Discovery of a faint, star-forming, multiply lensed, Lyman-alpha blob

We report the discovery of a multiply lensed Lyman-$\alpha$ blob (LAB) behind the galaxy cluster AS1063 using the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT). The background source is at $z=$ 3.117 and is intrinsically faint compared to almost all previously reported LABs. We used our highly precise strong lensing model to reconstruct the source properties, and we find an intrinsic luminosity of $L_{\rm Ly\alpha}$=$1.9\times10^{42}$ erg s$^{-1}$, extending to 33 kpc. We find that the LAB is associated with a group of galaxies, and possibly a protocluster, in agreement with previous studies that find LABs in overdensities. In addition to Lyman-$\alpha$ (Ly$\alpha$) emission, we find \ion{C}{IV}, \ion{He}{II}, and \ion{O}{III}] ultraviolet (UV) emission lines arising from the centre of the nebula. We used the compactness of these lines in combination with the line ratios to conclude that the \Lya nebula is likely powered by embedded star formation. Resonant scattering of the \Lya photons then produces the extended shape of the emission. Thanks to the combined power of MUSE and strong gravitational lensing, we are now able to probe the circumgalatic medium of sub-$L_{*}$ galaxies at $z\approx 3$.Comment: 7 pages, 7 figures; moderate changes to match the accepted A&A versoi

A highly-ionized region surrounding SN Refsdal revealed by MUSE

Supernova (SN) Refsdal is the first multiply-imaged, highly-magnified, and spatially-resolved SN ever observed. The SN exploded in a highly-magnified spiral galaxy at z=1.49 behind the Frontier Fields Cluster MACS1149, and provides a unique opportunity to study the environment of SNe at high z. We exploit the time delay between multiple images to determine the properties of the SN and its environment, before, during, and after the SN exploded. We use the integral-field spectrograph MUSE on the VLT to simultaneously target all observed and model-predicted positions of SN Refsdal. We find MgII emission at all positions of SN Refsdal, accompanied by weak FeII* emission at two positions. The measured ratios of [OII] to MgII emission of 10-20 indicate a high degree of ionization with low metallicity. Because the same high degree of ionization is found in all images, and our spatial resolution is too coarse to resolve the region of influence of SN Refsdal, we conclude that this high degree of ionization has been produced by previous SNe or a young and hot stellar population. We find no variability of the [OII] line over a period of 57 days. This suggests that there is no variation in the [OII] luminosity of the SN over this period, or that the SN has a small contribution to the integrated [OII] emission over the scale resolved by our observations.Comment: 5 pages, 4 figures, accepted for publication in A&

The story of supernova 'Refsdal' told by MUSE

We present MUSE observations in the core of the HFF galaxy cluster MACS J1149.5+2223, where the first magnified and spatially-resolved multiple images of SN 'Refsdal' at redshift 1.489 were detected. Thanks to a DDT program with the VLT and the extraordinary efficiency of MUSE, we measure 117 secure redshifts with just 4.8 hours of total integration time on a single target pointing. We spectroscopically confirm 68 galaxy cluster members, with redshift values ranging from 0.5272 to 0.5660, and 18 multiple images belonging to 7 background, lensed sources distributed in redshifts between 1.240 and 3.703. Starting from the combination of our catalog with those obtained from extensive spectroscopic and photometric campaigns using the HST, we select a sample of 300 (164 spectroscopic and 136 photometric) cluster members, within approximately 500 kpc from the BCG, and a set of 88 reliable multiple images associated to 10 different background source galaxies and 18 distinct knots in the spiral galaxy hosting SN 'Refsdal'. We exploit this valuable information to build 6 detailed strong lensing models, the best of which reproduces the observed positions of the multiple images with a rms offset of only 0.26". We use these models to quantify the statistical and systematic errors on the predicted values of magnification and time delay of the next emerging image of SN 'Refsdal'. We find that its peak luminosity should should occur between March and June 2016, and should be approximately 20% fainter than the dimmest (S4) of the previously detected images but above the detection limit of the planned HST/WFC3 follow-up. We present our two-dimensional reconstruction of the cluster mass density distribution and of the SN 'Refsdal' host galaxy surface brightness distribution. We outline the roadmap towards even better strong lensing models with a synergetic MUSE and HST effort.Comment: 21 pages, 9 figures, 6 tables; accepted for publication in the Astrophysical Journal - extra information on data analysis added, all model predictions and results unchange

CLASH-VLT: Strangulation of cluster galaxies in MACSJ0416.1-2403 as seen from their chemical enrichment

(abridged) We explore the Frontier Fields cluster MACS J0416.1-2403 at z=0.3972 with VIMOS/VLT spectroscopy from the CLASH-VLT survey covering a region which corresponds to almost three virial radii. We measure fluxes of 5 emission lines of 76 cluster members enabling us to unambiguously derive O/H gas metallicities, and also SFRs from Halpha. For intermediate massses we find a similar distribution of cluster and field galaxies in the MZR and mass vs. sSFR diagrams. Bulge-dominated cluster galaxies have on average lower sSFRs and higher O/Hs compared to their disk-dominated counterparts. We use the location of galaxies in the projected velocity vs. position phase-space to separate our cluster sample into a region of objects accreted longer time ago and a region of recently accreted and infalling galaxies. We find a higher fraction of accreted metal-rich galaxies (63%) compared to the fraction of 28% of metal-rich galaxies in the infalling regions. Intermediate mass galaxies falling into the cluster for the first time are found to be in agreement with predictions of the fundamental metallicity relation. In contrast, for already accreted star-forming galaxies of similar masses, we find on average metallicities higher than predicted by the models. This trend is intensified for accreted cluster galaxies of the lowest mass bin, that display metallicities 2-3 times higher than predicted by models with primordial gas inflow. Environmental effects therefore strongly influence gas regulations and control gas metallicities of log(M/Msun)<10.2 (Salpeter IMF) cluster galaxies. We also investigate chemical evolutionary paths of model galaxies with and without inflow of gas showing that strangulation is needed to explain the higher metallicities of accreted cluster galaxies. Our results favor a strangulation scenario in which gas inflow stops for log(M/Msun)<10.2 galaxies when accreted by the cluster.Comment: Version better matched to the published version, including table with observed and derived quantities for the 76 cluster galaxie

Statistical properties of a free-electron laser revealed by the Hanbury Brown and Twiss interferometry

We present a comprehensive experimental analysis of statistical properties of the self-amplified spontaneous emission (SASE) free-electron laser (FEL) FLASH at DESY in Hamburg by means of Hanbury Brown and Twiss (HBT) interferometry. The experiments were performed at the FEL wavelengths of 5.5 nm, 13.4 nm, and 20.8 nm. We determined the 2-nd order intensity correlation function for all wavelengths and different operation conditions of FLASH. In all experiments a high degree of spatial coherence (above 50%) was obtained. Our analysis performed in spatial and spectral domains provided us with the independent measurements of an average pulse duration of the FEL that were below 60 fs. To explain complicated behaviour of the 2-nd order intensity correlation function we developed advanced theoretical model that includes the presence of multiple beams and external positional jitter of the FEL pulses. By this analysis we determined that in most experiments several beams were present in radiating field and in one of the experiments external positional jitter was about 25% of the beam size. We envision that methods developed in our study will be used widely for analysis and diagnostics of the FEL radiation.Comment: 29 pages, 14 figures, 3 table

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies

The recent severe acute respiratory syndrome, known as Coronavirus Disease 2019 (COVID-19) has spread so much rapidly and severely to induce World Health Organization (WHO) to declare a state of emergency over the new coronavirus SARS-CoV-2 pandemic. While several countries have chosen the almost complete lock-down for slowing down SARS-CoV-2 spread, the scientific community is called to respond to the devastating outbreak by identifying new tools for diagnosis and treatment of the dangerous COVID-19. With this aim, we performed an in silico comparative modeling analysis, which allows gaining new insights into the main conformational changes occurring in the SARS-CoV-2 spike protein, at the level of the receptor-binding domain (RBD), along interactions with human cells angiotensin-converting enzyme 2 (ACE2) receptor, that favor human cell invasion. Furthermore, our analysis provides (1) an ideal pipeline to identify already characterized antibodies that might target SARS-CoV-2 spike RBD, aiming to&nbsp;prevent interactions with the human ACE2, and (2) instructions for building new possible neutralizing antibodies, according to chemical/physical space restraints and complementary determining regions (CDR) mutagenesis of the identified existing antibodies. The proposed antibodies show in silico high affinity for SARS-CoV-2 spike RBD and can be used as reference antibodies also for building new high-affinity antibodies against present and future coronaviruses able to invade human cells through interactions of their spike proteins with the human ACE2. More in general, our analysis provides indications for the set-up of the right biological molecular context for investigating spike RBD–ACE2 interactions for the development of new vaccines, diagnostic kits, and other treatments based on the targeting of SARS-CoV-2 spike protein

Seeded x-ray free-electron laser generating radiation with laser statistical properties

The invention of optical lasers led to a revolution in the field of optics and even to the creation of completely new fields of research such as quantum optics. The reason was their unique statistical and coherence properties. The newly emerging, short-wavelength free-electron lasers (FELs) are sources of very bright coherent extreme-ultraviolet (XUV) and x-ray radiation with pulse durations on the order of femtoseconds, and are presently considered to be laser sources at these energies. Most existing FELs are highly spatially coherent but in spite of their name, they behave statistically as chaotic sources. Here, we demonstrate experimentally, by combining Hanbury Brown and Twiss (HBT) interferometry with spectral measurements that the seeded XUV FERMI FEL-2 source does indeed behave statistically as a laser. The first steps have been taken towards exploiting the first-order coherence of FELs, and the present work opens the way to quantum optics experiments that strongly rely on high-order statistical properties of the radiation.Comment: 24 pages, 10 figures, 37 reference