Detection of Operator Performance Breakdown as an Automation Triggering Mechanism

Performance breakdown (PB) has been anecdotally described as a state where the human operator "loses control of context" and "cannot maintain required task performance." Preventing such a decline in performance is critical to assure the safety and reliability of human-integrated systems, and therefore PB could be useful as a point at which automation can be applied to support human performance. However, PB has never been scientifically defined or empirically demonstrated. Moreover, there is no validated objective way of detecting such a state or the transition to that state. The purpose of this work is: 1) to empirically demonstrate a PB state, and 2) to develop an objective way of detecting such a state. This paper defines PB and proposes an objective method for its detection. A human-in-the-loop study was conducted: 1) to demonstrate PB by increasing workload until the subject reported being in a state of PB, and 2) to identify possible parameters of a detection method for objectively identifying the subjectively-reported PB point, and 3) to determine if the parameters are idiosyncratic to an individual/context or are more generally applicable. In the experiment, fifteen participants were asked to manage three concurrent tasks (one primary and two secondary) for 18 minutes. The difficulty of the primary task was manipulated over time to induce PB while the difficulty of the secondary tasks remained static. The participants' task performance data was collected. Three hypotheses were constructed: 1) increasing workload will induce subjectively-identified PB, 2) there exists criteria that identifies the threshold parameters that best matches the subjectively-identified PB point, and 3) the criteria for choosing the threshold parameters is consistent across individuals. The results show that increasing workload can induce subjectively-identified PB, although it might not be generalizable-only 12 out of 15 participants declared PB. The PB detection method based on signal detection analysis was applied to the performance data and the results showed that PB can be identified using the method, particularly when the values of the parameters for the detection method were calibrated individually

The Spitzer c2d Survey Of Nearby Dense Cores. XI. Infrared And Submillimeter Observations Of CB130

We present new observations of the CB130 region composed of three separate cores. Using the Spitzer Space Telescope, we detected a Class 0 and a Class II object in one of these, CB130-1. The observed photometric data from Spitzer and ground-based telescopes are used to establish the physical parameters of the Class 0 object. Spectral energy distribution fitting with a radiative transfer model shows that the luminosity of the Class 0 object is 0.14-0.16 L-circle dot, which is low for a protostellar object. In order to constrain the chemical characteristics of the core having the low-luminosity object, we compare our molecular line observations to models of lines including abundance variations. We tested both ad hoc step function abundance models and a series of self-consistent chemical evolution models. In the chemical evolution models, we consider a continuous accretion model and an episodic accretion model to explore how variable luminosity affects the chemistry. The step function abundance models can match observed lines reasonably well. The best-fitting chemical evolution model requires episodic accretion and the formation of CO2 ice from CO ice during the low-luminosity periods. This process removes C from the gas phase, providing a much improved fit to the observed gas-phase molecular lines and the CO2 ice absorption feature. Based on the chemical model result, the low luminosity of CB130-1 is explained better as a quiescent stage between episodic accretion bursts rather than being at the first hydrostatic core stage.NASA 1224608, 1288664, 1407, NNX07AJ72G, 1279198, 1288806, 1342425NSF AST-0607793, AST-0708158Korea government (MEST) 2009-0062866Ministry of Education, Science and Technology 2010-0008704Astronom

Experimental and computational investigations of the effect of the electrode gap on capacitively coupled radio frequency oxygen discharges

Geometrically symmetric capacitively coupled oxygen plasmas are studied experimentally by optical emission spectroscopy and probe measurements as well as via numerical simulations using the kinetic Particle-in-Cell/Monte Carlo collision (PIC/MCC) approach. The experiments reveal that at a fixed pressure of 20 mTorr and a driving frequency of 13.56 MHz, the central electron density increases with an increased electrode gap, while the time averaged optical emission of atomic oxygen lines decreases. These results are reproduced and understood by the PIC/MCC simulations performed under identical conditions. The simulations show that the electron density increases due to a mode transition from the Drift-Ambipolar-mode to the a-mode induced by increasing the electrode gap. This mode transition is due to a drastic change of the electronegativity and the mean electron energy, which leads to the observed reduction of the emission intensity of an atomic oxygen line. The observed mode transition is also found to cause a complex non-monotonic dependence of the O2+ ion flux to the electrodes as a function of the electrode gap. These fundamental results are correlated with measurements of the etch rate of amorphous carbon layers at different gap distances

Evolution of electron temperature in inductively coupled plasma

It is generally recognized that the electron temperature T_e either remains constant or decreases slightly with plasma power (plasma density). This trend can be simply verified using a single-step or multi-step fluid global model. In this work, however, we experimentally observed that T_e evolved with plasma power in radio frequency (RF) inductively coupled plasmas. In this experiment, the measured electron energy distributions were nearly Maxwellian distribution. In the low RF power regime, T_e decreased with increasing plasma power, while it increased with plasma power in the high RF power regime. This evolution of T_e could be understood by considering the coupling effect between neutral gas heating and stepwise ionization. Measurement of gas temperature via laser Rayleigh scattering and calculation of T_e using the kinetic model, considering both multi-step ionization and gas heating, were in good agreement with the measured value of T_e. This result shows that T_e is in a stronger dependence on the plasma power

CO2 Ice toward Low-luminosity, Embedded Protostars: Evidence for Episodic Mass Accretion via Chemical History

We present Spitzer IRS spectroscopy of CO2 ice bending mode spectra at 15.2 micrometer toward 19 young stellar objects with luminosity lower than 1 Lsun (3 with luminosity lower than 0.1 Lsun). Ice on dust grain surfaces can encode the history of heating because pure CO2 ice forms only at elevated temperature, T > 20 K, and thus around protostars of higher luminosity. Current internal luminosities of YSOs with L < 1 Lsun do not provide the conditions needed to produce pure CO2 ice at radii where typical envelopes begin. The presence of detectable amounts of pure CO2 ice would signify a higher past luminosity. Many of the spectra require a contribution from a pure, crystalline CO2 component, traced by the presence of a characteristic band splitting in the 15.2 micrometer bending mode. About half of the sources (9 out of 19) in the low luminosity sample have evidence for pure CO2 ice, and six of these have significant double-peaked features, which are very strong evidence of pure CO2 ice. The presence of the pure CO2 ice component indicates that the dust temperature, and hence luminosity of the central star/accretion disk system, must have been higher in the past. An episodic accretion scenario, in which mixed CO-CO2 ice is converted to pure CO2 ice during each high luminosity phase, explains the presence of pure CO2 ice, the total amount of CO2 ice, and the observed residual C18O gas.Comment: Accepted for publication in ApJ, total 24 pages, 14 figure

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis

Tubulointerstitial fibrosis (TIF) is recognized as a final phenotypic manifestation in the transition from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Here we show that conditional inactivation of Sav1 in the mouse renal epithelium resulted in upregulated expression of profibrotic genes and TIF. Loss of Sav1 induced Stat3 activation and a senescence-associated secretory phenotype (SASP) that coincided with the development of tubulointerstitial fibrosis. Treatment of mice with the YAP inhibitor verteporfin (VP) inhibited activation of genes associated with senescence, SASPs, and activation of Stat3 as well as impeded the development of fibrosis. Collectively, our studies offer novel insights into molecular events that are linked to fibrosis development from Sav1 loss and implicate VP as a potential pharmacological inhibitor to treat patients at risk for developing CKD and TIF

TSCOT + Thymic Epithelial Cell-Mediated Sensitive CD4 Tolerance by Direct Presentation

Although much effort has been directed at dissecting the mechanisms of central tolerance, the role of thymic stromal cells remains elusive. In order to further characterize this event, we developed a mouse model restricting LacZ to thymic stromal cotransporter (TSCOT)-expressing thymic stromal cells (TDLacZ). The thymus of this mouse contains approximately 4,300 TSCOT+ cells, each expressing several thousand molecules of the LacZ antigen. TSCOT+ cells express the cortical marker CDR1, CD40, CD80, CD54, and major histocompatibility complex class II (MHCII). When examining endogenous responses directed against LacZ, we observed significant tolerance. This was evidenced in a diverse T cell repertoire as measured by both a CD4 T cell proliferation assay and an antigen-specific antibody isotype analysis. This tolerance process was at least partially independent of Autoimmune Regulatory Element gene expression. When TDLacZ mice were crossed to a novel CD4 T cell receptor (TCR) transgenic reactive against LacZ (BgII), there was a complete deletion of double-positive thymocytes. Fetal thymic reaggregate culture of CD45- and UEA-depleted thymic stromal cells from TDLacZ and sorted TCR-bearing thymocytes excluded the possibility of cross presentation by thymic dendritic cells and medullary epithelial cells for the deletion. Overall, these results demonstrate that the introduction of a neoantigen into TSCOT-expressing cells can efficiently establish complete tolerance and suggest a possible application for the deletion of antigen-specific T cells by antigen introduction into TSCOT+ cells

Markers of adiposity among children and adolescents: implications of the isotemporal substitution paradigm with sedentary behavior and physical activity patterns

Background The purpose of this study was to examine the association between daily movement patterns and dual energy X-ray absorptiometry-determined body fat percent (DXA-BF%) among children and adolescents while applying both traditional and novel analytical procedures. Methods Using data from the cross-sectional 2003–2006 National Health and Nutrition Examination Survey (n = 5607), physical activity was assessed via accelerometry, with the following movement patterns assessed: 1) meeting moderate-to-vigorous physical activity (MVPA) guidelines and engaging in more light-intensity physical activity (LIPA) than sedentary behavior (SB); 2) meeting MVPA guidelines, but engaging in less LIPA than SB; 3) not meeting MVPA guidelines, but engaging in more LIPA than SB; and 4) not meeting MVPA guidelines and engaging in less LIPA than SB. Various markers of adiposity (e.g., DXA-BF%) were assessed. Results Children in movement pattern 1 (52 %), compared to those in movement pattern 4, had significantly lower levels of BMI (∆ 2.2 kg/m2), waist circumference (∆ 6.5 cm), tricep skinfold (∆ 4.2 mm), subscapularis skinfold (∆ 2.6 mm), android BF% (∆ 7.6 %), gynoid BF% (∆ 5.1 %), and total BF% (∆ 5.2 %). Substituting 60 min/day of SB with MVPA resulted in a 4.6 % decreased estimate of total DXA-BF%. No findings were significant for adolescents. Conclusions The low proportion of children engaging in ≥ 60 min/day of MVPA and accumulating relatively more LIPA than SB had the lowest DXA-BF%