72 research outputs found

    Hard Hat Ambient Liability Observer (HALO)

    Get PDF
    Capturing workplace incident information is a growing area of concern for most companies. To assist with this, the design team proposed the H.A.L.O. This design uses time-of-flight sensors connected to LEDs to create a proximity-based hazard warning system. It also records incident data using an accelerometer and micro-SD card. This helps workers avoid some of the most common workplace injuries, slips, trips, and falls and accidental collisions. Students have created a design with engineering, and marketing requirements that accomplish this task. The proposed design allows for this monitoring and mitigation systems to be attached to hard hats. Team members developed software and hardware subsystems to fit on any hardhat without hindering worker safety. The completed design uses the systems listed above register hazardous objects within 1.5m and color shifts depending on distance. Within the 150-degree FOV, any objects approaching the device are registered. In case of a possible concussive event, collision data writes to a SD card for use during an incident investigation. After a semester of development and integration, the H.A.L.O. system met the engineering requirements to assist with preventing workplace injury in a cost-effective manner

    Antigen presenting cells link the female genital tract microbiome to mucosal inflammation, with hormonal contraception as an additional modulator of inflammatory signatures

    Get PDF
    The microbiome of the female genital tract (FGT) is closely linked to reproductive health outcomes. Diverse, anaerobe-dominated communities with lo

    Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures

    Get PDF
    The microbiome of the female genital tract (FGT) is closely linked to reproductive health outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance are associated with a number of adverse reproductive outcomes, such as preterm birth, cervical dysplasia, and sexually transmitted infections (STIs), including HIV. Vaginal dysbiosis is associated with local mucosal inflammation, which likely serves as a biological mediator of poor reproductive outcomes. Yet the precise mechanisms of this FGT inflammation remain unclear. Studies in humans have been complicated by confounding demographic, behavioral, and clinical variables. Specifically, hormonal contraception is associated both with changes in the vaginal microbiome and with mucosal inflammation. In this study, we examined the transcriptional landscape of cervical cell populations in a cohort of South African women with differing vaginal microbial community types. We also investigate effects of reproductive hormones on the transcriptional profiles of cervical cells, focusing on the contraceptive depot medroxyprogesterone acetate (DMPA), the most common form of contraception in sub-Saharan Africa. We found that antigen presenting cells (APCs) are key mediators of microbiome associated FGT inflammation. We also found that DMPA is associated with significant transcriptional changes across multiple cell lineages, with some shared and some distinct pathways compared to the inflammatory signature seen with dysbiosis. These results highlight the importance of an integrated, systems-level approach to understanding host-microbe interactions, with an appreciation for important variables, such as reproductive hormones, in the complex system of the FGT mucosa

    Chov axolotla (Ambystoma mexicanum)

    No full text
    corecore