Financial and credit mechanism for attraction of real investments in a system of money flows regulation

Optimization of funding sources of real investments is a key stage in development and successful functioning of enterprises' investment activity. Currently big attention is drawn to questions of state and private partnership during development of investment projects, as well as to possible prospects of development of state and private interaction forms in investment sphere, and concessions particularly. Improvement of forms of interaction between state and corporate sector of economy in the sphere of real investments and as a part of development of specific priority investment programs requiring considerable investments has a strategic federal and regional value. Thus, it is important to understand role and benefit of each participant of the investment market, to define clear statutory, legislative and contractual base, and to swiftly analyze financial efficiency of real investments at all stages of realization. In modern conditions, stable development of economy of any country depends on condition of investment process. Need to integrate finance capital and to promote investment activity is obvious in new management conditions of market relations development. The main condition of successful investment activity at each stage is a choice of effective and correct finance and credit mechanism as a tool of real investments financing. Prior to suggest modern tools of such financing, it is necessary to analyze theoretically proved program and targeted method of real investments financing within the state and private partnership, in order to improve previously examined methodology. © 2015, Mediterranean Center of Social and Educational Research. All rights reserved

Использование Урисана у больных подагрой

Objective: to evaluate the safety, tolerance, and efficacy of the herbal complex Urisan used in patients with gout within the Russian multicenter study. Subjects and methods. Thirty males aged 34 to 56 years with a valid diagnosis of gout after S.L. Wallace and a 1-7-year (mean 4,8 years) history of the disease were examined at the Rheumatology Unit of a Kursk regional hospital. Nineteen and 11 patients were stated to have tophaceous and nontophaceous gout, respectively. The total number of involved joints ranged from 3 to 10 (mean 4,6 joints). The study included patients with interictal gout. All the patients took Urisan in a full dose of 2 capsules (550 mg) twice daily for a month. Results. Prior to Urisan therapy, the mean serum level of uric acid (UA) was 569,5±102,4 ⎧mol/l; daily UA excretion averaged 4769,8 ⎧mol/l. Urisan therapy reduced UA levels by an average of 120 ⎧mol/l and increased daily urinary UA excretion by an average of 198,8 цmol/l. Conclusion. Urisan used against gout for 30 days causes an average 21% reduction in the serum levels of UA and a 4,1% increase in its urinary excretion. There were no exacerbations of gout during Urisan therapy.Цель исследования - оценка в рамках Российского многоцентрового исследования безопасности, переносимости и эффективности применения растительного комплекса Урисан у пациентов с подагрой. Материал и методы. В ревматологическом отделении областной больницы г. Курска обследованы 30 мужчин в возрасте от 34 до 56 лет с достоверным диагнозом подагры по S.L. Wallace и длительностью болезни от 1 года до 7 лет (в среднем - 4,8 года). У 19 пациентов констатирована тофусная подагра, у 11 - бестофусная. Общее количество пораженных суставов колебалось от 3 до 10 (среднем - 4,6 сустава). В исследование включали больных подагрой в межприступный период. Все пациенты принимали Урисан в полной дозе по 2 капсулы (по 550 мг) 2 раза в день в течение месяца. Результаты исследования. Средний уровень мочевой кислоты (МК) в сыворотке крови больных до терапии Урисаном составил 569,5±102,4 мкмоль/л, суточная экскреция МК - в среднем 4769,8 ммоль/л. На фоне терапии Урисаном у больных отмечены снижение уровня МК в среднем на 120 мкмоль/л, а также увеличение уровня экскреции МК с мочой в среднем на 198,8 ммоль/л в сутки. Выводы. Прием Урисана при подагре в течение 30 дней приводит к снижению сывороточного уровня МК в среднем на 21% и увеличению экскреции МК с мочой - на 4,1%. На фоне терапии Урисаном не наблюдалось обострений подагры

The effect of amber acid on the productivity and chemical composition of tomatoes grown in a climatic chamber

The research was carried out in 2019 - 2020 in the department of closed artificial agroecosystems for plant growing in the Federal State Budgetary Scientific Institution "Federal Scientific Agroengineering Center VIM", Moscow. The study focused on the seeds of tomatoes (Solanum lycopersicum L.) variety “Lyana”. Amber acid was used as a biostimulating factor at the stage of pre-sowing seed treatment and with constant drip irrigation of plants throughout the entire growing season - 145 day

Corrosion resistance of neodymium and dysprosium hydrides

This paper describes the methods of obtaining hydrides of rare earth elements such as dysprosium and neodymium. The properties and corrosion resistance of these elements are investigated. A synthesis method of monophasic dysprosium and neodymium dihydrides is presented. Synthesized dihydrides are agglomerates with an average size of 3-50 µm and are formed by crystalline grains of a nanometer size. BET specific surface area, morphology, elemental analyses and composition of samples have been studied. Corrosion stability in aqueous solutions of hydrochloric acid and sodium hydroxide were studied. It was determined that both hydrides undergo hydrolysis in acid and alkaline mediums. Neodymium hydride is more stable to corrosion than dysprosium hydride, which is proved by its longer exposure to aggressive medium to hydrides. The formation of insoluble /poorly soluble products of corrosion can make a significant contribution to the process of powder dissolution

Symmetries and modelling functions for diffusion processes

A constructive approach to theory of diffusion processes is proposed, which is based on application of both the symmetry analysis and method of modelling functions. An algorithm for construction of the modelling functions is suggested. This algorithm is based on the error functions expansion (ERFEX) of experimental concentration profiles. The high-accuracy analytical description of the profiles provided by ERFEX approximation allows a convenient extraction of the concentration dependence of diffusivity from experimental data and prediction of the diffusion process. Our analysis is exemplified by its employment to experimental results obtained for surface diffusion of lithium on the molybdenum (112) surface pre-covered with dysprosium. The ERFEX approximation can be directly extended to many other diffusion systems.Comment: 19 pages, 8 figure

Резерви енергозбереження при автоматизованному управлінні відцентровими насосами електростанцій

У статті проведено аналіз і обробку даних експериментального дослідження відцентрового насоса теплових електростанцій. Показано можливий економічний ефект від використання алгоритмів енергозберігаючого керування відцентровим насосом і визначено закон такого керування.In article is organized analysis and data processing the experimental study of the centrifugal pump heat power station. Possible economic effect is Shown when use algorithm энергосберегающего centrifugal pump management and is determined law of such management.В статье проведен анализ и обработка данных экспериментального исследования центробежного насоса тепловых электростанций. Показан возможный экономический эффект при использовании алгоритмов энергосберегающего управления центробежным насосом и определен закон такого управления

Assessment of the Potential Epidemic Hazard as Regards International Public Events in Terms of the Currently Important Infectious Diseases

International public events (IPE) present some actual epidemiological problems requiring proper methodological elaboration. In this respect for the first time developed has been the scheme of assessment of their potential epidemic hazard (PEH), based on integrated evaluation of epidemiological risk as regards infectious diseases listed in the IHR (2005). On the cholera model demonstrated is the fact that high priority hazard of public events emerges when those are combined with such elements of epidemiological risk as territory and time of a threat, as well as risk factors and risk contingents. Thus the integral effect of all elements realization is manifested through high probability of infectious disease importation, which is associated with emergency situation, into the public event location and the disturbance of mass gathering progress. Reliability and functionality of the developed scheme is verified on other infections too. PEH assessment procedure allows for timely identification of priority goals, for rating means and capacities, organizational resources, methodological and technological arrays for the provision of sanitary-epidemiological welfare and biological safety when managing public event

Подготовка специалистов в области электронного маркетинга: кадры для цифровой экономики Республики Беларусь

The tendencies of development of marketing in conditions of digital transformation of economy are considered in the article. The concept of electronic marketing is presented. The condition of training of specialists in the field of electronic marketing in the Republic of Belarus is described. The necessity of training of specialists in the field of e-marketing on the second stage of higher education is substantiated. The special features of this field of study are distinguished in comparison with the baccalaureate and in comparison with related directions of the master's programm. В статье рассматриваются тенденции развития маркетинга в условиях цифровой транс- формации экономики. Представлено понятие электронного маркетинга, дана характеристика состояния подготовки специалистов в области электронного маркетинга в Республике Беларусь. Обоснована необхо- димость открытия специальности «Электронный маркетинг» на II ступени высшего образования, выделены особен- ности данной специальности по сравнению с I ступенью и по сравнению со смежными направлениями подготовки магистров.

Effect of taxanes on the miR-106 and miR-200c expression in prostate cancer cells in vivo and in vitro

Introduction. A combination of antiandrogen and cytostatic drugs was justified in the neoadjuvant therapy of patients with high-risk prostate cancer (HiRPCa) in some clinical trials. The effectiveness of such therapy in each individual case depends on the sensitivity of cancer cells to the applied drugs. It makes possible the development of the new technologies to personalize therapeutic approach. MicroRNAs (miRNAs) are a class of regulatory molecules whose expression is altered in PCa cells and can be associated with the sensitivity/resistance of cancer cells to specific cytostatics, for instance, taxanes.Objective. To identify the potential-marker miRNAs of PCa cells sensitivity to taxanes.Materials and methods. Samples of PCa tissue (n. 56) obtained from patients underwent neo-adjuvant therapy (antiandrogen and taxanes) and radical prostatectomy; PCa cell lines (PC-3, DU-145, LNCap). Total RNAs isolation was carried out using miRNeasy FFPE Kit, LRU-100-50; miRCURY LNA miRNA Focus PCR Panel, All-MIR kits were used for semi-quantitative analysis of potentially marker microRNA molecules using sequential reverse transcription and PCR.Results. The effect of taxanes on PCa cells is associated with up-regulation of miR-106b expression and down-regulation of miR-200c expression in both in vivo and in vitro conditions.Conclusion. MiR-106b and miR-200c miRNAs are involved in the response of PCa cells to taxanes, and therapeutic modification of these molecules in PCa cells may present a potential strategy to increase their sensitivity to taxane-containing therapy. Appropriate innovative technology may be in demand in the treatment of HiRPCa-patients