A critical overview of how English health and social care publications represent autistic adults’ intimate lives

Autistic people face more social barriers to, and experience greater anxiety around, intimate relationships than the general population in our majority neurotypical society, leading to increased loneliness and social isolation. National health and social care policies and publications should recognise these inequalities and guide service systems in reducing them. In this paper, we employ a document analysis design to analyse a cross-section of English national health and social care publications to investigate how autistic adults’ intimate lives are represented and prioritised in these publications. Most publications do not adequately and proportionally recognise or prioritise autistic people's intimate lives. They focus on the risks associated with sex and relationships and overlook autism-specific intimacy needs. They prioritise participation in the workforce while renouncing government responsibility for supporting intimate relationships which can reduce loneliness and alienation. We offer recommendations to ensure that health and social care publication processes better recognise intimate lives

Evaluating Environmental Impact Assessment (EIA) report quality in South African national parks

This research evaluates Environmental Impact Assessment (EIA) report quality for a selected sample of development projects in South African national parks. It applies an adapted version of an international EIA report quality review package to 24 developments within 10 national parks, across three EIA regimes. The results suggest good EIA report quality across all four quality review areas, with improvement over time, but also highlight particular weaknesses in terms of dealing with waste and, to a lesser extent, with significance and mitigation. To build on this research, the development of a sector-specific EIA report quality review package is recommended, with more emphasis on the strategic context, waste and water-related aspects. The conclusion is that EIA is well positioned to remain an important decision support instrument for developments within national parks. Conservation implications: The results show that EIA reports for developments in South African national parks are generally of sufficient quality for decision-making that benefits conservation. However, weaker performance regarding waste, significance determination, water-related impacts and a lack of consideration of strategic context requires a conservation-specific EIA report quality review package to improve report quality in the areas of weakness and thereby increase the value of EIA as an instrument for environmental governance and sustainable development in conservation areas

The complete inventory of receptors encoded by the rat natural killer cell gene complex

The natural killer cell gene complex (NKC) encodes receptors belonging to the C-type lectin superfamily expressed primarily by NK cells and other leukocytes. In the rat, the chromosomal region that starts with the Nkrp1a locus and ends with the Ly49i8 locus is predicted to contain 67 group V C-type lectin superfamily genes, making it one of the largest congregation of paralogous genes in vertebrates. Based on physical proximity and phylogenetic relationships between these genes, the rat NKC can be divided into four major parts. We have previously reported the cDNA cloning of the majority of the genes belonging to the centromeric Nkrp1/Clr cluster and the two telomeric groups, the Klre1–Klri2 and the Ly49 clusters. Here, we close the gap between the Nkrp1/Clr and the Klre1–Klri2 clusters by presenting the cDNA cloning and transcription patterns of eight genes spanning from Cd69 to Dectin1, including the novel Clec2m gene. The definition, organization, and evolution of the rat NKC are discussed

Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease

Upper limb rehabilitation using robotic exoskeleton systems: a systematic review

Exoskeleton assisted therapy has been reported as a significant reduction in impairment and gain in functional abilities of stroke patients. In this paper, we conduct a systematic review on the upper limb rehabilitation using robotic exoskeleton systems. This review is based on typical mechanical structures and control strategies for exoskeletons in clinical rehabilitation conditions. A variety of upper limb exoskeletons are classified and reviewed according to their rehabilitation joints. Special attentions are paid to the performance control strategies and mechanism designs in clinical trials and to promote the adaptability to different patients and conditions. Finally, we analyze and highlight the current research gaps and the future directions in this field. We intend to offer informative resources and reliable guidance for relevant researcher’s further studies, and exert a far-reaching influence on the development of advanced upper limb exoskeleton robotic systems

Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.

Inhibitory receptors are required for the control of cellular activation and they play essential roles in regulating homeostasis and immunity. We previously identified a human inhibitory C-type lectin-like receptor, MICL (CLEC12A), a heavily glycosylated monomer predominantly expressed on myeloid cells. Here we characterise the murine homolog of MICL (mMICL), and demonstrate that the receptor is structurally and functionally similar to the human orthologue (hMICL), although there are some notable differences. mMICL is expressed as a dimer and is not heavily glycosylated; however, like hMICL, the receptor can recruit inhibitory phosphatases upon activation, and is down-regulated on leukocytes following stimulation with selected TLR agonists. Using novel monoclonal antibodies, we demonstrate that, like the human receptor, mMICL is predominantly expressed by myeloid cells. However, mMICL is also expressed by B cells and CD8+ T cells in peripheral blood, and NK cells in the bone marrow. Finally, we show that mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis

Passive Upper Limb Exoskeletons: An Experimental Campaign with Workers

Wearable exoskeletons are currently evaluated as technological aids for workers on the factory floor, as suggested by the philosophy of Industry 4.0. The paper presents the results of experimental tests carried out on a first prototype of a passive upper limbs exoskeleton developed by IUVO. Eighteen FCA workers participated to the study. Experimental tests were designed to evaluate the influence of the exoskeleton while accomplishing different tasks, both in static and dynamic conditions. Quantitative and qualitative parameters were analyzed to evaluate usability, potential benefits and acceptability of the device. Results show, on average, that wearing the exoskeleton has a positive effect in increasing: (i) endurance time while holding demanding postures with raised arms and/or having to lift and hold small work tools, (ii) endurance time and accuracy execution in precision tasks. The users also declared a lower perceived effort, while performing tasks with the exoskeleton