6,844 research outputs found
Building Vietnamese Health Information Capacity through Medical Library/Librarian Development: A report to the U.S. National Library of Medicine International Programs Office
H.E.S.S. observations of galaxy clusters
Clusters of galaxies, the largest gravitationally bound objects in the
universe, are expected to contain a significant population of hadronic and
leptonic cosmic rays. Potential sources for these particles are merger and
accretion shocks, starburst driven galactic winds and radio galaxies.
Furthermore, since galaxy clusters confine cosmic ray protons up to energies of
at least 1 PeV for a time longer than the Hubble time they act as storehouses
and accumulate all the hadronic particles which are accelerated within them.
Consequently clusters of galaxies are potential sources of VHE (> 100 GeV)
gamma rays. Motivated by these considerations, promising galaxy clusters are
observed with the H.E.S.S. experiment as part of an ongoing campaign. Here,
upper limits for the VHE gamma ray emission for the Abell 496 and Coma cluster
systems are reported.Comment: Contribution to the 30th ICRC, Merida Mexico, July 200
Effects of lattice distortion and Jahn–Teller coupling on the magnetoresistance of La0.7Ca0.3MnO3 and La0.5Ca0.5CoO3 epitaxial films
Studies of La0.7Ca0.3MnO3 epitaxial films on substrates with a range of lattice constants reveal two dominant contributions to the occurrence of colossal negative magnetoresistance (CMR) in these manganites: at high temperatures (T → TC, TC being the Curie temperature), the magnetotransport properties are predominantly determined by the conduction of lattice polarons, while at low temperatures (T ≪ TC/, the residual negative magnetoresistance is correlated with the substrate-induced lattice distortion which incurs excess magnetic domain wall scattering. The importance of lattice polaron conduction associated with the presence of Jahn–Teller coupling in the manganites is further verified by comparing the manganites with epitaxial films of another ferromagnetic perovskite, La0.5Ca0.5CoO3. Regardless of the differences in the substrate-induced lattice distortion, the cobaltite films exhibit much smaller negative magnetoresistance, which may be attributed to the absence of Jahn–Teller coupling and the high electron mobility that prevents the formation of lattice polarons. We therefore suggest that lattice polaron conduction associated with the Jahn–Teller coupling is essential for the occurrence of CMR, and that lattice distortion further enhances the CMR effects in the manganites
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The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells.
Background:Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics have been investigated in a variety of cancer types. particularly in diseases with high inflammation and NFĸB activation. Given that elevated TNFα levels and NFĸB activation is a characteristic feature of myeloproliferative neoplasms (MPN), we investigated the effect of the SMAC mimetic LCL-161 on MPN cell survival in vitro and disease development in vivo. Methods:To investigate the effect of the SMAC mimetic LCL-161 in vitro, we utilized murine and human cell lines to perform cell viability assays as well as primary bone marrow from mice or humans with JAK2V617F-driven MPN to interrogate myeloid colony formation. To elucidate the effect of the SMAC mimetic LCL-161 in vivo, we treated a JAK2V617F-driven mouse model of MPN with LCL-161 then assessed blood counts, splenomegaly, and myelofibrosis. Results:We found that JAK2V617F-mutated cells are hypersensitive to the SMAC mimetic LCL-161 in the absence of exogenous TNFα. JAK2 kinase activity and NFĸB activation is required for JAK2V617F-mediated sensitivity to LCL-161, as JAK or NFĸB inhibitors diminished the differential sensitivity of JAK2V617F mutant cells to IAP inhibition. Finally, LCL-161 reduces splenomegaly and may reduce fibrosis in a mouse model of JAK2V617F-driven MPN. Conclusion:LCL-161 may be therapeutically useful in MPN, in particular when exogenous TNFα signaling is blocked. NFĸB activation is a characteristic feature of JAK2V617F mutant cells and this sensitizes them to SMAC mimetic induced killing even in the absence of TNFα. However, when exogenous TNFα is added, NFĸB is activated in both mutant and wild-type cells, abolishing the differential sensitivity. Moreover, JAK kinase activity is required for the differential sensitivity of JAK2V617F mutant cells, suggesting that the addition of JAK2 inhibitors to SMAC mimetics would detract from the ability of SMAC mimetics to selectively target JAK2V617F mutant cells. Instead, combination therapy with other agents that reduce inflammatory cytokines but preserve JAK2 signaling in mutant cells may be a more beneficial combination therapy in MPN
Quantum coherence engineering in the integer quantum Hall regime
We present an experiment where the quantum coherence in the edge states of
the integer quantum Hall regime is tuned with a decoupling gate. The coherence
length is determined by measuring the visibility of quantum interferences in a
Mach-Zehnder interferometer as a function of temperature, in the quantum Hall
regime at filling factor two. The temperature dependence of the coherence
length can be varied by a factor of two. The strengthening of the phase
coherence at finite temperature is shown to arise from a reduction of the
coupling between co-propagating edge states. This opens the way for a strong
improvement of the phase coherence of Quantum Hall systems. The decoupling gate
also allows us to investigate how inter-edge state coupling influence the
quantum interferences' dependence on the injection bias. We find that the
finite bias visibility can be decomposed into two contributions: a Gaussian
envelop which is surprisingly insensitive to the coupling, and a beating
component which, on the contrary, is strongly affected by the coupling.Comment: 4 pages, 5 figure
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The pattern of foreign property investment in Vietnam: the apartment market in Ho Chi Minh City
As globalization proceeds, transnational property development is increasing. Especially in emerging markets, foreign developers’ influence in changing the local landscape is becoming significant. In this research, the behavioral patterns of foreign developers in the apartment market of Ho Chi Minh City, Vietnam were identified. To understand the dynamics of foreign developers, the types of products that were being created, where the investments were located, and the differences in development strategies adopted by foreign developers in comparison to domestic counterparts were identified. To accomplish this, data on apartment projects and statistics were collected, and a series of spatial analyses including sieve mapping, histogram analysis, factor analysis and logistic regression was conducted. In addition, closer examination was made of specific cases to understand the dynamics among foreign and domestic developers, also allowing the identification of some regularities in the patterns of foreign developments. Besides presenting detailed results, this paper also seeks to account for the conditions that appear to have generated these patterns and characteristics
Unary Pushdown Automata and Straight-Line Programs
We consider decision problems for deterministic pushdown automata over a
unary alphabet (udpda, for short). Udpda are a simple computation model that
accept exactly the unary regular languages, but can be exponentially more
succinct than finite-state automata. We complete the complexity landscape for
udpda by showing that emptiness (and thus universality) is P-hard, equivalence
and compressed membership problems are P-complete, and inclusion is
coNP-complete. Our upper bounds are based on a translation theorem between
udpda and straight-line programs over the binary alphabet (SLPs). We show that
the characteristic sequence of any udpda can be represented as a pair of
SLPs---one for the prefix, one for the lasso---that have size linear in the
size of the udpda and can be computed in polynomial time. Hence, decision
problems on udpda are reduced to decision problems on SLPs. Conversely, any SLP
can be converted in logarithmic space into a udpda, and this forms the basis
for our lower bound proofs. We show coNP-hardness of the ordered matching
problem for SLPs, from which we derive coNP-hardness for inclusion. In
addition, we complete the complexity landscape for unary nondeterministic
pushdown automata by showing that the universality problem is -hard, using a new class of integer expressions. Our techniques have
applications beyond udpda. We show that our results imply -completeness for a natural fragment of Presburger arithmetic and coNP lower
bounds for compressed matching problems with one-character wildcards
Suppression of backward scattering of Dirac fermions in iron pnictides Ba(FeRuAs)
We report electronic transport of Dirac cones when Fe is replaced by Ru,
which has an isoelectronic electron configuration to Fe, using single crystals
of Ba(FeRuAs). The electronic transport of parabolic bands is
shown to be suppressed by scattering due to the crystal lattice distortion and
the impurity effect of Ru, while that of the Dirac cone is not significantly
reduced due to the intrinsic character of Dirac cones. It is clearly shown from
magnetoresistance and Hall coefficient measurements that the inverse of average
mobility, proportional to cyclotron effective mass, develops as the square root
of the carrier number (n) of the Dirac cones. This is the unique character of
the Dirac cone linear dispersion relationship. Scattering of Ru on the Dirac
cones is discussed in terms of the estimated mean free path using experimental
parameters.Comment: 6 pages, 3 figures, To be published in Phys. Rev.
Long-term maintenance of pediatric asthma: focus on budesonide/formoterol inhalation aerosol
Current national and international asthma guidelines recommend treatment of children with asthma towards achieving and maintaining asthma control. These guidelines provide more stringent recommendations to increase therapy for patients with uncontrolled asthma in order to reduce asthma-related morbidity and mortality. Newer combination agents such as budesonide and formoterol have been shown to be safe and effective in treatment of asthma in children. Use of long-term controller agents like this in combination with improved compliance and treatment of co-morbid conditions have been successful in this endeavor. This review discusses control of pediatric asthma with focus on the use of budesonide in combination with formoterol
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