37 research outputs found
The comparative analysis of correlative interrelations of vegetative nervous and vascular components of communicative systems in case of precancer and cancer of mammary gland and cervical carcinoma
The results of comparative analysis of correlative interrelations of vegetative nervous and vascular components of communicative systems in case of precancer and breast cancer and cervical carcinoma are shown in the article. The obvious regularities in quantitative indicators of correlative interrelations of cellular microenvironment - as one of the component of communicative systems in breast and in uterine cervix in case of dysplasia and cancer are seen.Представлены результаты сравнительного анализа корреляционных взаимосвязей вегетативного нервного и сосудистого компонентов коммуникационных систем при предраке и раке молочной железы и шейки матки. Показано, что прослеживается наличие явных закономерностей в количественных показателях корреляционных взаимодействий клеточного микроокружения - одной из частей коммуникационных систем в молочной железе и шейке матки при дисплазиях и раке
ОЦЕНКА ЭФФЕКТИВНОСТИ ЖЕЛАТИНА ТАННАТА ПРИ ОСТРЫХ ИНФЕКЦИОННЫХ ДИАРЕЯХ У ДЕТЕЙ
Specific features of the course of acute intestinal infections of viral and bacterial etiology in children are described, features of the syndrome of endogenous intoxication in children carrying infectious diarrhea are characterized. As a result of the study, the efficacy and safety of gelatin tannate (LLC «YADRAN», Croatia) with intestinal infections of bacterial and viral etiology in children has been confirmed. Установлены особенности течения острых кишечных инфекций вирусной и бактериальной этиологии у детей, охарактеризованы особенности синдрома эндогенной интоксикции у детей, переносящих инфекционные диареи. В результате проведенного исследования подтвержена эффективность и безопасность желатина танната (ООО «ЯДРАН», Хорватия) при кишечных инфекциях бактериальной и вирусной этиологии у детей.
ВИСЦЕРАЛЬНЫЙ ЛЕЙШМАНИОЗ У РЕБЕНКА: СЛОЖНОСТИ ДИАГНОСТИКИ И ЛЕЧЕНИЯ
The case of diagnostics and differential diagnostics of a case of a visceral leushmaniosis at the child of early age with development an infectionassociated hemophagocytosis is provided. This complication demands carrying out broad diagnostic search, and therapy in our country represents considerable difficulties as drugs for treatment of a visceral leushmaniosis in Russia are unregistered.Представлен случай диагностики и дифференциальной диагностики случая висцерального лейшманиоза у ребенка раннего возраста с развитием инфекция-ассоциированного гемофагоцитоза. Данное осложнение требует проведения широкого диагностического поиска, а терапия в нашей стране представляет значительные сложности, так как препараты для лечения висцерального лейшманиоза в России не зарегистрированы
Педиатрический мультисистемный воспалительный синдром, ассоциированный с новой коронавирусной инфекцией: нерешенные проблемы
Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.С марта 2020 г. появились первые сообщения о возрастающем практически повсеместно количестве детей, перенесших новую короновирусную инфекцию, вызванную SARS-Co2v, с симптомокомплексом, напоминающим проявления болезни Кавасаки. Особенностью клинических проявлений при данном синдроме, который получил название «педиатрический мультисистемный воспалительный синдром, ассоциированный с COVID-19», является высокая частота возникновения жизнеугрожающих состояний, обусловленных резким развитием артериальной гипотензии на фоне кардиогенного или вазогенношого шока.В Санкт-Петербурге с конца декабря 2020 г. наблюдается резкий всплеск поступлений в ОРИТ различных стационаров детей с клиникой педиатрического мультисистемного воспалительного синдрома, имеющих лабораторное подтверждение перенесенного COVID-19.Целью настоящей статьи является привлечение внимания врачей различного профиля для объединения усилий по изучению данной патологии, определения критериев верификации диагноза, оптимальных схем терапии и диспансерного наблюдения за переболевшими
Ротавирусная инфекция у детей — нерешенная проблема. Обзор рекомендаций по вакцинопрофилактике
These clinical guidelines were developed by the professional association of pediatric specialists «Union of Pediatricians of Russia» and approved by the Association’s Executive Committee at the Congress of Pediatricians of Russia «Actual Problems of Pediatrics». Clinical guidelines are devoted to the problem of rotavirus infection, the relevance of which is determined by the high prevalence level and significant contribution of infectious diarrhea to the mortality pattern of children in the first 5 years of life. We present epidemiological data and detailed information on the infectious agent and pathogenesis of rotavirus infection progression. A detailed picture of clinical manifestations as well as extraintestinal complications is presented. The approach to specific prophylaxis has been reasoned. Practical recommendations for immunization as well as various regimens for administering the vaccine, depending on the age and condition of the patient, are given.Данные клинические рекомендации разработаны профессиональной ассоциацией детских специалистов «Союз педиатров России» и утверждены Исполкомом ассоциации на Съезде педиатров России «Актуальные проблемы педиатрии». Клинические рекомендации посвящены проблеме ротавирусной инфекции, актуальность которой определяется высоким уровнем распространенности и значительным вкладом инфекционной диареи в структуру смертности детей первых 5 лет жизни. Приводятся эпидемиологические данные, подробно описаны особенности возбудителя, патогенез развития ротавирусной инфекции. Представлена развернутая картина клинических проявлений, а также внекишечных осложнений. Обоснована тактика специфической профилактики. Даны практические рекомендации по проведению иммунизации, а также различные схемы введения вакцины в зависимости от возраста и состояния пациента
Polineoplasia in patients with cervical cancer in the Chelyabinsk region of Russia
The purpose of the study was to analyze the incidence of primary-multiple cancer (PMC) of the female reproductive system according to the population cancer register of the Chelyabinsk region for 15 years (1999-2013) using the example of PMC of the cervix. Carry out an analysis of the adjusted cumulative survival in the group of patients with PMC of the cervix as compared with solitary cervical cancer.Material and methods. The material was processed using the classification of Zisman I. F. and Kirichenko G. D. (1978) on the sequence of tumors: metachronous, synchronous, mechatronic-synchronous and synchronous-metachronous. The interval of metachronousness is 6 months. The survival rates of cancer patients in the Chelyabinsk region were calculated automatically with the use of the computer program "Calculation of survival rates" — an application to the population-based cancer registry of OOO Novell-SPb. Using the method of continuous sampling, we carried out a retrospective analysis of the case histories of patients with PMC of the female reproductive system treated in the SBEO CRCOD for 15 years (1999-2013).Results. During the period under review, 82 patients with PMC of the cervix uteri were examined, metachronous tumors prevailed in 55 (67.1%), synchronous tumors developed in 27 (33.75%). In the group of metachronous tumors in 12 (21.8%) patients had a combination of three tumors. Three (5.45%) patients had a combination of four tumors. Analysis of combinations of cervical cancer showed that more often, the cervical cancer metachronically met with breast cancer 35% (14 patients), endometrial cancer 17.5% (7 patients), ovarian cancer 7.5% (3 patients). Synchronously cervical cancer was more often combined with breast cancer 42.8% (9 patients), endometrium 28.6% (6 patients), ovaries 23.8% (5 patients) and rectal cancer 4.8% (1 patient).The results of calculation of the index of the adjusted cumulative survival of the study group of the PMC of the cervix showed that in the group of metachronous tumors, survival rates were significantly higher than in the group of synchronous tumors: single-year survival was 84.8 ± 6.3% against 82.4 ± 9.2, three-year survival — 66.8 ± 7.8% against 47, 1 ± 12.1, and five years after the diagnosis, 53.8 ± 8.6% of patients survived.Conclusion. Thus, patients with cervical cancer are at risk of developing cancer of other localizations that share common etiopathogenetic factors, such as HPV infection in women, hormonal disorders
Visceral leushmaniosis at the child: difficulties of diagnostics and treatment
The case of diagnostics and differential diagnostics of a case of a visceral leushmaniosis at the child of early age with development an infectionassociated hemophagocytosis is provided. This complication demands carrying out broad diagnostic search, and therapy in our country represents considerable difficulties as drugs for treatment of a visceral leushmaniosis in Russia are unregistered
EFFECTIVENESS OF GELATIN TANNATE IN ACUTE INFECTIOUS DIARRHEA IN CHILDREN
Specific features of the course of acute intestinal infections of viral and bacterial etiology in children are described, features of the syndrome of endogenous intoxication in children carrying infectious diarrhea are characterized. As a result of the study, the efficacy and safety of gelatin tannate (LLC «YADRAN», Croatia) with intestinal infections of bacterial and viral etiology in children has been confirmed