Optimization of underwater composite enclosure design using response surface methodology

222-226The present work deals with the development of optimized design of composite underwater enclosure using response surface methodology (RSM), the box-like shape of enclosure was proposed by using E-glass (Fiber Reinforced Polymer) FRP composite materials. The utilization of finite element analysis was more acceptable instead of experimental approach. The number of FEA simulation was simplified by using design of experiment (DOE) technique. A polynomial mathematical model, in term of enclosure shell thickness and pressure for the factors; stress and deflection for the response correlations was represented. As a result, all the factors indicate significantly affecting the optimization and the design process of the underwater enclosure

An expensive spice saffron (Crocus sativus L.): A case study from Kashmir, Iran, and Turkey

[No abstract available

Review of Factors Affecting Organogenesis, Somatic Embryogenesis and Agrobacterium tumefaciens-Mediated Transformation of Strawberry

Invited Review: Standardization of an efficient regeneration system for each strawberry genotype is generally an indispensible pre-requisite for the successful development of transgenic plants. In this paper, we review some key factors affecting the regeneration of strawberry plants via adventitious organogenesis or somatic embryogenesis, such as type of explant, growth regulators or dark/light treatments. Since Agrobacterium tumefaciens-mediated transformation is the method of choice for strawberry transformation, we review the strategies adopted by different scientists to achieve higher transformation efficiencies and recovery of marker-free transgenic plants. Sufficient Agrobacterium cells during cocultivation, an adequate cocultivation period, the use of vir gene inducers like acetosyringone, introduction of a pre-selection phase between co-cultivation and selection, and optimum selection pressure, are all important factors to obtain stable transformants. For effective transformation, the antibiotic regime should control bacterial growth without inhibiting the regeneration of plant cells. A general protocol for the Agrobacterium transformation of strawberry leaf discs is also described. Finally, we discuss the metrics employed by different researchers for measuring the success of transformation, and highlight the difference between transformation efficiency and transformation percentage

microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review

Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological processes and have been implicated in the development and progression of many diseases, including cancer. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two prominent classes of ncRNAs that have emerged as key players in cancer pathophysiology. In particular, miR-21 has been reported to exhibit oncogenic roles in various forms of human cancer, including prostate, breast, lung, and colorectal cancer. In this context, miR-21 overexpression is closely associated with tumor proliferation, growth, invasion, angiogenesis, and chemoresistance, whereas miR-21 inactivation is linked to the regression of most tumor-related processes. Accordingly, miR-21 is a crucial modulator of various canonical oncogenic pathways such as PTEN/PI3K/Akt, Wnt/β-catenin, STAT, p53, MMP2, and MMP9. Moreover, interplays between lncRNA and miRNA further complicate the regulatory mechanisms underlying tumor development and progression. In this regard, several lncRNAs have been found to interact with miR-21 and, by functioning as competitive endogenous RNAs (ceRNAs) or miRNA sponges, can modulate cancer tumorigenesis. This work presents and discusses recent findings highlighting the roles and pathophysiological implications of the miR-21-lncRNA regulatory axis in cancer occurrence, development, and progression. The data collected indicate that specific lncRNAs, such as MEG3, CASC2, and GAS5, are strongly associated with miR-21 in various types of cancer, including gastric, cervical, lung, and glioma. Indeed, these lncRNAs are well-known tumor suppressors and are commonly downregulated in different types of tumors. Conversely, by modulating various mechanisms and oncogenic signaling pathways, their overexpression has been linked with preventing tumor formation and development. This review highlights the significance of these regulatory pathways in cancer and their potential for use in cancer therapy as diagnostic and prognostic markers.This work was made possible by grants from \u201CProgetto Fondazione di Sardegna -Bando 2022\u20132023\u201D and \u201C, European Union\u2014 NextGenerationEU - DM 737/2021 resources 2021\u20132022\u201D

An anthology of islamic studies

This book discuss about antology of islamic studies and published by McGill Indonesia IAIN development project.162 p.: ilus.; 28 c

On islamic civilization : menyalakan kembali lentera peradaban islam yang sempat padam

Buku sederhana ini hanya mengatakan, "ketika Tuhan mulai kita tanggalkan, maka tsunami kehidupan akan segera menghampiri kita." Benar, tsunami kehidupan akan menghampiri siapa saja yang berani meninggalkan dan/atau menanggalkan Tuhan. Tanpa pilih kasih. Tanpa pandang bulu.xxii, 723 hlm.: ilus.; 23 c

On islamic civilization : menyalakan kembali lentera peradaban islam yang sempat padam

Buku sederhana ini hanya mengatakan, "ketika Tuhan mulai kita tanggalkan, maka tsunami kehidupan akan segera menghampiri kita." Benar, tsunami kehidupan akan menghampiri siapa saja yang berani meninggalkan dan/atau menanggalkan Tuhan. Tanpa pilih kasih. Tanpa pandang bulu.xxii, 723 hlm.: ilus.; 23 c