An analysis of the effect of a particular class of PFM on noise inputs

Statistical analysis of pulse frequency modulation systems with white noise inpu

Statistical and stability analyses of neural pulse frequency modulator Semiannual status report, period ending 1 Feb. 1969

Statistical analysis of neural pulse frequency modulato

The enviornmental assessment of a contemporary coal mining system

A contemporary underground coal mine in eastern Kentucky was assessed in order to determine potential off-site and on-site environmental impacts associated with the mining system in the given environmental setting. A 4 section, continuous room and pillor mine plan was developed for an appropriate site in eastern Kentucky. Potential environmental impacts were identified, and mitigation costs determined. The major potential environmental impacts were determined to be: acid water drainage from the mine and refuse site, uneven subsidence of the surface as a result of mining activity, and alteration of ground water aquifers in the subsidence zone. In the specific case examined, the costs of environmental impact mitigation to levels prescribed by regulations would not exceed $1/ton of coal mined, and post mining land values would not be affected

Observation of magnetocoriolis waves in a liquid metal Taylor-Couette experiment

The first observation of fast and slow magnetocoriolis (MC) waves in a laboratory experiment is reported. Rotating nonaxisymmetric modes arising from a magnetized turbulent Taylor-Couette flow of liquid metal are identified as the fast and slow MC waves by the dependence of the rotation frequency on the applied field strength. The observed slow MC wave is damped but the observation provides a means for predicting the onset of the Magnetorotational Instability

Local Rules and Procedures of the United States Court of Appeals for the Federal Circuit

The Federal Courts Improvement Act of 1982 abolished the United States Court of Claims and the United States Court of Customs and Patent Appeals and created the United States Court of Appeals for the Federal Circuit (CAFC) and the United States Claims Court. The Act provided for an advisory committee to be appointed by the CAFC in order to study the proposed rules of practice and internal operating procedures of the court. The recommendations of the advisory committee were given considerable weight when the court promulgated the Rules of the United States Court of Appeals for the Federal Circuit (CAFC Rules), and a procedural handbook effective October 1, 1982. The rules are intended to supplement the Federal Rules of Appellate Procedure and to reflect the court\u27s nationwide and varied jurisdiction, as well as a commitment to the expeditious determination of cases brought before it. This Article walks through the more pertinent rules which help to illustrate how the court will operate, as well as clarify earlier points of confusion

Dissipation in nanocrystalline-diamond nanomechanical resonators

We have measured the dissipation and frequency of nanocrystalline-diamond nanomechanical resonators with resonant frequencies between 13.7 MHz and 157.3 MHz, over a temperature range of 1.4–274 K. Using both magnetomotive network analysis and a time-domain ring-down technique, we have found the dissipation in this material to have a temperature dependence roughly following T^(0.2), with Q^(–1) ≈ 10^(–4) at low temperatures. The frequency dependence of a large dissipation feature at ~35–55 K is consistent with thermal activation over a 0.02 eV barrier with an attempt frequency of 10 GHz

The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes

Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts. The evolution of such gene families is typically driven by gene duplication, followed by point mutation and gene conversion. There is great interest in estimating the rates of these processes from molecular sequences for understanding the evolution of the pathogen and its significance for infection processes. In this study, a series of models are constructed to investigate hypotheses about the nucleotide diversity patterns between closely related gene sequences from the antigen gene archive of the African trypanosome, the protozoan parasite causative of human sleeping sickness in Equatorial Africa. We use a hidden Markov model approach to identify two scales of diversification: clustering of sequence mismatches, a putative indicator of gene conversion events with other lower-identity donor genes in the archive, and at a sparser scale, isolated mismatches, likely arising from independent point mutations. In addition to quantifying the respective probabilities of occurrence of these two processes, our approach yields estimates for the gene conversion tract length distribution and the average diversity contributed locally by conversion events. Model fitting is conducted using a Bayesian framework. We find that diversifying gene conversion events with lower-identity partners occur at least five times less frequently than point mutations on variant surface glycoprotein (VSG) pairs, and the average imported conversion tract is between 14 and 25 nucleotides long. However, because of the high diversity introduced by gene conversion, the two processes have almost equal impact on the per-nucleotide rate of sequence diversification between VSG subfamily members. We are able to disentangle the most likely locations of point mutations and conversions on each aligned gene pair

Prognostically controlled comparison of dialysis and renal transplantation

Prognostically controlled comparison of dialysis and renal transplantation. Because the comparison of survival in patients with renal failure treated by dialysis and transplantation may be biased by pretreatment prognostic differences in the patients who receive these two therapies, we quantified the pretreatment prognosis of all 430 dialysis and transplant patients who began therapy for end-stage renal disease at two hospitals from 1970 to 1980. Five pretreatment factors had a statistically significant adverse effect on survival: age, duration of diabetes, left ventricular failure, myocardial infarction, and other serious comorbid illness. Dialysis patients had a worse pretreatment prognosis than transplant patients did. When we controlled for these pretreatment differences, the actuarial 5-year patient survivals were 80% for dialysis (D), 79% for cadaver transplantation (CT), and 91% for living donor transplantation (LDT), (P = 0.9 for CT vs. D, and P = 0.05 for LDT vs. D). This similarity in survival with dialysis and cadaver transplantation was quite different from the results obtained when pretreatment prognosis was not controlled; the uncontrolled 5-year patient survivals were 43% for D, 77% for CT, and 89% for LDT (P < 0.001 for CT vs. D, and P < 0.001 for LDT vs. D). Our data suggest that the major factor determining differences in survival with dialysis and renal transplantation is not the relative efficacy of the two treatments but the pretreatment prognostic status of the patients chosen to receive them.Une comparaison contrôlée de façon pronostique entre la dialyse et la transplantation rénale. Puisque la comparaison de la survie des malades en insuffisance rénale traités par dialyse ou par transplantation peut être biaisée par des différences pronostiques pré-thérapeutiques entre les malades qui reçoivent ces deux traitements, nous avons quantifié le pronostic pré-thérapeutique de l'ensemble des 430 malades dialysés et transplantés qui ont commencé le traitement de leur insuffisance rénale dans deux hôpitaux de 1970 à 1980. Cinq facteurs préthérapeutiques possédaient un effet adverse statistiquement significatif sur la survie: l'âge, la durée du diabète, une insuffisance ventriculaire gauche, un infarctus du myocarde, et une autre maladie sérieuse associée. Les dialysés avaient un pronostic pré-thérapeutique plus mauvais que les transplantés. Lorsque nous avons contrôlé ces différences pré-thérapeutiques, la survie actuarielle à 5 ans des malades était de 80% pour la dialyse (D), 79% pour la transplantation cadavérique (CT), et 91% pour la transplantation avec donneur vivant (LDT) (P = 0,9 pour CT contre D, et P = 0,05 pour LDT contre D). Cette similitude de survie en dialyse ou après transplantation cadavérique était très différente des résultats obtenus lorsque le pronostic pré-thérapeutique n'était pas contrôlé; les survies non contrôlées à 5 ans des malades étaient de 43% pour D, 77% pour CT, et 89% pour LDT (P < 0,001 pour CT contre D, et P < 0,001 pour LDT contre D). Nos données suggèrent que le facteur principal déterminant les différences de survie en dialyse ou après transplantation rénale n'est pas l'efficacité relative des deux traitements, mais l'état pronostique pré-thérapeutique des malades choisis pour les recevoir