Hygienic requirements of urban living environment in the Russian Federation and in Italy: a comparison

Introduzione/scopo. La pianificazione urbana tende a contenere e regolamentare la crescita urbana consentendo uno sviluppo sostenibile a livello ambientale, sociale e sanitario. Nel presente lavoro gli autori hanno confrontato i quadri normativi della Federazione Russ e dell’Italia ponendo particolare attenzione agli aspetti urbani degli spazi abitativi. Metodo. Considerando la ponderosa produzione normativa nei due paesi, il lavoro ha preso in esame le normative a livello nazionale per l’Italia e federale per la Russia, tenendo principalmente conto dei seguenti aspetti: strumenti di pianificazione urbana e protezione ambientale e sanitaria degli spazi abitativi. Risultati. I problemi relativi alla sicurezza igienico-sanitaria dell’ambiente di vita in Russia sono essenzialmente riconducibili a due sistemi normativi (SNiP e SanPiN), mentre in Italia rientrano nel D.M. 05/07/1975. I principi fondamentali della pianificazione urbana in Russia sono dettati da una norma federale, mentre in Italia sono recepiti nel Piano Regolatore Generale (PRG) comunale e nei diversi regolamenti locali, dove si riasriassume tutta la normativa sovraordinata. Gli aspetti legati alla qualità ambientale, infine, in entrambi i paesi sono disciplinati da varie leggi specifiche (federali e statali); un articolato sistema di norme che tengono conto dei potenziali impatti sulla salute e sull’ambiente Conclusioni. Gli autori ritengono che dovrebbero essere sviluppati, specialmente in Italia che si trova nettamente più indietro da questo punto di vista, strumenti normativi chiari e aggiornati aventi per oggetto l’igiene degli edifici e degli ambienti urbani, basati sulle più recenti acquisizioni di letteratura scientifica internazionale nell’intento di garantire i più alti standard in materia di tutela della Salute Pubblica.Aim. Urban planning tries to contain and regulate the uncontrolled growth of cities, encouraging their sustainable development at environmental, social and health levels. In the present work, the authors compare the regulatory frameworks of the Russian Federation and of Italy, with particular attention paid to the urban aspects of living spaces. Method. Considering the extant normative production in the two countries, the authors examine national legislation for Italy and federal legislation for Russia, mainly taking into account the following aspects: urban planning tools and environmental and sanitary protection of living spaces. Results. Hygienic-sanitary requirements regarding living environment in Russia are essentially expressed by two regulatory systems (SNiP and SanPiN), while in Italy they are regulated by the D.M. 07/05/1975. The main principles of urban planning in Russia are expressed by federal standards, while in Italy they are incorporated in the Municipal General Plan (PRG) and in the various local regulations, where all the superordinate regulations are summarized. Finally, aspects related to environmental quality in both countries are governed by various specific laws (federal and state); a complex system of rules that take into account potential impacts on health and the environment. Conclusions. The authors reckon that clear and updated regulatory tools should be developed, especially in Italy that lags behind, regarding the building and urban hygiene, relying on the most recent acquisitions of international scientific literature in order to guarantee the highest standards in Public Health safeguard

The role of the environmental dimension in the performance management system: A systematic review and conceptual framework

The issues of sustainable development and green practices have received increased attention in recent decades. More and more companies are moving towards a strategic approach designed to integrate environmental considerations into their strategies. Nevertheless, a difficulty still remains in the strategic alignment between the environmental dimension of sustainability and performance management system (PMS). In this context, a 'state-of-the-art' analysis of related literature was used to support future research to develop integration of effective approaches and solutions. To achieve this objective, the authors sought to develop a clear picture about the key drivers of the integration process between the environmental dimension and PMS, and to identify the missing concepts, research challenges and opportunities. The authors systematically reviewed 71 English-language scientific papers published between 2002 and 2020, and identified the missing concepts by means of content analysis. The authors found a growing trend in the 18-year period of increasing theoretical research on environmental issues, but a gap was found in developing practical solutions. The findings were used to develop a conceptual model for integrating environmental drivers that emerged from the analysis in an early stage of strategy formulation, through a scorecard-based tool aimed at supporting strategic alignment. This study provides a novel and original framework for exploring environment aspect and PMS approach. We also propose a future research agenda and useful recommendations for scholars and practitioners. It lays a firm foundation for future studies and research debates. (C) 2021 Elsevier Ltd. All rights reserved

LED lighting systems for horticulture: Business growth and global distribution

In recent years, research on light emitting diodes (LEDs) has highlighted their great potential as a lighting system for plant growth, development and metabolism control. The suitability of LED devices for plant cultivation has turned the technology into a main component in controlled or closed plant-growing environments, experiencing an extremely fast development of horticulture LED metrics. In this context, the present study aims to provide an insight into the current global horticulture LED industry and the present features and potentialities for LEDs' applications. An updated review of this industry has been integrated through a database compilation of 301 manufacturers and 1473 LED lighting systems for plant growth. The research identifies Europe (40%) and North America (29%) as the main regions for production. Additionally, the current LED luminaires' lifespans show 10 and 30% losses of light output after 45,000 and 60,000 working hours on average, respectively, while the vast majority of worldwide LED lighting systems present efficacy values ranging from 2 to 3 μmol J-1 (70%). Thus, an update on the status of the horticultural LED sector, LEDs' applications and metrics, and the intense innovation are described and discussed

Growing e-waste management risk awareness points towards new recycling scenarios: The view of the Big Four's youngest consultants

The e-waste sector is characterised by a rapid growth at global level and therefore involves an area not yet sufficiently investigated in its risk management dimension. This research fills the gap of the absence of a holistic approach to risk identification and assessment in e-waste management, suggesting a new Risk Awareness Indicator (RAI). An integrated Multi-criteria decision analysis (MCDA)-Analytic Hierarchy Process (AHP) is proposed to calculate the new index. Weights and values will be proposed by twenty Big Four's youngest consultants (generation-Z and millennials). For e-waste, cyber risks related to personal data are critical in the collection phase, environmental risks in the transport phase, and financial and economic risks in the processing phase. Recycling scenarios pose less overall risk than landfill alternatives. The results can help policy makers to meet the circular economy targets set at the European Union level by implementing administrative and regulatory simplifications to support recycling supply chains and make them more efficient and resilient after the pandemic disruption. This work focuses on e-waste and the opinion of screenagers consultants, however the methodology used to design the RAI index makes it easy to replicate the analysis to other social settings and other waste supply chains

Potential application of pre-harvest LED interlighting to improve tomato quality and storability

Growing conditions and agronomical inputs play a key role in determining fruit qualitative and nutraceutical traits at harvest and post-harvest. The hereby presented research investigated the effects of pre-harvest supplemental LED interlighting on post-harvest quality of hydroponically grown tomatoes (Solanum lycopersicum “Siranzo”). Three LED treatments, applied for 16 h d-1 (h 8.00–00.00), were added to natural sunlight and consisted of Red and Blue (RB), Red and Blue + Far-Red (FR), and Red and Blue + Far-Red at the end-of-day for 30 min (EOD), with an intensity of 180 µmol m-2 s-1 for Red and Blue, plus 44 µmol m-2 s-1 for Far-Red. A control treatment (CK), where plants were grown only with sunlight, was also considered. Fruits at red stage were selected and placed in a storage room at 13 °C in darkness. Fruit quality assessment was performed at harvest time and after one week of storage. RB and FR increased fruit firmness compared to CK, opening possible benefits toward reducing fruit losses during post-harvest handling. RB treated fruits also maintained a higher content of lycopene and β-carotene after the first week of storage. The study demonstrates that supplementary LED interlighting during greenhouse tomato cultivation may enhance storability and help preserve fruit nutritional properties during post-harvest

Winter Greenhouse Tomato Cultivation : Matching Leaf Pruning and Supplementary Lighting for Improved Yield and Precocity

Unidad de excelencia María de Maeztu CEX2019-000940-MSolar radiation entering a high-wire tomato greenhouse is mostly intercepted by the top of the crop canopy, while the role of lower leaves diminishes with age, turning them into sink organs rather than sources. Accordingly, the defoliation of basal leaves is a widely applied agronomic practice in high-wire greenhouse cultivation management. However, the recent increase in the application of supplemental light emitting diode (LED) lighting for high-density tomato production may affect the role of basal leaves, promoting their source role for fruit development and growth. The present research aims to explore the application of supplementary LED lighting on Solanum lycopersicum cv. Siranzo in the Mediterranean area during the cold season in combination with two regimes of basal defoliation. The defoliation factors consisted of the early removal of the leaves (R) right under the developing truss before the fruit turning stage and a non-removal (NR) during the entire cultivation cycle. The lighting factors consisted of an artificial LED lighting treatment with red and blue diodes for 16 h d−1 (h 8-00) with an intensity of 180 µmol s−1 m−2 (RB) and a control cultivated under natural light only (CK). The results demonstrated a great effect of the supplemental LED light, which increased the total yield (+118%), favoring fruit setting (+46%) and faster ripening (+60%) regardless of defoliation regimes, although the increased energy prices hinder the economic viability of the technology. Concerning fruit quality, defoliation significantly reduced the soluble solid content, while it increased the acidity when combined with natural light

PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2

<p>Abstract</p> <p>Background</p> <p>In the last years, the transmembrane proteoglycan NG2 has gained interest as a therapeutic target for the treatment of diverse tumor types, including gliomas, because increases of its expression correlate with dismal prognosis. NG2 has been shown to function as a co-receptor for PDGF ligands whose aberrant expression is common in gliomas. We have recently generated a glioma model based on the overexpression of PDGF-B in neural progenitors and here we investigated the possible relevance of NG2 during PDGF-driven gliomagenesis.</p> <p>Methods</p> <p>The survival curves of NG2-KO mice overexpressing PDGF-B were compared to controls by using a Log-rank test. The characteristics of tumors induced in NG2-KO were compared to those of tumors induced in wild type mice by immunostaining for different cell lineage markers and by transplantation assays in adult mice.</p> <p>Results</p> <p>We showed that the lack of NG2 does not appreciably affect any of the characterized steps of PDGF-driven brain tumorigenesis, such as oligodendrocyte progenitor cells (OPC) induction, the recruitment of bystander OPCs and the progression to full malignancy, which take place as in wild type animals.</p> <p>Conclusions</p> <p>Our analysis, using both NG2-KO mice and a miRNA based silencing approach, clearly demonstrates that NG2 is not required for PDGF-B to efficiently induce and maintain gliomas from neural progenitors. On the basis of the data obtained, we therefore suggest that the role of NG2 as a target molecule for glioma treatment should be carefully reconsidered.</p

Re‐Thinking the Environment, Cities, and Living Spaces for Public Health Purposes, According with the COVID‐19 Lesson: The LVII Erice Charter

Urban planning is a key tool to promote health in cities. The COVID-19 emergency accelerated several social, environmental, and digital challenges, stressing the importance of some issues regarding housing, urban mobility, green areas, and health service networks, urban health policies, and actions. These issues were the subject of an intensive residential course (the 57th) held in Erice, Sicily, in June 2021 in the “International School of Epidemiology and Preventive Medicine G. D’Alessandro”, and the main findings are described here. Methods. Lectures presented the topics, subsequently developed them, and argued them in parallel practical sessions using the World Café technique, since it is well suited for the interaction of participants and the involvement of groups. Results. The World Café provides new insights into how to improve the livability and health of urban spaces, and a set of strategies and actions were proposed for each topic. Discussion and Conclusions. All attendees agreed on the importance of participation in the planning processes, but also on the need for strong political support to ensure the resources needed and a full integration of health with other local policies. A multidisciplinary approach to developing systemic operational capacities and health literacy is considered pivotal to raising awareness and participation

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant improvement has been made in last thirty years over the standard treatment with radiotherapy. To address the paucity of understanding of DIPGs, we have carried out integrated molecular profiling of a large series of samples obtained with stereotactic biopsy at diagnosis. While chromosomal imbalances did not distinguish DIPG and supratentorial tumors on CGHarrays, gene expression profiling revealed clear differences between them, with brainstem gliomas resembling midline/thalamic tumours, indicating a closely-related origin. Two distinct subgroups of DIPG were identified. The first subgroup displayed mesenchymal and pro-angiogenic characteristics, with stem cell markers enrichment consistent with the possibility to grow tumor stem cells from these biopsies. The other subgroup displayed oligodendroglial features, and appeared largely driven by PDGFRA, in particular through amplification and/or novel missense mutations in the extracellular domain. Patients in this later group had a significantly worse outcome with an hazard ratio for early deaths, ie before 10 months, 8 fold greater that the ones in the other subgroup (p = 0.041, Cox regression model). The worse outcome of patients with the oligodendroglial type of tumors was confirmed on a series of 55 paraffin-embedded biopsy samples at diagnosis (median OS of 7.73 versus 12.37 months, p = 0.045, log-rank test). Two distinct transcriptional subclasses of DIPG with specific genomic alterations can be defined at diagnosis by oligodendroglial differentiation or mesenchymal transition, respectively. Classifying these tumors by signal transduction pathway activation and by mutation in pathway member genes may be particularily valuable for the development of targeted therapies