Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding

Physics of Solar Prominences: II - Magnetic Structure and Dynamics

Observations and models of solar prominences are reviewed. We focus on non-eruptive prominences, and describe recent progress in four areas of prominence research: (1) magnetic structure deduced from observations and models, (2) the dynamics of prominence plasmas (formation and flows), (3) Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and large-scale patterns of the filament channels in which prominences are located. Finally, several outstanding issues in prominence research are discussed, along with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape

The Origin, Early Evolution and Predictability of Solar Eruptions

Coronal mass ejections (CMEs) were discovered in the early 1970s when space-borne coronagraphs revealed that eruptions of plasma are ejected from the Sun. Today, it is known that the Sun produces eruptive flares, filament eruptions, coronal mass ejections and failed eruptions; all thought to be due to a release of energy stored in the coronal magnetic field during its drastic reconfiguration. This review discusses the observations and physical mechanisms behind this eruptive activity, with a view to making an assessment of the current capability of forecasting these events for space weather risk and impact mitigation. Whilst a wealth of observations exist, and detailed models have been developed, there still exists a need to draw these approaches together. In particular more realistic models are encouraged in order to asses the full range of complexity of the solar atmosphere and the criteria for which an eruption is formed. From the observational side, a more detailed understanding of the role of photospheric flows and reconnection is needed in order to identify the evolutionary path that ultimately means a magnetic structure will erupt

Variations in settlement pattern of Irish Sea plaice (Pleuronectes platessa L.) as determined from a simulation model

A simulation model for the pelagic phase of Irish Sea plaice was constructed using parameters from the literature to estimate the distribution of settlement dates for the years 1963 to 1996. The numbers of individuals in the egg stages were reduced by age-one herring predation and a general source of mortality. The numbers of individuals in the larval stages were reduced by age-one herring predation and a food-related mortality. The duration of the egg and larval stages were temperature-dependent. Settlement patterns and numbers at metamorphosis were output. Settlement patterns and numbers at metamorphosis are driven by temperature. Increasing the temperature lowers the development time, increases the numbers at metamorphosis and lowers the pelagic daily instantaneous mortality. Later spawning caused later settlement and increased the final peak of settlement. Comparisons with unpublished field data on settlement for Port Erin Bay and data in the literature, showed similar patterns in settlement. However, comparisons with settlement data for 1986 in Red Wharf Bay showed a large difference between simulated and measured settlement pattern. More accurate parameter estimates, a better understanding of the processes in the pelagic phase and a critical evaluation of field estimation techniques are required to produce better models

Evolution of the pterosaur pelvis

Pterosaur pelvic girdles are complex structures that offer a wealth of phylogenetic and biomechanical information, but have been largely overlooked by pterosaur anatomists. Here, we review pterosaur pelvic morphology and find significant differences that correlate well with pterosaur clades identified in some phylogenetic analyses. We find that the length and orientation of the iliac processes, position of the acetabulum, extent of the ischiopubic plate and presence of supraneural fusion in adult individuals are taxonomically informative. Ontogenetic changes in pelvic morphology dictate that osteologically mature specimens are required to assess the development of many of these characteristics. We suggest that pelvic characters can readily be incorporated into pterosaur phylogenetic analyses and may assist in resolving the controversial interrelationships of this group. Distinctive pterosaur pelvic morphotypes suggest considerable differences in stance, locomotory kinematics and hindlimb functionality across the group

Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization

Host-parasite interactio