Cobalamin inactivation induces formyltetrahydrofolate synthetase

AbstractLoss of cobalamin function produces profound changes in the metabolism of formate. There is impaired synthesis of formyltetrahydropteroylglutamate synthetase (CHO-H4,PteGlu), accumulation of endogenous formate and impaired utilization of [14C]formate. There are contradictory reports on the effect of cobalamin inactivation on CHO-H4PteGlu synthetase. This study confirms a significant increase in synthetase activity following cobalamin inactivation

In-orbit Vignetting Calibrations of XMM-Newton Telescopes

We describe measurements of the mirror vignetting in the XMM-Newton Observatory made in-orbit, using observations of SNR G21.5-09 and SNR 3C58 with the EPIC imaging cameras. The instrument features that complicate these measurements are briefly described. We show the spatial and energy dependences of measured vignetting, outlining assumptions made in deriving the eventual agreement between simulation and measurement. Alternate methods to confirm these are described, including an assessment of source elongation with off-axis angle, the surface brightness distribution of the diffuse X-ray background, and the consistency of Coma cluster emission at different position angles. A synthesis of these measurements leads to a change in the XMM calibration data base, for the optical axis of two of the three telescopes, by in excess of 1 arcminute. This has a small but measureable effect on the assumed spectral responses of the cameras for on-axis targets.Comment: Accepted by Experimental Astronomy. 26 pages, 18 figure

Gamma Ray Large Area Space Telescope (GLAST) Balloon Flight Data Handling Overview

The GLAST Balloon Flight Engineering Model (BFEM) represents one of 16 towers that constitute the Large Area Telescope (LAT), a high-energy (>20 MeV) gamma-ray pair-production telescope being built by an international partnership of astrophysicists and particle physicists for a satellite launch in 2006. The prototype tower consists of a Pb/Si pair-conversion tracker (TKR), a CsI hodoscopic calorimeter (CAL), an anti-coincidence detector (ACD) and an autonomous data acquisition system (DAQ). The self-triggering capabilities and performance of the detector elements have been previously characterized using positron, photon and hadron beams. External target scintillators were placed above the instrument to act as sources of hadronic showers. This paper provides a comprehensive description of the BFEM data-reduction process, from receipt of the flight data from telemetry through event reconstruction and background rejection cuts. The goals of the ground analysis presented here are to verify the functioning of the instrument and to validate the reconstruction software and the background-rejection scheme.Comment: 5 pages, 4 figures, to be published in IEEE Transacations on Nuclear Science, August 200

Constraints on the distribution of absorption in the X-ray selected AGN population found in the 13H XMM-Newton/Chandra deep field

We present an analysis of the X-ray properties of sources detected in the 13H XMM-Newton deep (200ks) field. In order to constrain the absorbed AGN population, we use extensive Monte Carlo simulations to directly compare the X-ray colours of observed sources with those predicted by several model distributions. We have tested the simplest form of the AGN unified scheme, whereby the intrinsic XLF of absorbed AGN is set to be the same as that of their unabsorbed brethren, coupled with various model distributions of absorption. The best fitting of these models sets the fraction of AGN with absorbing column NH, proportional to (logNH)^8. We have also tested two extensions to the unified scheme: an evolving absorption scenario, and a luminosity dependent model distribution. Both of these provide poorer matches to the observed X-ray colour distributions than the best fitting simple unified model. We find that a luminosity dependent density evolution XLF reproduces poorly the 0.5-2 keV source counts seen in the 13H field. Field to field variations could be the cause of this disparity. Computing the simulated X-ray colours with a simple absorbed power-law + reflection spectral model is found to over-predict, by a factor of two, the fraction of hard sources that are completely absorbed below 0.5 keV, implying that an additional source of soft-band flux must be present for a number of the absorbed sources. Finally, we show that around 40% of the 13H sample are expected to be AGN with NH>10^22 cm^-2.Comment: 13 pages, 9 figures, Accepted for publication in MNRA

XMM-Newton observations of the Galactic Supernova Remnant CTB 109 (G109.1-1.0)

We present the analysis of the X-ray Multi-Mirror Mission (XMM-Newton) European Photon Imaging Camera (EPIC) data of the Galactic supernova remnant (SNR) CTB 109 (G109.1-1.0). CTB 109 is associated with the anomalous X-ray pulsar (AXP) 1E 2259+586 and has an unusual semi-circular morphology in both the X-ray and the radio, and an extended X-ray bright interior region known as the `Lobe'. The deep EPIC mosaic image of the remnant shows no emission towards the west where a giant molecular cloud complex is located. No morphological connection between the Lobe and the AXP is found. We find remarkably little spectral variation across the remnant given the large intensity variations. All spectra of the shell and the Lobe are well fitted by a single-temperature non-equilibrium ionization model for a collisional plasma with solar abundances (kT = 0.5 - 0.7 keV, tau = n_e t = 1 - 4 x 10^11 s cm^-3, N_H = 5 - 7 x 10^21 cm^-2). There is no indication of nonthermal emission in the Lobe or the shell. We conclude that the Lobe originated from an interaction of the SNR shock wave with an interstellar cloud. Applying the Sedov solution for the undisturbed eastern part of the SNR, and assuming full equilibration between the electrons and ions behind the shock front, the SNR shock velocity is derived as v_s = 720 +/- 60 km s^-1, the remnant age as t = (8.8 +/- 0.9) x 10^3 d_3 yr, the initial energy as E_0 = (7.4 +/- 2.9) x 10^50 d_3^2.5 ergs, and the pre-shock density of the nuclei in the ambient medium as n_0 = (0.16 +/- 0.02) d_3^-0.5 cm^-3, at an assumed distance of D = 3.0 d_3 kpc. Assuming CTB 109 and 1E 2259+586 are associated, these values constrain the age and the environment of the progenitor of the SNR and the pulsar.Comment: Accepted for publication in ApJ. 9 figures. Figs. 1 + 2 are in color (fig1.jpg, fig2.jpg

First test of a power-pulsed electronics system on a GRPC detector in a 3-Tesla magnetic field

An important technological step towards the realization of an ultra-granular hadronic calorimeter to be used in the future International Linear Collider (ILC) experiments has been made. A 33X50 cm2 GRPC detector equipped with a power-pulsed electronics board offering a 1cm2 lateral segmentation was successfully tested in a 3-Tesla magnet operating at the H2 beam line of the CERN SPS. An important reduction of power consumption with no deterioration of the detector performance is obtained when the power-pulsing mode is applied. This important result shows that ultra-granular calorimeters for ILC experiments are not only an attractive but also a realistic option.Comment: 10 pages, 9 figure