9 research outputs found
Investigating Middle School Students’ Metacognition and Mathematical Reasoning of Problem-Solving Skills
Demographic Determinants of Women Participation in Labour Force: Analysis of Turkey both General and Nuts 1 Regional Basis
F-18 FDG-PET/CT Findings for Staging and Therapy Response Assessment of a Rare Case: Primary Uterine Cervical Lymphoma
P939: THE RELATIONSHIP OF BONE MARROW FIBROSIS WITH EXTRAMEDULLARY DISEASE IN MULTIPLE MYELOMA
Which prognostic marker is responsible for the clinical heterogeneity in CLL with 13q deletion?
Background: Deletion of 13q14 [del(13q)] is the most common cytogenetic change (50%) in chronic lymphoblastic leukemia (CLL), and it is a good prognostic factor if it is detected as a sole aberration by FISH. However, it is observed the clinical course of CLL cases with del(13q) are quite heterogeneous and the responsible for this clinical heterogeneity has not been established yet. Some investigators suggest type II deletion (include RB1 gene) is associated with more aggressive clinical course. Also, it is suggested that the deletion burden and the deletion type have a prognostic effect. In this study, we aimed to investigate the effect of RB1 gene deletion, deletion burden and deletion type on overall survival (OS), disease stage and time to first treatment (TTFT) in patients with isolated del(3q). Sixty eight cases, detected isolated del(13q) were included in the study. Also, RB1 deletion was analyzed from peripheral blood of them using FISH