Utjecaj specifične veze između materijala i prevlake na tribološke i zaštitne karakteristike proizvoda

Today, parts and tools are increasingly made of composite materials. Realization of specific connection between basic material and coating is very important. The quality of coating on products, in terms of wear and resistance to destruction, has a large impact on productivity and reliability of production processes, in particular their life. In this paper, based on experimental investigations, the effect of specific relationship between the base material and coating on tribological and protective features of the product is analyzed.Danas se dijelovi i alati sve češće izrađuju iz kombiniranih materijala. Ostvarenje specifične veze između osnovnog materijala i prevlake je izuzetno značajno. Kvaliteta prevlake na proizvodima, sa aspekta habanja i otpornosti na razaranje, ima velik utjecaj na produktivnost i pouzdanost proizvodnih procesa, a osobito na njihov vijek trajanja. U radu je na temelju eksperimentalnih istraživanja analiziran utjecaj specifične veze između osnovnog materijala i prevlake na tribološke i zaštitne karakteristike proizvoda

Metodologija mjerenja karakteristika i izbor materijala elemenata tribomehaničkih sustava

Achieving the equality between the time of functional aging of mechanical systems and the time of allowed wear of the system elements is the main task of tribology. This can be reached by choosing the optimal material of elements of tribo-mehanical systems. The paper gives the results of experimental research of tribological and mechanical characteristics several pairs of material. Investigations were performed on the device with a rotating disc and static pin.Dostizanje jednakosti vjeka funkcionalnog starenja strojnih sustava i vjeka dopuštenog habanja elemenata sustava, je osnovni zadatak tribologije, koji je moguće izvesti izborom optimalnog materijala elemenata tribomehaničkog sustava. U radu se daju rezultati eksperimentalnih istraživanja triboloških i mehaničkih karakteristika više parova materijala. Istraživanja su izvedena na uređaju sa rotirajućim diskom i mirujućim pinom

Supplementary material for the article: Spahić, M. P.; Sakan, S.; Cvetković, Ž.; Tančić, P.; Trifković, J.; Nikić, Z.; Manojlović, D. Assessment of Contamination, Environmental Risk, and Origin of Heavy Metals in Soils Surrounding Industrial Facilities in Vojvodina, Serbia. Environmental Monitoring and Assessment 2018, 190 (4). https://doi.org/10.1007/s10661-018-6583-9

Supplementary material for: [https://doi.org/10.1007/s10661-018-6583-9]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2123

Supplementary data for the article: Spahić, M. P.; Manojlović, D.; Tančić, P.; Cvetković, Ž.; Nikić, Z.; Kovačević, R.; Sakan, S. Environmental Impact of Industrial and Agricultural Activities to the Trace Element Content in Soil of Srem (Serbia). Environmental Monitoring and Assessment 2019, 191 (3). https://doi.org/10.1007/s10661-019-7268-8

Supplementary material for: [https://doi.org/10.1007/s10661-019-7268-8]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2845

Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action

In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF) efficacy to moderate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular substrate of this dimorphism was explored. In rats of both sexes, DMF administration from the day of immunization attenuated EAE severity, but this effect was more prominent in males leading to loss of the sexual dimorphism observed in vehicle-administered controls. Consistently, in male rats, DMF was more efficient in diminishing the number of CD4+ T lymphocytes infiltrating spinal cord (SC) and their reactivation, the number of IL-17+ T lymphocytes and particularly cellularity of their highly pathogenic IFN-gamma+GM-CSF+IL-17+ subset. This was linked with changes in SC CD11b+CD45+TCR alpha beta- microglia/proinflammatory monocyte progeny, substantiated in a more prominent increase in the frequency of anti-inflammatory phygocyting CD163+ cells and the cells expressing high surface levels of immunoregulatory CD83 molecule (associated with apoptotic cells phagocytosis and implicated in downregulation of CD4+ T lymphocyte reactivation) among CD11b+CD45+TCR alpha beta- cells in male rat SC. These changes were associated with greater increase in the nuclear factor (erythroid-derived 2)-like 2 expression in male rats administered with DMF. In accordance with the previous findings, DMF diminished reactive nitrogen and oxygen species generation and consistently, SC level of advanced oxidation protein products, to the greater extent in male rats. Overall, our study indicates sex-specificity in the sensitivity of DMF cellular and molecular targets and encourages sex-based clinical research to define significance of sex for action of therapeutic agents moderating autoimmune neuroinflammation-/oxidative stress-related nervous tissue damage

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between the triggering of the unfolded protein response (UPR) and downstream mitochondrial dysfunction are poorly understood, the membranous contacts between the ER and mitochondria, called the mitochondria-associated membrane (MAM), could provide a functional link between these two mechanisms. Therefore, we investigated whether the guanosine triphosphatase (GTPase) Rab32, a known regulator of the MAM, mitochondrial dynamics, and apoptosis, could be associated with ER stress as well as mitochondrial dysfunction.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site

Genetic code expansion for multiprotein complex engineering

We present a baculovirus-based protein engineering method that enables site-specific introduction of unique functionalities in a eukaryotic protein complex recombinantly produced in insect cells. We demonstrate the versatility of this efficient and robust protein production platform, \u2018MultiBacTATAG\u2019, (i) for the fluorescent labeling of target proteins and biologics using click chemistries, (ii) for glycoengineering of antibodies, and (iii) for structure\u2013function studies of novel eukaryotic complexes using single-molecule F\uf6rster resonance energy transfer as well as site-specific crosslinking strategies

Measurement methodology of characteristics and election of materials of elements of tribomechanical systems

Achieving the equality between the time of functional aging of mechanical systems and the time of allowed wear of the system elements is the main task of tribology. This can be reached by choosing the optimal material of elements of tribo-mehanical systems. The paper gives the results of experimental research of tribological and mechanical characteristics several pairs of material. Investigations were performed on the device with a rotating disc and static pin

Utjecaj specifične veze između materijala i prevlake na tribološke i zaštitne karakteristike proizvoda

Today, parts and tools are increasingly made of composite materials. Realization of specific connection between basic material and coating is very important. The quality of coating on products, in terms of wear and resistance to destruction, has a large impact on productivity and reliability of production processes, in particular their life. In this paper, based on experimental investigations, the effect of specific relationship between the base material and coating on tribological and protective features of the product is analyzed.Danas se dijelovi i alati sve češće izrađuju iz kombiniranih materijala. Ostvarenje specifične veze između osnovnog materijala i prevlake je izuzetno značajno. Kvaliteta prevlake na proizvodima, sa aspekta habanja i otpornosti na razaranje, ima velik utjecaj na produktivnost i pouzdanost proizvodnih procesa, a osobito na njihov vijek trajanja. U radu je na temelju eksperimentalnih istraživanja analiziran utjecaj specifične veze između osnovnog materijala i prevlake na tribološke i zaštitne karakteristike proizvoda

The effect of specifi c relationship between material and coating on tribological and protective features of the product

Today, parts and tools are increasingly made of composite materials. Realization of specifi c connection between basic material and coating is very important. The quality of coating on products, in terms of wear and resistance to destruction, has a large impact on productivity and reliability of production processes, in particular their life. In this paper, based on experimental investigations, the effect of specific relationship between the base material and coating on tribological and protective features of the product is analyzed