Good and bad muslims, real and fake seculars: center-periphery relations and hegomony in Turkey through the February 28 and April 27 processes

The dissertation is about the media role during February 28 and April 27 military intervention ProcessesLEI Universiteit LeidenMiddle Eastern Studie

Mechanics of milling 48-2-2 gamma titanium aluminide

Accurate and fast prediction of cutting forces is important in high-performance cutting in the aerospace industry. Gamma titanium aluminide (gamma-TiAl) is a material of choice for aerospace and automotive applications due to its superior thermo-mechanical properties. Nevertheless, it is a difficult to machine material. This article presents the prediction of cutting forces for Ti-48Al-2Cr-2Nb (48-2-2) gamma-TiAl in milling process using orthogonal to oblique transformation technique. The novelty of this paper lies in reporting the orthogonal database of 48-2-2 gamma-TiAl. Fundamental cutting parameters such as shear stress, friction angle and shear angle are calculated based on experimental measurements. Friction coefficients are identified for two different coating conditions which are AlTiN, and AlCrN on carbide tools. Predicted results are validated with the experimental cutting forces during end milling and ball-end milling operations for different cutting conditions. The simulated results showed good agreement with the experimental results, which confirms the validity of the force modelWOS:000568177300002Scopus - Affiliation ID: 60105072Science Citation Index ExpandedQ2ArticleUluslararası işbirliği ile yapılan - EVETAğustos2020YÖK - 2019-2

A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole

WOS: 000438500700010The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal infections. In this study, VRZ embedded in a polymeric matrix composed of biocompatible poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu). The mats were prepared via solvent evaporation and fully characterized by Fourier-Transformed Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), in vitro hydrolysis and release studies. The prepared blends defined as immiscible by DSC and SEM while FTIR spectroscopy did not disclose noticeable interactions between the polymers. It was found that hydrolysis was improved by increasing PESu content into the blend. VRZ loaded blends spectra exhibit slight differentiation compared to neat blends while the absence of VRZ melting peak, as DSC illustrated, indicated drug amorphization. Lastly, in vitro release studies depicted a controlled release pattern dependent on mats' hydrolysis degree. An improved antifungal activity of mats was detected by disc diffusion method against various microorganisms. Ex vivo studies of VRZ did not determine high permeation while histopathology results using mice were profitable. The irritation experiments displayed that the mats did not induce any skin irritation

Existence of Hamiltonians for Some Singular Interactions on Manifolds

The existence of the Hamiltonians of the renormalized point interactions in two and three dimensional Riemannian manifolds and that of a relativistic extension of this model in two dimensions are proven. Although it is much more difficult, the proof of existence of the Hamiltonian for the renormalized resolvent for the non-relativistic Lee model can still be given. To accomplish these results directly from the resolvent formula, we employ some basic tools from the semigroup theory.Comment: 33 pages, no figure

Protein and gene delivery systems for neurodegenerative disorders: Where do we stand today?

It has been estimated that every year, millions of people are affected by neurodegenerative disorders, which complicate their lives and their caregivers’ lives. To date, there has not been an approved pharmacological approach to provide the complete treatment of neurodegenerative disorders. The only available drugs may only relieve the symptoms or slow down the progression of the disease. The absence of any treatment is quite rational given that neurodegeneration occurs by the progressive loss of the function or structure of the nerve cells of the brain or the peripheral nervous system, which eventually leads to their death either by apoptosis or necrotic cell death. According to a recent study, even though adult brain cells are injured, they can revert to an embryonic state, which may help to restore their function. These interesting findings might open a new path for the development of more efficient therapeutic strategies to combat devastating neurodegenerative disorders. Gene and protein therapies have emerged as a rapidly growing field for various disorders, especially neurodegenerative diseases. Despite these promising therapies, the complete treatment of neurodegenerative disorders has not yet been achieved. Therefore, the aim of this review is to address the most up-to-date data for neurodegenerative diseases, but most importantly, to summarize the available delivery systems incorporating proteins, peptides, and genes that can potentially target such diseases and pass into the blood–brain barrier. The authors highlight the advancements, at present, on delivery based on the carrier, i.e., lipid, polymeric, and inorganic, as well as the recent studies on radiopharmaceutical theranostics

CAPP Axion Search Experiments with Quantum Noise Limited Amplifiers

The axion is expected to solve the strong CP problem of quantum chromodynamics and is one of the leading candidates for dark matter. CAPP in South Korea has several axion search experiments based on cavity haloscopes in the frequency range of 1-6 GHz. The main effort focuses on operation of the experiments with the highest possible sensitivity. It requires maintenance of the haloscopes at the lowest physical temperature in the range of mK and usage of low noise components to amplify the weak axion signal. We report development and operation of low noise amplifiers for 5 haloscope experiments targeting at different frequency ranges. The amplifiers show noise temperatures approaching the quantum limit.Comment: 6 pages, 7 figures, 29th International Conference on Low Temperature Physics, August 18-24, 2022, Sapporo, Japa

Four-channel System for Characterization of Josephson Parametric Amplifiers

The axion search experiments based on haloscopes at the Center for Axion and Precision Physics Research (CAPP) of the Institute for Basic Science (IBS) in South Korea are performed in the frequency range from 1 GHz to 6 GHz. In order to perform the experiments in a strong magnetic field of 12 T and a large-volume cavity of close to 40 liters, we use He wet dilution refrigerators with immersed superconducting magnets. The measurements require continuous operation for months without interruptions for microwave component replacements. This is achieved by using different cryogenic engineering approaches including microwave RF-switching. The critical components, defining the scanning rate and the sensitivity of the setup, are the Josephson parametric amplifiers (JPA) and cryogenic low noise amplifiers (cLNA) based on high-electron-mobility-transistor (HEMT) technology. It is desirable for both devices to have a wide frequency range and low noise close to the quantum limit for the JPA. In this paper, we show a recent design of a 4-channel measurement setup for JPA and HEMT measurements. The setup is based on a 4-channel wideband noise source (NS) and is used for both JPA and HEMT gain and noise measurements. The setup is placed at 20 mK inside the dry dilution refrigerator. The NS is thermally decoupled from the environment using plastic spacers, superconducting wires and superconducting coaxial cables. We show the gain and noise temperature curves measured for 4 HEMT amplifiers and 2 JPAs in one cool-downComment: to be published in JPS Conference Proceedings (LT29

Josephson Parametric Amplifier in Axion Experiments

The axion is a hypothetical particle, a promising candidate for dark matter, and a solution to the strong CP problem. Axion haloscope search experiments deal with a signal power comparable to noise uncertainty at millikelvin temperature. We use a flux-driven Josephson parametric amplifier (JPA) with the aim of approaching a noise level near the theoretically allowed limit of half quanta. In our measurements to characterize the JPA we have found the added noise to the system with a JPA as the first-stage amplifier to be lower than 110 mK at the frequencies from 0.938 GHz to 0.963 GHz.Comment: to be published in JPS Conference Proceedings (LT29

Search for the Sagittarius Tidal Stream of Axion Dark Matter around 4.55 μ\mueV

We report the first search for the Sagittarius tidal stream of axion dark matter around 4.55 $\mu$eV using CAPP-12TB haloscope data acquired in March of 2022. Our result excluded the Sagittarius tidal stream of Dine-Fischler-Srednicki-Zhitnitskii and Kim-Shifman-Vainshtein-Zakharov axion dark matter densities of $\rho_a\gtrsim0.184$ and $\gtrsim0.025$ GeV/cm$^{3}$, respectively, over a mass range from 4.51 to 4.59 $\mu$eV at a 90% confidence level.Comment: 6 pages, 7 Figures, PRD Letter accepte