Farfield inflight measurement of high-speed turboprop noise

A flight program was carried out to determine the variation of noise level with distance from a model high speed propeller. Noise measurements were obtained at different distances from a SR-3 propeller mounted on a JetStar aircraft, with the test instrumentation mounted on a Lear jet flown in formation. The propeller was operated at 0.8 flight Mach number, 1.12 helical tip Mach number and at 0.7 flight Mach number, 1.0 helical tip Mach number. The instantaneous pressure from individual blades was observed to rise faster at the 0.8 M flight speed, than at the 0.7 M flight speed. The measured levels appeared to decrease in good agreement with a 6 dB/doubling of distance decay, over the measurement range of approximately 16 m to 100 m distance. Further extrapolation, to the distances represented by a community, would suggest that the propagated levels during cruise would not cause a serious community annoyance

Acoustic design of the QCSEE propulsion systems

Acoustic design features and techniques employed in the Quiet Clean Short-Haul Experimental Engine (QCSEE) Program are described. The role of jet/flap noise in selecting the engine fan pressure ratio for powered lift propulsion systems is discussed. The QCSEE acoustic design features include a hybrid inlet (near-sonic throat velocity with acoustic treatment); low fan and core pressure ratios; low fan tip speeds; gear-driven fans; high and low frequency stacked core noise treatment; multiple-thickness treatment; bulk absorber treatment; and treatment on the stator vanes. The QCSEE designs represent and anticipated acoustic technology improvement of 12 to 16 PNdb relative to the noise levels of the low-noise engines used on current wide-body commercial jet transport aircraft

Hypervelocity impact damage characteristics in beryllium and graphite plates and tubes

Hypervelocity impact damage characteristics in beryllium and graphite plates and tube

Comparison of NASA and contractor results from aeroacoustic tests of QCSEE OTW engine

The aerodynamics and acoustics of the over-the-wing (OTW) Quiet, Clean, Short Haul Experimental Engine (QCSEE) were tested. A boilerplate (nonflight weight), high-throat Mach number, acoustically treated inlet and a D-shaped OTW exhaust nozzle with variable position side doors were used. Some acoustic directivity results for the type "D" nozzle and acoustic effects of variations in the nozzle side door positions are included. It was found that the results are in agreement with those previously obtained

Dynamics and gravitational wave signature of collapsar formation

We perform 3+1 general relativistic simulations of rotating core collapse in the context of the collapsar model for long gamma-ray bursts. We employ a realistic progenitor, rotation based on results of stellar evolution calculations, and a simplified equation of state. Our simulations track self-consistently collapse, bounce, the postbounce phase, black hole formation, and the subsequent early hyperaccretion phase. We extract gravitational waves from the spacetime curvature and identify a unique gravitational wave signature associated with the early phase of collapsar formatio

Changes in the milk metabolome of the Giant Panda (Ailuropoda melanoleuca) with time after birth: three phases in early lactation and progressive individual differences

Ursids (bears) in general, and giant pandas in particular, are highly altricial at birth. The components of bear milks and their changes with time may be uniquely adapted to nourish relatively immature neonates, protect them from pathogens, and support the maturation of neonatal digestive physiology. Serial milk samples collected from three giant pandas in early lactation were subjected to untargeted metabolite profiling and multivariate analysis. Changes in milk metabolites with time after birth were analysed by Principal Component Analysis, Hierarchical Cluster Analysis and further supported by Orthogonal Partial Least Square-Discriminant Analysis, revealing three phases of milk maturation: days 1–6 (Phase 1), days 7–20 (Phase 2), and beyond day 20 (Phase 3). While the compositions of Phase 1 milks were essentially indistinguishable among individuals, divergences emerged during the second week of lactation. OPLS regression analysis positioned against the growth rate of one cub tentatively inferred a correlation with changes in the abundance of a trisaccharide, isoglobotriose, previously observed to be a major oligosaccharide in ursid milks. Three artificial milk formulae used to feed giant panda cubs were also analysed, and were found to differ markedly in component content from natural panda milk. These findings have implications for the dependence of the ontogeny of all species of bears, and potentially other members of the Carnivora and beyond, on the complexity and sequential changes in maternal provision of micrometabolites in the immediate period after birth

Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

BACKGROUND: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice. Topical therapy with fusidic acid (FA) is an attractive alternative to systemic therapy based on low minimum inhibitory concentrations (MICs, commonly <0.03 mg/l) documented in canine pathogenic staphylococci, including strains of MRSA and MRSP (methicillin-resistant Staphylococcus aureus and S. pseudintermedius). However, permeation of canine skin by FA has not been evaluated in detail. This study aimed to define the degree and extent of FA permeation in canine skin in vitro from two sites with different hair follicle density following application of a licensed ophthalmic formulation that shares the same vehicle as an FA-betamethasone combination product approved for dermal application in dogs. Topical FA application was modelled using skin held in Franz-type diffusion cells. Concentrations of FA in surface swabs, receptor fluid, and transverse skin sections of defined anatomical depth were determined using high-performance liquid chromatography and ultraviolet (HPLC-UV) analysis. RESULTS: The majority of FA was recovered by surface swabs after 24 h, as expected (mean ± SEM: 76.0 ± 17.0%). FA was detected within 424/470 (90%) groups of serial sections of transversely cryotomed skin containing follicular infundibula, but never in 48/48 (100%) groups of sections containing only deeper follicular structures, nor in receptor fluid, suggesting that FA does not permeate beyond the infundibulum. The FA concentration (mean ± SEM) in the most superficial 240 μm of skin was 2000 ± 815 μg/g. CONCLUSIONS: Topically applied FA can greatly exceed MICs for canine pathogenic staphylococci at the most common sites of infection. Topical FA therapy should now be evaluated using available formulations in vivo as an alternative to systemic therapy for canine superficial bacterial folliculitis.Peer reviewedFinal Published versio

Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca

Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection. Comparison of bear milks with milks of other eutherians yielded distinctive protein profiles. Proteomic and metabolomic analysis of serial milk samples collected from six giant pandas showed a prolonged transition from colostrum to main-phase lactation over approximately 30 days. Particularly striking are the persistence or sequential appearance of adaptive and innate immune factors. The endurance of immunoglobulin G suggests an unusual duration of trans-intestinal absorption of maternal antibodies, and is potentially relevant to the underdeveloped lymphoid system of giant panda neonates. Levels of certain milk oligosaccharides known to exert anti-microbial activities and/or that are conducive to the development of neonatal gut microbiomes underwent an almost complete changeover around days 20–30 postpartum, coincident with the maturation of the protein profile. A potential metabolic marker of starvation was detected, the prominence of which may reflect the natural postpartum period of anorexia in giant panda mothers. Early lactation in giant pandas, and possibly in other ursids, appears to be adapted for the unique requirements of unusually altricial eutherian neonates