Initial experience in self-monitoring of intraocular pressure.

Background/aims: Diurnal variation in intraocular pressure (IOP) is a routine assessment in glaucoma management. Providing patients the opportunity to perform self-tonometry might empower them and free hospital resource. We previously demonstrated that 74% of patients can use the Icare® HOME tonometer. This study further explores Icare® HOME patient self-monitoring. Methods: Patients were trained by standard protocol to use the Icare® HOME rebound tonometer. Patient self-tonometry was compared to Goldmann applanation tonometry (GAT) over one clinical day. Following this, each patient was instructed to undertake further data collection that evening and over the subsequent two days. Results: Eighteen patients (35 eyes) participated. Good agreement was demonstrated between GAT and Icare® HOME for IOPs up to 15 mm Hg. Above this IOP the Icare® tended to over-read, largely explained by 2 patients with corneal thickness >600 um. The mean peak IOP during ‘clinic hours’ phasing was 16.7 mm Hg and 18.5 mm Hg (p = 0.24) over three days. An average range of 5.0, 7.0 and 9.8 mm Hg was shown during single day clinic, single day home and three day home phasing respectively (p =<0.001). The range of IOP was lower in eyes with prior trabeculectomy (6.1 mm Hg vs 12.2 mm Hg). All patients undertook one reading in the early morning at home with an average of 4.8 readings during, and 3.1 readings after office hours. Conclusions: This small study shows that self-tonometry is feasible. The findings from home phasing demonstrated higher peak and trough IOPs, providing additional clinical information. Home phasing is a viable alternative. The cost-effectiveness of this approach has yet to be addressed

Comparison of Gravitational Wave Detector Network Sky Localization Approximations

Gravitational waves emitted during compact binary coalescences are a promising source for gravitational-wave detector networks. The accuracy with which the location of the source on the sky can be inferred from gravitational wave data is a limiting factor for several potential scientific goals of gravitational-wave astronomy, including multi-messenger observations. Various methods have been used to estimate the ability of a proposed network to localize sources. Here we compare two techniques for predicting the uncertainty of sky localization -- timing triangulation and the Fisher information matrix approximations -- with Bayesian inference on the full, coherent data set. We find that timing triangulation alone tends to over-estimate the uncertainty in sky localization by a median factor of $4$ for a set of signals from non-spinning compact object binaries ranging up to a total mass of $20 M_\odot$, and the over-estimation increases with the mass of the system. We find that average predictions can be brought to better agreement by the inclusion of phase consistency information in timing-triangulation techniques. However, even after corrections, these techniques can yield significantly different results to the full analysis on specific mock signals. Thus, while the approximate techniques may be useful in providing rapid, large scale estimates of network localization capability, the fully coherent Bayesian analysis gives more robust results for individual signals, particularly in the presence of detector noise.Comment: 11 pages, 7 Figure

Facilitating Building Information Modelling (BIM) using Integrated Project Delivery (IPD): A UK perspective

The Construction industry is a major player in the UK economy and is in need of continuous improvement. In an attempt to do so, in 2011 the UK government made Building Information Modelling (BIM) level 2 a mandate for all public projects by 2016. Integrated Project Delivery (IPD) is a project delivery approach closely attributed to BIM. However, it does not seem to have received proportionate level of attention and uptake in the UK

Early Advanced LIGO binary neutron-star sky localization and parameter estimation

2015 will see the first observations of Advanced LIGO and the start of the gravitational-wave (GW) advanced-detector era. One of the most promising sources for ground-based GW detectors are binary neutron-star (BNS) coalescences. In order to use any detections for astrophysics, we must understand the capabilities of our parameter-estimation analysis. By simulating the GWs from an astrophysically motivated population of BNSs, we examine the accuracy of parameter inferences in the early advanced-detector era. We find that sky location, which is important for electromagnetic follow-up, can be determined rapidly (~5 s), but that sky areas may be hundreds of square degrees. The degeneracy between component mass and spin means there is significant uncertainty for measurements of the individual masses and spins; however, the chirp mass is well measured (typically better than 0.1%).Comment: 4 pages, 2 figures. Published in the proceedings of Amaldi 1

Supplement: Going the Distance: Mapping Host Galaxies of LIGO and Virgo Sources in Three Dimensions Using Local Cosmography and Targeted Follow-up

This is a supplement to the Letter of Singer et al. (https://arxiv.org/abs/1603.07333), in which we demonstrated a rapid algorithm for obtaining joint 3D estimates of sky location and luminosity distance from observations of binary neutron star mergers with Advanced LIGO and Virgo. We argued that combining the reconstructed volumes with positions and redshifts of possible host galaxies can provide large-aperture but small field of view instruments with a manageable list of targets to search for optical or infrared emission. In this Supplement, we document the new HEALPix-based file format for 3D localizations of gravitational-wave transients. We include Python sample code to show the reader how to perform simple manipulations of the 3D sky maps and extract ranked lists of likely host galaxies. Finally, we include mathematical details of the rapid volume reconstruction algorithm.Comment: For associated data release, see http://asd.gsfc.nasa.gov/Leo.Singer/going-the-distanc

Assessment of surface wind datasets for estimating offshore wind energy along the Central California Coast

In the United States, Central California has gained significant interest in offshore wind energy due to its strong winds and proximity to existing grid connections. This study provides a comprehensive evaluation of near-surface wind datasets in this region, including satellite-based observations (QuikSCAT, ASCAT, and CCMP V2.0), reanalysis (NARR and MERRA), and regional atmospheric models (WRF and WIND Toolkit). This work highlights spatiotemporal variations in the performance of the respective datasets in relation to in-situ buoy measurements using error metrics over both seasonal and diurnal time scales. The two scatterometers(QuikSCAT and ASCAT) showed the best overall performance, albeit with significantly less spatial and temporal resolution relative to other datasets. These datasets only slightly outperformed the next best dataset (WIND Toolkit), which has significantly greater temporal and spatial resolution as well as estimates of winds aloft. Considering tradeoffs between spatiotemporal resolution of the underlying datasets, error metrics relative to in-situ measurements, and the availability of data aloft, the WIND Toolkit appears to be the best dataset for this region. The framework and tradeoff analysis this research developed and demonstrated to assess offshore wind datasets can be applied in other regions where offshore wind energy is being considered

Counseling for Young People and Families Affected by Child Sexual Exploitation and Abuse: A Qualitative Investigation of the Perspective of Young People, Parents, and Professionals

Despite growing awareness of the negative impact of child sexual exploitation on young people’s psychological, emotional and relational lives, little is known about how counseling can support young people and their families. The aim of this study was to explore the experience of counseling for young people and parents affected by child sexual exploitation and abuse, with a view to examining what facilitates progress, from the perspective of young people, parents and professionals. In-depth semi-structured interviews were conducted with 10 young people, 8 parents and 7 professionals and were analyzed using thematic analysis. Findings suggest that through counseling, young people experienced affective and relational improvements that were attributed to the process. Characteristics of the counseling relationship that facilitated progress included being able to talk openly in a caring, non-judgmental and unpressurized environment, as well as receiving advice, techniques or solutions within a holistic approach. Facets of service delivery were also highlighted, including the provision of confidentiality, flexibility and consistency, along with a multi-agency approach that promoted engagement. Perceived obstacles to progress included resistance at the outset and service location issues

The monitored performance of the first new London dwelling certified to the Passive House standard

The monitored performance of the first new London dwelling certified to the Passive House standard is presented. The first detailed analysis of the energy consumption of the heating, ventilation and domestic hot water systems are given. The annual space heating demand of the 2 bedroom, 101 m2 dwelling was 12.1 kWh/m2, achieving the 15 kWh/m2 Passive House target. The annual primary energy demand was 125kWh/m2, marginally above the 120 kWh/m2 target. The measured internal heat gains of 3.65 W/m2 are much greater than the 2.1 W/m2 suggested as standard for dwellings. The Passive House Planning Package, PHPP, is found to be a good predictor of space heating demand and the risk of summer time over heating. Winter space heating demand is sensitive to occupant blind use. With a total metered energy consumption of 65 kWh/m2, the Camden Passive House is one of the lowest energy, small family dwellings, monitored in the UK

Wireless recording of the calls of Rousettus aegyptiacus and their reproduction using electrostatic transducers

Bats are capable of imaging their surroundings in great detail using echolocation. To apply similar methods to human engineering systems requires the capability to measure and recreate the signals used, and to understand the processing applied to returning echoes. In this work, the emitted and reflected echolocation signals of Rousettus aegyptiacus are recorded while the bat is in flight, using a wireless sensor mounted on the bat. The sensor is designed to replicate the acoustic gain control which bats are known to use, applying a gain to returning echoes that is dependent on the incurred time delay. Employing this technique allows emitted and reflected echolocation calls, which have a wide dynamic range, to be recorded. The recorded echoes demonstrate the complexity of environment reconstruction using echolocation. The sensor is also used to make accurate recordings of the emitted calls, and these calls are recreated in the laboratory using custom-built wideband electrostatic transducers, allied with a spectral equalization technique. This technique is further demonstrated by recreating multi-harmonic bioinspired FM chirps. The ability to record and accurately synthesize echolocation calls enables the exploitation of biological signals in human engineering systems for sonar, materials characterization and imaging