Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria

There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal transmission. We hypothesize that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimize transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the basic reproduction number R0 to investigate how transmission potential varies with relapse frequency and seasonality. In tropical zones with year-round transmission, transmission potential is optimized at intermediate relapse frequencies of two to three months: slower-relapsing strains increase the opportunity for onward transmission to mosquitoes, but also increase the risk of being outcompeted by faster-relapsing strains. Seasonality is an important driver of relapse frequency for temperate strains, with the time to first relapse predicted to be six to nine months, coinciding with the duration between seasonal transmission peaks. We predict that there is a threshold degree of seasonality, below which fast-relapsing tropical strains are selected for, and above which slow-relapsing temperate strains dominate, providing an explanation for the observed global distribution of relapse phenotypes

Pengaruh Partisipasi Manajer Terhadap Efektivitas Sistem Informasi Akuntansi

The development of the business environment in globalization era has been triggered an increasingly tight business competition. Every companies who have an established its own strategies to manage a variety of information, human resources, allocation of funds and others. Accounting information system is a great resources that very valuable to an organization for the smoothness management of the company's financial and decision making wheter it is to long term and short term, however there are several aspect that can be a factors the effectiveness of the accounting information system, that is manager's participation. The research is aimed to proves that manager's participation and manager's involvement had a positive influence on the effectiveness of accounting information system (AIS) at manufacturing company, especially in the industrial zone Batamindo Mukakuning Batam City. The research method is using regression analysis to proves are the manager's participation (independent variable) and manager's involvement (independent variable) gives effect to the effectiveness of information system (dependent variable) or not. The result of this research is shows that variable of manager's participation and manager's involvement has a significant influence to the effectiveness of information system. The method is using purposive sampling is done by taking a sampling of the population according to certain criteria

Pengaruh Model Children Learning in Science(clis) Disertai Lks Berbasis Multirepresentasi Terhadap Aktivitas Belajar Siswa Dan Hasil Belajar Siswa Dalam Pembelajaran Fisika Di SMA Kabupaten Jember

This research focused on the application of children learning in science ( clis ) model accompanied lks multirepresentasi based .The purpose in this research is to assess the effect of a model of children learning in science ( clis ) accompanied lks multirepresentasi based on student learning activities in learning physics and the effect of a model of children learning in science ( clis ) accompanied lks multirepresentasi based on learning outcomes of students in learning physics .A kind of this research is research experiment conducted in SMAN 1 Jenggawah .Data collection method used is a documentary , observation , interview , and tests .Data analysis technique used is independent test sample t-test spss assistance with 16. The analysis to the activity of student learning at 0,000 ≤ 0.05 in the first meeting and by 0,000 ≤ 0.05 in the second .The analysis to achievments of 0,0015 ≤ 0.05 in the first meeting and by 0,0095 ≤ 0.05 in the second .Based on the results of the t , can be concluded that the model children learning in science ( clis ) accompanied lks based multirepresentasi significant to the activity of student learning .A model of children learning in science ( clis ) accompanied lks based multirepresentasi significant of achievments

Non-Functional Requirements Elicitation Guideline for Agile Methods

One of the essential activities in software development is elicitation of requirement. Majority of the studies has pointed out that less attention is given to the NonFunctional Requirement (NFR). The negligence of NFR elicitation is due to lack of knowledge of the user and developer about NFR. Our study presents elicitation guidelines for NFRs in agile methods. This guideline will helps developers as well as users in agile methods. A case study is conducted on the group of master students for eliciting NFR with the help of elicitation guidelines. In addition, the initial results were obtained by extracting NFRs from eProcurement document that carries requirements of major European Union projects. The result of the case study is positive and encouraging for the new developers and users having less awareness about NFRs. Furthermore, the study describes the role of cloud computing in agile methods, especially in elicitation activity

Disclosure Of EVA Use In Corporate Financial Reports: A Descriptive Analysis

This descriptive study examines a sample of 269 firms that mentioned EVA in their public disclosures.  The key findings of our study are: (1) the use of EVA is found in a cross-section of the industries; (2) the most commonly used source of disclosure is the proxy statement; (3) a majority of the firms use only EVA rather than EVA in combination with other traditional measures; (4) a majority of the sample firms apply EVA at the corporate level alone; (5) three-fourths of the sample firms use EVA as an incentive compensation tool; (6) most firms apply EVA and other metrics only at the executive level for compensation and performance evaluation; and (7) two common modes of compensation using EVA determination are bonus plans and stock options.  The results of our study indicate that firms are steadily adopting EVA as one component of their value management system.  In a related decision context, investors estimate the cost of equity capital to arrive at the intrinsic value of the firm.  Firms can help investors reduce this estimation error by reporting their own estimate of the cost of equity capital, in turn, reducing the valuation error. Our findings have implications for the Securities and Exchange Commission and the Financial Accounting Standards Board in that they should recognize the need to address this issue thereby enhancing the decision usefulness of public reporting