6 research outputs found
A Simple Deposition Model for Debris Flow Simulation Considering the Erosion–Entrainment–Deposition Process
This study aimed to determine the depositional effect and improve the identification of debris flow risk zones. To accomplish this goal, we developed a two-dimensional debris flow model (Deb2D) based on a hyperbolic conservation form of the mass and the momentum balance equation with consideration of the erosion–entrainment effect as well as the depositional effect. In this model, we implemented a widely-used rheological equation—the Voellmy equation—and a quadtree adaptive grid-based shallow-water equation. This model was applied to two study sites to assess the depositional effect. The impact area, volume of soil loss, maximum velocity, inundated depth, and erosion depth resulting from the debris-flow modeling were compared with the field data. The simulation results with/without deposition were evaluated using the receiver operating characteristic method. The implementation results of the erosion–entrainment model with deposition showed superior accuracy when estimating the damage range and flow time
A Simple Deposition Model for Debris Flow Simulation Considering the Erosion–Entrainment–Deposition Process
This study aimed to determine the depositional effect and improve the identification of debris flow risk zones. To accomplish this goal, we developed a two-dimensional debris flow model (Deb2D) based on a hyperbolic conservation form of the mass and the momentum balance equation with consideration of the erosion–entrainment effect as well as the depositional effect. In this model, we implemented a widely-used rheological equation—the Voellmy equation—and a quadtree adaptive grid-based shallow-water equation. This model was applied to two study sites to assess the depositional effect. The impact area, volume of soil loss, maximum velocity, inundated depth, and erosion depth resulting from the debris-flow modeling were compared with the field data. The simulation results with/without deposition were evaluated using the receiver operating characteristic method. The implementation results of the erosion–entrainment model with deposition showed superior accuracy when estimating the damage range and flow time
A Study on the Slope Failure Monitoring of a Model Slope by the Application of a Displacement Sensor
Cell Isolation and Recovery Using Hollow Glass Microspheres Coated with Nanolayered Films for Applications in Resource-Limited Settings
Established cell
isolation and purification techniques such as
fluorescence-activated cell sorting (FACS), isolation through magnetic
micro/nanoparticles, and recovery via microfluidic devices have limited
application as disposable technologies appropriate for point-of-care
use in remote areas where lab equipment as well as electrical, magnetic,
and optical sources are restricted. We report a simple yet effective
method for cell isolation and recovery that requires neither specialized
lab equipment nor any form of power source. Specifically, self-floating
hollow glass microspheres were coated with an enzymatically degradable
nanolayered film and conjugated with antibodies to allow both fast
capture and release of subpopulations of cells from a cell mixture.
Targeted cells were captured by the microspheres and allowed to float
to the top of the hosting liquid, thereby isolating targeted cells.
To minimize nonspecific adhesion of untargeted cells and to enhance
the purity of the isolated cell population, an antifouling polymer
brush layer was grafted onto the nanolayered film. Using the EpCAM-expressing
cancer cell line PC-3 in blood as a model system, we have demonstrated
the isolation and recovery of cancer cells without compromising cell
viability or proliferative potential. The whole process takes less
than 1 h. To support the rational extension of this platform technology,
we introduce extensive characterization of the critical design parameters:
film formation and degradation, grafting with a poly(ethylene glycol)
(PEG) sheath, and introducing functional antibodies. Our approach
is expected to overcome practical hurdles and provide viable targeted
cells for downstream analyses in resource-limited settings