Senescence and host–pathogen interactions

Damage to our genomes triggers cellular senescence characterised by stable cell cycle arrest and a pro-inflammatory secretome that prevents the unrestricted growth of cells with pathological potential. In this way, senescence can be considered a powerful innate defence against cancer and viral infection. However, damage accumulated during ageing increases the number of senescent cells and this contributes to the chronic inflammation and deregulation of the immune function, which increases susceptibility to infectious disease in ageing organisms. Bacterial and viral pathogens are masters of exploiting weak points to establish infection and cause devastating diseases. This review considers the emerging importance of senescence in the host–pathogen interaction: we discuss the pathogen exploitation of ageing cells and senescence as a novel hijack target of bacterial pathogens that deploys senescence-inducing toxins to promote infection. The persistent induction of senescence by pathogens, mediated directly through virulence determinants or indirectly through inflammation and chronic infection, also contributes to age-related pathologies such as cancer. This review highlights the dichotomous role of senescence in infection: an innate defence that is exploited by pathogens to cause disease

Results of an aqueous source term model for a radiological risk assessment of the Drigg LLW Site, U.K.

A radionuclide source term model has been developed which simulates the biogeochemical evolution of the Drigg low level waste (LLW) disposal site. The DRINK (DRIgg Near field Kinetic) model provides data regarding radionuclide concentrations in groundwater over a period of 100,000 years, which are used as input to assessment calculations for a groundwater pathway. The DRINK model also provides input to human intrusion and gaseous assessment calculations through simulation of the solid radionuclide inventory. These calculations are being used to support the Drigg post closure safety case. The DRINK model considers the coupled interaction of the effects of fluid flow, microbiology, corrosion, chemical reaction, sorption and radioactive decay. It represents the first direct use of a mechanistic reaction-transport model in risk assessment calculations

HD101584: Circumstellar characteristics and evolutionary status

We have performed a study of the characteristics of the circumstellar environment of the binary object HD101584, that provides information on a likely evolutionary scenario. We have obtained and analysed ALMA observations, complemented with observations using APEX, of a large number of molecular lines. An analysis of the spectral energy distribution has also been performed. Emissions from 12 molecular species (not counting isotopologues) have been observed, and most of them mapped with angular resolutions in the range 0.1" to 0.6". Four circumstellar components are identified: i) a central compact source of size 0.15", ii) an expanding equatorial density enhancement (a flattened density distribution in the plane of the orbit) of size 3", iii) a bipolar high-velocity outflow (150 km/s), and iv) an hourglass structure. The outflow is directed almost along the line of sight. There is evidence of a second bipolar outflow. The mass of the circumstellar gas is 0.5[D/1 kpc]^2 Msun, about half of it lies in the equatorial density enhancement. The dust mass is 0.01[D/1 kpc]^2 Msun, and a substantial fraction of this is in the form of large-sized, up to 1 mm, grains. The estimated kinetic age of the outflow is 770[D/1 kpc] yr. The kinetic energy and the scalar momentum of the accelerated gas are estimated to be 7x10^(45)[D/1 kpc]^2 erg and 10^(39)[D/1 kpc]^2 g cm/s, respectively. We provide good evidence that the binary system HD101584 is in a post-common-envelope-evolution phase, that ended before a stellar merger. Isotope ratios combined with stellar mass estimates suggest that the primary star's evolution was terminated already on the first red giant branch (RGB). Most of the energy required to drive the outflowing gas was probably released when material fell towards the companion.Comment: Accepted for publication in A&

Environmental and ecological citizenship in civil society

Drawing from the work of Andrew Dobson, two notions of citizenship in civil society can be distinguished: environmental citizenship, which focuses on environmental rights and seeks to redefine the relationship between the state and the citizen; and ecological citizenship, which goes beyond a rights-based notion of citizenship to advocate the fair usage of ecological space across international borders. Using civil society initiatives to conserve forests, this article argues that these two notions of citizenship should be seen as overlapping in that civil society groups seek to work through national and international law to reduce the ecological footprint of some countries on others. The article concludes by drawing a distinction between the environmental state and the ecological state

Strongly star-forming rotating disks in a complex merging system at z = 4,7 as revealed by ALMA

We performed a kinematical analysis of the [CII] line emission of the BR 1202-0725 system at z~4,7 using ALMA observations. The most prominent sources of this system are a quasar and a submillimeter galaxy, separated by a projected distance of about 24 kpc and characterized by very high SFR, higher than 1000 Msun/yr. However, the ALMA observations reveal that these galaxies apparently have undisturbed rotating disks, which is at variance with the commonly accepted scenario in which strong star formation activity is induced by a major merger. We also detected faint components which, after spectral deblending, were spatially resolved from the main QSO and SMG emissions. The relative velocities and positions of these components are compatible with orbital motions within the gravitational potentials generated by the QSO host galaxy and the SMG, suggesting that they are smaller galaxies in interaction or gas clouds in accretion flows of tidal streams. We did not find any clear spectral evidence for outflows caused by AGN or stellar feedback. This suggests that the high star formation rates might be induced by interactions or minor mergers with these companions, which do not affect the large-scale kinematics of the disks, however. Our kinematical analysis also indicates that the QSO and the SMG have similar Mdyn, mostly in the form of molecular gas, and that the QSO host galaxy and the SMG are seen close to face-on with slightly different disk inclinations: the QSO host galaxy is seen almost face-on (i~15), while the SMG is seen at higher inclinations (i~25). Finally, the ratio between the black hole mass of the QSO, obtained from XShooter spectroscopy, and the Mdyn of the host galaxy is similar to value found in very massive local galaxies, suggesting that the evolution of black hole galaxy relations is probably better studied with dynamical than with stellar host galaxy masses.Comment: Accepted for publication in Astronomy and Astrophysic

Aero-acoustics of Drag Generating Swirling Exhaust Flows

Aircraft on approach in high-drag and high-lift configuration create unsteady flow structures which inherently generate noise. For devices such as flaps, spoilers and the undercarriage there is a strong correlation between overall noise and drag such that, in the quest for quieter aircraft, one challenge is to generate drag at low noise levels. This paper presents a rigorous aero-acoustic assessment of a novel drag concept. The idea is that a swirling exhaust flow can yield a steady, and thus relatively quiet, streamwise vortex which is supported by a radial pressure gradient responsible for pressure drag. Flows with swirl are naturally limited by instabilities such as vortex breakdown. The paper presents a first aero-acoustic assessment of ram pressure driven swirling exhaust flows and their associated instabilities. The technical approach combines an in-depth aerodynamic analysis, plausibility arguments to qualitatively describe the nature of acoustic sources, and detailed, quantitative acoustic measurements using a medium aperture directional microphone array in combination with a previously established Deconvolution Approach for Mapping of Acoustic Sources (DAMAS). A model scale engine nacelle with stationary swirl vanes was designed and tested in the NASA Langley Quiet Flow Facility at a full-scale approach Mach number of 0.17. The analysis shows that the acoustic signature is comprised of quadrupole-type turbulent mixing noise of the swirling core flow and scattering noise from vane boundary layers and turbulent eddies of the burst vortex structure near sharp edges. The exposed edges are the nacelle and pylon trailing edge and the centerbody supporting the vanes. For the highest stable swirl angle setting a nacelle area based drag coefficient of 0.8 was achieved with a full-scale Overall Sound Pressure Level (OASPL) of about 40dBA at the ICAO approach certification point

K-orbit closures on G/B as universal degeneracy loci for flagged vector bundles with symmetric or skew-symmetric bilinear form

We use equivariant localization and divided difference operators to determine formulas for the torus-equivariant fundamental cohomology classes of $K$-orbit closures on the flag variety $G/B$, where G = GL(n,\C), and where $K$ is one of the symmetric subgroups O(n,\C) or Sp(n,\C). We realize these orbit closures as universal degeneracy loci for a vector bundle over a variety equipped with a single flag of subbundles and a nondegenerate symmetric or skew-symmetric bilinear form taking values in the trivial bundle. We describe how our equivariant formulas can be interpreted as giving formulas for the classes of such loci in terms of the Chern classes of the various bundles.Comment: Minor revisions and corrections suggested by referees. Final version, to appear in Transformation Group

Two New LBV Candidates in the M33 Galaxy

We present two new luminous blue variable (LBV) candidate stars discovered in the M33 galaxy. We identified these stars (Valeev et al. 2010) as massive star candidates at the final stages of evolution, presumably with a notable interstellar extinction. The candidates were selected from the Massey et al. (2006) catalog based on the following criteria: emission in Halpha, V<18.5 and 0.35<(B-V)<1.2. The spectra of both stars reveal a broad and strong Halpha emission with extended wings (770 and 1000 km/s). Based on the spectra we estimated the main parameters of the stars. Object N45901 has a bolometric luminosity log(L/Lsun)=6.0-6.2 with the value of interstellar extinction Av=2.3+-0.1. The temperature of the star's photosphere is estimated as Tstar~13000-15000K its probable mass on the Zero Age Main Sequence is M~60-80Msun. The infrared excess in N45901 corresponds to the emission of warm dust with the temperature Twarm~1000K, and amounts to 0.1% of the bolometric luminosity. A comparison of stellar magnitude estimates from different catalogs points to the probable variability of the object N45901. Bolometric luminosity of the second object, N125093, is log(L/Lsun)=6.3-6.6, the value of interstellar extinction is Av=2.75+-0.15. We estimate its photosphere's temperature as Tstar~13000-16000K, the initial mass as M~90-120Msun. The infrared excess in N125093 amounts to 5-6% of the bolometric luminosity. Its spectral energy distribution reveals two thermal components with the temperatures Twarm~1000K and Tcold~480K. The [CaII] lines (7291A and 7323A), observed in LBV-like stars VarA and N93351 in M33, are also present in the spectrum of N125093. These lines indicate relatively recent gas eruptions and dust activity linked with them. High bolometric luminosity of these stars and broad Halpha emissions allow classifying the studied objects as LBV candidates.Comment: 14 pages, 4 figure

Stability conditions and Stokes factors

Let A be the category of modules over a complex, finite-dimensional algebra. We show that the space of stability conditions on A parametrises an isomonodromic family of irregular connections on P^1 with values in the Hall algebra of A. The residues of these connections are given by the holomorphic generating function for counting invariants in A constructed by D. Joyce.Comment: Very minor changes. Final version. To appear in Inventione

Electron Beam Nano-Etching in Oxides, Fluorides, Metals and Semiconductors

Etching, lithography, hole formation, surface restructuring and external machining can all be performed on a nanometre scale using an intense electron beam. Results are presented for a range of different materials which demonstrate the variety of mechanisms by which electron beam nano-etching can occur. For example, in crystalline 13-alumina hole formation occurs by surface indentations growing inwards to join up and form a nanometre diameter hole. In amorphous alumina, on the other hand, hole formation is from the inside-out: oxygen gas bubbles form under the electron beam, coalesce, and burst to leave a well defined nanometre diameter hole. In MgO and Si, holes develop from the electron exit surface: whereas in Al voids form along the irradiated volume, leading eventually to the development of a hole at the electron entrance surface. The potential of electron beam nano-etching to lithography and information storage is demonstrated by showing that the entire contents of the Encyclopaedia Britannica can be written on a pinhead