Pengembangan Komik Biografi Sir Isaac Newton sebagai Media Pembelajaran Fisika Menggunakan Aplikasi Paint Tool SAI

Penelitian ini berisi teknik merancang komik tokoh Sir Isaac Newton menggunakan aplikasi Paint Tool SAI. Komik tokoh Sir Isaac Newton yang dirancang dapat digunakan sebagai media pembelajaran fisika. Komik tokoh Sir Isaac Newton tersebut mengacu kepada buku–buku sejarah mengenai tokoh yang diceritakan. Metode yang digunakan dalam penelitian ini adalah metode research and development (R&D) dengan model ADDIE. Pengembangan ini terdiri dari 5 tahap, yaitu: analisis, desain, pengembangan, uji coba, dan evaluasi produk. Berdasarkan hasil uji kelayakan, diperoleh rata-rata persentase hasil ahli materi 80,95% dan ahli media 77,69%. Komik sebagai media pembelajaran dapat dirancang dengan mudah menggunakan aplikasi Paint Tool SAI pada gawai yang kita miliki dengan sistem operasi android

Behavioural support and nicotine replacement therapy for Smokeless Tobacco cessation:Protocol for a pilot randomised-controlled multi-country trial

Background Smokeless tobacco (ST) is consumed globally by more than 350 million people, with approximately 85% of all users based in South and Southeast Asia. In this region, ST products are cheap and easily accessible. Evidence-based interventions to people quit ST use are lacking. This study aims to test the feasibility of conducting a future definitive trial of ST cessation, using a culturally adapted behavioural intervention, and/or nicotine replacement therapy (NRT) in three South Asian countries. Methods We will conduct a factorial design, randomised-controlled pilot trial in Bangladesh, India and Pakistan. Daily ST users will be recruited from primary health care settings in Dhaka, Noida and Karachi. Participants will be individually randomised to receive intervention A (4 or 6 mg NRT chewing gum for 8-weeks), intervention B (BISCA: face-to-face behavioural support for ST cessation), a combination of interventions A and B or usual care (Very Brief Advice - VBA). The participants will provide demographic and ST use related data at baseline, and at 6, 12 and 26 weeks of follow-up. Salivary cotinine samples will be collected at baseline and 26 weeks. The analyses will undertake an assessment of the feasibility of recruitment, randomisation, data collection and participant retention, as well as the feasibility of intervention delivery. We will also identify potential cessation outcomes to inform the main trial, understand the implementation, context and mechanisms of impact through a process evaluation and, thirdly, establish health resource use and impact on the quality of life through health economic data. Discussion The widespread and continued use of ST products in South Asia is consistent with a high rate of associated diseases and negative impact on the quality of life. The identification of feasible, effective and cost-effective interventions for ST is necessary to inform national and regional efforts to reduce ST use at the population level. The findings of this pilot trial will inform the development of larger trials for ST cessation among South Asian users, with relevance to wider regions and populations having high rates of ST use. Trial registration ISRCTN identifier 6510939

Behavioural support and nicotine replacement therapy for smokeless tobacco cessation: protocol for a pilot randomised-controlled multi-country trial

Availability of data and materials: Not applicable.Supplementary Information: Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents, available at https://ndownloader.figstatic.com/files/36767631Copyright © The Author(s) 2022. Background: Smokeless tobacco (ST) is consumed globally by more than 350 million people, with approximately 85% of all users based in South and Southeast Asia. In this region, ST products are cheap and easily accessible. Evidence-based interventions to people quit ST use are lacking. This study aims to test the feasibility of conducting a future definitive trial of ST cessation, using a culturally adapted behavioural intervention, and/or nicotine replacement therapy (NRT) in three South Asian countries. Methods: We will conduct a factorial design, randomised-controlled pilot trial in Bangladesh, India and Pakistan. Daily ST users will be recruited from primary health care settings in Dhaka, Noida and Karachi. Participants will be individually randomised to receive intervention A (4 or 6 mg NRT chewing gum for 8-weeks), intervention B (BISCA: face-to-face behavioural support for ST cessation), a combination of interventions A and B or usual care (Very Brief Advice - VBA). The participants will provide demographic and ST use related data at baseline, and at 6, 12 and 26 weeks of follow-up. Salivary cotinine samples will be collected at baseline and 26 weeks. The analyses will undertake an assessment of the feasibility of recruitment, randomisation, data collection and participant retention, as well as the feasibility of intervention delivery. We will also identify potential cessation outcomes to inform the main trial, understand the implementation, context and mechanisms of impact through a process evaluation and, thirdly, establish health resource use and impact on the quality of life through health economic data. Discussion: The widespread and continued use of ST products in South Asia is consistent with a high rate of associated diseases and negative impact on the quality of life. The identification of feasible, effective and cost-effective interventions for ST is necessary to inform national and regional efforts to reduce ST use at the population level. The findings of this pilot trial will inform the development of larger trials for ST cessation among South Asian users, with relevance to wider regions and populations having high rates of ST use. Trial registration: ISRCTN identifier 65109397NIHR, using UK aid from the UK government (Programme reference 17/63/76/Global Health Research Groups); University of York, UK; UK Prevention Research Partnership (UKPRP) - UK Research and Innovation Councils; UKPRP via the SPECTRUM Consortium (Grant ref MR/S037519/1); Department of Health and Social Care (England); UK devolved administrations, and leading health research charities

Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections

Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro. Results: While IFNs alone were insufficient to completely abolish replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IFNα, in combination with remdesivir, EIDD-2801, camostat, cycloheximide, or convalescent serum, proved to be more effective. Transcriptome and metabolomic analyses revealed that the IFNα–remdesivir combination suppressed SARS-CoV-2-mediated changes in Calu-3 cells and lung organoids, although it altered the homeostasis of uninfected cells and organoids. We also demonstrated that IFNα combinations with sofosbuvir, telaprevir, NITD008, ribavirin, pimodivir, or lamivudine were effective against HCV, HEV, FLuAV, or HIV at lower concentrations, compared to monotherapies. Conclusions: Altogether, our results indicated that IFNα can be combined with drugs that affect viral RNA transcription, protein synthesis, and processing to make synergistic combinations that can be attractive targets for further pre-clinical and clinical development against emerging and re-emerging viral infections

PENGARUH MODEL PEMBELAJARAN PROBLEM POSING TIPE PRE-SOLUTION POSING TERHADAP HASIL BELAJAR FISIKA DAN KARAKTER SISWA SMA

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Problem Posing Tipe Pre-Solution Posing terhadap hasil belajar Fisika siswa SMA dan karakter yang bisa dikembangkan. Penelitian ini menggunakan metode quasi eksperimen, populasi yang dipakai adalah seluruh peserta siswa di SMA Labschool Jakarta, dengan sampel dua kelas yang berasal dari kelas IX SMA Labschool Jakarta satu kelas sebagai kelas eksperimen dan kelas lainnya sebagai kelas kontrol. Melalui model pembelajaran ini juga dapat dikembangkan karakter siswa meliputi berfikir kreatif, kritis dan logis bekerja dengan teliti, jujur dan berperilaku santun serta keterampilan social seperti bekerja sama dan saling menghargai. Kesimpulannya adalah adanya pengaruh model pembelajaran Problem Posing tipe Pre-Solution Posing terhadap hasil belajar Fisika siswa, dimana kelas yang diajar dengan model Problem Posing tipe Pre-Solution Posing lebih besar dari pada kelas yang tidak diajar dengan model Problem Posing tipe Pre-Solution.The research was aimed to find out the effect of learning model of Problem Posing, Pre-Solution Posing Type, on the outcome of Physics Learning and the potentially developed characters of senior high school students. This research was conducted by using experimental quasi method. Research population were all students of Labschool Senior High School Jakarta. The samples were two classes taken from IX grade of Labschool Senior High School. One class was treated as the experimental class and the other as the control. The potentially developed characters of students taught by applying this learning type were creative, critical and logical thinking, thorough, honest, and courteous. It was concluded that there was an effect of learning model of Problem Posing, Pre-Solution Posing Type, on the outcome of Physics Learning. The class taught by applying learning model of Problem Posing, Pre-solution type, gained better mark of Physics subjec

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viii, 141 hlm.; 26 c

Analysis of the Need for Interactive Multimedia Development Based on Inquiry Training on Science Learning in the Pandemic Period

This study aims to analyze students' needs for inquiry-based interactive multimedia in science learning during the pandemic. The research subjects were 125 elementary school students in Setiabudi District who were selected by random sampling. Data were collected using semi-structured interview techniques and questionnaires to several teachers and students. The results of semi-structured interviews show that there are limitations to the media that teachers provide to students in science learning during this pandemic. The results of the questionnaire analysis of student needs show that 1) the teaching media needed by students is interactive multimedia and 2) the material needed by students is the digestive and respiratory systems in humans, as well as the reproductive and circulatory systems in humans