Induction of mitotic and meiotic gynogenesis and production of genetic clones in rohu, Labeo rohita Ham.

Studies were undertaken to produce genetic clones derived from all homozygous mitotic gynogenetic individuals in rohu, Labeo rohita Ham. ln view of this, attempts were made to interfere with the normal functioning of the spindle apparatus during the first mitotic cell division of developing eggs using heat shocks, there by leading to the induction of mitotic gynogenetic diploids in the F1 generation. Afterwards, viable mitotic gynogenetic alevins were reared and a selected mature female fish was used to obtain ovulated eggs which were fertilized later with UV-irradiated milt. Milt was diluted with Cortland’s solution and the sperm concentration was maintained at 10⁸/ml. The UV-irradiation was carried out for 2 minutes at the intensity of 200 to 250 µW/cm² at 28± 1°C. The optimal heat shock of 40°C for 2 minutes applied at 25 to 30 minutes a.f. was used to induce mitotic gynogenesis in first (F1) generation and at 3 to 5 minutes a.f. to induce meiotic gynogenesis in the second (F2) generation. The results obtained are presented and the light they shed on the timing of the mitotic and meiotic cell division in this species is discussed

Digital wellbeing tools through users lens

There is a growing recognition of excessive, compulsive, and hasty use of technology as an emerging form of problematic behavior affecting individuals' emotional, social, and occupational wellbeing. Smartphone overuse, in particular, has been linked to negative effects on users' quality of life, such as anxiety, depression, sleep disturbance and loss in productivity. One strategy to help regulate digital usage and, potentially, increase digital wellbeing is to devise smartphone applications to collect data about usage and increase users' awareness of it and enable them to set limits and alert users accordingly. However, such applications have not been extensively evaluated from the users' perspective and whether they help the basic requirements for digital wellbeing. In this paper, we examine the quality of the emerging family of digital wellbeing smartphone applications from the users' perspective and based on persuasive design and established behavioral change theories. We performed a thematic analysis on the users’ reviews on two popular applications, SPACE Break Phone Addiction and Google Digital Wellbeing (GDW). We report on the factors influencing user acceptance and rejection towards digital wellbeing applications and identify possible challenges and opportunities to improve their design and role in future releases

3-years later… a reassessment of the need for something ‘in-between’

Welcome to the 2017 issue of INTER-SECTION: Innovative approaches by Junior Archaeological Researchers. In this issue, we present a total of five papers written by archaeology students in close collaboration with their academic referees, reflecting the wide range of both research and teaching at Leiden's Faculty of Archaeology from the the BA to the MA level

New Universality of Baryon Isgur--Wise Form Factor in the Large NcN_c limit

New universality appears for the baryon Isgur--Wise form factor in the large $N_c$ limit. It is found that the semileptonic $\Lambda_b \rightarrow \Lambda_c$ and $\Sigma_b^{(*)} \rightarrow \Sigma^{(*)}_c$ decays are described by the same form factor, which can be calculated analytically. In the exact chiral $SU(3)$ limit, the same form factor is applicable to semileptonic $\Omega_b^{(*)} \rightarrow \Omega^{(*)}_c$ decays.Comment: 5 pages in REVTEX galley style, CALT-68-194

Second Order Power Corrections in the Heavy Quark Effective Theory I. Formalism and Meson Form Factors

In the heavy quark effective theory, hadronic matrix elements of currents between two hadrons containing a heavy quark are expanded in inverse powers of the heavy quark masses, with coefficients that are functions of the kinematic variable $v\cdot v'$. For the ground state pseudoscalar and vector mesons, this expansion is constructed at order $1/m_Q^2$. A minimal set of universal form factors is defined in terms of matrix elements of higher dimension operators in the effective theory. The zero recoil normalization conditions following from vector current conservation are derived. Several phenomenological applications of the general results are discussed in detail. It is argued that at zero recoil the semileptonic decay rates for $B\to D\,\ell\,\nu$ and $B\to D^*\ell\,\nu$ receive only small second order corrections, which are unlikely to exceed the level of a few percent. This supports the usefulness of the heavy quark expansion for a reliable determination of $V_{cb}$.Comment: (34 pages, REVTEX, two postscript figures available upon request), SLAC-PUB-589

\Omb \rightarrow \Omc , \Omc ^* $ transitions: Model-independent bounds on invariant form factors

In this note we report some model-independent bounds involving transition form factors for \Omb \rightarrow \Omc and \Omb \rightarrow \Omc ^* and the nonperturbative matrix elements of the \Omb system. They are derived by using operator product expansion (OPE) in Heavy Quark Effective Theory .Comment: Latex, 7 page

Excited ΛQ\Lambda_Q Baryons in the Large NcN_c Limit

The spectrum of excited $\Lambda_Q$-type heavy baryons is considered in the large $N_c$ limit. The universal form factors for $\Lambda_b$ semileptonic decay to excited charmed baryons are calculated in the large $N_c$ limit. We find that the Bjorken sum rule (for the slope of the Isgur--Wise function) and Voloshin sum rule (for the mass of the light degrees of freedom) are saturated by the first doublet of excited $\Lambda_Q$ states.Comment: 9 pages, use phyzzx, CALT-68-191

Leptonic and Semileptonic Decays of Charm and Bottom Hadrons

We review the experimental measurements and theoretical descriptions of leptonic and semileptonic decays of particles containing a single heavy quark, either charm or bottom. Measurements of bottom semileptonic decays are used to determine the magnitudes of two fundamental parameters of the standard model, the Cabibbo-Kobayashi-Maskawa matrix elements $V_{cb}$ and $V_{ub}$. These parameters are connected with the physics of quark flavor and mass, and they have important implications for the breakdown of CP symmetry. To extract precise values of $|V_{cb}|$ and $|V_{ub}|$ from measurements, however, requires a good understanding of the decay dynamics. Measurements of both charm and bottom decay distributions provide information on the interactions governing these processes. The underlying weak transition in each case is relatively simple, but the strong interactions that bind the quarks into hadrons introduce complications. We also discuss new theoretical approaches, especially heavy-quark effective theory and lattice QCD, which are providing insights and predictions now being tested by experiment. An international effort at many laboratories will rapidly advance knowledge of this physics during the next decade.Comment: This review article will be published in Reviews of Modern Physics in the fall, 1995. This file contains only the abstract and the table of contents. The full 168-page document including 47 figures is available at http://charm.physics.ucsb.edu/papers/slrevtex.p

Comprehensive lung injury pathology induced by mTOR inhibitors

Molecular Targets in Oncology[Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibro-proliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors