej zasadzie działania, wykorzystuje między innymi analizę układu kostnego, a zalecana pozycja podczas zdjęcia nie rejestruje postawy habitualnej.Problemy podobnej natury występują także w pomiarze wielkości cech krwi. Dla zachowania wysokiej standaryzacji pobrań i analizy materiału należy zadbać aby: pobór krwi nastąpił przez tą samą osobę i w tych samych warunkach socjalnych, z tego samego odcinka żyły, w tym samym ustawieniem kończyny górnej o rozluźniony mięśniach, strzykawką tej samej firmy, zastosowano te same warunki i metodę analizy krwi. Nie bez znaczenia jest także czas po jakim nastąpiła analiza cech krwi, stosowana procedura analizy i producent stosowanych odczynników. W związku z tym, w ocenie wielkości cech krwi należy brać pod uwagę podawane przez laboratorium analityczne obowiązujące wielkości referencyjne. Abstract Despite the many developed the concept of evaluation of the body posture, overexposure x-ray is still the most popular method. Orthopedists, comparing the various methods of treatment, they tend to formulate proposals on the basis of x-ray pictures. It should be noted that a study using projection moire does not replace diagnostic x-ray attitude. Because it is based on a different principle, inter alia, an analysis of the skeletal system, and recommended items during the photos does not record the attitude of habitual.            Problems of a similar nature occur also in measuring the size of blood characteristics. To preserve the high standardisation of donations and material analysis, care should be taken to: collection of blood followed by the same person and the same social conditions, with the same section of the vein at the same setting of the upper extremity of relaxed muscles, inject the same company, the same conditions and method of analysis of the blood. Not without significance is also the time that there had been an analysis of the characteristics of the blood analysis procedure used and the manufacturer used reagents. Therefore, in assessing the size of the blood characteristics have to be taken into account given by the analytical laboratory, the existing benchmarks

Sociocultural Component in the Content of Teaching Foreign Languages to Pre-school Children

The paper is aimed at studying efficiency of learning languages by pre-school children. Different types of memory that are at high level of its development at this age promote children's abilities to acquire languages. Also psychologically, pre-school children are fit to develop speech and communication skills by using adequate materials and tasks. A set of criteria are evaluated to introduce socio-cultural content for promoting effective language learning

Effectiveness of neoton in patients with chronic heart failure depending on the left ventricular ejection fraction. Sub-analysis of the BYHEART study

Aim. To study the effectiveness of exogenous phosphocreatine (EPCr) therapy in patients with heart failure (HF) with reduced and mildly reduce dejection fraction (EF).Material and methods. The all-Russian prospective observational study BYHEART included 842 patients who underwent aEPCr therapy course. Before and after the course of EPCr therapy, the following studies were carried out: a questionnaire on the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the clinical assessment scale (CAS), transthoracic echocardiography with an assessment of the left ventricular EF, a 6-minute walk test, N-terminal pro-brain natriuretic peptide (NT-proBNP). All patients before the EPCr course received long-term optimal therapy for HF.Results. Data analysis was carried out for patients in groups with heart failure with reduced ejection fraction (HFrEF) and with mildly reduced ejection fraction (HFmrEF) within the group depending on the course of EPCr treatment: subgroup A — patients who received EPCr therapy less than 20 g/course and subgroup B — patients who received EPCr therapy ≥20 g/course. The results obtained demonstrate an increase in the quality of life and exercise tolerance, an improvement according to the CAS, a decrease in NT-proBNP levels, and an improvement in left ventricular systolic function in patients with both HFrEF and HFmrEF during the course of intravenous EPCr therapy.Conclusion. The use of EPCr is a promising tool in addition to optimal therapy in patients with HFrEF and HFmrEF

Magnetic Resonance (MR) rectography in diagnostics of small-size rectal neoplasms

Purpose was the assessment of diagnostic efficiency of MR-rectography in diagnostics of small-size rectal neoplasms. 12 patients with polyps and small tumors of a rectum are examined, the size of detected neoplasms varied in the range 3-18 mm. Native MRI and MRI with retrograde contrasting by ultrasonic gel was carried out. Results of MRI are compared with results of videocolonoscopy. Sensitivity of native MRT was 24%, MR- rectography was 88%. MR-rectography can be used in diagnostics of small-size rectal neoplasms

Hypersegmentation of neutrophil nuclei in peripheral blood of patients with localized and advanced cancer of the larynx and laryngopharynx

Neutrophilic granulocytes have a wide spectrum of functional activity. In recent years, the functional significance of neutrophils in the development and course of malignant neoplasms has been discussed. It has been shown that neutrophilic granulocytes can play pro- or antitumor activity. The aim of the study was to assess the structural and functional features of neutrophils in patients with varying degrees of prevalence of cancer of the larynx and laryngopharynx. Forty-one patients (aged 35-67) with newly diagnosed cancer of the larynx and laryngopharynx were examined and divided into subgroups according to the TNM classification: the first subgroup (14 patients) with a localized tumor process consisted; and the second subgroup (27 patients) with a widespread tumor process. The relative and absolute number of neutrophils was assessed, and the neutrophil-lymphocyte ratio (NLR) was determined. The content of neutrophils with varying degrees of nuclear segmentation in the blood was calculated, the activity of myeloperoxidase, cationic proteins, alkaline phosphatase, and the degree of neutrophil activation in the NBT test was determined cytochemically. Concentration of interleukin-8 was determined using ELISA. In patients with cancer of the larynx and laryngopharynx the number of neutrophils (p = 0.045) and NLR (p = 0.033), as well as serum concentration of interleukin 8 (p = 0.011), increased compared to healthy individuals. The proportion of cells with hypersegmented nuclei in the neutrophil population (p < 0.001) and cytotoxic potential increased with the spread of tumor process. A direct correlation (r = 0.42, p = 0.03) was found between the T index, which reflects the volume of the tumor, and the content of hypersegmented neutrophils. It can be argued that such a simple and accessible laboratory parameter as the degree of segmentation of the nuclei of neutrophilic granulocytes can be used as one of the criteria to assess and predict the course of the tumor process

Functional analysis of electronic trading platforms used in the implementation of drug provision in the segment of the hospital market

The article presents a comparative analysis of the functionality of the main electronic trading platforms used in the implementation of drug provision in the segment of the hospital marketВ статье проведен сравнительный анализ функциональных возможностей основных электронных торговых площадок, используемых при реализации лекарственного обеспечения в сегменте госпитального рынк

Пневмонии и их диагностика в стационарах Санкт-Петербурга по данным аутопсий

15 633 records of postmortem examinations of the St.-Petersburg municipal bureaus were analyzed for 1993— 1995. All kinds of pneumonia were revealed in 38% of cases. The frequency of primary and secondary pneumonia including pneumonia as a manifestation of chronic bronchitis exacerbation, was analyzed. The low quality of pneumonia diagnosis in non-specialized hospitals as well as its reasons are shown.Проанализированы 15 633 протокола патологоанатомических вскрытий городского бюро Санкт-Петербурга за 1993—1995 гг. Выявлено, что все виды пневмоний обнаружены в 38% наблюдений. Проанализирована частота первичных и вторичных пневмоний, а также пневмоний, явившихся проявлением обострения хронического бронхита. Показан низкий уровень диагностики пневмоний в стационарах общего профиля и его причины

Efficiency of radiotherapy during local hyperthermia in the treatment of laryngeal and laryngopharyngeal cancer

Cancer of the larynx and laryngopharynx, which is accessible to visual and instrumental examination, remains the most relevant and complicated problem among head and neck malignances as before. Investigations show that the incidence of cancer at these sites in Russia in the last decade has risen from 4.5 to 9.67 %. This is a severe and poor prognostic form of cancer, which is characterized by its nonspecific early clinical manifestations, complex anatomic and topographic structure, and a high rate of regional metastases. The mainstay of treatment for head and neck cancer involves 3 components: surgery, chemotherapy, and radiotherapy (RT), which are performed alone or in combination. The most commonly used technique is combined, frequently crippling due to organ-removing operations. The clinical introduction of current radio modifiers, local and deep hyperthermia systems, is a promising approach to improving the results of treatment, to enhancing the radiation damage of RT, and to achieving the tumor regression sufficient for surgical intervention without augmenting the early and late toxicity inherent in chemoradiation treatment. The results of the performed study of 35 patients with T2–3N0–2M0 laryngeal and laryngopharyngeal cancer proved the high efficiency of local hyperthermia in treating malignancies in this region during both preoperative (grades III– IV therapeutic pathomorphism) and radical beam RT