Non-equilibrium mechanics and dynamics of motor activated gels

The mechanics of cells is strongly affected by molecular motors that generate forces in the cellular cytoskeleton. We develop a model for cytoskeletal networks driven out of equilibrium by molecular motors exerting transient contractile stresses. Using this model we show how motor activity can dramatically increase the network's bulk elastic moduli. We also show how motor binding kinetics naturally leads to enhanced low-frequency stress fluctuations that result in non-equilibrium diffusive motion within an elastic network, as seen in recent \emph{in vitro} and \emph{in vivo} experiments.Comment: 21 pages, 8 figure

A new comparison between solid-state thermionics and thermoelectrics

It is shown that equations for electrical current in solid-state thermionic and thermoelectric devices converge for devices with a width equal to the mean free path of electrons, yielding a common expression for intensive electronic efficiency in the two types of devices. This result is used to demonstrate that the materials parameters for thermionic and thermoelectric devices are equal, rather than differing by a multiplicative factor as previously thought

Low-Mass X-ray Binaries and Globular Clusters in Early-Type Galaxies. I. Chandra Observations

We present a Chandra survey of LMXBs in 24 early-type galaxies. Correcting for detection incompleteness, the X-ray luminosity function (XLF) of each galaxy is consistent with a powerlaw with negative logarithmic differential slope, beta~2.0. However, beta strongly correlates with incompleteness, indicating the XLF flattens at low-Lx. The composite XLF is well-fitted by a powerlaw with a break at 2.21(+0.65,-0.56)E38 erg/s and beta=1.40(+0.10,-0.13) and 2.84(+0.39,-0.30) below and above it, respectively. The break is close to the Eddington limit for a 1.4Msun neutron-star, but the XLF shape rules out its representing the division between neutron-star and black-hole systems. Although the XLFs are similar, we find evidence of some variation between galaxies. The high-Lx XLF slope does not correlate with age, but may correlate with [alpha/Fe]. Considering only LMXBs with Lx>1E37 erg/s, matching the LMXBs with globular clusters (GCs) identified in HST observations of 19 of the galaxies, we find the probability a GC hosts an LMXB is proportional to LGC^alpha ZFe^gamma} where alpha=1.01+/-0.19 and gamma=0.33+/-0.11. Correcting for GC luminosity and colour effects, and detection incompleteness, we find no evidence that the fraction of LMXBs with Lx>1e37 erg/s in GCs (40%), or the fraction of GCs hosting LMXBs (~6.5%) varies between galaxies. The spatial distribution of LMXBs resembles that of GCs, and the specific frequency of LMXBs is proportional to the GC specific luminosity, consistent with the hypothesis that all LMXBs form in GCs. If the LMXB lifetime is tau and the duty cycle is Fd, our results imply ~1.5 (tau/1E8 yr)^-1 /Fd LMXBs are formed per Gyr per GC and we place an upper limit of 1 active LMXB in the field per 3.4E9Lsun of V-band luminosity.Comment: 24 pages, 17 figures and 6 tables. Accepted for publication in the Astrophysical Journal. Expanded discussion and various minor revisions to improve robustness of results. Conclusions unchange

VLT and GTC observations of SDSS J0123+00: a type 2 quasar triggered in a galaxy encounter?

We present long-slit spectroscopy, continuum and [OIII]5007 imaging data obtained with the Very Large Telescope and the Gran Telescopio Canarias of the type 2 quasar SDSS J0123+00 at z=0.399. The quasar lies in a complex, gas-rich environment. It appears to be physically connected by a tidal bridge to another galaxy at a projected distance of ~100 kpc, which suggests this is an interacting system. Ionized gas is detected to a distance of at least ~133 kpc from the nucleus. The nebula has a total extension of ~180 kpc. This is one of the largest ionized nebulae ever detected associated with an active galaxy. Based on the environmental properties, we propose that the origin of the nebula is tidal debris from a galactic encounter, which could as well be the triggering mechanism of the nuclear activity. SDSS J0123+00 demonstrates that giant, luminous ionized nebulae can exist associated with type 2 quasars of low radio luminosities, contrary to expectations based on type 1 quasar studies.Comment: 6 pages, 5 figures. Accepted for publication in MNRAS Letter

Increasing concentrations of dichloromethane, CH2Cl2, inferred from CARIBIC air samples collected 1998–2012

Atmospheric concentrations of dichloromethane, CH2Cl2, a regulated toxic air pollutant and minor contributor to stratospheric ozone depletion, were reported to have peaked around 1990 and to be declining in the early part of the 21st century. Recent observations suggest this trend has reversed and that CH2Cl2 is once again increasing in the atmosphere. Despite the importance of ongoing monitoring and reporting of atmospheric CH2Cl2, no time series has been discussed in detail since 2006. The CARIBIC project (Civil Aircraft for the Regular Investigation of the atmosphere Based on an Instrument Container) has analysed the halocarbon content of whole-air samples collected at altitudes of between ~10–12 km via a custom-built container installed on commercial passenger aircraft since 1998, providing a long-term record of CH2Cl2 observations. In this paper we present this unique CH2Cl2 time series, discussing key flight routes which have been used at various times over the past 15 years. Between 1998 and 2012 increases were seen in all northern hemispheric regions and at different altitudes, ranging from ~7–10 ppt in background air to ~13–15 ppt in regions with stronger emissions (equating to a 38–69% increase). Of particular interest is the rising importance of India as a source of atmospheric CH2Cl2: based on CARIBIC data we provide regional emission estimates for the Indian subcontinent and show that regional emissions have increased from 3–14 Gg yr^-1 (1998–2000) to 16–25 Gg yr^-1 (2008). Potential causes of the increasing atmospheric burden of CH2Cl2 are discussed. One possible source is the increased use of CH2Cl2 as a feedstock for the production of HFC-32, a chemical used predominantly as a replacement for ozone-depleting substances in a variety of applications including air conditioners and refrigeration

Nematic and Polar order in Active Filament Solutions

Using a microscopic model of interacting polar biofilaments and motor proteins, we characterize the phase diagram of both homogeneous and inhomogeneous states in terms of experimental parameters. The polarity of motor clusters is key in determining the organization of the filaments in homogeneous isotropic, polarized and nematic states, while motor-induced bundling yields spatially inhomogeneous structures.Comment: 4 pages. 3 figure

VIMOS-VLT spectroscopy of the giant Ly-alpha nebulae associated with three z~2.5 radio galaxies

The morphological and spectroscopic properties of the giant (>60 kpc) Ly-alpha nebulae associated with three radio galaxies at z~2.5 (MRC 1558-003, MRC 2025-218 and MRC 0140-257) have been investigated using integral field spectroscopic data obtained with VIMOS on VLT. The morphologies are varied. The nebula of one source has a centrally peaked, rounded appearance. In the other two objects, it consists of two spatial components. The three nebulae are aligned with the radio axis within <30 deg. The total Ly-alpha luminosities are in the range (0.3-3.4) x 1e44 erg s-1. The Ly-alpha spectral profile shows strong variation through the nebulae, with FWHM values in the range ~400-1500 km s-1 and velocity shifts V~120-600 km s-1. We present an infall model which can explain successfully most Ly-alpha morphological and spectroscopic properties of the nebula associated with MRC 1558-003. This adds further support to our previous conclusion that the _quiescent_ giant nebulae associated with this and other high redshift powerful radio galaxies are in infall. A problem for this model is the difficulty to reproduce the large Ly-alpha FWHM values. We have discovered a giant (~85 kpc) Ly-alpha nebula associated with the radio galaxy MRC 0140-257 at z=2.64. It shows strikingly relaxed kinematics (FWHM2) radio galaxies.Comment: 14 pages, 13 figures. Accepted for publication in MNRA

Trypanocidal efficacy of two indigeneous ethanolic plant extracts (Mimosa pigra and Ipomoea asarifolia) against Trypanosoma evansi phospholipase A2 activity

AbstractObjectiveTo study the inhibitory activity of ethanolic extract from Mimosa pigra and Ipomoea asarifolia against Trypanosoma evansi (T. evansi) calcium dependent phospholipase A2.MethodsThe calcium dependent phospholipase A2 (E C 3.1.1.4) enzyme was isolated from T. evansi and purified to electrophoretic homogeneity under non denaturing conditions. It was solubilized from T. evansi cells recovered from white albino rats which were previously inoculated by intraperitoneal injection of infected camel blood. Two indigeneous ethanolic plant extracts used locally for treatment of trypanosomiasis were tested for the inhibition of phospholipases A2.ResultsDouble reciprocal plots of the initial velocity data of the inhibition by the indigenous plant extracts revealed a noncompetitive pattern of inhibition for the Ipomoea asarifolia and a competitive inhibition for Mimosa pigra in a dose dependent fashion. The extrapolated inhibition binding constant (Ki) of these extracts were found to be 2.0×102 μg/mL and 1.12×102 μg/mL respectively.ConclusionsThe low Ki values obtained for these extracts towards this enzyme are an indication of high affinity of the extract or the active components (present in the plants) are for these enzyme and therefore, could be explored to serve as a cheap source of T. evansi PLA2 antidote and as well help in designing a novel drug with high efficiency

Antihyperglycaemic and hypolipidemic effect of methanol extracts of Ageratum conyzoides L (Asteraceae) in normal and diabetic rats

Purpose: To investigate the antihyperglycaemic and hypolipidemic potential of the methanol extracts of leaf, stem and root of Ageratum conyzoides in streptozotocin (STZ)-induced diabetic rats.Methods: The extract of each of the plant part was obtained by extraction in methanol. A total of 60 male Wistar albino rats (30 induced with diabetes and 30 normoglycaemic) were assigned into diabetic and normoglycaemic groups of 6 rats each. Methanol extracts of leaf, stem and root of Ageratum conyzoides were administered orally at a dose of 100 mg/kg to the rats for a period of 14 days, with glibenclamide as the standard drug (1 mg/kg). Fasting blood glucose and lipid profile were determined to ascertain the antihyperglycaemic and hypolipidemic activities of the different parts of the plant.Results: Ageratum conyzoides significantly (p &lt; 0.05) reduced fasting blood glucose (FBG) levels in diabetic rats by 38.71 ± 19.41 % (leaf), 25.64 ± 20.53 % (stem), and 34.76 ± 18.03 % (root) on day 14 of the treatment, compared with untreated diabetic rats where FBG increased by 11.33±8.91 %. Total cholesterol (leaf, 119.10 ± 8.12 mg/dl; stem, 109.28 ± 8.13 mg/dl) and triglycerides (leaf, 61.71 ± 9.37 mg/dl; stem, 72.45 ± 3.39 mg/dl) levels were also significantly (p &lt; 0.05) lowered in diabetic rats. Low density lipoprotein cholesterol (leaf, 77.21 ± 8.12 mg/dl; stem, 64.76 ± 8.04 mg/dl; root, 79.08 ± 10.61mg/dl) levels were significantly (p &lt; 0.05) lowered in all treated diabetic groups compared with the untreated diabetic rats (103.19 ± 6.08 mg/dl).Conclusion: The results from this study indicate that Ageratum conyzoides has hypoglycaemic and hypolipidemic properties in rats, and this probably justifies its reported use in the traditional management of diabetes mellitus.Keywords: Ageratum conyzoides, Diabetes mellitus, Antihyperglycaemic, Hypolipidemi