1,355 research outputs found
Reliability History and Improvements to the ANL 50 MEV H- Accelerator
The H- Accelerator consists of a 750 keV Cockcroft Walton preaccelerator and
an Alvarez type 50 MeV linac. The accelerator has been in operation since 1961.
Since 1981, it has been used as the injector for the Intense Pulsed Neutron
Source (IPNS), a national user facility for neutron scattering. The linac
delivers about 3.5x1012 H- ions per pulse, 30 times per second (30 Hz), for
multi-turn injection to a 450 MeV Rapid Cycling Synchrotron (RCS). IPNS
presently operates about 4,000 hours per year, and operating when scheduled is
critical to meeting the needs of the user community. For many years the IPNS
injector/RCS has achieved an average reliability of 95%, helped in large part
by the preaccelerator/linac which has averaged nearly 99%. To maintain and
improve system reliability, records need to show what each subsystem
contributes to the total down time. The history of source and linac subsystem
reliability, and improvements that have been made to improve reliability, will
be described. Plans to maintain or enhance this reliability for at least
another ten years of operation, will also be discussed.Comment: 3 pages, 1 figur
A Review of Estimating Population Exposure to Sea-Level Rise and the Relevance for Migration
This review analyses global or near-global estimates of population exposure to sea-level rise (SLR) and related hazards, followed by critically examining subsequent estimates of population migration due to this exposure. Our review identified 33 publications that provide global or near-global estimates of population exposure to SLR and associated hazards. They fall into three main categories of exposure, based on definitions in the publications: (i) the population impacted by specified levels of SLR; (ii) the number of people living in floodplains that are subject to coastal flood events with a specific return period; and (iii) the population living in low-elevation coastal zones (LECZs). Twenty of these 33 publications discuss connections between population migration and SLR. In our analysis of the exposure and migration data, we consider datasets, analytical methods, and the challenges of estimating exposure to SLR followed by potential human migration. We underscore the complex connections among SLR, exposure to its impacts, and migration. Human mobility to and from coastal areas is shaped by diverse socioeconomic, demographic, institutional, and political factors; there may be 'trapped' populations as well as those who prefer not to move for social, cultural, and political reasons; and migration can be delayed or forestalled through other adaptive measures. While global estimates of exposed and potentially migrating populations highlight the significant threats of SLR for populations living in low-lying areas at or near coastlines, further research is needed to understand the interactions among localised SLR and related hazards, social and political contexts, adaptation possibilities, and potential migration and (im)mobility decision-making
Organizing knowledge to enable personalization of medicine in cancer
Interpretation of the clinical significance of genomic alterations remains the most severe bottleneck preventing the realization of personalized medicine in cancer. We propose a knowledge commons to facilitate collaborative contributions and open discussion of clinical decision-making based on genomic events in cancer
Adiabatic Domain Wall Motion and Landau-Lifshitz Damping
Recent theory and measurements of the velocity of current-driven domain walls
in magnetic nanowires have re-opened the unresolved question of whether
Landau-Lifshitz damping or Gilbert damping provides the more natural
description of dissipative magnetization dynamics. In this paper, we argue that
(as in the past) experiment cannot distinguish the two, but that
Landau-Lifshitz damping nevertheless provides the most physically sensible
interpretation of the equation of motion. From this perspective, (i) adiabatic
spin-transfer torque dominates the dynamics with small corrections from
non-adiabatic effects; (ii) the damping always decreases the magnetic free
energy, and (iii) microscopic calculations of damping become consistent with
general statistical and thermodynamic considerations
A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: An interim report
Background. Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. Methods. An Institutional Review Board-approved, open-label prospective randomized protocol was initiated to study the efficacy and toxicity of Tac and steroids (double-drug therapy) versus Tac, steroids, and MMF (triple-drug therapy) in primary adult liver transplant recipients. Both groups of patients began on the same doses of Tac and steroids. Patients randomized to triple-drug therapy also received 1 g of MMF twice a day. Results. Between August 1995 and January 1997, 200 patients were enrolled, 99 in double-drug therapy and 101 in triple-drug therapy. All patients were followed until May 1997, with a mean follow-up of 12.7 months. During the study period, 28 of 99 patients in double-drug therapy received MMF to control ongoing acute rejection, nephrotoxicity, and/or neurotoxicity. On the other hand, 61 patients in triple-drug therapy discontinued MMF for infection, myelosuppression, and/or gastrointestinal disturbances. By an 'intention-to-treat analysis,' the actuarial 1-year patient survival rate was 85.1% in double-drug therapy and 83.1% in triple-drug therapy (P=0.77). The actuarial 1-year graft survival rate was 80.2% for double-drug therapy and 79.2% for triple-drug therapy (P=0.77). Forty-one patients (41.4%) in double- drug therapy and 32 (31.7%) in triple-drug therapy had at least one episode of rejection, but this was not statistically significant (P=0.15). The mean maintenance dose of corticosteroids was slightly lower in triple-drug compared with double-drug therapy. Conclusion. Patient and graft survival rates were similar in both groups. There was a trend to a lower incidence of rejection, reduced nephrotoxicity, and a lesser amount of maintenance corticosteroids in triple-drug therapy compared with double-drug therapy
Current-Driven Microwave Dynamics in Magnetic Point Contacts as a Function of Applied Field Angle
We have measured microwave frequency, current-driven magnetization dynamics
in point contacts made to Co90Fe10/Cu/ Ni80Fe20 spin valves as a function of
applied field strength and angle relative to the film plane. As the field
direction is varied from parallel to nearly perpendicular, the device power
output increases by roughly two orders of magnitude while the frequencies of
the excitations decrease. For intermediate angles the excited frequency does
not monotonically vary with applied current and also exhibits abrupt,
current-dependent jumps. For certain ranges of current, and applied field
strength and direction, the excitation linewidths decrease to a few megahertz,
leading to quality factors over 18,000
An Ill Wind? Climate Change, Migration, and Health
Background: Climate change is projected to cause substantial increases in population movement in coming decades. Previous research has considered the likely causal influences and magnitude of such movements and the risks to national and international security. There has been little research on the consequences of climate-related migration and the health of people who move
Navigating precarious terrains: Reconceptualizing refugee youth settlement
Settlement is widely understood as the final stage of the refugee journey: a durable solution to forced displacement and a stable environment in which former refugees can rebuild their lives. However, settlement is shaped by rapidly changing socio-political forces producing contingent, unpredictable, and even hostile environments. This article draws upon Vigh’s concept of social navigation to reconceptualize settlement as a continuation of a fraught journey in which refugee settlers must continually seek new strategies to pursue viable futures. We illustrate with an in-depth case study of the settlement journey of one refugee-background young man over his first eight years in Melbourne, Australia
Reflection of light from a disordered medium backed by a phase-conjugating mirror
This is a theoretical study of the interplay of optical phase-conjugation and
multiple scattering. We calculate the intensity of light reflected by a
phase-conjugating mirror when it is placed behind a disordered medium. We
compare the results of a fully phase-coherent theory with those from the theory
of radiative transfer. Both methods are equivalent if the dwell time
\tau_{dwell} of a photon in the disordered medium is much larger than the
inverse of the frequency shift 2\Delta\omega acquired at the phase-conjugating
mirror. When \tau_{dwell} \Delta\omega < 1, in contrast, phase coherence
drastically affects the reflected intensity. In particular, a minimum in the
dependence of the reflectance on the disorder strength disappears when
\Delta\omega is reduced below 1/\tau_{dwell}. The analogies and differences
with Andreev reflection of electrons at the interface between a normal metal
and a superconductor are discussed.Comment: 27 pages RevTeX with 11 figures included with psfi
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