Do hands-free cell phone conversation while driving increase the risk of cognitive distraction among drivers? A cross-over quasi-experimental study

Background: Background: Conversation over the cell phone while driving is a known risk factor for road traffic crash. Using handsfree to talk on the cell phone may remove visual and manual distraction yet not the cognitive distraction. Objectives: The purpose of this study was to better understand the mechanisms of cognitive distraction due to hands-free cell phone conversation (HFPC) while driving. Methods: Twelve male and 12 female University students in Tehran, Iran, were selected via the consecutive convenient sampling method, and randomly assigned to one of the following administrations of cross-over quasi-experimental study design, during year 2016: Administration 1, participants performed the tests while involved in HFPC, took rest for 60 minute, and then performed the tests another time without HFPC; Administration 2, participants performed the tests without HFPC, took rest, and then performed the tests another time with HFPC. Each participant moved to the other administration after 7 to 10 days. The Vienna test system (VTS) was used to measure simple and choice reaction time, selective attention, visual orientation, and visual memory. Linear regression analysis was used to study the change in test scores due to HFPC. Results: The mean age of participants was 27.1±5.3 years. A history of road traffic crash (regardless of severity) was reported among 9 (37.5) participants in the previous year. Hands-free cell phone conversation while driving was directly associated with mean time correct rejection score (P < 0.01) (selective attention), omitted response (P < 0.01) and median reaction time (P < 0.01) (choice reaction time), and mean reaction time (P < 0.01) (Simple reaction time). Moreover, HPFC was inversely associated with sum hits (P = 0.05) (selective attention), incorrect (P < 0.02) and correct response (P < 0.01) (choice reaction time), score based on viewing and working time (P < 0. 01) (visual orientation), and visual memory performance (P < 0.01). Conclusions: Using hands-free devices to converse during driving, impaired reaction time, selective attention, visual orientation and visual memory, which are essential for safe driving. Thus, the use of these devices does not preclude cognitive distraction and should be restricted. © 2018, Iranian Red Crescent Medical Journal

Do hands-free cell phone conversation while driving increase the risk of cognitive distraction among drivers? A cross-over quasi-experimental study

Background: Background: Conversation over the cell phone while driving is a known risk factor for road traffic crash. Using handsfree to talk on the cell phone may remove visual and manual distraction yet not the cognitive distraction. Objectives: The purpose of this study was to better understand the mechanisms of cognitive distraction due to hands-free cell phone conversation (HFPC) while driving. Methods: Twelve male and 12 female University students in Tehran, Iran, were selected via the consecutive convenient sampling method, and randomly assigned to one of the following administrations of cross-over quasi-experimental study design, during year 2016: Administration 1, participants performed the tests while involved in HFPC, took rest for 60 minute, and then performed the tests another time without HFPC; Administration 2, participants performed the tests without HFPC, took rest, and then performed the tests another time with HFPC. Each participant moved to the other administration after 7 to 10 days. The Vienna test system (VTS) was used to measure simple and choice reaction time, selective attention, visual orientation, and visual memory. Linear regression analysis was used to study the change in test scores due to HFPC. Results: The mean age of participants was 27.1±5.3 years. A history of road traffic crash (regardless of severity) was reported among 9 (37.5) participants in the previous year. Hands-free cell phone conversation while driving was directly associated with mean time correct rejection score (P < 0.01) (selective attention), omitted response (P < 0.01) and median reaction time (P < 0.01) (choice reaction time), and mean reaction time (P < 0.01) (Simple reaction time). Moreover, HPFC was inversely associated with sum hits (P = 0.05) (selective attention), incorrect (P < 0.02) and correct response (P < 0.01) (choice reaction time), score based on viewing and working time (P < 0. 01) (visual orientation), and visual memory performance (P < 0.01). Conclusions: Using hands-free devices to converse during driving, impaired reaction time, selective attention, visual orientation and visual memory, which are essential for safe driving. Thus, the use of these devices does not preclude cognitive distraction and should be restricted. © 2018, Iranian Red Crescent Medical Journal

Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression

IQGAPs genes play critical role in either induction or suppression of cancer and its progression, however the relationship between Ras genes and these genes are still unclear. In this study, we tried to understand the mechanistic action of IQGAPs genes and its correlation with Ras genes in mouse hepatic cancer model. The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice. Genotoxic agent diethylnitrosamine (DEN)-induced hepatic cancer model was induced in male mice and recorded the occurrence of hepatocellular carcinoma by morphological and histological changes in the liver. It was observed that mRNA expressions of IQGAP1, Hras, Kras, Nras, Mras, Caspase3, and BAX genes were highly elevated in hepatocellular carcinoma cells when compared with normal liver cells, additionally their expressions increased by concentrating the dose of DEN. While, the expressions of IQGAP2 and IQGAP3 were significantly decreased in hepatocellular carcinoma cells when compared with normal liver cells, as well as their expressions decreased more with increasing the dose of DEN. It was concluded from this study that IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma

Developments in Nanoparticles Enhanced Biofuels and Solar Energy in Malaysian Perspective: A Review of State of the Art

The rapid rise in global oil prices, the scarcity of petroleum sources, and environmental concerns have all created severe issues. As a result of the country's rapid expansion and financial affluence, Malaysia's energy consumption has skyrocketed. Biodiesel and solar power are currently two of the most popular alternatives to fossil fuels in Malaysia. These two types of renewable energy sources appear to be viable options because of their abundant availability together with environmental and performance competence to highly polluting and fast depleting fossil fuels. The purpose of adopting renewable technology is to expand the nation's accessibility to a reliable and secure power supply. The current review article investigates nonconventional energy sources added with nanosized metal particles called as nanomaterials including biodiesel and solar, as well as readily available renewable energy options. Concerning the nation's energy policy agenda, the sources of energy demand are also investigated. The article evaluates Malaysia's existing position in renewable energy industries, such as biodiesel and solar, as well as the impact of nanomaterials. This review article discusses biodiesel production, applications, and government policies in Malaysia, as well as biodiesel consumption and recent developments in the bioenergy sector, such as biodiesel property modifications utilizing nanoparticle additions. In addition, the current review study examines the scope of solar energy, different photovoltaic concentrators, types of solar energy harvesting systems, photovoltaic electricity potential in Malaysia, and the experimental setup of solar flat plate collectors (FPC) with nanotechnology

Bio-nanotechnology application in wastewater treatment

The nanoparticles have received high interest in the field of medicine and water purification, however, the nanomaterials produced by chemical and physical methods are considered hazardous, expensive, and leave behind harmful substances to the environment. This chapter aimed to focus on green-synthesized nanoparticles and their medical applications. Moreover, the chapter highlighted the applicability of the metallic nanoparticles (MNPs) in the inactivation of microbial cells due to their high surface and small particle size. Modifying nanomaterials produced by green-methods is safe, inexpensive, and easy. Therefore, the control and modification of nanoparticles and their properties were also discussed

Developments in nanoparticles enhanced biofuels and solar energy in Malaysian perspective: a review of state of the art

The rapid rise in global oil prices, the scarcity of petroleum sources, and environmental concerns have all created severe issues. As a result of the country’s rapid expansion and financial affluence, Malaysia’s energy consumption has skyrocketed. Biodiesel and solar power are currently two of the most popular alternatives to fossil fuels in Malaysia. These two types of renewable energy sources appear to be viable options because of their abundant availability together with environmental and performance competence to highly polluting and fast depleting fossil fuels. The purpose of adopting renewable technology is to expand the nation’s accessibility to a reliable and secure power supply. The current review article investigates nonconventional energy sources added with nanosized metal particles called nanomaterials including biodiesel and solar, as well as readily available renewable energy options. Concerning the nation’s energy policy agenda, the sources of energy demand are also investigated. The article evaluates Malaysia’s existing position in renewable energy industries, such as biodiesel and solar, as well as the impact of nanomaterials. This review article discusses biodiesel production, applications, and government policies in Malaysia, as well as biodiesel consumption and recent developments in the bioenergy sector, such as biodiesel property modifications utilizing nanoparticle additions. In addition, the current review study examines the scope of solar energy, different photovoltaic concentrators, types of solar energy harvesting systems, photovoltaic electricity potential in Malaysia, and the experimental setup of solar flat plate collectors (FPC) with nanotechnology

Hydrogen injection in a dual fuel engine fueled with low-pressure injection of methyl ester of peruvenia thevetia [MEPT] for diesel engine maintenance application

The present work is mapped to scrutinize the consequence of biodiesel and gaseous fuel properties, and their impact on compression-ignition (CI) engine combustion and emission characteristics in single and dual fuel operation. Biodiesel prepared from non-edible oil source derived from Thevetia peruviana belonging to the plant family of Apocynaceaeis. The fuel has been referred as methyl ester of Thevetia peruviana (METP) and adopted as pilot fuel for the effective combustion of compressed gaseous fuel of hydrogen. This investigation is an effort to augment the engine performance of a biodiesel-gaseous fueled diesel engine operated under varied engine parameters. Subsequently, consequences of gas flow rate, injection timing, gas entry type, and manifold gas injection on the modified dual-fuel engine using conventional mechanical fuel injections (CMFIS) for optimum engine performance were investigated. Fuel consumption, CO, UHC, and smoke formations are spotted to be less besides higher NOx emissions compared to CMFIS operation. The fuel burning features such as ignition delay, burning interval, and variation of pressure and heat release rates with crank angle are scrutinized and compared with base fuel. Sustained research in this direction can convey practical engine technology, concerning fuel combinations in the dual fuel mode, paving the way to alternatives which counter the continued fossil fuel utilization that has detrimental impacts on the climate

SSR markers in revealing extent of genetic diversity and phylogenetic relationships among chickpea core collection accessions for Western Himalayas

Background The exploration of genetic diversity is the key source of germplasm conservation and potential to broaden its genetic base. The globally growing demand for chickpea suggests superior/climate-resilient varieties, which in turn necessitates the germplasm characterization to unravel underlying genetic variation. Methodology and results A chickpea core collection comprising of diverse 192 accessions which include cultivated Cicer arietinum, and wild C. reticulatum, C. echinospermum, and C. microphyllum species were investigated to analyze their genetic diversity and relationship, by assaying 33 unlinked simple sequence repeat (SSR) markers. The results amplified a total of 323 alleles (Na), ranging from 2 to 8 with an average of 4.25 alleles per locus. Expected heterozygosity (He) differed from 0.46 to 0.86 with an average of 0.68. Polymorphic information content (PIC) ranged from 0.73 to 0.98 with an average of 0.89. Analysis of molecular variance (AMOVA) showed that most of the variation was among individuals (87%). Cluster analysis resulted in the formation of four distinct clusters. Cluster I represented all cultivated and clusters II, III, and IV comprised a heterogeneous group of cultivated and wild chickpea accessions. Conclusion We report considerable diversity and greater resolving power of SSR markers for assessing variability and interrelationship among the chickpea accessions. The chickpea core is expected to be an efficient resource for breeders for broadening the chickpea genetic base and could be useful for selective breeding of desirable traits and in the identification of target genes for genomics-assisted breeding

Predicting severe pain after major surgery: a secondary analysis of the Peri-operative Quality Improvement Programme (PQIP) dataset

Acute postoperative pain is common, distressing and associated with increased morbidity. Targeted interventions can prevent its development. We aimed to develop and internally validate a predictive tool to pre-emptively identify patients at risk of severe pain following major surgery. We analysed data from the UK Peri-operative Quality Improvement Programme to develop and validate a logistic regression model to predict severe pain on the first postoperative day using pre-operative variables. Secondary analyses included the use of peri-operative variables. Data from 17,079 patients undergoing major surgery were included. Severe pain was reported by 3140 (18.4%) patients; this was more prevalent in females, patients with cancer or insulin-dependent diabetes, current smokers and in those taking baseline opioids. Our final model included 25 pre-operative predictors with an optimism-corrected c-statistic of 0.66 and good calibration (mean absolute error 0.005, p = 0.35). Decision-curve analysis suggested an optimal cut-off value of 20–30% predicted risk to identify high-risk individuals. Potentially modifiable risk factors included smoking status and patient-reported measures of psychological well-being. Non-modifiable factors included demographic and surgical factors. Discrimination was improved by the addition of intra-operative variables (likelihood ratio χ2 496.5, p < 0.001) but not by the addition of baseline opioid data. On internal validation, our pre-operative prediction model was well calibrated but discrimination was moderate. Performance was improved with the inclusion of peri-operative covariates suggesting pre-operative variables alone are not sufficient to adequately predict postoperative pain