Constraints on DD Dimensional Warped Spaces

In order to investigate the phenomenological implications of allowing gauge fields to propagate in warped spaces of more than five dimensions, we consider a toy model of a space warped by the presence of a anisotropic bulk cosmological constant. After solving the Einstein equation, three classes of solutions are found, those in which the additional ($D>5$) dimensions are growing, shrinking or remaining constant. It is found that gauge fields propagating in these spaces have a significantly different Kaluza Klein (KK) mass spectrum and couplings from that of the Randall and Sundrum model. This leads to a greatly reduced lower bound on the KK scale, arising from electroweak constraints, for spaces growing towards the IR brane.Comment: 6 pages, 5 figures PASCOS2010 International Symposium proceedin

Baryon Number in Warped GUTs : Model Building and (Dark Matter Related) Phenomenology

In the past year, a new non-supersymmetric framework for electroweak symmetry breaking (with or without Higgs) involving SU(2)_L * SU(2)_R * U(1)_{B-L} in higher dimensional warped geometry has been suggested. In this work, we embed this gauge structure into a GUT such as SO(10) or Pati-Salam. We showed recently (in hep-ph/0403143) that in a warped GUT, a stable Kaluza-Klein fermion can arise as a consequence of imposing proton stability. Here, we specify a complete realistic model where this particle is a weakly interacting right-handed neutrino, and present a detailed study of this new dark matter candidate, providing relic density and detection predictions. We discuss phenomenological aspects associated with the existence of other light (<~ TeV) KK fermions (related to the neutrino), whose lightness is a direct consequence of the top quark's heaviness. The AdS/CFT interpretation of this construction is also presented. Most of our qualitative results do not depend on the nature of the breaking of the electroweak symmetry provided that it happens near the TeV brane.Comment: 61 pages, 12 figures; v2: minor changes; v3: Two additional diagrams in Fig. 10; a numerical factor corrected in section 16.1 (baryogenesis section), corresponding discussion slightly modified but qualitative results unchange

Mass and Gauge Invariance IV (Holography for the Karch-Randall Model)

We argue that the Karch-Randall compactification is holographically dual to a 4-d conformal field theory coupled to gravity on Anti de Sitter space. Using this interpretation we recover the mass spectrum of the model. In particular, we find no massless spin-2 states. By giving a purely 4-d interpretation to the compactification we make clear that it represents the first example of a local 4-d field theory in which general covariance does not imply the existence of a massless graviton. We also discuss some variations of the Karch-Randall model discussed in the literature, and we examine whether its properties are generic to all conformal field theory.Comment: 26 pages, uses package latexsym. Note added in proo

Interpolating between low and high energy QCD via a 5D Yang-Mills model

We describe the Goldstone bosons of massless QCD together with an infinite number of spin-1 mesons. The field content of the model is SU(Nf)xSU(Nf) Yang-Mills in a compact extra-dimension. Electroweak interactions reside on one brane. Breaking of chiral symmetry occurs due to the boundary conditions on the other brane, away from our world, and is therefore spontaneous. Our implementation of the holographic recipe maintains chiral symmetry explicit throughout. For intermediate energies, we extract resonance couplings. These satisfy sum rules due to the 5D nature of the model. These sum rules imply, when taking the high energy limit, that perturbative QCD constraints are satisfied. We also illustrate how the 5D model implies a definite prescription for handling infinite sums over 4D resonances. Taking the low energy limit, we recover the chiral expansion and the corresponding non-local order parameters. All local order parameters are introduced separately.Comment: Corresponds to published version, with some typos correcte

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

Inflammation is a double-edged sword with both detrimental and beneficial consequences. Understanding of the mechanisms of crosstalk between the inflammatory milieu and human adult mesenchymal stem cells is an important basis for clinical efforts. Here, we investigate changes in the transcriptional response of human adipose-derived stem cells to physiologically relevant levels of IL-2 (IL-2 priming) upon replicative senescence. Our data suggest that replicative senescence might dramatically impede human mesenchymal stem cell (MSC) function via global transcriptional deregulation in response to IL-2. We uncovered a novel senescence-associated transcriptional signature in human adipose-derived MSCs hADSCs after exposure to pro-inflammatory environment: significant enhancement of the expression of the genes encoding potent growth factors and cytokines with anti-inflammatory and migration-promoting properties, as well as genes encoding angiogenic and antiapoptotic promoting factors, all of which could participate in the establishment of a unique microenvironment. We observed transcriptional up-regulation of critical components of the nitric oxide synthase pathway (iNOS) in hADSCs upon replicative senescence suggesting, that senescent stem cells can acquire metastasis-promoting properties via stem cell-mediated immunosuppression. Our study highlights the importance of age as a factor when designing cell-based or pharmacological therapies for older patients and predicts measurable biomarkers characteristic of an environment that is conducive to cancer cells invasiveness and metastasis.LM and BGG was supported by grants from the Spanish Ministry of Science and Innovation (SAF 2010-15239) to BGG and. LMP are supported by FPI fellowships from the Spanish Ministry, and BGG acknowledges support from the ``Ramon y Cajal´´ tenure track programme from the Spanish Ministry of Science and Innovation (RYC2009-04669). AS and AA are fellows of Bolashak International Scholarship, AA, AN, AS are sponsored by KazNMU sponsored program.S

RS1, Higher Derivatives and Stability

We demonstrate the classical stability of the weak/Planck hierarchy within the Randall-Sundrum scenario, incorporating the Goldberger-Wise mechanism and higher-derivative interactions in a systematic perturbative expansion. Such higher-derivative interactions are expected if the RS model is the low-energy description of some more fundamental theory. Generically, higher derivatives lead to ill-defined singularities in the vicinity of effective field theory branes. These are carefully treated by the methods of classical renormalization.Comment: 30 page

Gauge-gravity correspondence in de Sitter braneworld

We study the braneworld solutions based on a solvable model of 5d gauged supergravity with two scalars of conformal dimension three, which correspond to bilinear operators of fermions in the dual $\mathcal{N}=4$ super Yang-Mills theory on the boundary. An accelerating braneworld solution is obtained when both scalars are taken as the form of deformations of the super Yang-Mills theory and the bulk supersymmetry is broken. This solution is smoothly connected to the Poincare invariant brane in the limit of vanishing cosmological constant. The stability of this brane-solution and the correspondence to the gauge theory are addressed.Comment: 16 pages, 1 figur

The structure of radiatively induced Lorentz and CPT violation in QED at finite temperature

We obtain the induced Lorentz- and CPT-violating term in QED at finite temperature using imaginary-time formalism and dimensional regularization. Its form resembles a Chern-Simons-like structure, but, unexpectedly, it does not depend on the temporal component of the fixed $b_\mu$ constant vector that is coupled to the axial current. Nevertheless Ward identities are respected and its coefficient vanishes at T=0, consistently with previous computations with the same regularization procedure, and it is a non-trivial function of temperature. We argue that at finite $T$ a Chern-Simons-like Lorentz- and CPT-violating term is generically present, the value of its coefficient being unambiguously determined up to a $T-$independent constant, related to the zero-temperature renormalization conditions.Comment: 15 pages, Latex, 1 figure in eps-format (included

Mechanisms linking excess adiposity and carcinogenesis promotion

Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate cancer. Cancer is the first death cause in developed countries and the second one in developing countries, with high incidence rates around the world. Furthermore, it has been estimated that 15-20% of all cancer deaths may be attributable to obesity. Tumor growth is regulated by interactions between tumor cells and their tissue microenvironment. In this sense, obesity may lead to cancer development through dysfunctional adipose tissue and altered signaling pathways. In this review, three main pathways relating obesity and cancer development are examined: (i) inflammatory changes leading to macrophage polarization and altered adipokine profile; (ii) insulin resistance development; and (iii) adipose tissue hypoxia. Since obesity and cancer present a high prevalence, the association between these conditions is of great public health significance and studies showing mechanisms by which obesity lead to cancer development and progression are needed to improve prevention and management of these diseases

"Gaugomaly" Mediated SUSY Breaking and Conformal Sequestering

Anomaly-mediated supersymmetry breaking in the context of 4D conformally sequestered models is combined with Poppitz-Trivedi D-type gauge-mediation. The implementation of the two mediation mechanisms naturally leads to visible soft masses at the same scale so that they can cooperatively solve the mu and flavor problems of weak scale supersymmetry, as well as the tachyonic slepton problem of pure anomaly-mediation. The tools are developed in a modular fashion for more readily fitting into the general program of optimizing supersymmetric dynamics in hunting for the most attractive weak scale phenomenologies combined with Planck-scale plausibility.Comment: 14 pages, Late