The role of early determination of β-human chorionic gonadotropin levels in predicting the success of single-dose methotrexate treatment in ectopic pregnancy

Objective: The aim of the study was to determine the importance of β-hCG level on day 4 following methotrexate (MTX) administration, and the difference between β-hCG levels assessed on day 0 and day 4 in predicting treatment success. Material and methods: A total of 68 women with tubal pregnancy, treated with a single dose of MTX, were selected for this retrospective study. Results: The success rate of single-dose MTX treatment in our clinic was 75% (51/68). Among 51 patients in whom MTX treatment was successful, 25 (36.8%) showed a decrease in β-hCG level of > 15% on days 0 and 4, and 44 (64.7%) showed a β-hCG level decrease of > 15% on days 4 and 7. For subjects with β-hCG decrease of > 15% on days 4 and 7, the standard error was 6.5%, and the area under the ROC curve was 81.7%, while the corresponding values for days 0 and 4 were 7.2% and 64%, respectively. Conclusions: A decrease of > 15 % in β-hCG levels between days 0 and 4 does not seem to be a better predictor for success of single-dose MTX treatment for ectopic pregnancy than between days 4 and 7. A statistically significant difference was observed only in β-hCG levels on day 7 in both, successful and unsuccessful single-dose MTX groups

Siber Zorbalık ve Mağduriyetin Yaygınlığının ve Risk Faktörlerinin İncelenmesi

The aim of this study was to examine risk factors related to cyber bullying and victimization. The study was carried out with 160 adolescents applying to the Child/Adolescent Psychiatry Outpatient Clinic of the Faculty of Medicine of Süleyman Demirel University in Isparta, Turkey. Data was collected through using the Socio-Demographic Information Form, Internet Addiction Scale, and Cyber Victim and Bullying Scale. The results of the study showed that cyber bullying was related to gender, the risk of Internet addiction, the frequency of visiting Internet cafes, adolescents’ perception of their mothers’ Internet skills, the daily duration of visiting social networking sites, usage of the Internet predominantly to play online games, the monthly income of the family, and the mothers’ educational status. Cyber victimization, on the other hand, was found to be related to the risk of Internet addiction, the frequency of visiting Internet cafes, adolescents’ perception of their mothers’ Internet skills, and usage of the Internet predominantly to play online games. The results of the study were discussed in the light of relevant literature.Bu araştırmanın amacı siber zorba, siber mağdur, siber zorba/mağdur ve siber zorbalığa hiçbir biçimde karışmamış bireylerin oranını araştırmak ve siber zorbalık ve mağduriyete ilişkin risk faktörlerini belirlemektir. Araştırma Süleyman Demirel Üniversitesi Tıp Fakültesi Çocuk ve Ergen Psikiyatrisi polikliniğine başvuran 160 ergenle yürütülmüştür. Veriler Sosyodemografik Bilgi Formu, İnternet Bağımlılığı Ölçeği ve Siber Mağduriyet ve Zorbalık Ölçeği kullanılarak toplanmıştır. Araştırma sonuçları siber zorbalığın cinsiyet, internet kafeye gitme sıklığı, ergenin annesinin internet becerisine ilişkin algısı, günlük sosyal paylaşım sitelerine girme süresi, internet bağımlılığı riski, interneti en çok çevrimiçi oyun oynamak amacıyla kullanma ve ailenin aylık geliri ile ilişkili olduğunu göstermiştir. Öte yandan siber mağduriyetin ise internet kafeye gitme sıklığı, ergenin annesinin internet becerisine ilişkin algısı, interneti en çok çevrimiçi oyun oynamak amacıyla kullanma ve internet bağımlılığı riski ile ilişkili olduğu bulunmuştur. Araştırma sonuçları alanyazın ışığında tartışılmıştır

Hepatitis B And Hepatitis C Seropositivity Rates In Pregnants Who Live In Kırıkkale Region.

ÖZET Amaç: Bu çalışmada Kırıkkale bölgesinde yaşayan gebelerde HBsAg, Anti-HBs, Anti-HCV pozitiflik oranlarını belirlemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya Haziran 2012-Haziran 2014 tarihleri arasında Kırıkkale Üniversitesi Tıp Fakül- tesi Kadın Hastalıkları ve Doğum polikliniğine gebelik takibi nedeniyle başvuran gebelerden HBsAg, Anti-HBs, Anti-HCV sonuçlarına ulaşılabilen hastalar dahil edildi. HBsAg serolojisi yönünden 8442, Anti HBS serolojisi yönünden 3094, Anti-HCV serolojisi yönünden 8120 gebe değerlendirilmiştir. Hastalar 18-30 yaş ve 30 yaş üstü olarak iki gruba ayrılmış olup her iki grubun seropozitiflik oranları karşılaştırılmıştır. Hastalarda HBsAg, Anti-HBs Anti-HCV düzeyleri ELİSA yöntemi ile Kırıkkale Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları ve Klinik Mikro- biyoloji laboratuarında çalışılmıştır. Bulgular: Seropozitiflik oranları 18-30 yaş arasında HBsAg için %2,34, 30 yaş üzerinde %4,79, Anti HBs için 18- 30 yaş arası %58,51, 30 yaş üzerinde %29,6, Anti-HCV için 18-30 yaş arası %0,31, 30 yaş üzerinde %0,59 olarak hesaplanmıştır. HBs Ag pozitiflik oranı 30 yaş üstü grupta, 18-30 yaş arası gruba oranla anlamlı olarak daha yüksek (p0,001) bulundu. Anti HBs pozitiflik oranı 30 yaş üstü grupta anlamlı olarak daha düşüktü (p0,001). Anti-HCV pozitiflik oranı da 30 yaş üstü grupta daha yüksek olmakla birlikte bu değer istatistiksel olarak anlamlı değildi (p:0,061). Sonuç: Gebelerde yaptığımız bu çalışmada seropozitiflik oranları sonuçları ülkemizin diğer bölgelerine benzer bulunmuştur. HBsAg seropozitiflik oranında yıllar içinde düşme görülmesi etkin aşılama programlarına atfedi- lebilir. İstatistiksel olarak anlamlı olmasa da düşme eğiliminde olan Anti-HCV pozitifliği ise muhtemelen etkin sterilizasyon ve dezenfeksiyon stratejilerinin sonucudur.Aim: The aim of our study was determine the seroprevalence of HBsAg, Anti-HBs, Anti-HCV in pregnant women living in Kırıkkale city. Material and Methods: HBsAg, Anti-HBs and Anti-HCV results of the pregnant women that admitted to the obstetrics and gynecology clinics between June 2012 and June 2014 were retrospectively investigated. 8442 pregnant women for HBsAg serology , 3094 pregnant women for Anti HBS serology, 8120 pregnant women for Anti-HCV were examined. Patients aged 18-30 years and 30 were divided into two groups and seropositivity rates of the two groups were compared. HBsAg, Anti-HBs and Anti-HCV levels by ELISA method has been studied in Kirikkale University School of Medicine, Infectious Diseases and Clinical Microbiology laboratory. Results: HBsAg positivity were 2.34% in the 18-30 age group and were 4,79% in the above 30 years group; Anti HBs positivity were 58,51% in the 18-30 age group and were 29,6% in the above 30 years group; Anti-HCV positivity were 0,31% in the 18-30 age group and were 0,59% in the above 30 years group. HBs Ag positivity rates were higher in patients over the age of 30 (p<0,001). Anti-HBs positive rate was lower in the group above 30 years of age (p<0,001). Anti-HCV positivity rate was higher in the group above 30 years of age but values were not statistically significant (p:0,061). Conclusion: Results of the study were similar to other regions of our country. HBsAg seropositivity rate decrease may be attributed to the effective vaccination program. Anti-HCV positivity is probably the result of effective sterilization and disinfection strategies

Perineal-Inguinal Herpes Zoster Infection in Labor: A Rare Case Report

Amaç: Herpes Zoster (zona) enfeksiyonu yaşam boyu görülme sıklığı % 0,3-0,8 olan, varisella zoster virusunun (VZV) primer olarak nöral dokuyu tuttuğu fakat komplikasyonları dermatolojik, nörolojik, oftalmolojik ya da visseral olabilen viral enfeksiyondur Gebelikte varisella zoster enfeksiyonu 1-5/10.000 gibi düşük insidansa sahipken olgulardaki VZV seropozitifliği oldukça yüksektir (> % 95). Gebelikte bulaş in-utero, perinatal, postnatal olabilir. Mortalitesi yüksek olan neonatal suçiçeği enfeksiyonu ise doğum sırasındaki bulaş sonucu ortaya çıkar. Bu yazıda gebeliğinde travay takibinde zona enfeksiyonu geçiren ve bunun üzerine sezeryan ile doğumu gerçekleştirilen bir olgu sunularak konu literatur bilgileri eşliğinde tartışıldı.Aim: Herpes zoster (shingles), is a viral infection, with the life time incidence between % 0.30.8, that can primarily effect the neural tissue but which has dermatological, neurological, ophtalmological or visceral complications, caused by varicella zoster virus (VZV)As VZV infection has low incidence as 1-5/10.000 and the patients have significantly high seropositivity (>%95). Transmission in pregnancy can occur in utero, perinatally or postnatally. Neonatal chickenpox infection, on the other hand, is transmitted during labor which has high mortality rates. In this report, a case which had HZ infection during labor and and thus gone to caeserian section with a live birth has been presented and this topic have been discussed by the literature knowledge

Anticholinergic, antioxidant, and antibacterial properties of vitex agnus-castus L. seed extract: assessment of Its phenolic content by LC/MS/MS

In this current study, Vitex agnus-castus seed ethanol extracts were analyzed for their phytochemical component content, anticholinergic and antioxidant activities, and antibacterial properties. The phenolic compound composition of these seeds was determined by using LC/MS/MS. Antioxidant activity of the seeds was examined by the DPPH, ABTS, Fe3+–Fe2+ reducing, and CUPRAC. Also, the anticholinergic activity was measured by the inhibition of acetylcholinesterase (AChE). The antibacterial activity was performed by disc diffusion and minimum inhibitory concentration methods. The main phenolic compound was vanillic acid (22812.05 μg/L) and followed by luteolin, fumaric acid, quercetin, caffeic acid, 4-hydroxybenzoic acid, salicylic acid, kaempferol, butein, ellagic acid, resveratrol, catechin hydrate, phloridzin dehydrate, naringenin, respectively. The DPPH free radical scavenging value of ethanol extract of plant seeds was 9.41 %, while the ABTS radical scavenging activity was determined as 12.66 %. The ethanol extract of the seeds exhibited antibacterial activity on Escherichia coli, Staphylococcus aureus, and Salmonella Typhimurium, differently. S. aureus was found to be more susceptible to the extract than other bacteria. Also, the inhibition effect of seed ethanolic extract on the AChE with IC50 values were 36.34±5.6 μg/mL. From the results, V. agnus-castus seed can be suggested as a promising natural antioxidant and antibacterial candidate for the preservation of foods

Phytochemical, phenolic profile, antioxidant, anticholinergic and antibacterial properties of Epilobium angustifolium (Onagraceae)

Epilobium angustifolium is widely used in medicine for disease treatments, as well as in the cosmetic and food industries. The aim of this research was to investigate the antioxidant, and anticholinergic properties, phenolics profile and antibacterial activities of the E. angustifolium ethanol extract. The analysis of phenolic compounds was performed with LC-MS/MS. The antioxidant capacity (radical scavenging, metal-reducing power and total antioxidant activity) was assessed by DPPH, ABTS, Cu2+-Cu+ reducing (CUPRAC), Fe3+-Fe2+ reducing and ferric thiocyanate methods. The antibacterial activity was determined by disc diffusion and MIC (Minimum inhibitory concentration) methods and the anticholinergic property was predicted by inhibition of acetylcholinesterase (AChE). The major phenolic compounds, founding in the plant extract were luteolin, fumaric acid, vanillic acid, and caffeic acid. The ethanol extract of the plant showed DPPH free radical scavenging value of 11.3%, while the ABTS radical scavenging activity was 19.4% and showed moderately metal-reducing power. Also, the extract had 39.3% inhibition on lipid peroxidation of linoleic acid emulsion and showed an inhibition effect on the AChE with IC50 values (0.14 mg mL(-1)). The ethanol extract of the plant showed antibacterial effect on Staphylococcus aureus, Escherichia coli, and Salmonella Typhimurium at different levels. These results suggested that E. angustifolium extract might be a suitable natural antioxidant in the preservation of foods by preventing the oxidation of pol

Phenolic profile and antioxidant, anticholinergic, and antibacterial properties of corn tassel

Corn tassel (CT) is a waste part of the corn plant. It is a good co-product and rich in terms of bioactive compounds and phytochemicals. This research tried to show the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The phenolic content analysis of the CT was determined quantitatively by LC-MS/MS, and the antioxidant capacity was measured using ABTS, DPPH, Cu2+-Cu+, and Fe3+-Fe2+ reducing methods. The anticholinergic measurements of CT were detected by inhibition of acetylcholinesterase (AChE). The antibacterial activity was determined by MIC and disc diffusion methods. Many phenolic compounds such as vanillic acid, caffeic acid, fumaric acid, acetohydroxamic acid, butein, myricetin, resveratrol, catechin hydrate, and 4-hydroxybenzoic acid were detected in ethanol extract of CT. The obtained plant ethanol extract had a 7.04% DPPH value, while it showed ABTS activity at 9.45%. Moreover, it had a 0.10 mg/mL inhibition effect on the AChE in terms of IC50 values. The ethanol extract of the CT had an antibacterial property on the investigated bacteria at different ratios. In conclusion, this research aims to consider CT as a source of phenolic compounds and to reveal its bioactive properties and its effects on the treatment of some diseases