Rytm zatokowo-komorowy oraz następcze uniesienie odcinka ST u pacjenta z ketonową kwasicą cukrzycową

Ketonowa kwasica cukrzycowa jest jedną z głównych przyczyn hospitalizacji i śmiertelności u chorych na cukrzycę typu 1. Zawał serca jest jednym z rzadkich czynników, choć dobrze rozpoznanym i opisanym, który sprzyja rozwinięciu się ketonowej kwasicy cukrzycowej. Jej częstość ocenia się na około 1% przypadków chorych na cukrzycę. U wielu pacjentów z rozwiniętą ketonową kwasicą cukrzycową pierwszym objawem laboratoryjnym jest hiperkaliemia, która może istotnie zmieniać morfologię zapisu elektrokardiograficznego. W niniejszej pracy przedstawiono przypadek chorego z ketonową kwasicą cukrzycową oraz hiperkaliemią, u którego w badaniu elektrokardiograficznym wykonanym w pierwszej fazie choroby zaobserwowano rytm zatokowo-komorowy, a w późniejszym okresie - elektrokardiograficzną morfologię pseudozawału serca. (Folia Cardiologica Excerpta 2008; 3: 46-49

Decreased glutathione levels and impaired antioxidant enzyme activities in drug-naive first-episode schizophrenic patients

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to determine glutathione levels and antioxidant enzyme activities in the drug-naive first-episode patients with schizophrenia in comparison with healthy control subjects.</p> <p>Methods</p> <p>It was a case-controlled study carried on twenty-three patients (20 men and 3 women, mean age = 29.3 ± 7.5 years) recruited in their first-episode of schizophrenia and 40 healthy control subjects (36 men and 9 women, mean age = 29.6 ± 6.2 years). In patients, the blood samples were obtained prior to the initiation of neuroleptic treatments. Glutathione levels: total glutathione (GSHt), reduced glutathione (GSHr) and oxidized glutathione (GSSG) and antioxidant enzyme activities: superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) were determined by spectrophotometry.</p> <p>Results</p> <p>GSHt and reduced GSHr were significantly lower in patients than in controls, whereas GSSG was significantly higher in patients. GPx activity was significantly higher in patients compared to control subjects. CAT activity was significantly lower in patients, whereas the SOD activity was comparable to that of controls.</p> <p>Conclusion</p> <p>This is a report of decreased plasma levels of GSHt and GSHr, and impaired antioxidant enzyme activities in drug-naive first-episode patients with schizophrenia. The GSH deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in schizophrenia early in the course of illness. Finally, our results provide support for further studies of the possible role of antioxidants as neuroprotective therapeutic strategies for schizophrenia from early stages.</p

The risk for paediatric obstructive sleep apnoea in rural Queensland

The importance of assessing patients for paediatric obstructive sleep apnoea (OSA) cannot be more highly stressed and orthodontists may play an essential role in risk screening. The Paediatric Sleep Questionnaire (PSQ) is a validated tool to identify whether a child is at risk for paediatric OSA. The likelihood of paediatric OSA in school-aged children residing in Far North Queensland (FNQ) will be assessed using the PSQ. Parents of children aged between 4 and 18 years were invited to participate through schools and social media messaging to complete an online PSQ questionnaire to assess their OSA risk and demographics. The final sample consisted of 404 school-aged children of whom 62.5% were found to be at a high-risk for paediatric OSA. The high risk was significantly associated with males and those of overweight/obese BMI status (p 0.05). Within the contributing sample of school-aged children in FNQ, a significant number were found to be at high-risk of paediatric OSA. Males and overweight/obese children were measured risk factors

Assessment of a protic ionic liquid with respect to fractionation and changes in the structural features of hardwood and softwood

In this work, the potential of protic ionic liquid, triethylammonium hydrogen sulfate (TEAHSO4) was shown regarding the pretreatment of the hardwood, hornbeam and softwood, pine at different temperatures and times. TEAHSO4 was effective for lignin extraction and enhancing the enzymatic digestibility of both the biomass. Cellulose content of hornbeam increased to 85% with 87% lignin extraction from the biomass subjected to pretreatment at 150 °C for 3 h which was then readily converted into glucose with 97% yield. On the other hand, pine as a softwood demonstrated more resilience to deconstruction; 76% glucose yield was achieved following the enzymatic hydrolysis of biomass pretreated at 150 °C for 30 min. As put forward in the present work through TEAHSO4 pretreatment, any lignocellulosic feedstock that can be effectively disassembled into cellulose and lignin should be regarded as high value for the production of liquid and gaseous fuels through thermochemical and biochemical routes. © 2019 Elsevier Ltd116M444 Türkiye Bilimsel ve Teknolojik Araştirma KurumuThe authors acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK) via project 116M444 . Appendix

The relationship between uric acid levels and graft function in renal transplant patients who discontinued steroid therapy.

Introduction: High uric acid levels are commonly encountered in kidney transplant recipients, and can be associated with allograft dysfunction. Our study aims to examine the relationship between UA levels and graft function in patients discontinuing steroids.Methods: In this single-center-retrospective study, 56 patients discontinued steroid therapy from among 678 RT patients transplanted from living donors between 1999-2020 were included. The mean age of the study group was 45.8 +/- 8.8 years. Causes of steroid discontinuation, creatinine levels concurrent with uric acid levels before and after steroid discontinuation (mean 3.9 +/- 2.1 years), acute rejection numbers, demographics, durations of dialysis and transplantation, medications, laboratory data, human leukocyte antigen (HLA) mismatch numbers, blood-pressure (BP), body mass index, delayed acute rejection (DAR) numbers (3 months post-transplantation) were all recorded.Results: Creatinine and uric acid levels were seen to have increased after steroid discontinuation, there was a significant relationship between them (p0.001). Statistically significant correlation was found between increased creatinine levels after steroid discontinuation and graft survival with higher HLA mismatch; 39 (69.6%) patients with mismatch >= 2, and 17 patients with mismatch 2 (30.4%) (p=0.049) . No significant relationship was found between DAR numbers before and after steroid discontinuation, and creatinine levels after steroid discontinuation.Conclusion: Per model obtained as a result of multivariate linear analysis, hyperuricemia and HLA mismatch numbers (p= 0.048 and p= 0.044, respectively) are independent predictive factors for graft dysfunction in patients discontinuing steroids. Accordingly, negative effects of modeling should be kept in mind for long-term graft survival in patients who plan to continue with steroid-sparing regimens