The X-ray Transient XTE J2012+381

We present optical and infrared observations of the soft X-ray transient (SXT) XTE J2012+381 and identify the optical counterpart with a faint red star heavily blended with a brighter foreground star. The fainter star is coincident with the radio counterpart and appears to show weak H alpha emission and to have faded between observations. The RXTE/ASM lightcurve of XTE J2012+381 is unusual for an SXT in that after an extended linear decay, it settled into a plateau state for about 40 days before undergoing a weak mini-outburst. We discuss the nature of the object and suggest similarities to long orbital period SXTs.Comment: 5 pages, 7 postscript figures included, uses mn.sty. Accepted for publication in MNRA

Why are nit-2 transformants of Aspergillus nidulans partially derepressed?

The major nitrogen metabolite repression control genes of Aspergillus nidulans and Neurospora crassa are the areA and nit-2 genes respectively. Both genes encode transcriptional activators with highly conserved C2-X17-C2 zinc finger DNA binding domains which recognize similar WGATAR DNA sequences (Kudla et al., 1990 EMBO J. 9: 1355-1364; Fu and Marzluf, 1990 Proc. Natl. Acad. Sci USA 87: 5331-5335). We have shown previously that the N. crassa nit-2 gene can fully complement an areA loss-of-function mutation in A. nidulans, restoring growth on a wide variety of nitrogen sources. However, the nit-2 transformants are partially derepressed (Davis and Hynes, 1987 Proc. Natl. Acad. Sci. USA 84: 3753-3757)

The Structure Of The Accretion Disk In The ADC Source 4U 1822-371

The low-mass X-ray binary (LMXB) 4U 1822-371 has an accretion disk corona (ADC) that scatters X-ray photons from the inner disk and neutron star out of the line of sight. It has a high orbital inclination and the secondary star eclipses the disk and ADC. We have obtained new time-resolved UV spectrograms and V- and I-band photometry of 4U 1822-371. The large quadratic term in our new optical eclipse ephemeris confirms that the system has an extremely high rate of mass transfer and mass accretion. The C IV lambda lambda = 1548 - 1550 angstrom emission line has a half width of similar to 4400 km/s, indicating a strong, high velocity wind is being driven off the accretion disk. Near the disk the wind is optically thick in UV, V, and J and the eclipse analysis shows that in V and J the optically thick wind extends nearly to the outer edge of the disk. The ADC must also extend vertically to a height equal to approximately half the disk radius.Astronom

An examination of the molecular mechanisms controlling the tissue accumulation of conjugated linoleic acid (CLA) in cattle

End of project reportLong chain n-3 polyunsaturated fatty acids (n-3 PUFA) and conjugated linoleic acid (CLA) have demonstrable and potential human health benefits in terms of preventing cancer, diabetes, chronic inflammation, obesity and coronary heart disease. Supplementation of cattle diets with a blend of oils rich in n-3 PUFA and linoleic acid have a synergistic effect on the accumulation of ruminal and tissue concentrations of trans vaccenic acid (TVA), the main substrate for ?-9 desaturase which is responsible for de novo tissue synthesis of the cis 9, trans 11 isomer of CLA. This dietary strategy translates into increases in milk concentrations of CLA in dairy cows; however, concentrations in the muscle of beef animals have not always been increased. There is an apparent paradox in that n-3 PUFA supplementation enhances ruminal synthesis of trans-vaccenic acid (TVA), but then inhibits its conversion to CLA possibly through altering the activity of ?-9 desaturase. Recently, the promoter regions of the bovine ?- 9 desaturase gene has been isolated and analysed and has been shown to contain a conserved PUFA response region

A continental rift model for the La Grande greenstone belt

Stratigraphic relationships and the geochemistry of volcanic rocks contrain the nature and timing of the tectonic and magmatic processes in the pre-deformational history of the La Grande greenstone belt in the Superior Province of north-central Quebec. The lowermost supracrustals in this belt are obscured by syntectonic granitoid intrusives. The supracrustal succession in the western part of the belt consists of a lower sequence of immature clastic sediments and mafic volcanoclastics, overlain by pillowed and massive basalts. Further east, along tectonic strike, a lower sequence of mafic volcanoclastics and immature clastic sediments is overlain by a thick sequence of pillowed and massive basalts, and resedimented coarse clastic sediments and banded iron formation. These are overlain by assive basaltic andesites, andesites and intermediate volcanoclastics intercalated with immature clastic sediments. In contrast, in the eastern part of the belt lenses of felsic volcanics and volcanoclastics occur at the base of the succession and pillowed and massive basalts are overlain by komatiites at the top. The La Grande greenstone belt can be explained as the product of continental rifting. The restricted occurence of komatiites, and eastwardly directed paleocurrents in clastic sediments in the central part of the belt are consistent with rifting commencing in the east and propagating westward with time. The increase in depth of emplacement and deposition with time of the lower three units in the central part of the belt reflects deposition in a subsiding basin. These supracrustal rocks are believed to represent the initial rift succession

Expanding hot flow in the black hole binary SWIFT J1753.5-0127: evidence from optical timing

We describe the evolution of optical and X-ray temporal characteristics during the outburst decline of the black hole X-ray binary SWIFT J1753.5-0127. The optical/X-ray cross-correlation function demonstrates a single positive correlation at the outburst peak, then it has multiple dips and peaks during the decline stage, which are then replaced by the precognition dip plus peak structure in the outburst tail. Power spectral densities and phase lags show a complex evolution, revealing the presence of intrinsically connected optical and X-ray quasi-periodic oscillations. For the first time, we quantitatively explain the evolution of these timing properties during the entire outburst within one model, the essence of which is the expansion of the hot accretion flow towards the tail of the outburst. The pivoting of the spectrum produced by synchrotron Comptonization in the hot flow is responsible for the appearance of the anti-correlation with the X-rays and for the optical quasi-periodic oscillations. Our model reproduces well the cross-correlation and phase lag spectrum during the decline stage, which could not be understood with any model proposed before.Comment: 13 pages, 11 figures, MNRAS submitte

The Political Economy of Property Exemption Laws

Exemption laws enable people who default on loans to protect certain assets from liquidation. Every state has its own set of exemption laws, and they vary widely. The 1978 federal bankruptcy law contains a set of national exemptions, which debtors in bankruptcy are permitted to use instead of their state\u27s exemptions unless the state has formally opted out of the federal system. We contend that states\u27 decisions to opt out shed light on their exemption levels. We find that states are more likely to opt out if their state exemption is lower than the federal exemption and that states are more likely to opt out if they also have a high bankruptcy filing rate and transfer little money to the poor. These latter findings suggest that studies that examine the impact of exemptions on, for example, the bankruptcy rate should not treat exemption levels as exogenous variables

The Role of Overexpressed HER2 in Transformation

The HER family of receptors has an important role in the network of cell signals controlling cell growth and differentiation. Although the activity of the HER receptor is strictly controlled in normal cells, HER2 receptor overexpression plays a pivotal role in transformation and tumorigenesis. HER2 gene amplification and/or overexpression of the receptor has been detected in subsets of a wide range of human cancers including breast cancer, and is an indicator of poor prognosis. It is proposed that overexpressed HER2 in combination with HER3 causes high activity of cell-signaling networks, thereby resulting in tumor cell proliferation. Thus, the HER2 receptor is an attractive target for new anti-cancer treatments. Mono-clonal antibodies directed against the receptor are the most promising of these, and the humanized anti-HER2 monoclonal antibody trastuzumab (Herceptin) has shown significant clinical efficacy in clinical trials. The anti-tumor mechanisms of anti-HER2 monoclonal antibodies are not completely understood. However, some tumor types are not sensitive to trastuzumab, suggesting that the response of a tumor to trastuzumab may not only be dependent on overexpressed HER2, but may also be influenced by other members of the HER receptor family expressed in the tumor cel

Optical and Near Infrared Monitoring of the Black-Hole X-ray Binary GX 339-4 During 2002-2010

We present the optical/infra-red lightcurve (O/IR) of the black hole X-ray binary GX 339-4 collected at the SMARTS 1.3m telescope from 2002 to 2010. During this time the source has undergone numerous state transitions including hard-to-soft state transitions when we see large changes in the near-IR flux accompanied by modest changes in optical flux, and three rebrightening events in 2003, 2005 and 2007 after GX 339-4 transitioned from the soft state to the hard. All but one outburst show similar behavior in the X-ray hardness-intensity diagram. We show that the O/IR colors follow two distinct tracks that reflect either the hard or soft X-ray state of the source. Thus, either of these two X-ray states can be inferred from O/IR observations alone. From these correlations we have constructed spectral energy distributions of the soft and hard states. During the hard state, the near-IR data have the same spectral slope as simultaneous radio data when GX 339-4 was in a bright optical state, implying that the near-IR is dominated by a non-thermal source, most likely originating from jets. Non-thermal emission dominates the near-IR bands during the hard state at all but the faintest optical states, and the fraction of non-thermal emission increases with increasing optical brightness. The spectral slope of the optical bands indicate that a heated thermal source is present during both the soft and hard X-ray states, even when GX 339-4 is at its faintest optical state. We have conducted a timing analysis of the light curve for the hard and soft states and find no evidence of a characteristic timescale within the range of 4-230 days.Comment: Accepted for publication in AJ, Table 3 can be viewed at http://www.astro.yale.edu/buxton/GX339